TP53 C135W

CI-VAR-00000273Explore in graph →NP_000537.3:p.Cys135TrpNM_000546.5:c.405C>GClinVar 376561 CIViC 924 rs1057519976

Curated evidence

Evidence by cancer (1 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–1 of 1 evidence items across 1 cancer context on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Unmapped disease1unmapped disease
TP53 C135W	(functional)	Functional	D	Does Not Support Dominant Negative	3	accepted	EID10557 Yeast strain yIG397 was cultured to express both wild-type (WT) and mutant C135W originally identified in glioblastoma. Should the mutant be dominant-negative (DN), TP53 will not bind and transactivat… (full text at CIViC) PMID 10519380 · Marutani et al., 1999 · Open in CIViC	civic

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
376561	Conflicting classifications of pathogenicity	criteria provided, conflicting classifications	1	Li-Fraumeni syndrome; Hereditary cancer-predisposing syndrome; Li-Fraumeni syndrome 1	germline	4	Apr 15, 2024	clinvar