TP53 P72R

CI-VAR-00003390Explore in graph →NP_000537.3:p.Pro72ArgNM_000546.5:c.215C>GClinVar 12351 CIViC 531 rs1042522

Curated evidence

Evidence by cancer (3 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–3 of 3 evidence items across 3 cancer contexts on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Lung Carcinoma1
TP53 P72R	(prognostic)	Prognostic	B	Does Not Support Poor Outcome	3	accepted	EID1303 Pooled data from 13 studies of patients with lung cancer found little effect of codon 72 allele on the overall survival of patients with lung cancer. Proline homozygous patients were correlated with s… (full text at CIViC) PMID 12840112 · Matakidou et al., 2003 · Open in CIViC	civic
Malignant Cervical Neoplasm1
TP53 P72R	(prognostic)	Prognostic	B	Does Not Support Poor Outcome	2	accepted	EID1304 In a relatively small meta-analysis of 119 women with cervical cancer and 127 controls, associations with homozygosity for arginine, and heterozygosity at this locus were both associated with odds rat… (full text at CIViC) PMID 11535556 ·

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
12351	Benign	reviewed by expert panel	3	TP53 POLYMORPHISM; Hereditary cancer-predisposing syndrome; Li-Fraumeni syndrome 1; Li-Fraumeni syndrome; Hereditary breast ovarian cancer syndrome; Acute myeloid leukemia; Neoplasm; Cervical cancer	germline/somatic	34	Dec 05, 2025	clinvar

Oligodendroglioma1
TP53 P72R	(prognostic)	Prognostic	B	Does Not Support Poor Outcome	2	submitted	EID6932 In the evaluation of 275 oligodendroglial tumors, the specific genotype at amino acid 72 of TP53 (Arg/Arg, Arg/Pro, or Pro/Pro) was not associated grade of malignancy (low- vs. high-grade, P = 0.650) … (full text at CIViC) PMID 17854663 · Idbaih et al., 2007 · Open in CIViC	civic