TP53 C242F

CI-VAR-00000298Explore in graph →NP_000537.3:p.Cys242PheNM_000546.5:c.725G>TClinVar 376578 CIViC 1062 rs121912655

Curated evidence

Evidence by cancer (2 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–2 of 2 evidence items across 1 cancer context on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Unmapped disease2unmapped disease
TP53 C242F	(functional)	Functional	D	Supports Loss Of Function	2	accepted	EID9451 Fifty missense mutations identified in sporadic breast cancer were assessed for qualitative and quantitative changes in their ability to transactivate from 11 human promoter response elements in a yea… (full text at CIViC) PMID 20407015 · Jordan et al., 2010 · Open in CIViC	civic
TP53 C242F	(functional)	Functional	D	Supports Loss Of Function	3	submitted	EID13191 In matched biopsy and surgical specimens from a patient with lung squamous cell carcinoma, split FASAY identified TP53 C242F (codon 242 TGC>TTC). The mutant-containing 3′ fragment from the biopsy samp… (full text at CIViC) PMID 15161705 · Fouquet et al., 2004 · Open in CIViC	civic

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
376578	Conflicting classifications of pathogenicity	criteria provided, conflicting classifications	1	Ovarian neoplasm; Li-Fraumeni syndrome; Hereditary cancer-predisposing syndrome; Neoplasm	germline/somatic	4	Dec 14, 2025	clinvar