TP53 Truncating Mutation

CI-VAR-00004371Explore in graph →CIViC 223

Curated evidence

Evidence by cancer (2 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–2 of 2 evidence items across 1 cancer context on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Head and Neck Squamous Cell Carcinoma2
TP53 Truncating Mutation	(prognostic)	Prognostic	B	Supports Poor Outcome	4	accepted	EID525 In patients with head and neck squamous cell carcinoma, in a multivariate analysis those with truncating mutations in TP53 had worse progression-free and overall survival than wild-type patients. PMID 21467160 · Lindenbergh-van der Plas et al., 2011 · Open in CIViC	civic
TP53 Truncating Mutation	(prognostic)	Prognostic	B	Does Not Support Poor Outcome	4	accepted	EID526 In patients with head and neck squamous cell carcinoma, when comparing patients with any mutation in TP53 to wild-type, there was not a significant difference in overall survival in a multivariate ana… (full text at CIViC) PMID 21467160 · Lindenbergh-van der Plas et al., 2011 · Open in CIViC	civic

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.