Variant · Expression
TP53 Overexpression
CI-VAR-00003173Explore in graph →CIViC 1306
Curated evidence
Evidence by cancer (4 items)
Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 21525573
- Run
- ING-CIVIC-20260908-000001
| Molecular profile | Therapy | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| Kidney Wilms Tumor1 | ||||||||
| TP53 Overexpression | (prognostic) | Prognostic | B | Supports Poor Outcome | 3 | accepted | EID894544 archival FFPE samples from confirmed cases of Wilms tumor with mean age 3 years 2 months, and taken from the most histologically aggressive parts of each tumor, were stained with p53 monoclonal ant… (full text at CIViC) PMID 21525573 · Jadali et al., 2011 · Open in CIViC | civic |
| Malignant Gastric Neoplasm1 | ||||||||
| TP53 Overexpression | Cisplatin + Etoposide + MitomycinCombination | Predictive | B | Supports Sensitivity Response | 4 | accepted | EID2799In a Phase II trial of 25 patients with metastaic gastric cancer, patients received preoperative high dose chemotherapy (HDCT) consisting of etoposide, cisplatin and mitomycin. Patients with greater t… | |
ClinVar
Clinical significance (0)
ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.
Data not yet available