TP53 G105C

CI-VAR-00001563Explore in graph →CIViC 5547

Curated evidence

Evidence by cancer (5 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–5 of 5 evidence items across 1 cancer context on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Unmapped disease5unmapped disease
TP53 G105C	(functional)	Functional	D	Supports Loss Of Function	3	rejected	EID13160 In a comprehensive yeast-based functional screen of 2,314 TP53 missense variants, TP53 G105C was evaluated for sequence-specific transcriptional activity using reporter constructs containing p53-bindi… (full text at CIViC) PMID 12826609 · Kato et al., 2003 · Open in CIViC	civic
TP53 G105C	(functional)	Functional	D	Supports Loss Of Function	2	submitted	EID13188 In a surgical specimen from a patient with lung squamous cell carcinoma, split functional analysis of separated alleles in yeast (FASAY) identified a transcriptionally impaired TP53 allele containing … (full text at CIViC) PMID 15161705 · Fouquet et al., 2004 · Open in CIViC	civic

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.