Variant · Snv

TP53 R282W

CI-VAR-00003812Explore in graph →NP_000537.3:p.Arg282TrpNM_000546.5:c.844C>TClinVar 12364 CIViC 916 rs28934574

Curated evidence

Evidence by cancer (2 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–2 of 2 evidence items across 1 cancer context on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Unmapped disease2unmapped disease
TP53 R282W	(functional)	Functional	D	Does Not Support Neomorphic	3	accepted	EID7531 The R282W mutation was used to create isogenic AML cell lines using MOLM13 and K526 lines. R282W/- cells showed resistance to chemotherapeutic agents and failure to induce p21, indicating disruption o… (full text at CIViC) PMID 31395785 · Boettcher et al., 2019 · Open in CIViC	civic
TP53 R282W	(functional)	Functional	D	Does Not Support Dominant Negative	3	submitted	EID10580 Yeast strain yIG397 was cultured to express both wild-type (WT) and mutant R282W originally identified in breast cancer. Should the mutant be dominant-negative (DN), TP53 will not bind and transactiva… (full text at CIViC) PMID 10519380 · Marutani et al., 1999 · Open in CIViC	civic

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
12364	Pathogenic/Likely pathogenic	criteria provided, multiple submitters, no conflicts	2	Li-fraumeni-like syndrome; Li-Fraumeni syndrome 1; Li-Fraumeni syndrome; Hereditary cancer-predisposing syndrome; Squamous cell carcinoma of the head and neck; Astrocytoma, anaplastic; Pleomorphic xanthoastrocytoma; Ovarian neoplasm; Colorectal cancer; Diffuse pediatric-type high-grade glioma, H3-wildtype and IDH-wildtype; Neoplasm; Adrenocortical carcinoma, hereditary; TP53-related disorder; Melanoma; Low grade glioma; Astrocytoma IDH-mutant; Diffuse midline glioma, H3 K27M-mutant; Medulloblastoma WNT activated; Juvenile type testicular granulosa cell tumor; Rhabdomyosarcoma; Diffuse glioma, H3 G34 mutant; Signet ring cell carcinoma