Variant · Snv

TP53 G245D

CI-VAR-00001674Explore in graph →NP_000537.3:p.Gly245AspNM_000546.5:c.734G>AClinVar 12355 CIViC 1036 rs121912656

Curated evidence

Evidence by cancer (2 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–2 of 2 evidence items across 1 cancer context on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Unmapped disease2unmapped disease
TP53 G245D	(functional)	Functional	D	Supports Dominant Negative	3	accepted	EID10254 A set of previously characterized p53 mutants was tested in the yeast assay to understand their transdominant potential (dominant negative). Each mutant was expressed equally with the wild-type p53. T… (full text at CIViC) PMID 11896595 · Monti et al., 2002 · Open in CIViC	civic
TP53 G245D	(functional)	Functional	D	Supports Dominant Negative	3	submitted	EID10533 Yeast strain yIG397 was cultured to express both wild-type (WT) and mutant G245D originally identified in an oral lesion. Should the mutant be dominant-negative (DN), TP53 will not bind and transactiv… (full text at CIViC) PMID 10519380 · Marutani et al., 1999 · Open in CIViC	civic

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
12355	Pathogenic/Likely pathogenic	criteria provided, multiple submitters, no conflicts	2	Li-Fraumeni syndrome 1; Hereditary cancer-predisposing syndrome; Li-Fraumeni syndrome; Ovarian neoplasm; Embryonal rhabdomyosarcoma; Adrenocortical carcinoma, hereditary; Astrocytoma IDH-mutant; Diffuse midline glioma, H3 K27M-mutant	germline/somatic	12	May 22, 2025