TP53 R337P

CI-VAR-00003827Explore in graph →CIViC 3582

Curated evidence

Evidence by cancer (2 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–2 of 2 evidence items across 1 cancer context on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Unmapped disease2unmapped disease
TP53 R337P	(functional)	Functional	D	Supports Loss Of Function	3	accepted	EID9808 Cancer-associated TP53 mutations were assessed for effects on the stability and oligomeric structure of p53. TP53 R337P protein eluted as a single peak contemporaneously with the known monomer mutant … (full text at CIViC) PMID 20978130 · Kamada et al., 2011 · Open in CIViC	civic
TP53 R337P	(functional)	Functional	D	Does Not Support Dominant Negative	3	submitted	EID10582 Yeast strain yIG397 was cultured to express both wild-type (WT) and mutant R337P originally identified in breast cancer. Should the mutant be dominant-negative (DN), TP53 will not bind and transactiva… (full text at CIViC) PMID 10519380 · Marutani et al., 1999 · Open in CIViC	civic

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.