TP53 Y126C

CI-VAR-00417004Explore in graph →CIViC 5576

Curated evidence

Evidence by cancer (2 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–2 of 2 evidence items across 1 cancer context on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Unmapped disease2unmapped disease
TP53 Y126C	(functional)	Functional	D	Supports Loss Of Function	3	accepted	EID13259 In pooled saturation-mutagenesis screens using TP53-null A549 lung carcinoma cells, TP53 Y126C showed behavior consistent with loss of p53 function. Y126C had a Z-score of 1.11 under nutlin-3 selectio… (full text at CIViC) PMID 30224644 · Giacomelli et al., 2018 · Open in CIViC	civic
TP53 Y126C	(functional)	Functional	D	Supports Dominant Negative	3	accepted	EID13260 In TP53-WT A549 cells (human lung adenocarcinoma cell line) expressing a pooled TP53 mutant library, TP53 Y126C was enriched during nutlin-3 selection with a Z-score of 1.40, consistent with interfere… (full text at CIViC) PMID 30224644 · Giacomelli et al., 2018 · Open in CIViC	civic

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.