TP53 T125T

CI-VAR-00004270Explore in graph →CIViC 3684

Curated evidence

Evidence by cancer (1 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–1 of 1 evidence items across 1 cancer context on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Unmapped disease1unmapped disease
TP53 T125T	(functional)	Functional	D	Supports Loss Of Function	4	accepted	EID10059 TP53 mutant cell lines were treated with an MDM2 inhibitor (AMG 232) and expression of TP53, MDM2 and p21 were measured by immunoblot. Lack of upregulation was seen in all TP53 mutant (G>A transversio… (full text at CIViC) PMID 25730903 · Saiki et al., 2015 · Open in CIViC	civic

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.