TP53 R282L

CI-VAR-00003811Explore in graph →NP_000537.3:p.Arg282LeuNM_000546.5:c.845G>TClinVar 182938 CIViC 1108 rs730882008

Curated evidence

Evidence by cancer (1 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–1 of 1 evidence items across 1 cancer context on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Gastric Carcinoma1
TP53 R282L	EAP Protocol	Predictive	C	Supports Sensitivity Response	—	accepted	EID2818 In a study of 25 patients with advanced gastric cancer, mutations in TP53 were identified in 32% of primary tumors. TP53 mutations were associated with an improved response to preoperative treatment o… (full text at CIViC) PMID 14514923 · Bataille et al., 2003 · Open in CIViC	civic

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
182938	Uncertain significance	reviewed by expert panel	3	Hereditary cancer-predisposing syndrome; Li-Fraumeni syndrome; Adrenocortical carcinoma, hereditary	germline	8	Apr 03, 2025	clinvar