Malignant Uterine Corpus Neoplasm — Genomics

Malignant Uterine Corpus Neoplasm — Genomics · CancerIndex

Genomics

Gene alteration frequencies by cohort

20 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.

Endometrial cancer HR-positive (MSK, 2024) uec_msk_2024MSK

23 cases with simple somatic mutation data · 24 cases total · 2026-01-20 · mapped to Endometrial Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	PTEN	Ssm	15

Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.

Endometrial Cancer (MSK, 2018) ucec_msk_2018MSK

197 cases with simple somatic mutation data · 197 cases total · 2026-01-13 · mapped to Endometrial Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	107	197	54.3%	cbioportal
2	PIK3CA	Ssm	80	197	40.6%	cbioportal
3	ARID1A	Ssm	59	197	29.9%	cbioportal
4	PTEN	Ssm	57	197	28.9%	cbioportal
5	PIK3R1	Ssm	46	197	23.4%	cbioportal
6	KRAS	Ssm	42	197	21.3%	cbioportal
7	KMT2D	Ssm	32	197	16.2%	cbioportal
8	CTNNB1	Ssm	30	197	15.2%	cbioportal
9	PPP2R1A	Ssm	30	197	15.2%	cbioportal
10	FBXW7	Ssm	28	197	14.2%	cbioportal
18	ZFHX3	Ssm	16	128	12.5%	cbioportal
11	CTCF	Ssm	23	197	11.7%	cbioportal
12	BCOR	Ssm	20	197	10.2%	cbioportal
13	ATM	Ssm	19	197	9.6%	cbioportal
14	FAT1	Ssm	19	197	9.6%	cbioportal
15	JAK1	Ssm	19	197	9.6%	cbioportal
16	KMT2C	Ssm	17	197	8.6%	cbioportal
17	NOTCH3	Ssm	16	197	8.1%	cbioportal
20	MTOR	Ssm	15	197	7.6%	cbioportal
19	MED12	Ssm	15	197	7.6%	cbioportal
21	SMARCA4	Ssm	15	197	7.6%	cbioportal
23	SPEN	Ssm	14	197	7.1%	cbioportal
22	EP300	Ssm	14	197	7.1%	cbioportal
24	AKT1	Ssm	13	197	6.6%	cbioportal
28	TSC2	Ssm	13	197	6.6%	cbioportal
27	KDM5C	Ssm	13	197	6.6%	cbioportal
26	FGFR2	Ssm	13	197	6.6%	cbioportal
25	ARID1B	Ssm	13	197	6.6%	cbioportal
54	ANKRD11	Ssm	8	128	6.3%	cbioportal
29	ERBB3	Ssm	12	197	6.1%	cbioportal

Data updated 21 days agoSource updated 2026-01-13

Endometrial Cancer (MSK, Cancer Discovery 2023) ucec_ancestry_cds_msk_2023MSK

1,882 cases with simple somatic mutation data · 1,882 cases total · 2026-01-13 · mapped to Endometrial Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	PTEN	Ssm	941	1,882	50%	cbioportal
2	TP53	Ssm	850	1,882	45.2%	cbioportal
3	PIK3CA	Ssm	824	1,882	43.8%	cbioportal
4	ARID1A	Ssm	793	1,882	42.1%	cbioportal
5	PIK3R1	Ssm	484	1,882	25.7%	cbioportal
6	KRAS	Ssm	357	1,882	19%	cbioportal
7	CTCF	Ssm	305	1,882	16.2%	cbioportal
8	CTNNB1	Ssm	296	1,882	15.7%	cbioportal
9	FBXW7	Ssm	276	1,882	14.7%	cbioportal
10	ZFHX3	Ssm	237	1,824	13%	cbioportal
13	KMT2B	Ssm	208	1,661	12.5%	cbioportal
11	KMT2D	Ssm	231	1,882	12.3%	cbioportal
12	PPP2R1A	Ssm	226	1,882	12%	cbioportal
15	INPPL1	Ssm	171	1,661	10.3%	cbioportal
14	BCOR	Ssm	184	1,882	9.8%	cbioportal
16	JAK1	Ssm	171	1,882	9.1%	cbioportal
17	RNF43	Ssm	154	1,882	8.2%	cbioportal
18	FGFR2	Ssm	151	1,882	8%	cbioportal
19	ATM	Ssm	139	1,882	7.4%	cbioportal
20	NF1	Ssm	118	1,882	6.3%	cbioportal
21	NSD1	Ssm	103	1,882	5.5%	cbioportal
22	ARID1B	Ssm	102	1,882	5.4%	cbioportal
23	ARID5B	Ssm	96	1,882	5.1%	cbioportal
24	KMT2C	Ssm	96	1,882	5.1%	cbioportal
25	SOX17	Ssm	93	1,882	4.9%	cbioportal
26	CCND1	Ssm	92	1,882	4.9%	cbioportal
27	FAT1	Ssm	91	1,882	4.8%	cbioportal
28	POLE	Ssm	91	1,882	4.8%	cbioportal
29	MED12	Ssm	89	1,882	4.7%	cbioportal
30	RASA1	Ssm	88	1,882	4.7%	cbioportal

Data updated 21 days agoSource updated 2026-01-13

Endometrial Carcinoma cfDNA (MSK, Clin Cancer Res 2022) ucec_ccr_cfdna_msk_2022MSK

44 cases with simple somatic mutation data · 44 cases total · 2026-01-13 · mapped to Endometrial Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	22	44	50%	cbioportal
2	PIK3CA	Ssm	21	44	47.7%	cbioportal
3	PTEN	Ssm	21	44	47.7%	cbioportal
4	ARID1A	Ssm	15	44	34.1%	cbioportal
5	FBXW7	Ssm	12	44	27.3%	cbioportal
6	KRAS	Ssm	11	44	25%	cbioportal
7	PIK3R1	Ssm	9	44	20.5%	cbioportal
8	CTCF	Ssm	8	44	18.2%	cbioportal
9	KMT2A	Ssm	8	44	18.2%	cbioportal
10	KMT2B	Ssm	8	44	18.2%	cbioportal
11	KMT2D	Ssm	7	44	15.9%	cbioportal
12	JAK1	Ssm	6	44	13.6%	cbioportal
13	BCOR	Ssm	5	44	11.4%	cbioportal
14	EP300	Ssm	5	44	11.4%	cbioportal
15	INPPL1	Ssm	5	44	11.4%	cbioportal
16	NFE2L2	Ssm	5	44	11.4%	cbioportal
17	POLD1	Ssm	5	44	11.4%	cbioportal
18	RNF43	Ssm	5	44	11.4%	cbioportal
19	ZFHX3	Ssm	5	44	11.4%	cbioportal
20	AR	Ssm	4	44	9.1%	cbioportal
21	ATR	Ssm	4	44	9.1%	cbioportal
22	CREBBP	Ssm	4	44	9.1%	cbioportal
23	ERF	Ssm	4	44	9.1%	cbioportal
24	NOTCH4	Ssm	4	44	9.1%	cbioportal
25	PBRM1	Ssm	4	44	9.1%	cbioportal
26	PGR	Ssm	4	44	9.1%	cbioportal
28	RRAS2	Ssm	4	44	9.1%	cbioportal
27	PPP2R1A	Ssm	4	44	9.1%	cbioportal
34	EGFR	Ssm	3	44	6.8%	cbioportal
29	ANKRD11	Ssm	3	44	6.8%	cbioportal

Data updated 21 days agoSource updated 2026-01-13

Endometrial Carcinoma (CPTAC, Cell 2020) ucec_cptac_2020CPTAC

95 cases with simple somatic mutation data · 81 cases total · 2026-01-13 · mapped to Endometrial Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	PTEN	Ssm	75	95	78.9%	cbioportal
2	PIK3CA	Ssm	47	95	49.5%	cbioportal
3	ARID1A	Ssm	43	95	45.3%	cbioportal
4	PIK3R1	Ssm	36	95	37.9%	cbioportal
5	KRAS	Ssm	31	95	32.6%	cbioportal
6	CTNNB1	Ssm	29	95	30.5%	cbioportal
7	CTCF	Ssm	27	95	28.4%	cbioportal
8	KMT2B	Ssm	23	95	24.2%	cbioportal
10	ZFHX3	Ssm	21	95	22.1%	cbioportal
9	TP53	Ssm	21	95	22.1%	cbioportal
12	INPPL1	Ssm	19	95	20%	cbioportal
13	ZFHX4	Ssm	19	95	20%	cbioportal
11	DOCK3	Ssm	19	95	20%	cbioportal
14	FBXW7	Ssm	18	95	18.9%	cbioportal
15	MUC16	Ssm	18	95	18.9%	cbioportal
17	KMT2D	Ssm	17	95	17.9%	cbioportal
16	HERC2	Ssm	17	95	17.9%	cbioportal
20	NSD1	Ssm	16	95	16.8%	cbioportal
25	SYNE1	Ssm	16	95	16.8%	cbioportal
24	SCAF4	Ssm	16	95	16.8%	cbioportal
23	RPL22	Ssm	16	95	16.8%	cbioportal
22	RBM27	Ssm	16	95	16.8%	cbioportal
21	PCLO	Ssm	16	95	16.8%	cbioportal
18	JAK1	Ssm	16	95	16.8%	cbioportal
19	LRTM3	Ssm	16	95	16.8%	cbioportal
28	HUWE1	Ssm	15	95	15.8%	cbioportal
27	DNAH17	Ssm	15	95	15.8%	cbioportal
26	AHNAK	Ssm	15	95	15.8%	cbioportal
31	ZNF469	Ssm	15	95	15.8%	cbioportal
29	LMAN1	Ssm	15	95	15.8%	cbioportal

Data updated 21 days agoSource updated 2026-01-13

Endometrial Carcinoma MSI (MSK, Clin Cancer Res 2022) ucec_ccr_msk_2022MSK

181 cases with simple somatic mutation data · 181 cases total · 2026-01-13 · mapped to Endometrial Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	ARID1A	Ssm	160	181	88.4%	cbioportal
2	PTEN	Ssm	156	181	86.2%	cbioportal
3	KMT2D	Ssm	122	181	67.4%	cbioportal
5	KMT2B	Ssm	106	169	62.7%	cbioportal
4	PIK3CA	Ssm	112	181	61.9%	cbioportal
6	CTCF	Ssm	101	181	55.8%	cbioportal
8	INPPL1	Ssm	86	169	50.9%	cbioportal
7	ZFHX3	Ssm	90	180	50%	cbioportal
10	RNF43	Ssm	76	181	42%	cbioportal
9	JAK1	Ssm	76	181	42%	cbioportal
11	ARID1B	Ssm	67	181	37%	cbioportal
13	PIK3R1	Ssm	62	181	34.3%	cbioportal
12	FAT1	Ssm	62	181	34.3%	cbioportal
14	CIC	Ssm	54	181	29.8%	cbioportal
15	NOTCH3	Ssm	53	181	29.3%	cbioportal
16	ANKRD11	Ssm	51	180	28.3%	cbioportal
17	BCOR	Ssm	51	181	28.2%	cbioportal
18	KMT2C	Ssm	51	181	28.2%	cbioportal
19	CREBBP	Ssm	50	181	27.6%	cbioportal
20	MSH6	Ssm	48	181	26.5%	cbioportal
21	SMARCA4	Ssm	48	181	26.5%	cbioportal
23	POLD1	Ssm	47	180	26.1%	cbioportal
22	KRAS	Ssm	47	181	26%	cbioportal
24	FGFR2	Ssm	46	181	25.4%	cbioportal
26	SPEN	Ssm	46	181	25.4%	cbioportal
25	PTPRS	Ssm	46	181	25.4%	cbioportal
27	IRS2	Ssm	45	181	24.9%	cbioportal
28	FBXW7	Ssm	44	181	24.3%	cbioportal
30	CCND1	Ssm	43	181	23.8%	cbioportal
29	ATM	Ssm	43	181	23.8%	cbioportal

Data updated 21 days agoSource updated 2026-01-13

Endometrial Carcinoma (MSK, Molecular Oncology 2024) ucs_msk_2024MSK

69 cases with simple somatic mutation data · 69 cases total · 2026-03-09 · mapped to Endometrial Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	ERBB2	Ssm	69	69	100%	cbioportal
2	ARID1A	Ssm	47	69	68.1%	cbioportal
3	PIK3CA	Ssm	41	69	59.4%	cbioportal
4	PTEN	Ssm	40	69	58%	cbioportal
6	TP53	Ssm	35	69	50.7%	cbioportal
5	KMT2D	Ssm	35	69	50.7%	cbioportal
7	FBXW7	Ssm	27	69	39.1%	cbioportal
15	KMT2B	Ssm	20	57	35.1%	cbioportal
8	FAT1	Ssm	24	69	34.8%	cbioportal
9	NOTCH3	Ssm	24	69	34.8%	cbioportal
10	ZFHX3	Ssm	23	68	33.8%	cbioportal
104	ARHGAP35	Ssm	8	25	32%	cbioportal
11	NOTCH1	Ssm	22	69	31.9%	cbioportal
12	ERBB3	Ssm	21	69	30.4%	cbioportal
13	KMT2C	Ssm	21	69	30.4%	cbioportal
14	ATM	Ssm	20	69	29%	cbioportal
16	POLE	Ssm	20	69	29%	cbioportal
18	CREBBP	Ssm	19	69	27.5%	cbioportal
19	SMARCA4	Ssm	19	69	27.5%	cbioportal
17	ARID1B	Ssm	19	69	27.5%	cbioportal
20	ANKRD11	Ssm	18	68	26.5%	cbioportal
33	DROSHA	Ssm	15	57	26.3%	cbioportal
34	INPPL1	Ssm	15	57	26.3%	cbioportal
21	BCOR	Ssm	18	69	26.1%	cbioportal
23	NSD1	Ssm	18	69	26.1%	cbioportal
22	MSH2	Ssm	18	69	26.1%	cbioportal
24	PIK3R1	Ssm	18	69	26.1%	cbioportal
25	CTCF	Ssm	17	69	24.6%	cbioportal
27	SPEN	Ssm	17	69	24.6%	cbioportal
26	PPP2R1A	Ssm	17	69	24.6%	cbioportal

Data updated 21 days agoSource updated 2026-03-09

Endometrial Carcinoma (TCGA GDC, 2025) ucec_tcga_gdcTCGA GDC

511 cases with simple somatic mutation data · 547 cases total · 2026-01-14 · mapped to Endometrial Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	PTEN	Ssm	334	511	65.4%	cbioportal
2	PIK3CA	Ssm	252	511	49.3%	cbioportal
3	ARID1A	Ssm	235	511	46%	cbioportal
4	TTN	Ssm	194	511	38%	cbioportal
5	TP53	Ssm	190	511	37.2%	cbioportal
6	PIK3R1	Ssm	166	511	32.5%	cbioportal
7	KMT2D	Ssm	140	511	27.4%	cbioportal
8	CTNNB1	Ssm	130	511	25.4%	cbioportal
9	MUC16	Ssm	127	511	24.9%	cbioportal
10	CTCF	Ssm	126	511	24.7%	cbioportal
11	CSMD3	Ssm	121	511	23.7%	cbioportal
12	ZFHX3	Ssm	118	511	23.1%	cbioportal
13	RYR2	Ssm	116	511	22.7%	cbioportal
14	KMT2B	Ssm	114	511	22.3%	cbioportal
15	OBSCN	Ssm	111	511	21.7%	cbioportal
16	DST	Ssm	109	511	21.3%	cbioportal
18	ZFHX4	Ssm	105	511	20.5%	cbioportal
17	MUC5B	Ssm	105	511	20.5%	cbioportal
19	CHD4	Ssm	104	511	20.4%	cbioportal
20	FAT1	Ssm	104	511	20.4%	cbioportal
21	SYNE1	Ssm	103	511	20.2%	cbioportal
22	DNAH7	Ssm	102	511	20%	cbioportal
23	MACF1	Ssm	102	511	20%	cbioportal
25	TAF1	Ssm	101	511	19.8%	cbioportal
24	FAT4	Ssm	101	511	19.8%	cbioportal
26	ARHGAP35	Ssm	98	511	19.2%	cbioportal
27	PCLO	Ssm	98	511	19.2%	cbioportal
30	DNAH5	Ssm	96	511	18.8%	cbioportal
28	ATM	Ssm	96	511	18.8%	cbioportal
29	DMD	Ssm	96	511	18.8%	cbioportal

Data updated 21 days agoSource updated 2026-01-14

Evolution and co-occurrence of PI3K pathway gene mutations in endometrial carcinoma molecular subtypes at the single-cell level ucec_msk_dacruzpaula_2025

11 cases with simple somatic mutation data · 11 cases total · 2026-01-20 · mapped to Endometrial Carcinoma EXACT_IDENTIFIER

cbioportalObserved25 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	PTEN	Ssm	10	11	90.9%	cbioportal
2	PIK3R1	Ssm	9	11	81.8%	cbioportal
3	PIK3CA	Ssm	7	11	63.6%	cbioportal
4	CTCF	Ssm	5	11	45.5%	cbioportal
5	FGFR2	Ssm	4	11	36.4%	cbioportal
6	ARID1A	Ssm	3	11	27.3%	cbioportal
7	KRAS	Ssm	3	11	27.3%	cbioportal
8	TP53	Ssm	3	11	27.3%	cbioportal
14	PDGFRA	Ssm	2	11	18.2%	cbioportal
9	ATM	Ssm	2	11	18.2%	cbioportal
10	CTNNB1	Ssm	2	11	18.2%	cbioportal
11	EGFR	Ssm	2	11	18.2%	cbioportal
12	ERBB4	Ssm	2	11	18.2%	cbioportal
13	FBXW7	Ssm	2	11	18.2%	cbioportal
21	NOTCH1	Ssm	1	11	9.1%	cbioportal
23	SMAD4	Ssm	1	11	9.1%	cbioportal
22	RB1	Ssm	1	11	9.1%	cbioportal
20	MTOR	Ssm	1	11	9.1%	cbioportal
19	MET	Ssm	1	11	9.1%	cbioportal
18	HRAS	Ssm	1	11	9.1%	cbioportal
17	HNF1A	Ssm	1	11	9.1%	cbioportal
16	GNAQ	Ssm	1	11	9.1%	cbioportal
15	BRAF	Ssm	1	11	9.1%	cbioportal
25	VHL	Ssm	1	11	9.1%	cbioportal
24	SMARCB1	Ssm	1	11	9.1%	cbioportal

Data updated 21 days agoSource updated 2026-01-20

Uterine Carcinosarcoma (Johns Hopkins, Nat Commun 2014) ucs_jhu_2014Johns Hopkins

22 cases with simple somatic mutation data · 22 cases total · 2026-01-16 · mapped to Uterine Malignant Mixed Mesodermal (Mullerian) Tumor EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	16	22	72.7%	cbioportal
2	PIK3CA	Ssm	9	22	40.9%	cbioportal
3	PTEN	Ssm	9	22	40.9%	cbioportal
4	ARID1A	Ssm	8	22	36.4%	cbioportal
6	KRAS	Ssm	6	22	27.3%	cbioportal
5	KMT2C	Ssm	6	22	27.3%	cbioportal
7	PXDNL	Ssm	6	22	27.3%	cbioportal
8	TTN	Ssm	6	22	27.3%	cbioportal
17	LRP2	Ssm	5	22	22.7%	cbioportal
9	APOB	Ssm	5	22	22.7%	cbioportal
10	BCOR	Ssm	5	22	22.7%	cbioportal
11	BLTP1	Ssm	5	22	22.7%	cbioportal
12	CDHR3	Ssm	5	22	22.7%	cbioportal
13	CNTNAP2	Ssm	5	22	22.7%	cbioportal
14	FAM135B	Ssm	5	22	22.7%	cbioportal
15	FBXW7	Ssm	5	22	22.7%	cbioportal
16	HMCN1	Ssm	5	22	22.7%	cbioportal
18	LTBP2	Ssm	5	22	22.7%	cbioportal
19	MDN1	Ssm	5	22	22.7%	cbioportal
20	PLEC	Ssm	5	22	22.7%	cbioportal
21	SPEG	Ssm	5	22	22.7%	cbioportal
22	SPTBN5	Ssm	5	22	22.7%	cbioportal
23	TRRAP	Ssm	5	22	22.7%	cbioportal
24	URB1	Ssm	5	22	22.7%	cbioportal
26	ABI3BP	Ssm	4	22	18.2%	cbioportal
27	ADAMTSL4	Ssm	4	22	18.2%	cbioportal
28	ADGRF4	Ssm	4	22	18.2%	cbioportal
29	ADGRG4	Ssm	4	22	18.2%	cbioportal
25	A2M	Ssm	4	22	18.2%	cbioportal
85	FNDC1	Ssm	4	22	18.2%	cbioportal

Data updated 21 days agoSource updated 2026-01-16

Uterine Carcinosarcoma (TCGA, Firehose Legacy) ucs_tcgaTCGA

57 cases with simple somatic mutation data · 57 cases total · 2026-01-13 · mapped to Uterine Malignant Mixed Mesodermal (Mullerian) Tumor EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	52	57	91.2%	cbioportal
2	FBXW7	Ssm	22	57	38.6%	cbioportal
3	FRG1BP	Ssm	21	57	36.8%	cbioportal
4	PIK3CA	Ssm	20	57	35.1%	cbioportal
5	PPP2R1A	Ssm	16	57	28.1%	cbioportal
6	MUC4	Ssm	13	57	22.8%	cbioportal
7	PTEN	Ssm	11	57	19.3%	cbioportal
9	TTN	Ssm	10	57	17.5%	cbioportal
8	CHD4	Ssm	10	57	17.5%	cbioportal
10	ARID1A	Ssm	8	57	14%	cbioportal
11	KRAS	Ssm	7	57	12.3%	cbioportal
13	MUC17	Ssm	7	57	12.3%	cbioportal
12	LRP1B	Ssm	7	57	12.3%	cbioportal
23	ZBTB7B	Ssm	6	57	10.5%	cbioportal
24	ZNF814	Ssm	6	57	10.5%	cbioportal
22	VPS13B	Ssm	6	57	10.5%	cbioportal
21	SYNE1	Ssm	6	57	10.5%	cbioportal
20	RB1	Ssm	6	57	10.5%	cbioportal
19	PIK3R1	Ssm	6	57	10.5%	cbioportal
18	MUC16	Ssm	6	57	10.5%	cbioportal
17	MGAM	Ssm	6	57	10.5%	cbioportal
16	KMT2D	Ssm	6	57	10.5%	cbioportal
15	FLNA	Ssm	6	57	10.5%	cbioportal
14	ARHGAP35	Ssm	6	57	10.5%	cbioportal
25	ATP4A	Ssm	5	57	8.8%	cbioportal
26	DOP1A	Ssm	5	57	8.8%	cbioportal
27	FCGBP	Ssm	5	57	8.8%	cbioportal
28	FER1L6	Ssm	5	57	8.8%	cbioportal
29	FLG	Ssm	5	57	8.8%	cbioportal
30	LRP2	Ssm	5	57	8.8%	cbioportal

Data updated 21 days agoSource updated 2026-01-13

Uterine Carcinosarcoma (TCGA, PanCancer Atlas) ucs_tcga_pan_can_atlas_2018TCGA

57 cases with simple somatic mutation data · 57 cases total · 2026-06-05 · mapped to Uterine Malignant Mixed Mesodermal (Mullerian) Tumor EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	52	57	91.2%	cbioportal
2	FBXW7	Ssm	22	57	38.6%	cbioportal
3	PIK3CA	Ssm	20	57	35.1%	cbioportal
4	PPP2R1A	Ssm	16	57	28.1%	cbioportal
5	PTEN	Ssm	11	57	19.3%	cbioportal
6	TTN	Ssm	11	57	19.3%	cbioportal
7	CHD4	Ssm	10	57	17.5%	cbioportal
8	ARID1A	Ssm	7	57	12.3%	cbioportal
9	KRAS	Ssm	7	57	12.3%	cbioportal
13	KMT2D	Ssm	6	57	10.5%	cbioportal
19	ZBTB7B	Ssm	6	57	10.5%	cbioportal
18	VPS13B	Ssm	6	57	10.5%	cbioportal
17	SYNE1	Ssm	6	57	10.5%	cbioportal
16	PIK3R1	Ssm	6	57	10.5%	cbioportal
15	MUC16	Ssm	6	57	10.5%	cbioportal
14	MGAM	Ssm	6	57	10.5%	cbioportal
12	FLNA	Ssm	6	57	10.5%	cbioportal
11	ARHGAP35	Ssm	6	57	10.5%	cbioportal
10	AHNAK	Ssm	6	57	10.5%	cbioportal
21	FER1L6	Ssm	5	57	8.8%	cbioportal
20	DOP1A	Ssm	5	57	8.8%	cbioportal
22	FLG	Ssm	5	57	8.8%	cbioportal
23	LRP1B	Ssm	5	57	8.8%	cbioportal
24	LRP2	Ssm	5	57	8.8%	cbioportal
25	MUC17	Ssm	5	57	8.8%	cbioportal
26	RB1	Ssm	5	57	8.8%	cbioportal
27	ABCA12	Ssm	4	57	7%	cbioportal
28	ADAMTSL1	Ssm	4	57	7%	cbioportal
29	BRWD1	Ssm	4	57	7%	cbioportal
30	COL11A1	Ssm	4	57	7%	cbioportal

Data updated 21 days agoSource updated 2026-06-05

Uterine Carcinosarcoma/Uterine Malignant Mixed Mullerian Tumor (TCGA GDC, 2025) ucs_tcga_gdcTCGA GDC

57 cases with simple somatic mutation data · 57 cases total · 2026-01-14 · mapped to Uterine Malignant Mixed Mesodermal (Mullerian) Tumor EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	49	57	86%	cbioportal
2	FBXW7	Ssm	22	57	38.6%	cbioportal
3	PIK3CA	Ssm	20	57	35.1%	cbioportal
4	PPP2R1A	Ssm	16	57	28.1%	cbioportal
5	PTEN	Ssm	11	57	19.3%	cbioportal
6	CHD4	Ssm	10	57	17.5%	cbioportal
7	PIK3R1	Ssm	9	57	15.8%	cbioportal
9	KRAS	Ssm	7	57	12.3%	cbioportal
10	TTN	Ssm	7	57	12.3%	cbioportal
8	ARID1A	Ssm	7	57	12.3%	cbioportal
12	ARHGAP35	Ssm	6	57	10.5%	cbioportal
16	MGAM	Ssm	6	57	10.5%	cbioportal
14	KMT2D	Ssm	6	57	10.5%	cbioportal
13	FLNA	Ssm	6	57	10.5%	cbioportal
15	LRP2	Ssm	6	57	10.5%	cbioportal
17	SYNE1	Ssm	6	57	10.5%	cbioportal
18	ZBTB7B	Ssm	6	57	10.5%	cbioportal
11	AHNAK	Ssm	6	57	10.5%	cbioportal
23	VPS13B	Ssm	5	57	8.8%	cbioportal
20	MUC16	Ssm	5	57	8.8%	cbioportal
21	MUC17	Ssm	5	57	8.8%	cbioportal
19	DOP1A	Ssm	5	57	8.8%	cbioportal
22	RB1	Ssm	5	57	8.8%	cbioportal
32	EPHA5	Ssm	4	57	7%	cbioportal
34	FAM135B	Ssm	4	57	7%	cbioportal
33	ERBB3	Ssm	4	57	7%	cbioportal
35	FLG	Ssm	4	57	7%	cbioportal
36	FMN2	Ssm	4	57	7%	cbioportal
37	GPRASP1	Ssm	4	57	7%	cbioportal
31	EPG5	Ssm	4	57	7%	cbioportal

Data updated 21 days agoSource updated 2026-01-14

Uterine Clear Cell Carcinoma (NIH, Cancer 2017) uccc_nih_2017NIH

16 cases with simple somatic mutation data · 16 cases total · 2026-01-13 · mapped to Human Papillomavirus-Independent Cervical Adenocarcinoma, Clear Cell-Type EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	7	16	43.8%	cbioportal
2	KMT2C	Ssm	5	16	31.3%	cbioportal
4	ZNF717	Ssm	4	16	25%	cbioportal
3	TAF1	Ssm	4	16	25%	cbioportal
7	PIK3CA	Ssm	3	16	18.8%	cbioportal
5	AGAP4	Ssm	3	16	18.8%	cbioportal
6	FAM136A	Ssm	3	16	18.8%	cbioportal
45	PPP2R1A	Ssm	2	16	12.5%	cbioportal
43	PI4KA	Ssm	2	16	12.5%	cbioportal
42	PHLPP1	Ssm	2	16	12.5%	cbioportal
41	PAF1	Ssm	2	16	12.5%	cbioportal
40	MYH3	Ssm	2	16	12.5%	cbioportal
39	MIB2	Ssm	2	16	12.5%	cbioportal
38	MAP3K9	Ssm	2	16	12.5%	cbioportal
37	MAGEE1	Ssm	2	16	12.5%	cbioportal
36	MAGED2	Ssm	2	16	12.5%	cbioportal
35	LTN1	Ssm	2	16	12.5%	cbioportal
34	LRRN2	Ssm	2	16	12.5%	cbioportal
33	LMCD1	Ssm	2	16	12.5%	cbioportal
32	GXYLT1	Ssm	2	16	12.5%	cbioportal
31	GRAMD4	Ssm	2	16	12.5%	cbioportal
30	GART	Ssm	2	16	12.5%	cbioportal
29	FRG2C	Ssm	2	16	12.5%	cbioportal
28	FRG1	Ssm	2	16	12.5%	cbioportal
46	PPP6R1	Ssm	2	16	12.5%	cbioportal
44	PIK3R1	Ssm	2	16	12.5%	cbioportal
47	PRKDC	Ssm	2	16	12.5%	cbioportal
48	REXO1L1P	Ssm	2	16	12.5%	cbioportal
49	RNF145	Ssm	2	16	12.5%	cbioportal
50	RPSA	Ssm	2	16	12.5%	cbioportal

Data updated 21 days agoSource updated 2026-01-13

Uterine Corpus Endometrial Carcinoma TCGA-UCECTCGA

559 cases with simple somatic mutation data · 560 cases total · Data Release 46.0 · mapped to Endometrial Carcinoma ONTOLOGY_EXACT

gdcObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	PTEN	Ssm	418	559	74.8%	gdc
2	PIK3CA	Ssm	349	559	62.4%	gdc
3	ARID1A	Ssm	319	559	57.1%	gdc
4	TTN	Ssm	297	559	53.1%	gdc
5	OBSCN	Ssm	296	559	53%	gdc
6	RYR2	Ssm	291	559	52.1%	gdc
7	ASH1L	Ssm	289	559	51.7%	gdc
8	USH2A	Ssm	286	559	51.2%	gdc
9	FLG	Ssm	283	559	50.6%	gdc
10	CACNA1E	Ssm	281	559	50.3%	gdc
11	HMCN1	Ssm	278	559	49.7%	gdc
14	CEP350	Ssm	277	559	49.6%	gdc
13	HRNR	Ssm	277	559	49.6%	gdc
12	CSMD3	Ssm	277	559	49.6%	gdc
15	CTCF	Ssm	276	559	49.4%	gdc
17	ASPM	Ssm	275	559	49.2%	gdc
16	GON4L	Ssm	275	559	49.2%	gdc
18	ZFHX3	Ssm	275	559	49.2%	gdc
19	NFASC	Ssm	271	559	48.5%	gdc
20	CSMD1	Ssm	270	559	48.3%	gdc
21	PDE4DIP	Ssm	269	559	48.1%	gdc
22	SPTA1	Ssm	269	559	48.1%	gdc
23	INSRR	Ssm	269	559	48.1%	gdc
24	SETDB1	Ssm	267	559	47.8%	gdc
25	F5	Ssm	266	559	47.6%	gdc
26	MUC16	Ssm	266	559	47.6%	gdc
27	COPA	Ssm	266	559	47.6%	gdc
29	ARHGEF2	Ssm	265	559	47.4%	gdc
28	PRRC2C	Ssm	265	559	47.4%	gdc
31	NES	Ssm	264	559	47.2%	gdc

Data updated 22 days agoSource updated Data Release 46.0

Uterine Corpus Endometrial Carcinoma (TCGA, Firehose Legacy) ucec_tcgaTCGA

248 cases with simple somatic mutation data · 549 cases total · 2026-01-13 · mapped to Endometrial Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	PTEN	Ssm	161	248	64.9%	cbioportal
2	PIK3CA	Ssm	132	248	53.2%	cbioportal
3	ARID1A	Ssm	83	248	33.5%	cbioportal
4	PIK3R1	Ssm	82	248	33.1%	cbioportal
5	TTN	Ssm	79	248	31.9%	cbioportal
6	CTNNB1	Ssm	74	248	29.8%	cbioportal
7	TP53	Ssm	69	248	27.8%	cbioportal
8	KRAS	Ssm	52	248	21%	cbioportal
9	MUC16	Ssm	48	248	19.4%	cbioportal
10	CSMD3	Ssm	47	248	19%	cbioportal
11	CTCF	Ssm	45	248	18.1%	cbioportal
12	ZFHX3	Ssm	44	248	17.7%	cbioportal
13	MUC5B	Ssm	43	248	17.3%	cbioportal
14	RYR2	Ssm	41	248	16.5%	cbioportal
16	FAT4	Ssm	40	248	16.1%	cbioportal
15	FAT1	Ssm	40	248	16.1%	cbioportal
17	OBSCN	Ssm	39	248	15.7%	cbioportal
19	FBXW7	Ssm	38	248	15.3%	cbioportal
18	DMD	Ssm	38	248	15.3%	cbioportal
20	NEB	Ssm	37	248	14.9%	cbioportal
23	ZFHX4	Ssm	36	248	14.5%	cbioportal
21	ARHGAP35	Ssm	36	248	14.5%	cbioportal
22	FAT3	Ssm	36	248	14.5%	cbioportal
26	TAF1	Ssm	35	248	14.1%	cbioportal
24	CHD4	Ssm	35	248	14.1%	cbioportal
25	DNAH5	Ssm	35	248	14.1%	cbioportal
27	USH2A	Ssm	35	248	14.1%	cbioportal
28	RYR3	Ssm	34	248	13.7%	cbioportal
31	KMT2D	Ssm	33	248	13.3%	cbioportal
29	ANK3	Ssm	33	248	13.3%	cbioportal

Data updated 21 days agoSource updated 2026-01-13

Uterine Corpus Endometrial Carcinoma (TCGA, Nature 2013) ucec_tcga_pubTCGA

248 cases with simple somatic mutation data · 373 cases total · 2026-01-16 · mapped to Endometrial Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	PTEN	Ssm	161	248	64.9%	cbioportal
2	PIK3CA	Ssm	132	248	53.2%	cbioportal
3	ARID1A	Ssm	83	248	33.5%	cbioportal
4	PIK3R1	Ssm	81	248	32.7%	cbioportal
5	TTN	Ssm	79	248	31.9%	cbioportal
6	CTNNB1	Ssm	74	248	29.8%	cbioportal
7	TP53	Ssm	69	248	27.8%	cbioportal
8	KRAS	Ssm	52	248	21%	cbioportal
9	MUC16	Ssm	48	248	19.4%	cbioportal
10	CSMD3	Ssm	47	248	19%	cbioportal
11	CTCF	Ssm	45	248	18.1%	cbioportal
12	ZFHX3	Ssm	44	248	17.7%	cbioportal
13	MUC5B	Ssm	43	248	17.3%	cbioportal
14	RYR2	Ssm	41	248	16.5%	cbioportal
15	FAT1	Ssm	40	248	16.1%	cbioportal
16	FAT4	Ssm	40	248	16.1%	cbioportal
17	OBSCN	Ssm	39	248	15.7%	cbioportal
18	DMD	Ssm	38	248	15.3%	cbioportal
19	FBXW7	Ssm	38	248	15.3%	cbioportal
20	NEB	Ssm	37	248	14.9%	cbioportal
23	ZFHX4	Ssm	36	248	14.5%	cbioportal
21	ARHGAP35	Ssm	36	248	14.5%	cbioportal
22	FAT3	Ssm	36	248	14.5%	cbioportal
24	CHD4	Ssm	35	248	14.1%	cbioportal
27	USH2A	Ssm	35	248	14.1%	cbioportal
26	TAF1	Ssm	35	248	14.1%	cbioportal
25	DNAH5	Ssm	35	248	14.1%	cbioportal
28	RYR3	Ssm	34	248	13.7%	cbioportal
30	DNAH10	Ssm	33	248	13.3%	cbioportal
29	ANK3	Ssm	33	248	13.3%	cbioportal

Data updated 21 days agoSource updated 2026-01-16

Uterine Corpus Endometrial Carcinoma (TCGA, PanCancer Atlas) ucec_tcga_pan_can_atlas_2018TCGA

517 cases with simple somatic mutation data · 529 cases total · 2026-06-04 · mapped to Endometrial Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	PTEN	Ssm	337	517	65.2%	cbioportal
2	PIK3CA	Ssm	259	517	50.1%	cbioportal
3	ARID1A	Ssm	227	517	43.9%	cbioportal
4	TTN	Ssm	206	517	39.8%	cbioportal
5	TP53	Ssm	193	517	37.3%	cbioportal
6	PIK3R1	Ssm	159	517	30.8%	cbioportal
7	KMT2D	Ssm	143	517	27.7%	cbioportal
8	MUC16	Ssm	142	517	27.5%	cbioportal
9	CTNNB1	Ssm	133	517	25.7%	cbioportal
10	CTCF	Ssm	127	517	24.6%	cbioportal
11	RYR2	Ssm	125	517	24.2%	cbioportal
12	ZFHX3	Ssm	123	517	23.8%	cbioportal
13	CSMD3	Ssm	122	517	23.6%	cbioportal
14	MUC5B	Ssm	117	517	22.6%	cbioportal
15	OBSCN	Ssm	117	517	22.6%	cbioportal
16	SYNE1	Ssm	114	517	22.1%	cbioportal
18	KMT2B	Ssm	113	517	21.9%	cbioportal
17	CHD4	Ssm	113	517	21.9%	cbioportal
19	FLG	Ssm	112	517	21.7%	cbioportal
20	MACF1	Ssm	109	517	21.1%	cbioportal
21	ZFHX4	Ssm	109	517	21.1%	cbioportal
22	FAT4	Ssm	108	517	20.9%	cbioportal
23	NEB	Ssm	106	517	20.5%	cbioportal
24	USH2A	Ssm	105	517	20.3%	cbioportal
25	TAF1	Ssm	104	517	20.1%	cbioportal
29	FAT1	Ssm	103	517	19.9%	cbioportal
26	ARHGAP35	Ssm	103	517	19.9%	cbioportal
27	DMD	Ssm	103	517	19.9%	cbioportal
28	DNAH7	Ssm	103	517	19.9%	cbioportal
30	PCLO	Ssm	102	517	19.7%	cbioportal

Data updated 21 days agoSource updated 2026-06-04

Uterine Endometrioid Carcinoma (CPTAC GDC, 2025) uec_cptac_gdcCPTAC GDC

247 cases with simple somatic mutation data · 442 cases total · 2026-01-14 · mapped to Endometrial Endometrioid Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	PTEN	Ssm	194	247	78.5%	cbioportal
2	ARID1A	Ssm	136	247	55.1%	cbioportal
3	PIK3CA	Ssm	105	247	42.5%	cbioportal
4	PIK3R1	Ssm	91	247	36.8%	cbioportal
5	TTN	Ssm	89	247	36%	cbioportal
6	CTNNB1	Ssm	71	247	28.7%	cbioportal
7	KRAS	Ssm	67	247	27.1%	cbioportal
8	OBSCN	Ssm	65	247	26.3%	cbioportal
9	KMT2B	Ssm	62	247	25.1%	cbioportal
10	INPPL1	Ssm	61	247	24.7%	cbioportal
12	TP53	Ssm	61	247	24.7%	cbioportal
11	KMT2D	Ssm	61	247	24.7%	cbioportal
13	CTCF	Ssm	56	247	22.7%	cbioportal
14	SYNE1	Ssm	54	247	21.9%	cbioportal
15	ZFHX3	Ssm	54	247	21.9%	cbioportal
16	PCLO	Ssm	51	247	20.6%	cbioportal
17	MUC16	Ssm	49	247	19.8%	cbioportal
18	MUC5B	Ssm	48	247	19.4%	cbioportal
19	FSIP2	Ssm	47	247	19%	cbioportal
20	CSMD3	Ssm	46	247	18.6%	cbioportal
21	RYR1	Ssm	45	247	18.2%	cbioportal
22	ZFHX4	Ssm	45	247	18.2%	cbioportal
24	RYR2	Ssm	43	247	17.4%	cbioportal
23	JAK1	Ssm	43	247	17.4%	cbioportal
25	DNAH5	Ssm	42	247	17%	cbioportal
27	FAT3	Ssm	41	247	16.6%	cbioportal
28	HERC2	Ssm	41	247	16.6%	cbioportal
26	CHD4	Ssm	41	247	16.6%	cbioportal
30	FBXW7	Ssm	40	247	16.2%	cbioportal
29	DNAH17	Ssm	40	247	16.2%	cbioportal

Data updated 21 days agoSource updated 2026-01-14

Uterine Sarcoma/Mesenchymal (MSK, Clin Cancer Res 2020) usarc_msk_2020MSK

108 cases with simple somatic mutation data · 108 cases total · 2026-01-19 · mapped to Uterine Corpus Sarcoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	40	108	37%	cbioportal
2	ATRX	Ssm	25	108	23.1%	cbioportal
3	RB1	Ssm	12	108	11.1%	cbioportal
4	MED12	Ssm	11	108	10.2%	cbioportal
5	BRCA2	Ssm	7	108	6.5%	cbioportal
7	PTEN	Ssm	6	108	5.6%	cbioportal
6	FAT1	Ssm	6	108	5.6%	cbioportal
145	TEK	Ssm	1	20	5%	cbioportal
130	PPARG	Ssm	1	20	5%	cbioportal
57	AGO2	Ssm	1	20	5%	cbioportal
9	ROS1	Ssm	5	108	4.6%	cbioportal
8	AR	Ssm	5	108	4.6%	cbioportal
14	PIK3CA	Ssm	4	108	3.7%	cbioportal
10	ARID2	Ssm	4	108	3.7%	cbioportal
11	KDR	Ssm	4	108	3.7%	cbioportal
12	NSD1	Ssm	4	108	3.7%	cbioportal
13	PDGFRB	Ssm	4	108	3.7%	cbioportal
24	TERT	Ssm	3	108	2.8%	cbioportal
17	BRD4	Ssm	3	108	2.8%	cbioportal
15	ARID1A	Ssm	3	108	2.8%	cbioportal
16	ASXL1	Ssm	3	108	2.8%	cbioportal
18	CARD11	Ssm	3	108	2.8%	cbioportal
19	DAXX	Ssm	3	108	2.8%	cbioportal
20	ERBB4	Ssm	3	108	2.8%	cbioportal
21	KMT2A	Ssm	3	108	2.8%	cbioportal
22	MET	Ssm	3	108	2.8%	cbioportal
23	NF1	Ssm	3	108	2.8%	cbioportal
52	RBM10	Ssm	2	108	1.9%	cbioportal
44	MEN1	Ssm	2	108	1.9%	cbioportal
51	PTPRS	Ssm	2	108	1.9%	cbioportal

Data updated 21 days agoSource updated 2026-01-19