EGFR D770_P772dup

CI-VAR-00000548Explore in graph →CIViC 5107

Curated evidence

Evidence by cancer (6 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–6 of 6 evidence items across 1 cancer context on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Malignant Neoplasm6
EGFR D770_P772dup	(oncogenic)	Oncogenic	D	Supports Oncogenicity	1	submitted	EID12298 NIH3T3 cells transfected with the variant P772_H773insDNP, also known as D770_P772dup, results in focus formation. PMID 33395611 · Hirose et al., 2021 · Open in CIViC	civic
EGFR D770_P772dup	Afatinib	Predictive	D	Supports Resistance	2	submitted	EID12300 Sensitivity of a series of EGFR exon 20 insertion mutations to EGFR tyrosine kinase inhibitors was assessed using in vitro and in vivo mixed-all-nominated-in-one (MANO) method (PMID: 29141884) as well… (full text at CIViC) PMID 33395611 · Hirose et al., 2021 · Open in CIViC	civic
EGFR D770_P772dup

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.