Variant · Snv

TP53 R213*

CI-VAR-00003763Explore in graph →p.Arg213TerNM_000546.6:c.637C>TClinVar 43590 CIViC 2711 rs397516436

Curated evidence

Evidence by cancer (2 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–2 of 2 evidence items across 2 cancer contexts on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Malignant Colorectal Neoplasm1
TP53 R273C OR TP53 G245S OR TP53 R213*	Pazopanib + VorinostatCombination	Predictive	C	Supports Sensitivity Response	2	accepted	EID12732 In the phase I study of pazopanib and vorinostat in 36 patients with advanced solid tumors, detection of hotspot TP53 mutation was associated with a higher rate of SD ≥6 months/PR, longer median PFS (… (full text at CIViC) PMID 25669829 · Fu et al., 2015 · Open in CIViC	civic
Salivary Gland Mucinous Adenocarcinoma1
TP53 R213*	(predisposing)	Predisposing	E	Supports Pathogenic	3	submitted	EID7321 As seen in Figure 1, the R213* mutation is predominantly found in colorectal and breast cancers. The variant was described as being a frequent p53 nonsense mutation in melanoma, kidney chromophobe, es…

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
43590	Pathogenic	criteria provided, multiple submitters, no conflicts	2	Li-Fraumeni syndrome; Hereditary cancer-predisposing syndrome; Li-Fraumeni syndrome 1; Ovarian neoplasm; Squamous cell carcinoma of the head and neck; Familial cancer of breast; Colorectal cancer; TP53-related disorder; Neoplasm; Malignant glioma	germline/somatic	19	Jan 10, 2026