TP53

← targets

Eprenetapoptsmall_molecule

—

STABILISER

—

Curated

chembl

Malignant Neoplasm,Malignant Breast Neoplasm,Myeloid Neoplasm+2

TP53 has variant …HAS_VARIANTderived200 of 3,971show all (up to 200)
→ has variant	Mutationother 27 accepted CIViC evidence items	—	—	Malignant Neoplasm,Malignant Breast Neoplasm,Myeloid Neoplasm+2	27	Curated	civic	graph →
→ has variant	Deleterious Mutation 7 accepted CIViC evidence items	—	—	Malignant Neoplasm,Leukemia,Sarcoma+2	7	Curated	civic	graph →
→ has variant	R175HSNV 7 accepted CIViC evidence items	—	—	Malignant Neoplasm,Malignant Breast Neoplasm,Sarcoma+1	7	Curated	civic	graph →
→ has variant	R248QSNV 7 accepted CIViC evidence items	—	—	Malignant Neoplasm,Lymphoma,Malignant Breast Neoplasm	7	Curated	civic	graph →
→ has variant	R273CSNV 6 accepted CIViC evidence items	—	—	Malignant Neoplasm,Malignant Breast Neoplasm,Gastric Carcinoma+1	6	Curated	civic	graph →
→ has variant	Wildtypeother 6 accepted CIViC evidence items	—	—	Malignant Neoplasm,Leukemia,Esophageal Carcinoma+2	6	Curated	civic	graph →
→ has variant	G245SSNV 5 accepted CIViC evidence items	—	—	Malignant Neoplasm,Malignant Colorectal Neoplasm	5	Curated	civic	graph →
→ has variant	R273HSNV 5 accepted CIViC evidence items	—	—	Malignant Neoplasm,Malignant Breast Neoplasm,Osteosarcoma	5	Curated	civic	graph →
→ has variant	Overexpressionexpression 4 accepted CIViC evidence items	—	—	Kidney Wilms Tumor,Malignant Gastric Neoplasm,Malignant Ovarian Neoplasm	4	Curated	civic	graph →
→ has variant	Y220CSNV 4 accepted CIViC evidence items	—	—	Malignant Neoplasm,Gastric Carcinoma	4	Curated	civic	graph →
→ has variant	ALTERATIONother 3 accepted CIViC evidence items	—	—	Malignant Ovarian Neoplasm,Rhabdomyosarcoma	3	Curated	civic	graph →
→ has variant	R158HSNV 3 accepted CIViC evidence items	—	—	Malignant Neoplasm	3	Curated	civic	graph →
→ has variant	R248WSNV 3 accepted CIViC evidence items	—	—	Malignant Neoplasm,Malignant Breast Neoplasm	3	Curated	civic	graph →
→ has variant	R249SSNV 3 accepted CIViC evidence items	—	—	Malignant Neoplasm	3	Curated	civic	graph →
→ has variant	C238YSNV 2 accepted CIViC evidence items	—	—	Malignant Breast Neoplasm	2	Curated	civic	graph →
→ has variant	C242YSNV 2 accepted CIViC evidence items	—	—	not mapped	2	Curated	civic	graph →
→ has variant	DNA Binding Domain Mutation 2 accepted CIViC evidence items	—	—	Malignant Breast Neoplasm,Oral Cavity Squamous Cell Carcinoma	2	Curated	civic	graph →
→ has variant	G266ESNV 2 accepted CIViC evidence items	—	—	not mapped	2	Curated	civic	graph →
→ has variant	M237ISNV 2 accepted CIViC evidence items	—	—	Malignant Neoplasm	2	Curated	civic	graph →
→ has variant	P152LSNV 2 accepted CIViC evidence items	—	—	not mapped	2	Curated	civic	graph →
→ has variant	P72RSNV 2 accepted CIViC evidence items	—	—	Lung Carcinoma,Malignant Cervical Neoplasm	2	Curated	civic	graph →
→ has variant	Truncating Mutationindel 2 accepted CIViC evidence items	—	—	Head and Neck Squamous Cell Carcinoma	2	Curated	civic	graph →
→ has variant	Y126CSNV 2 accepted CIViC evidence items	—	—	not mapped	2	Curated	civic	graph →
→ has variant	A161TSNV 1 accepted CIViC evidence items	—	—	not mapped	1	Curated	civic	graph →
→ has variant	A276VSNV 1 accepted CIViC evidence items	—	—	not mapped	1	Curated	civic	graph →
→ has variant	C124RSNV 1 accepted CIViC evidence items	—	—	not mapped	1	Curated	civic	graph →
→ has variant	C135WSNV 1 accepted CIViC evidence items	—	—	not mapped	1	Curated	civic	graph →
→ has variant	C242FSNV 1 accepted CIViC evidence items	—	—	not mapped	1	Curated	civic	graph →
→ has variant	C242SSNV 1 accepted CIViC evidence items	—	—	not mapped	1	Curated	civic	graph →
→ has variant	CONSERVED DOMAIN MUT 1 accepted CIViC evidence items	—	—	Malignant Ovarian Neoplasm	1	Curated	civic	graph →
→ has variant	D259VSNV 1 accepted CIViC evidence items	—	—	not mapped	1	Curated	civic	graph →
→ has variant	D281ESNV 1 accepted CIViC evidence items	—	—	not mapped	1	Curated	civic	graph →
→ has variant	D281NSNV 1 accepted CIViC evidence items	—	—	not mapped	1	Curated	civic	graph →
→ has variant	E224KSNV 1 accepted CIViC evidence items	—	—	not mapped	1	Curated	civic	graph →
→ has variant	E258KSNV 1 accepted CIViC evidence items	—	—	not mapped	1	Curated	civic	graph →
→ has variant	E285KSNV 1 accepted CIViC evidence items	—	—	not mapped	1	Curated	civic	graph →
→ has variant	E286KSNV 1 accepted CIViC evidence items	—	—	not mapped	1	Curated	civic	graph →
→ has variant	E68GSNV 1 accepted CIViC evidence items	—	—	not mapped	1	Curated	civic	graph →
→ has variant	F270SSNV 1 accepted CIViC evidence items	—	—	not mapped	1	Curated	civic	graph →
→ has variant	G154SSNV 1 accepted CIViC evidence items	—	—	not mapped	1	Curated	civic	graph →
→ has variant	G244SSNV 1 accepted CIViC evidence items	—	—	not mapped	1	Curated	civic	graph →
→ has variant	G245DSNV 1 accepted CIViC evidence items	—	—	not mapped	1	Curated	civic	graph →
→ has variant	G262DSNV 1 accepted CIViC evidence items	—	—	not mapped	1	Curated	civic	graph →
→ has variant	G266RSNV 1 accepted CIViC evidence items	—	—	not mapped	1	Curated	civic	graph →
→ has variant	G266VSNV 1 accepted CIViC evidence items	—	—	not mapped	1	Curated	civic	graph →
→ has variant	G279ESNV 1 accepted CIViC evidence items	—	—	not mapped	1	Curated	civic	graph →
→ has variant	H115YSNV 1 accepted CIViC evidence items	—	—	not mapped	1	Curated	civic	graph →
→ has variant	H168YSNV 1 accepted CIViC evidence items	—	—	not mapped	1	Curated	civic	graph →
→ has variant	H178PSNV 1 accepted CIViC evidence items	—	—	not mapped	1	Curated	civic	graph →
→ has variant	H179RSNV 1 accepted CIViC evidence items	—	—	not mapped	1	Curated	civic	graph →
→ has variant	H179YSNV 1 accepted CIViC evidence items	—	—	not mapped	1	Curated	civic	graph →
→ has variant	H193RSNV 1 accepted CIViC evidence items	—	—	Sarcoma	1	Curated	civic	graph →
→ has variant	I162FSNV 1 accepted CIViC evidence items	—	—	not mapped	1	Curated	civic	graph →
→ has variant	K139ESNV 1 accepted CIViC evidence items	—	—	not mapped	1	Curated	civic	graph →
→ has variant	L111RSNV 1 accepted CIViC evidence items	—	—	not mapped	1	Curated	civic	graph →
→ has variant	L139NSNV 1 accepted CIViC evidence items	—	—	not mapped	1	Curated	civic	graph →
→ has variant	L252FSNV 1 accepted CIViC evidence items	—	—	not mapped	1	Curated	civic	graph →
→ has variant	L257PSNV 1 accepted CIViC evidence items	—	—	not mapped	1	Curated	civic	graph →
→ has variant	L308MSNV 1 accepted CIViC evidence items	—	—	not mapped	1	Curated	civic	graph →
→ has variant	L323PSNV 1 accepted CIViC evidence items	—	—	not mapped	1	Curated	civic	graph →
→ has variant	L330PSNV 1 accepted CIViC evidence items	—	—	not mapped	1	Curated	civic	graph →
→ has variant	L330RSNV 1 accepted CIViC evidence items	—	—	not mapped	1	Curated	civic	graph →
→ has variant	L344PSNV 1 accepted CIViC evidence items	—	—	not mapped	1	Curated	civic	graph →
→ has variant	Lossdeletion_cna 1 accepted CIViC evidence items	—	—	Lung Non-Small Cell Carcinoma	1	Curated	civic	graph →
→ has variant	M246LSNV 1 accepted CIViC evidence items	—	—	not mapped	1	Curated	civic	graph →
→ has variant	N239SSNV 1 accepted CIViC evidence items	—	—	not mapped	1	Curated	civic	graph →
→ has variant	P151HSNV 1 accepted CIViC evidence items	—	—	not mapped	1	Curated	civic	graph →
→ has variant	P151SSNV 1 accepted CIViC evidence items	—	—	not mapped	1	Curated	civic	graph →
→ has variant	P152TSNV 1 accepted CIViC evidence items	—	—	not mapped	1	Curated	civic	graph →
→ has variant	P177FSNV 1 accepted CIViC evidence items	—	—	not mapped	1	Curated	civic	graph →
→ has variant	P177HSNV 1 accepted CIViC evidence items	—	—	not mapped	1	Curated	civic	graph →
→ has variant	P177SSNV 1 accepted CIViC evidence items	—	—	not mapped	1	Curated	civic	graph →
→ has variant	P219HSNV 1 accepted CIViC evidence items	—	—	not mapped	1	Curated	civic	graph →
→ has variant	P250LSNV 1 accepted CIViC evidence items	—	—	not mapped	1	Curated	civic	graph →
→ has variant	P278SSNV 1 accepted CIViC evidence items	—	—	not mapped	1	Curated	civic	graph →
→ has variant	P47SSNV 1 accepted CIViC evidence items	—	—	Malignant Neoplasm	1	Curated	civic	graph →
→ has variant	P98LSNV 1 accepted CIViC evidence items	—	—	not mapped	1	Curated	civic	graph →
→ has variant	P98SSNV 1 accepted CIViC evidence items	—	—	not mapped	1	Curated	civic	graph →
→ has variant	Q144PSNV 1 accepted CIViC evidence items	—	—	not mapped	1	Curated	civic	graph →
→ has variant	R156HSNV 1 accepted CIViC evidence items	—	—	not mapped	1	Curated	civic	graph →
→ has variant	R156PSNV 1 accepted CIViC evidence items	—	—	not mapped	1	Curated	civic	graph →
→ has variant	R158GSNV 1 accepted CIViC evidence items	—	—	not mapped	1	Curated	civic	graph →
→ has variant	R158LSNV 1 accepted CIViC evidence items	—	—	Malignant Neoplasm	1	Curated	civic	graph →
→ has variant	R181CSNV 1 accepted CIViC evidence items	—	—	not mapped	1	Curated	civic	graph →
→ has variant	R181GSNV 1 accepted CIViC evidence items	—	—	not mapped	1	Curated	civic	graph →
→ has variant	R181HSNV 1 accepted CIViC evidence items	—	—	not mapped	1	Curated	civic	graph →
→ has variant	R181PSNV 1 accepted CIViC evidence items	—	—	not mapped	1	Curated	civic	graph →
→ has variant	R213*SNV 1 accepted CIViC evidence items	—	—	Malignant Colorectal Neoplasm	1	Curated	civic	graph →
→ has variant	R213PSNV 1 accepted CIViC evidence items	—	—	Gastric Carcinoma	1	Curated	civic	graph →
→ has variant	R249 1 accepted CIViC evidence items	—	—	Malignant Breast Neoplasm	1	Curated	civic	graph →
→ has variant	R273LSNV 1 accepted CIViC evidence items	—	—	Malignant Ovarian Neoplasm	1	Curated	civic	graph →
→ has variant	R280KSNV 1 accepted CIViC evidence items	—	—	Malignant Neoplasm	1	Curated	civic	graph →
→ has variant	R280TSNV 1 accepted CIViC evidence items	—	—	Malignant Neoplasm	1	Curated	civic	graph →
→ has variant	R282LSNV 1 accepted CIViC evidence items	—	—	Gastric Carcinoma	1	Curated	civic	graph →
→ has variant	R282WSNV 1 accepted CIViC evidence items	—	—	not mapped	1	Curated	civic	graph →
→ has variant	R283HSNV 1 accepted CIViC evidence items	—	—	not mapped	1	Curated	civic	graph →
→ has variant	R337PSNV 1 accepted CIViC evidence items	—	—	not mapped	1	Curated	civic	graph →
→ has variant	R342PSNV 1 accepted CIViC evidence items	—	—	not mapped	1	Curated	civic	graph →
→ has variant	R72PSNV 1 accepted CIViC evidence items	—	—	Malignant Breast Neoplasm	1	Curated	civic	graph →
→ has variant	S241FSNV 1 accepted CIViC evidence items	—	—	not mapped	1	Curated	civic	graph →
→ has variant	S241TSNV 1 accepted CIViC evidence items	—	—	not mapped	1	Curated	civic	graph →
→ has variant	T125TSNV 1 accepted CIViC evidence items	—	—	not mapped	1	Curated	civic	graph →
→ has variant	T230SSNV 1 accepted CIViC evidence items	—	—	not mapped	1	Curated	civic	graph →
→ has variant	V157FSNV 1 accepted CIViC evidence items	—	—	Malignant Neoplasm	1	Curated	civic	graph →
→ has variant	V272GSNV 1 accepted CIViC evidence items	—	—	not mapped	1	Curated	civic	graph →
→ has variant	V274FSNV 1 accepted CIViC evidence items	—	—	not mapped	1	Curated	civic	graph →
→ has variant	Y126DSNV 1 accepted CIViC evidence items	—	—	not mapped	1	Curated	civic	graph →
→ has variant	Y126SSNV 1 accepted CIViC evidence items	—	—	not mapped	1	Curated	civic	graph →
→ has variant	Y163HSNV 1 accepted CIViC evidence items	—	—	not mapped	1	Curated	civic	graph →
→ has variant	Y163NSNV 1 accepted CIViC evidence items	—	—	not mapped	1	Curated	civic	graph →
→ has variant	Y220HSNV 1 accepted CIViC evidence items	—	—	not mapped	1	Curated	civic	graph →
→ has variant	Y234CSNV 1 accepted CIViC evidence items	—	—	Malignant Ovarian Neoplasm	1	Curated	civic	graph →
→ has variant	Y234HSNV 1 accepted CIViC evidence items	—	—	not mapped	1	Curated	civic	graph →
→ has variant	Y236SSNV 1 accepted CIViC evidence items	—	—	not mapped	1	Curated	civic	graph →
→ has variant	A129 no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	A138KSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	A138VSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	A159SSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	A159VSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	A161DSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	A161GSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	A161VSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	A347GSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	A83ESNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	A86ESNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	A86TSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	C135*SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	C135FSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	C135fsindel no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	C135YSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	C141WSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	C176FSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	C176SSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	C176YSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	C238FSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	C275FSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	C275GSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	C275YSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	C277YSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	D184 no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	D259YSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	D281GSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	D281HSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	D281YSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	D42YSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	Deletiondeletion_cna no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	E180KSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	E180XSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	E198*SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	E204 no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	E285VSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	E286VSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	E298XSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	F134SSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	G105CSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	G177ESNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	G244RSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	G244VSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	G245 no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	G245NSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	G245VSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	G262CSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	G266 no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	GRCh38/hg38 17p13.1(chr17:7674702-7677679)x1deletion_cna no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	H168QSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	H168RSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	H178DSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	H179DSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	H179QSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	H193LSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	H214RSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	I195NSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	I251TSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	I255SSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	K120ESNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	K120RSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	K132 no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	K132ESNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	K132NSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	K132QSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	K132RSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	K132TSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	K305MSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	K305NSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	L114 no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	L130VSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	L194PSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	L194RSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	L201FSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	L206 no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	L305MSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	L3 Domain Mutation no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	M160KSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	M243TSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	M243VSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	M246ASNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	M246RSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	M246TSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	Mutationsother no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	N239DSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →

TP53 has variant …HAS_VARIANTderived200 of 3,971show all (up to 200)

→ has variant

Mutationother

27 accepted CIViC evidence items

—

Curated

→ has variant

Deleterious Mutation

7 accepted CIViC evidence items

—

Malignant Neoplasm,Leukemia,Sarcoma+2

Curated

Malignant Neoplasm,Malignant Breast Neoplasm,Sarcoma+1

→ has variant

R175HSNV

7 accepted CIViC evidence items

—

Curated

Malignant Neoplasm,Lymphoma,Malignant Breast Neoplasm

→ has variant

R248QSNV

7 accepted CIViC evidence items

—

Curated

Malignant Neoplasm,Malignant Breast Neoplasm,Gastric Carcinoma+1

→ has variant

R273CSNV

6 accepted CIViC evidence items

—

Curated

Malignant Neoplasm,Leukemia,Esophageal Carcinoma+2

→ has variant

Wildtypeother

6 accepted CIViC evidence items

—

Curated

Malignant Neoplasm,Malignant Colorectal Neoplasm

→ has variant

G245SSNV

5 accepted CIViC evidence items

—

Curated

Malignant Neoplasm,Malignant Breast Neoplasm,Osteosarcoma

→ has variant

R273HSNV

5 accepted CIViC evidence items

—

Curated

Kidney Wilms Tumor,Malignant Gastric Neoplasm,Malignant Ovarian Neoplasm

→ has variant

Overexpressionexpression

4 accepted CIViC evidence items

—

Curated

Malignant Neoplasm,Gastric Carcinoma

→ has variant

Y220CSNV

4 accepted CIViC evidence items

—

Curated

Malignant Ovarian Neoplasm,Rhabdomyosarcoma

→ has variant

ALTERATIONother

3 accepted CIViC evidence items

—

Curated

→ has variant

R158HSNV

3 accepted CIViC evidence items

—

Curated

Malignant Neoplasm,Malignant Breast Neoplasm

→ has variant

R248WSNV

3 accepted CIViC evidence items

—

Curated

→ has variant

R249SSNV

3 accepted CIViC evidence items

—

Curated

Malignant Breast Neoplasm

→ has variant

C238YSNV

2 accepted CIViC evidence items

—

Curated

→ has variant

C242YSNV

2 accepted CIViC evidence items

—

not mapped

Curated

DNA Binding Domain Mutation

→ has variant

2 accepted CIViC evidence items

—

Malignant Breast Neoplasm,Oral Cavity Squamous Cell Carcinoma

Curated

→ has variant

G266ESNV

2 accepted CIViC evidence items

—

not mapped

Curated

→ has variant

M237ISNV

2 accepted CIViC evidence items

—

Curated

→ has variant

P152LSNV

2 accepted CIViC evidence items

—

not mapped

Curated

Lung Carcinoma,Malignant Cervical Neoplasm

→ has variant

P72RSNV

2 accepted CIViC evidence items

—

Curated

Head and Neck Squamous Cell Carcinoma

→ has variant

Truncating Mutationindel

2 accepted CIViC evidence items

—

Curated

→ has variant

Y126CSNV

2 accepted CIViC evidence items

—

not mapped

Curated

→ has variant

A161TSNV

1 accepted CIViC evidence items

—

not mapped

Curated

→ has variant

A276VSNV

1 accepted CIViC evidence items

—

not mapped

Curated

→ has variant

C124RSNV

1 accepted CIViC evidence items

—

not mapped

Curated

→ has variant

C135WSNV

1 accepted CIViC evidence items

—

not mapped

Curated

→ has variant

C242FSNV

1 accepted CIViC evidence items

—

not mapped

Curated

→ has variant

C242SSNV

1 accepted CIViC evidence items

—

not mapped

Curated

Malignant Ovarian Neoplasm

→ has variant

CONSERVED DOMAIN MUT

1 accepted CIViC evidence items

—

Curated

→ has variant

D259VSNV

1 accepted CIViC evidence items

—

not mapped

Curated

→ has variant

D281ESNV

1 accepted CIViC evidence items

—

not mapped

Curated

→ has variant

D281NSNV

1 accepted CIViC evidence items

—

not mapped

Curated

→ has variant

E224KSNV

1 accepted CIViC evidence items

—

not mapped

Curated

→ has variant

E258KSNV

1 accepted CIViC evidence items

—

not mapped

Curated

→ has variant

E285KSNV

1 accepted CIViC evidence items

—

not mapped

Curated

→ has variant

E286KSNV

1 accepted CIViC evidence items

—

not mapped

Curated

→ has variant

E68GSNV

1 accepted CIViC evidence items

—

not mapped

Curated

→ has variant

F270SSNV

1 accepted CIViC evidence items

—

not mapped

Curated

→ has variant

G154SSNV

1 accepted CIViC evidence items

—

not mapped

Curated

→ has variant

G244SSNV

1 accepted CIViC evidence items

—

not mapped

Curated

→ has variant

G245DSNV

1 accepted CIViC evidence items

—

not mapped

Curated

→ has variant

G262DSNV

1 accepted CIViC evidence items

—

not mapped

Curated

→ has variant

G266RSNV

1 accepted CIViC evidence items

—

not mapped

Curated

→ has variant

G266VSNV

1 accepted CIViC evidence items

—

not mapped

Curated

→ has variant

G279ESNV

1 accepted CIViC evidence items

—

not mapped

Curated

→ has variant

H115YSNV

1 accepted CIViC evidence items

—

not mapped

Curated

→ has variant

H168YSNV

1 accepted CIViC evidence items

—

not mapped

Curated

→ has variant

H178PSNV

1 accepted CIViC evidence items

—

not mapped

Curated

→ has variant

H179RSNV

1 accepted CIViC evidence items

—

not mapped

Curated

→ has variant

H179YSNV

1 accepted CIViC evidence items

—

not mapped

Curated

→ has variant

H193RSNV

1 accepted CIViC evidence items

—

Sarcoma

Curated

→ has variant

I162FSNV

1 accepted CIViC evidence items

—

not mapped

Curated

→ has variant

K139ESNV

1 accepted CIViC evidence items

—

not mapped

Curated

→ has variant

L111RSNV

1 accepted CIViC evidence items

—

not mapped

Curated

→ has variant

L139NSNV

1 accepted CIViC evidence items

—

not mapped

Curated

→ has variant

L252FSNV

1 accepted CIViC evidence items

—

not mapped

Curated

→ has variant

L257PSNV

1 accepted CIViC evidence items

—

not mapped

Curated

→ has variant

L308MSNV

1 accepted CIViC evidence items

—

not mapped

Curated

→ has variant

L323PSNV

1 accepted CIViC evidence items

—

not mapped

Curated

→ has variant

L330PSNV

1 accepted CIViC evidence items

—

not mapped

Curated

→ has variant

L330RSNV

1 accepted CIViC evidence items

—

not mapped

Curated

→ has variant

L344PSNV

1 accepted CIViC evidence items

—

not mapped

Curated

Lung Non-Small Cell Carcinoma

→ has variant

Lossdeletion_cna

1 accepted CIViC evidence items

—

Curated

→ has variant

M246LSNV

1 accepted CIViC evidence items

—

not mapped

Curated

→ has variant

N239SSNV

1 accepted CIViC evidence items

—

not mapped

Curated

→ has variant

P151HSNV

1 accepted CIViC evidence items

—

not mapped

Curated

→ has variant

P151SSNV

1 accepted CIViC evidence items

—

not mapped

Curated

→ has variant

P152TSNV

1 accepted CIViC evidence items

—

not mapped

Curated

→ has variant

P177FSNV

1 accepted CIViC evidence items

—

not mapped

Curated

→ has variant

P177HSNV

1 accepted CIViC evidence items

—

not mapped

Curated

→ has variant

P177SSNV

1 accepted CIViC evidence items

—

not mapped

Curated

→ has variant

P219HSNV

1 accepted CIViC evidence items

—

not mapped

Curated

→ has variant

P250LSNV

1 accepted CIViC evidence items

—

not mapped

Curated

→ has variant

P278SSNV

1 accepted CIViC evidence items

—

not mapped

Curated

→ has variant

P47SSNV

1 accepted CIViC evidence items

—

Curated

→ has variant

P98LSNV

1 accepted CIViC evidence items

—

not mapped

Curated

→ has variant

P98SSNV

1 accepted CIViC evidence items

—

not mapped

Curated

→ has variant

Q144PSNV

1 accepted CIViC evidence items

—

not mapped

Curated

→ has variant

R156HSNV

1 accepted CIViC evidence items

—

not mapped

Curated

→ has variant

R156PSNV

1 accepted CIViC evidence items

—

not mapped

Curated

→ has variant

R158GSNV

1 accepted CIViC evidence items

—

not mapped

Curated

→ has variant

R158LSNV

1 accepted CIViC evidence items

—

Curated

→ has variant

R181CSNV

1 accepted CIViC evidence items

—

not mapped

Curated

→ has variant

R181GSNV

1 accepted CIViC evidence items

—

not mapped

Curated

→ has variant

R181HSNV

1 accepted CIViC evidence items

—

not mapped

Curated

→ has variant

R181PSNV

1 accepted CIViC evidence items

—

not mapped

Curated

Malignant Colorectal Neoplasm

→ has variant

R213*SNV

1 accepted CIViC evidence items

—

Curated

Malignant Breast Neoplasm

→ has variant

R213PSNV

1 accepted CIViC evidence items

—

Curated

→ has variant

1 accepted CIViC evidence items

—

Curated

Malignant Ovarian Neoplasm

→ has variant

R273LSNV

1 accepted CIViC evidence items

—

Curated

→ has variant

R280KSNV

1 accepted CIViC evidence items

—

Curated

→ has variant

R280TSNV

1 accepted CIViC evidence items

—

Curated

→ has variant

R282LSNV

1 accepted CIViC evidence items

—

Gastric Carcinoma

Curated

→ has variant

R282WSNV

1 accepted CIViC evidence items

—

not mapped

Curated

→ has variant

R283HSNV

1 accepted CIViC evidence items

—

not mapped

Curated

→ has variant

R337PSNV

1 accepted CIViC evidence items

—

not mapped

Curated

→ has variant

R342PSNV

1 accepted CIViC evidence items

—

not mapped

Curated

Malignant Breast Neoplasm

→ has variant

R72PSNV

1 accepted CIViC evidence items

—

Curated

→ has variant

S241FSNV

1 accepted CIViC evidence items

—

not mapped

Curated

→ has variant

S241TSNV

1 accepted CIViC evidence items

—

not mapped

Curated

→ has variant

T125TSNV

1 accepted CIViC evidence items

—

not mapped

Curated

→ has variant

T230SSNV

1 accepted CIViC evidence items

—

not mapped

Curated

→ has variant

V157FSNV

1 accepted CIViC evidence items

—

Curated

→ has variant

V272GSNV

1 accepted CIViC evidence items

—

not mapped

Curated

→ has variant

V274FSNV

1 accepted CIViC evidence items

—

not mapped

Curated

→ has variant

Y126DSNV

1 accepted CIViC evidence items

—

not mapped

Curated

→ has variant

Y126SSNV

1 accepted CIViC evidence items

—

not mapped

Curated

→ has variant

Y163HSNV

1 accepted CIViC evidence items

—

not mapped

Curated

→ has variant

Y163NSNV

1 accepted CIViC evidence items

—

not mapped

Curated

→ has variant

Y220HSNV

1 accepted CIViC evidence items

—

not mapped

Curated

Malignant Ovarian Neoplasm

→ has variant

Y234CSNV

1 accepted CIViC evidence items

—

Curated

→ has variant

Y234HSNV

1 accepted CIViC evidence items

—

not mapped

Curated

→ has variant

Y236SSNV

1 accepted CIViC evidence items

—

not mapped

Curated

→ has variant

A129

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

A138KSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

A138VSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

A159SSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

A159VSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

A161DSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

A161GSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

A161VSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

A347GSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

A83ESNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

A86ESNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

A86TSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

C135*SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

C135FSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

C135fsindel

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

C135YSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

C141WSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

C176FSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

C176SSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

C176YSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

C238FSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

C275FSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

C275GSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

C275YSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

C277YSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

D184

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

D259YSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

D281GSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

D281HSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

D281YSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

D42YSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

Deletiondeletion_cna

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

E180KSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

E180XSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

E198*SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

E204

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

E285VSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

E286VSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

E298XSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

F134SSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

G105CSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

G177ESNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

G244RSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

G244VSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

G245

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

G245NSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

G245VSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

G262CSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

G266

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

GRCh38/hg38 17p13.1(chr17:7674702-7677679)x1deletion_cna

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

H168QSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

H168RSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

H178DSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

H179DSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

H179QSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

H193LSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

H214RSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

I195NSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

I251TSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

I255SSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

K120ESNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

K120RSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

K132

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

K132ESNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

K132NSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

K132QSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

K132RSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

K132TSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

K305MSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

K305NSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

L114

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

L130VSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

L194PSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

L194RSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

L201FSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

L206

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

L305MSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

L3 Domain Mutation

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

M160KSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

M243TSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

M243VSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

M246ASNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

M246RSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

M246TSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

Mutationsother

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

N239DSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

TP53 altered in cohorts of …ALTERED_INderived15 of 54show all (up to 200)
→ altered in cohorts of	Uterine Carcinosarcoma 52 / 57 cases (91 %) · ssm · TCGA-UCS	—	—	Uterine Carcinosarcoma	1	Observed	gdc	graph →
→ altered in cohorts of	Uterine Malignant Mixed Mesodermal (Mullerian) Tumor 52 / 57 cases (91 %) · ssm · ucs_tcga · largest of 3 cohorts	—	—	Uterine Malignant Mixed Mesodermal (Mullerian) Tumor	3	Observed	cbioportal	graph →
→ altered in cohorts of	Esophageal Carcinomasubtype 167 / 185 cases (90 %) · ssm · TCGA-ESCA	—	—	Esophageal Carcinoma	1	Observed	gdc	graph →
→ altered in cohorts of	Lung Squamous Cell Carcinoma 453 / 504 cases (90 %) · ssm · TCGA-LUSC · largest of 7 cohorts	—	—	Lung Squamous Cell Carcinoma	7	Observed	gdc	graph →
→ altered in cohorts of	Head and Neck Carcinoma, Other 96 / 108 cases (89 %) · ssm · ohnca_cptac_gdc	—	—	Head and Neck Carcinoma, Other	1	Observed	cbioportal	graph →
→ altered in cohorts of	Lung Small Cell Carcinoma 103 / 120 cases (86 %) · ssm · sclc_ucologne_2015 · largest of 3 cohorts	—	—	Lung Small Cell Carcinoma	3	Observed	cbioportal	graph →
→ altered in cohorts of	Esophageal Adenocarcinoma 156 / 185 cases (84 %) · ssm · esca_tcga_gdc · largest of 4 cohorts	—	—	Esophageal Adenocarcinoma	4	Observed	cbioportal	graph →
→ altered in cohorts of	Ovarian Serous Cystadenocarcinoma 483 / 603 cases (80 %) · ssm · TCGA-OV	—	—	Ovarian Serous Cystadenocarcinoma	1	Observed	gdc	graph →
→ altered in cohorts of	Head and Neck Squamous Cell Carcinomasubtype 392 / 528 cases (74 %) · ssm · TCGA-HNSC · largest of 7 cohorts	—	—	Head and Neck Squamous Cell Carcinoma	7	Observed	gdc	graph →
→ altered in cohorts of	Rectal Adenocarcinoma 5,295 / 7,237 cases (73 %) · ssm · crc_msk_2026 · largest of 3 cohorts	—	—	Rectal Adenocarcinoma	3	Observed	cbioportal	graph →
→ altered in cohorts of	Colorectal Adenocarcinoma 824 / 1,134 cases (73 %) · ssm · crc_msk_2017 · largest of 15 cohorts	—	—	Colorectal Adenocarcinoma	15	Observed	cbioportal	graph →
→ altered in cohorts of	High-Grade Serous Ovarian Cancer 373 / 523 cases (71 %) · ssm · ov_tcga_pan_can_atlas_2018 · largest of 5 cohorts	—	—	High-Grade Serous Ovarian Cancer	5	Observed	cbioportal	graph →
→ altered in cohorts of	Chromophobe Renal Cell Carcinoma 59 / 86 cases (69 %) · ssm · TCGA-KICH · largest of 5 cohorts	—	—	Chromophobe Renal Cell Carcinoma	5	Observed	gdc	graph →
→ altered in cohorts of	Skin Squamous Cell Carcinoma 55 / 83 cases (66 %) · ssm · cscc_ucsf_2021 · largest of 4 cohorts	—	—	Skin Squamous Cell Carcinoma	4	Observed	cbioportal	graph →
→ altered in cohorts of	Sarcomacancer_family 167 / 261 cases (64 %) · ssm · TCGA-SARC	—	—	Sarcoma	1	Observed	gdc	graph →

TP53 altered in cohorts of …ALTERED_INderived15 of 54show all (up to 200)

→ altered in cohorts of

Uterine Carcinosarcoma

52 / 57 cases (91 %) · ssm · TCGA-UCS

—

Uterine Carcinosarcoma

Observed

gdc