TP53 E180K

CI-VAR-00000679Explore in graph →CIViC 3585

Curated evidence

Evidence by cancer (1 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–1 of 1 evidence items across 1 cancer context on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Unmapped disease1unmapped disease
TP53 E180K	(functional)	Functional	D	Supports Loss Of Function	3	submitted	EID9811 The E180K mutation in the DNA binding domain of TP53 caused reduced affinity for BCL-xL by an order of magnitude, as measured by a fluorescence polarization assay. E180K mutant p53 also showed weaker … (full text at CIViC) PMID 24814347 · Follis et al., 2014 · Open in CIViC	civic

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.