Variant · Snv

TP53 C238Y

CI-VAR-00000297Explore in graph →NP_000537.3:p.Cys238TyrNM_000546.5:c.713G>AClinVar 182935 CIViC 2648 rs730882005

Curated evidence

Evidence by cancer (2 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–2 of 2 evidence items across 2 cancer contexts on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Malignant Breast Neoplasm1
TP53 C238Y	(prognostic)	Prognostic	E	Supports Poor Outcome	3	accepted	EID7173 Cys-238 was directly bound to zinc molecule. Patients with missense mutations affecting amino acids directly involved in DNA or zinc binding displayed a very aggressive clinical phenotype. When patien… (full text at CIViC) PMID 11051239 · Alsner et al., 2000 · Open in CIViC	civic
Unmapped disease1unmapped disease
TP53 C238Y	(functional)	Functional	D	Supports Dominant Negative	2	accepted	EID7215 This study evaluated the dominant negative potential of 103 p53 germline mutations contained in the IRAC database. The C238Y variant was considered severely deficient as cotransformation with empty ve… (full text at CIViC) PMID 21343334 ·

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
182935	Pathogenic/Likely pathogenic	criteria provided, multiple submitters, no conflicts	2	Hereditary cancer-predisposing syndrome; Li-Fraumeni syndrome; Ovarian neoplasm; Gallbladder cancer; Li-Fraumeni syndrome 1; Adrenocortical carcinoma, hereditary; Neoplasm; Hereditary breast ovarian cancer syndrome; TP53-related disorder	germline/somatic	14	Jan 28, 2026