Malignant Uterine Neoplasm — Genomics

Malignant Uterine Neoplasm — Genomics · CancerIndex

Genomics

Gene alteration frequencies by cohort

26 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.

Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma TCGA-CESCTCGA

306 cases with simple somatic mutation data · 307 cases total · Data Release 46.0 · mapped to Cervical Carcinoma CURATED_BROADER

gdcObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source

Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.

Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA, Firehose Legacy) cesc_tcgaTCGA

194 cases with simple somatic mutation data · 310 cases total · 2026-01-05 · mapped to Cervical Squamous Cell Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TTN	Ssm	62	194	32%	cbioportal
2	PIK3CA	Ssm	53	194	27.3%	cbioportal
3	MUC4	Ssm	37	194	19.1%	cbioportal
4	KMT2C	Ssm	29	194	14.9%	cbioportal
5	MUC16	Ssm	28	194	14.4%	cbioportal
6	ADGRV1	Ssm	26	194	13.4%	cbioportal
7	SYNE1	Ssm	23	194	11.9%	cbioportal
8	KMT2D	Ssm	22	194	11.3%	cbioportal
10	RYR2	Ssm	21	194	10.8%	cbioportal
9	EP300	Ssm	21	194	10.8%	cbioportal
12	FLG	Ssm	20	194	10.3%	cbioportal
13	SYNE2	Ssm	20	194	10.3%	cbioportal
11	DMD	Ssm	20	194	10.3%	cbioportal
14	FBXW7	Ssm	19	194	9.8%	cbioportal
15	USH2A	Ssm	18	194	9.3%	cbioportal
16	OBSCN	Ssm	17	194	8.8%	cbioportal
22	MUC5B	Ssm	16	194	8.2%	cbioportal
17	HLA-A	Ssm	16	194	8.2%	cbioportal
19	MACF1	Ssm	16	194	8.2%	cbioportal
18	HMCN1	Ssm	16	194	8.2%	cbioportal
20	MDN1	Ssm	16	194	8.2%	cbioportal
21	MUC12	Ssm	16	194	8.2%	cbioportal
25	ARID1A	Ssm	15	194	7.7%	cbioportal
27	NEB	Ssm	15	194	7.7%	cbioportal
28	PCLO	Ssm	15	194	7.7%	cbioportal
29	PTEN	Ssm	15	194	7.7%	cbioportal
23	ABCA12	Ssm	15	194	7.7%	cbioportal
24	APOB	Ssm	15	194	7.7%	cbioportal
26	DNAH6	Ssm	15	194	7.7%	cbioportal
30	CREBBP	Ssm	14	194	7.2%	cbioportal

Data updated 22 days agoSource updated 2026-01-05

Cervical Squamous Cell Carcinoma (TCGA GDC, 2025) cesc_tcga_gdcTCGA GDC

289 cases with simple somatic mutation data · 309 cases total · 2026-01-13 · mapped to Cervical Squamous Cell Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TTN	Ssm	87	289	30.1%	cbioportal
2	PIK3CA	Ssm	81	289	28%	cbioportal
3	KMT2C	Ssm	54	289	18.7%	cbioportal
4	MUC16	Ssm	49	289	17%	cbioportal
5	KMT2D	Ssm	39	289	13.5%	cbioportal
6	FLG	Ssm	37	289	12.8%	cbioportal
7	EP300	Ssm	36	289	12.5%	cbioportal
9	SYNE1	Ssm	35	289	12.1%	cbioportal
8	DMD	Ssm	35	289	12.1%	cbioportal
10	FBXW7	Ssm	34	289	11.8%	cbioportal
11	LRP1B	Ssm	33	289	11.4%	cbioportal
12	RYR2	Ssm	32	289	11.1%	cbioportal
13	DST	Ssm	31	289	10.7%	cbioportal
14	ADGRV1	Ssm	29	289	10%	cbioportal
15	USH2A	Ssm	29	289	10%	cbioportal
16	HUWE1	Ssm	28	289	9.7%	cbioportal
17	MUC17	Ssm	28	289	9.7%	cbioportal
20	NEB	Ssm	24	289	8.3%	cbioportal
18	LRP2	Ssm	24	289	8.3%	cbioportal
19	NAV3	Ssm	24	289	8.3%	cbioportal
21	SYNE2	Ssm	24	289	8.3%	cbioportal
22	PCLO	Ssm	23	289	8%	cbioportal
24	DNAH2	Ssm	22	289	7.6%	cbioportal
28	MUC5B	Ssm	22	289	7.6%	cbioportal
27	MDN1	Ssm	22	289	7.6%	cbioportal
26	HMCN1	Ssm	22	289	7.6%	cbioportal
25	FAT1	Ssm	22	289	7.6%	cbioportal
23	CREBBP	Ssm	22	289	7.6%	cbioportal
29	CSMD1	Ssm	21	289	7.3%	cbioportal
30	HYDIN	Ssm	21	289	7.3%	cbioportal

Data updated 22 days agoSource updated 2026-01-13

Cervical Squamous Cell Carcinoma (TCGA, PanCancer Atlas) cesc_tcga_pan_can_atlas_2018TCGA

291 cases with simple somatic mutation data · 297 cases total · 2026-06-05 · mapped to Cervical Squamous Cell Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TTN	Ssm	91	291	31.3%	cbioportal
2	PIK3CA	Ssm	83	291	28.5%	cbioportal
3	KMT2C	Ssm	54	291	18.6%	cbioportal
4	MUC4	Ssm	50	291	17.2%	cbioportal
5	MUC16	Ssm	48	291	16.5%	cbioportal
6	KMT2D	Ssm	41	291	14.1%	cbioportal
7	FLG	Ssm	38	291	13.1%	cbioportal
8	DMD	Ssm	37	291	12.7%	cbioportal
9	SYNE1	Ssm	37	291	12.7%	cbioportal
12	RYR2	Ssm	35	291	12%	cbioportal
11	FBXW7	Ssm	35	291	12%	cbioportal
10	EP300	Ssm	35	291	12%	cbioportal
14	USH2A	Ssm	33	291	11.3%	cbioportal
13	LRP1B	Ssm	33	291	11.3%	cbioportal
15	ADGRV1	Ssm	30	291	10.3%	cbioportal
16	MUC17	Ssm	30	291	10.3%	cbioportal
17	HUWE1	Ssm	28	291	9.6%	cbioportal
18	CSMD1	Ssm	27	291	9.3%	cbioportal
19	NEB	Ssm	26	291	8.9%	cbioportal
20	NAV3	Ssm	25	291	8.6%	cbioportal
25	SYNE2	Ssm	24	291	8.2%	cbioportal
23	LRP2	Ssm	24	291	8.2%	cbioportal
22	HMCN1	Ssm	24	291	8.2%	cbioportal
21	AHNAK2	Ssm	24	291	8.2%	cbioportal
24	PCLO	Ssm	24	291	8.2%	cbioportal
30	FAT1	Ssm	23	291	7.9%	cbioportal
27	DNAH2	Ssm	23	291	7.9%	cbioportal
28	DST	Ssm	23	291	7.9%	cbioportal
29	EYS	Ssm	23	291	7.9%	cbioportal
26	CREBBP	Ssm	23	291	7.9%	cbioportal

Data updated 22 days agoSource updated 2026-06-05

Endometrial cancer HR-positive (MSK, 2024) uec_msk_2024MSK

23 cases with simple somatic mutation data · 24 cases total · 2026-01-20 · mapped to Endometrial Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	PTEN	Ssm	15	24	62.5%	cbioportal
2	ARID1A	Ssm	14	24	58.3%	cbioportal
3	PIK3CA	Ssm	12	24	50%	cbioportal
4	PIK3R1	Ssm	10	24	41.7%	cbioportal
5	CTNNB1	Ssm	9	24	37.5%	cbioportal
6	KRAS	Ssm	6	24	25%	cbioportal
7	BCOR	Ssm	5	24	20.8%	cbioportal
8	FGFR2	Ssm	4	24	16.7%	cbioportal
11	ZFHX3	Ssm	4	24	16.7%	cbioportal
9	KMT2D	Ssm	4	24	16.7%	cbioportal
10	PIK3CG	Ssm	4	24	16.7%	cbioportal
15	KMT2B	Ssm	3	23	13%	cbioportal
19	TP53	Ssm	3	24	12.5%	cbioportal
12	CCND1	Ssm	3	24	12.5%	cbioportal
18	SPOP	Ssm	3	24	12.5%	cbioportal
17	NOTCH1	Ssm	3	24	12.5%	cbioportal
16	MAP3K1	Ssm	3	24	12.5%	cbioportal
14	JAK1	Ssm	3	24	12.5%	cbioportal
13	CTCF	Ssm	3	24	12.5%	cbioportal
78	GAB1	Ssm	1	9	11.1%	cbioportal
124	SPRTN	Ssm	1	9	11.1%	cbioportal
120	SMARCE1	Ssm	1	9	11.1%	cbioportal
108	REST	Ssm	1	9	11.1%	cbioportal
68	ETAA1	Ssm	1	9	11.1%	cbioportal
27	INPPL1	Ssm	2	23	8.7%	cbioportal
39	SLX4	Ssm	2	23	8.7%	cbioportal
20	ACVR1	Ssm	2	24	8.3%	cbioportal
22	ANKRD11	Ssm	2	24	8.3%	cbioportal
37	POLD1	Ssm	2	24	8.3%	cbioportal
21	AKT1	Ssm	2	24	8.3%	cbioportal

Data updated 22 days agoSource updated 2026-01-20

Endometrial Cancer (MSK, 2018) ucec_msk_2018MSK

197 cases with simple somatic mutation data · 197 cases total · 2026-01-13 · mapped to Endometrial Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	107	197	54.3%	cbioportal
2	PIK3CA	Ssm	80	197	40.6%	cbioportal
3	ARID1A	Ssm	59	197	29.9%	cbioportal
4	PTEN	Ssm	57	197	28.9%	cbioportal
5	PIK3R1	Ssm	46	197	23.4%	cbioportal
6	KRAS	Ssm	42	197	21.3%	cbioportal
7	KMT2D	Ssm	32	197	16.2%	cbioportal
9	PPP2R1A	Ssm	30	197	15.2%	cbioportal
8	CTNNB1	Ssm	30	197	15.2%	cbioportal
10	FBXW7	Ssm	28	197	14.2%	cbioportal
18	ZFHX3	Ssm	16	128	12.5%	cbioportal
11	CTCF	Ssm	23	197	11.7%	cbioportal
12	BCOR	Ssm	20	197	10.2%	cbioportal
14	FAT1	Ssm	19	197	9.6%	cbioportal
13	ATM	Ssm	19	197	9.6%	cbioportal
15	JAK1	Ssm	19	197	9.6%	cbioportal
16	KMT2C	Ssm	17	197	8.6%	cbioportal
17	NOTCH3	Ssm	16	197	8.1%	cbioportal
20	MTOR	Ssm	15	197	7.6%	cbioportal
19	MED12	Ssm	15	197	7.6%	cbioportal
21	SMARCA4	Ssm	15	197	7.6%	cbioportal
23	SPEN	Ssm	14	197	7.1%	cbioportal
22	EP300	Ssm	14	197	7.1%	cbioportal
26	FGFR2	Ssm	13	197	6.6%	cbioportal
27	KDM5C	Ssm	13	197	6.6%	cbioportal
24	AKT1	Ssm	13	197	6.6%	cbioportal
28	TSC2	Ssm	13	197	6.6%	cbioportal
25	ARID1B	Ssm	13	197	6.6%	cbioportal
54	ANKRD11	Ssm	8	128	6.3%	cbioportal
29	ERBB3	Ssm	12	197	6.1%	cbioportal

Data updated 22 days agoSource updated 2026-01-13

Endometrial Cancer (MSK, Cancer Discovery 2023) ucec_ancestry_cds_msk_2023MSK

1,882 cases with simple somatic mutation data · 1,882 cases total · 2026-01-13 · mapped to Endometrial Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	PTEN	Ssm	941	1,882	50%	cbioportal
2	TP53	Ssm	850	1,882	45.2%	cbioportal
3	PIK3CA	Ssm	824	1,882	43.8%	cbioportal
4	ARID1A	Ssm	793	1,882	42.1%	cbioportal
5	PIK3R1	Ssm	484	1,882	25.7%	cbioportal
6	KRAS	Ssm	357	1,882	19%	cbioportal
7	CTCF	Ssm	305	1,882	16.2%	cbioportal
8	CTNNB1	Ssm	296	1,882	15.7%	cbioportal
9	FBXW7	Ssm	276	1,882	14.7%	cbioportal
10	ZFHX3	Ssm	237	1,824	13%	cbioportal
13	KMT2B	Ssm	208	1,661	12.5%	cbioportal
11	KMT2D	Ssm	231	1,882	12.3%	cbioportal
12	PPP2R1A	Ssm	226	1,882	12%	cbioportal
15	INPPL1	Ssm	171	1,661	10.3%	cbioportal
14	BCOR	Ssm	184	1,882	9.8%	cbioportal
16	JAK1	Ssm	171	1,882	9.1%	cbioportal
17	RNF43	Ssm	154	1,882	8.2%	cbioportal
18	FGFR2	Ssm	151	1,882	8%	cbioportal
19	ATM	Ssm	139	1,882	7.4%	cbioportal
20	NF1	Ssm	118	1,882	6.3%	cbioportal
21	NSD1	Ssm	103	1,882	5.5%	cbioportal
22	ARID1B	Ssm	102	1,882	5.4%	cbioportal
24	KMT2C	Ssm	96	1,882	5.1%	cbioportal
23	ARID5B	Ssm	96	1,882	5.1%	cbioportal
25	SOX17	Ssm	93	1,882	4.9%	cbioportal
26	CCND1	Ssm	92	1,882	4.9%	cbioportal
28	POLE	Ssm	91	1,882	4.8%	cbioportal
27	FAT1	Ssm	91	1,882	4.8%	cbioportal
29	MED12	Ssm	89	1,882	4.7%	cbioportal
30	RASA1	Ssm	88	1,882	4.7%	cbioportal

Data updated 22 days agoSource updated 2026-01-13

Endometrial Carcinoma cfDNA (MSK, Clin Cancer Res 2022) ucec_ccr_cfdna_msk_2022MSK

44 cases with simple somatic mutation data · 44 cases total · 2026-01-13 · mapped to Endometrial Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	22	44	50%	cbioportal
3	PTEN	Ssm	21	44	47.7%	cbioportal
2	PIK3CA	Ssm	21	44	47.7%	cbioportal
4	ARID1A	Ssm	15	44	34.1%	cbioportal
5	FBXW7	Ssm	12	44	27.3%	cbioportal
6	KRAS	Ssm	11	44	25%	cbioportal
7	PIK3R1	Ssm	9	44	20.5%	cbioportal
9	KMT2A	Ssm	8	44	18.2%	cbioportal
8	CTCF	Ssm	8	44	18.2%	cbioportal
10	KMT2B	Ssm	8	44	18.2%	cbioportal
11	KMT2D	Ssm	7	44	15.9%	cbioportal
12	JAK1	Ssm	6	44	13.6%	cbioportal
13	BCOR	Ssm	5	44	11.4%	cbioportal
19	ZFHX3	Ssm	5	44	11.4%	cbioportal
18	RNF43	Ssm	5	44	11.4%	cbioportal
17	POLD1	Ssm	5	44	11.4%	cbioportal
16	NFE2L2	Ssm	5	44	11.4%	cbioportal
15	INPPL1	Ssm	5	44	11.4%	cbioportal
14	EP300	Ssm	5	44	11.4%	cbioportal
24	NOTCH4	Ssm	4	44	9.1%	cbioportal
20	AR	Ssm	4	44	9.1%	cbioportal
21	ATR	Ssm	4	44	9.1%	cbioportal
22	CREBBP	Ssm	4	44	9.1%	cbioportal
23	ERF	Ssm	4	44	9.1%	cbioportal
25	PBRM1	Ssm	4	44	9.1%	cbioportal
26	PGR	Ssm	4	44	9.1%	cbioportal
27	PPP2R1A	Ssm	4	44	9.1%	cbioportal
28	RRAS2	Ssm	4	44	9.1%	cbioportal
29	ANKRD11	Ssm	3	44	6.8%	cbioportal
30	APC	Ssm	3	44	6.8%	cbioportal

Data updated 22 days agoSource updated 2026-01-13

Endometrial Carcinoma (CPTAC, Cell 2020) ucec_cptac_2020CPTAC

95 cases with simple somatic mutation data · 81 cases total · 2026-01-13 · mapped to Endometrial Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	PTEN	Ssm	75	95	78.9%	cbioportal
2	PIK3CA	Ssm	47	95	49.5%	cbioportal
3	ARID1A	Ssm	43	95	45.3%	cbioportal
4	PIK3R1	Ssm	36	95	37.9%	cbioportal
5	KRAS	Ssm	31	95	32.6%	cbioportal
6	CTNNB1	Ssm	29	95	30.5%	cbioportal
7	CTCF	Ssm	27	95	28.4%	cbioportal
8	KMT2B	Ssm	23	95	24.2%	cbioportal
9	TP53	Ssm	21	95	22.1%	cbioportal
10	ZFHX3	Ssm	21	95	22.1%	cbioportal
13	ZFHX4	Ssm	19	95	20%	cbioportal
11	DOCK3	Ssm	19	95	20%	cbioportal
12	INPPL1	Ssm	19	95	20%	cbioportal
14	FBXW7	Ssm	18	95	18.9%	cbioportal
15	MUC16	Ssm	18	95	18.9%	cbioportal
16	HERC2	Ssm	17	95	17.9%	cbioportal
17	KMT2D	Ssm	17	95	17.9%	cbioportal
18	JAK1	Ssm	16	95	16.8%	cbioportal
19	LRTM3	Ssm	16	95	16.8%	cbioportal
20	NSD1	Ssm	16	95	16.8%	cbioportal
21	PCLO	Ssm	16	95	16.8%	cbioportal
22	RBM27	Ssm	16	95	16.8%	cbioportal
23	RPL22	Ssm	16	95	16.8%	cbioportal
24	SCAF4	Ssm	16	95	16.8%	cbioportal
25	SYNE1	Ssm	16	95	16.8%	cbioportal
30	OBSCN	Ssm	15	95	15.8%	cbioportal
26	AHNAK	Ssm	15	95	15.8%	cbioportal
27	DNAH17	Ssm	15	95	15.8%	cbioportal
28	HUWE1	Ssm	15	95	15.8%	cbioportal
29	LMAN1	Ssm	15	95	15.8%	cbioportal

Data updated 22 days agoSource updated 2026-01-13

Endometrial Carcinoma MSI (MSK, Clin Cancer Res 2022) ucec_ccr_msk_2022MSK

181 cases with simple somatic mutation data · 181 cases total · 2026-01-13 · mapped to Endometrial Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	ARID1A	Ssm	160	181	88.4%	cbioportal
2	PTEN	Ssm	156	181	86.2%	cbioportal
3	KMT2D	Ssm	122	181	67.4%	cbioportal
5	KMT2B	Ssm	106	169	62.7%	cbioportal
4	PIK3CA	Ssm	112	181	61.9%	cbioportal
6	CTCF	Ssm	101	181	55.8%	cbioportal
8	INPPL1	Ssm	86	169	50.9%	cbioportal
7	ZFHX3	Ssm	90	180	50%	cbioportal
9	JAK1	Ssm	76	181	42%	cbioportal
10	RNF43	Ssm	76	181	42%	cbioportal
11	ARID1B	Ssm	67	181	37%	cbioportal
13	PIK3R1	Ssm	62	181	34.3%	cbioportal
12	FAT1	Ssm	62	181	34.3%	cbioportal
14	CIC	Ssm	54	181	29.8%	cbioportal
15	NOTCH3	Ssm	53	181	29.3%	cbioportal
16	ANKRD11	Ssm	51	180	28.3%	cbioportal
17	BCOR	Ssm	51	181	28.2%	cbioportal
18	KMT2C	Ssm	51	181	28.2%	cbioportal
19	CREBBP	Ssm	50	181	27.6%	cbioportal
21	SMARCA4	Ssm	48	181	26.5%	cbioportal
20	MSH6	Ssm	48	181	26.5%	cbioportal
23	POLD1	Ssm	47	180	26.1%	cbioportal
22	KRAS	Ssm	47	181	26%	cbioportal
25	PTPRS	Ssm	46	181	25.4%	cbioportal
24	FGFR2	Ssm	46	181	25.4%	cbioportal
26	SPEN	Ssm	46	181	25.4%	cbioportal
27	IRS2	Ssm	45	181	24.9%	cbioportal
28	FBXW7	Ssm	44	181	24.3%	cbioportal
30	CCND1	Ssm	43	181	23.8%	cbioportal
29	ATM	Ssm	43	181	23.8%	cbioportal

Data updated 22 days agoSource updated 2026-01-13

Endometrial Carcinoma (MSK, Molecular Oncology 2024) ucs_msk_2024MSK

69 cases with simple somatic mutation data · 69 cases total · 2026-03-09 · mapped to Endometrial Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	ERBB2	Ssm	69	69	100%	cbioportal
2	ARID1A	Ssm	47	69	68.1%	cbioportal
3	PIK3CA	Ssm	41	69	59.4%	cbioportal
4	PTEN	Ssm	40	69	58%	cbioportal
6	TP53	Ssm	35	69	50.7%	cbioportal
5	KMT2D	Ssm	35	69	50.7%	cbioportal
7	FBXW7	Ssm	27	69	39.1%	cbioportal
15	KMT2B	Ssm	20	57	35.1%	cbioportal
9	NOTCH3	Ssm	24	69	34.8%	cbioportal
8	FAT1	Ssm	24	69	34.8%	cbioportal
10	ZFHX3	Ssm	23	68	33.8%	cbioportal
104	ARHGAP35	Ssm	8	25	32%	cbioportal
11	NOTCH1	Ssm	22	69	31.9%	cbioportal
13	KMT2C	Ssm	21	69	30.4%	cbioportal
12	ERBB3	Ssm	21	69	30.4%	cbioportal
14	ATM	Ssm	20	69	29%	cbioportal
16	POLE	Ssm	20	69	29%	cbioportal
18	CREBBP	Ssm	19	69	27.5%	cbioportal
19	SMARCA4	Ssm	19	69	27.5%	cbioportal
17	ARID1B	Ssm	19	69	27.5%	cbioportal
20	ANKRD11	Ssm	18	68	26.5%	cbioportal
34	INPPL1	Ssm	15	57	26.3%	cbioportal
33	DROSHA	Ssm	15	57	26.3%	cbioportal
24	PIK3R1	Ssm	18	69	26.1%	cbioportal
23	NSD1	Ssm	18	69	26.1%	cbioportal
22	MSH2	Ssm	18	69	26.1%	cbioportal
21	BCOR	Ssm	18	69	26.1%	cbioportal
27	SPEN	Ssm	17	69	24.6%	cbioportal
26	PPP2R1A	Ssm	17	69	24.6%	cbioportal
25	CTCF	Ssm	17	69	24.6%	cbioportal

Data updated 22 days agoSource updated 2026-03-09

Endometrial Carcinoma (TCGA GDC, 2025) ucec_tcga_gdcTCGA GDC

511 cases with simple somatic mutation data · 547 cases total · 2026-01-14 · mapped to Endometrial Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	PTEN	Ssm	334	511	65.4%	cbioportal
2	PIK3CA	Ssm	252	511	49.3%	cbioportal
3	ARID1A	Ssm	235	511	46%	cbioportal
4	TTN	Ssm	194	511	38%	cbioportal
5	TP53	Ssm	190	511	37.2%	cbioportal
6	PIK3R1	Ssm	166	511	32.5%	cbioportal
7	KMT2D	Ssm	140	511	27.4%	cbioportal
8	CTNNB1	Ssm	130	511	25.4%	cbioportal
9	MUC16	Ssm	127	511	24.9%	cbioportal
10	CTCF	Ssm	126	511	24.7%	cbioportal
11	CSMD3	Ssm	121	511	23.7%	cbioportal
12	ZFHX3	Ssm	118	511	23.1%	cbioportal
13	RYR2	Ssm	116	511	22.7%	cbioportal
14	KMT2B	Ssm	114	511	22.3%	cbioportal
15	OBSCN	Ssm	111	511	21.7%	cbioportal
16	DST	Ssm	109	511	21.3%	cbioportal
17	MUC5B	Ssm	105	511	20.5%	cbioportal
18	ZFHX4	Ssm	105	511	20.5%	cbioportal
20	FAT1	Ssm	104	511	20.4%	cbioportal
19	CHD4	Ssm	104	511	20.4%	cbioportal
21	SYNE1	Ssm	103	511	20.2%	cbioportal
22	DNAH7	Ssm	102	511	20%	cbioportal
23	MACF1	Ssm	102	511	20%	cbioportal
25	TAF1	Ssm	101	511	19.8%	cbioportal
24	FAT4	Ssm	101	511	19.8%	cbioportal
26	ARHGAP35	Ssm	98	511	19.2%	cbioportal
27	PCLO	Ssm	98	511	19.2%	cbioportal
30	DNAH5	Ssm	96	511	18.8%	cbioportal
29	DMD	Ssm	96	511	18.8%	cbioportal
28	ATM	Ssm	96	511	18.8%	cbioportal

Data updated 22 days agoSource updated 2026-01-14

Evolution and co-occurrence of PI3K pathway gene mutations in endometrial carcinoma molecular subtypes at the single-cell level ucec_msk_dacruzpaula_2025

11 cases with simple somatic mutation data · 11 cases total · 2026-01-20 · mapped to Endometrial Carcinoma EXACT_IDENTIFIER

cbioportalObserved25 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	PTEN	Ssm	10	11	90.9%	cbioportal
2	PIK3R1	Ssm	9	11	81.8%	cbioportal
3	PIK3CA	Ssm	7	11	63.6%	cbioportal
4	CTCF	Ssm	5	11	45.5%	cbioportal
5	FGFR2	Ssm	4	11	36.4%	cbioportal
8	TP53	Ssm	3	11	27.3%	cbioportal
6	ARID1A	Ssm	3	11	27.3%	cbioportal
7	KRAS	Ssm	3	11	27.3%	cbioportal
13	FBXW7	Ssm	2	11	18.2%	cbioportal
14	PDGFRA	Ssm	2	11	18.2%	cbioportal
12	ERBB4	Ssm	2	11	18.2%	cbioportal
11	EGFR	Ssm	2	11	18.2%	cbioportal
10	CTNNB1	Ssm	2	11	18.2%	cbioportal
9	ATM	Ssm	2	11	18.2%	cbioportal
21	NOTCH1	Ssm	1	11	9.1%	cbioportal
22	RB1	Ssm	1	11	9.1%	cbioportal
25	VHL	Ssm	1	11	9.1%	cbioportal
23	SMAD4	Ssm	1	11	9.1%	cbioportal
18	HRAS	Ssm	1	11	9.1%	cbioportal
19	MET	Ssm	1	11	9.1%	cbioportal
17	HNF1A	Ssm	1	11	9.1%	cbioportal
16	GNAQ	Ssm	1	11	9.1%	cbioportal
15	BRAF	Ssm	1	11	9.1%	cbioportal
20	MTOR	Ssm	1	11	9.1%	cbioportal
24	SMARCB1	Ssm	1	11	9.1%	cbioportal

Data updated 22 days agoSource updated 2026-01-20

HIV+ Tumor Molecular Characterization Project - Cervical Cancer CGCI-HTMCP-CCCGCI

208 cases with simple somatic mutation data · 212 cases total · Data Release 46.0 · mapped to Cervical Carcinoma CURATED_BROADER

gdcObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	PIK3CA	Ssm	112	208	53.8%	gdc
2	MUC4	Ssm	100	208	48.1%	gdc
3	LRCH3	Ssm	98	208	47.1%	gdc
12	MUC20	Ssm	97	208	46.6%	gdc
5	PIGX	Ssm	97	208	46.6%	gdc
13	PAK2	Ssm	97	208	46.6%	gdc
4	SENP5	Ssm	97	208	46.6%	gdc
6	NCBP2AS2	Ssm	97	208	46.6%	gdc
7	DLG1	Ssm	97	208	46.6%	gdc
8	NRROS	Ssm	97	208	46.6%	gdc
10	CEP19	Ssm	97	208	46.6%	gdc
9	NCBP2	Ssm	97	208	46.6%	gdc
11	PIGZ	Ssm	97	208	46.6%	gdc
19	UBXN7	Ssm	96	208	46.2%	gdc
20	TM4SF19-TCTEX1D2	Ssm	96	208	46.2%	gdc
21	TM4SF19	Ssm	96	208	46.2%	gdc
22	BDH1	Ssm	96	208	46.2%	gdc
24	MELTF	Ssm	96	208	46.2%	gdc
25	PCYT1A	Ssm	96	208	46.2%	gdc
27	AC069257.3	Ssm	96	208	46.2%	gdc
28	SMCO1	Ssm	96	208	46.2%	gdc
29	SI	Ssm	96	208	46.2%	gdc
30	FBXO45	Ssm	96	208	46.2%	gdc
31	ZDHHC19	Ssm	96	208	46.2%	gdc
23	TFRC	Ssm	96	208	46.2%	gdc
14	SLC51A	Ssm	96	208	46.2%	gdc
15	RUBCN	Ssm	96	208	46.2%	gdc
16	WDR53	Ssm	96	208	46.2%	gdc
17	RNF168	Ssm	96	208	46.2%	gdc
18	FYTTD1	Ssm	96	208	46.2%	gdc

Data updated 22 days agoSource updated Data Release 46.0

Uterine Carcinosarcoma TCGA-UCSTCGA

57 cases with simple somatic mutation data · 57 cases total · Data Release 46.0 · mapped to Uterine Carcinosarcoma ONTOLOGY_EXACT

gdcObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	52	57	91.2%	gdc
3	MELTF	Ssm	46	57	80.7%	gdc
2	PIK3CA	Ssm	46	57	80.7%	gdc
10	ATP13A4	Ssm	45	57	78.9%	gdc
16	TRA2B	Ssm	45	57	78.9%	gdc
15	APOD	Ssm	45	57	78.9%	gdc
14	EEF1AKMT4-ECE2	Ssm	45	57	78.9%	gdc
13	MUC4	Ssm	45	57	78.9%	gdc
12	FGF12	Ssm	45	57	78.9%	gdc
11	RNF168	Ssm	45	57	78.9%	gdc
9	MB21D2	Ssm	45	57	78.9%	gdc
8	YEATS2	Ssm	45	57	78.9%	gdc
7	ATP13A5	Ssm	45	57	78.9%	gdc
6	ADRM1	Ssm	45	57	78.9%	gdc
5	LAMA5	Ssm	45	57	78.9%	gdc
4	SENP5	Ssm	45	57	78.9%	gdc
21	PSMA7	Ssm	45	57	78.9%	gdc
20	OPA1	Ssm	45	57	78.9%	gdc
19	FBXO45	Ssm	45	57	78.9%	gdc
18	GATA5	Ssm	45	57	78.9%	gdc
17	OSTN	Ssm	45	57	78.9%	gdc
65	ACAP2	Ssm	44	57	77.2%	gdc
29	RBBP8NL	Ssm	44	57	77.2%	gdc
28	AHSG	Ssm	44	57	77.2%	gdc
27	SLC51A	Ssm	44	57	77.2%	gdc
26	TNK2	Ssm	44	57	77.2%	gdc
25	NCBP2AS2	Ssm	44	57	77.2%	gdc
24	DVL3	Ssm	44	57	77.2%	gdc
23	PIGX	Ssm	44	57	77.2%	gdc
22	SS18L1	Ssm	44	57	77.2%	gdc

Data updated 22 days agoSource updated Data Release 46.0

Uterine Carcinosarcoma (Johns Hopkins, Nat Commun 2014) ucs_jhu_2014Johns Hopkins

22 cases with simple somatic mutation data · 22 cases total · 2026-01-16 · mapped to Uterine Malignant Mixed Mesodermal (Mullerian) Tumor EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	16	22	72.7%	cbioportal
3	PTEN	Ssm	9	22	40.9%	cbioportal
2	PIK3CA	Ssm	9	22	40.9%	cbioportal
4	ARID1A	Ssm	8	22	36.4%	cbioportal
8	TTN	Ssm	6	22	27.3%	cbioportal
7	PXDNL	Ssm	6	22	27.3%	cbioportal
6	KRAS	Ssm	6	22	27.3%	cbioportal
5	KMT2C	Ssm	6	22	27.3%	cbioportal
24	URB1	Ssm	5	22	22.7%	cbioportal
20	PLEC	Ssm	5	22	22.7%	cbioportal
21	SPEG	Ssm	5	22	22.7%	cbioportal
22	SPTBN5	Ssm	5	22	22.7%	cbioportal
23	TRRAP	Ssm	5	22	22.7%	cbioportal
11	BLTP1	Ssm	5	22	22.7%	cbioportal
9	APOB	Ssm	5	22	22.7%	cbioportal
10	BCOR	Ssm	5	22	22.7%	cbioportal
12	CDHR3	Ssm	5	22	22.7%	cbioportal
13	CNTNAP2	Ssm	5	22	22.7%	cbioportal
14	FAM135B	Ssm	5	22	22.7%	cbioportal
15	FBXW7	Ssm	5	22	22.7%	cbioportal
16	HMCN1	Ssm	5	22	22.7%	cbioportal
17	LRP2	Ssm	5	22	22.7%	cbioportal
18	LTBP2	Ssm	5	22	22.7%	cbioportal
19	MDN1	Ssm	5	22	22.7%	cbioportal
25	A2M	Ssm	4	22	18.2%	cbioportal
28	ADGRF4	Ssm	4	22	18.2%	cbioportal
29	ADGRG4	Ssm	4	22	18.2%	cbioportal
27	ADAMTSL4	Ssm	4	22	18.2%	cbioportal
26	ABI3BP	Ssm	4	22	18.2%	cbioportal
121	OTOG	Ssm	4	22	18.2%	cbioportal

Data updated 22 days agoSource updated 2026-01-16

Uterine Carcinosarcoma (TCGA, Firehose Legacy) ucs_tcgaTCGA

57 cases with simple somatic mutation data · 57 cases total · 2026-01-13 · mapped to Uterine Malignant Mixed Mesodermal (Mullerian) Tumor EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	52	57	91.2%	cbioportal
2	FBXW7	Ssm	22	57	38.6%	cbioportal
3	FRG1BP	Ssm	21	57	36.8%	cbioportal
4	PIK3CA	Ssm	20	57	35.1%	cbioportal
5	PPP2R1A	Ssm	16	57	28.1%	cbioportal
6	MUC4	Ssm	13	57	22.8%	cbioportal
7	PTEN	Ssm	11	57	19.3%	cbioportal
9	TTN	Ssm	10	57	17.5%	cbioportal
8	CHD4	Ssm	10	57	17.5%	cbioportal
10	ARID1A	Ssm	8	57	14%	cbioportal
12	LRP1B	Ssm	7	57	12.3%	cbioportal
13	MUC17	Ssm	7	57	12.3%	cbioportal
11	KRAS	Ssm	7	57	12.3%	cbioportal
20	RB1	Ssm	6	57	10.5%	cbioportal
24	ZNF814	Ssm	6	57	10.5%	cbioportal
23	ZBTB7B	Ssm	6	57	10.5%	cbioportal
22	VPS13B	Ssm	6	57	10.5%	cbioportal
21	SYNE1	Ssm	6	57	10.5%	cbioportal
19	PIK3R1	Ssm	6	57	10.5%	cbioportal
18	MUC16	Ssm	6	57	10.5%	cbioportal
17	MGAM	Ssm	6	57	10.5%	cbioportal
16	KMT2D	Ssm	6	57	10.5%	cbioportal
15	FLNA	Ssm	6	57	10.5%	cbioportal
14	ARHGAP35	Ssm	6	57	10.5%	cbioportal
25	ATP4A	Ssm	5	57	8.8%	cbioportal
30	LRP2	Ssm	5	57	8.8%	cbioportal
29	FLG	Ssm	5	57	8.8%	cbioportal
28	FER1L6	Ssm	5	57	8.8%	cbioportal
27	FCGBP	Ssm	5	57	8.8%	cbioportal
26	DOP1A	Ssm	5	57	8.8%	cbioportal

Data updated 22 days agoSource updated 2026-01-13

Uterine Carcinosarcoma (TCGA, PanCancer Atlas) ucs_tcga_pan_can_atlas_2018TCGA

57 cases with simple somatic mutation data · 57 cases total · 2026-06-05 · mapped to Uterine Malignant Mixed Mesodermal (Mullerian) Tumor EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	52	57	91.2%	cbioportal
2	FBXW7	Ssm	22	57	38.6%	cbioportal
3	PIK3CA	Ssm	20	57	35.1%	cbioportal
4	PPP2R1A	Ssm	16	57	28.1%	cbioportal
6	TTN	Ssm	11	57	19.3%	cbioportal
5	PTEN	Ssm	11	57	19.3%	cbioportal
7	CHD4	Ssm	10	57	17.5%	cbioportal
9	KRAS	Ssm	7	57	12.3%	cbioportal
8	ARID1A	Ssm	7	57	12.3%	cbioportal
18	VPS13B	Ssm	6	57	10.5%	cbioportal
19	ZBTB7B	Ssm	6	57	10.5%	cbioportal
17	SYNE1	Ssm	6	57	10.5%	cbioportal
16	PIK3R1	Ssm	6	57	10.5%	cbioportal
15	MUC16	Ssm	6	57	10.5%	cbioportal
14	MGAM	Ssm	6	57	10.5%	cbioportal
13	KMT2D	Ssm	6	57	10.5%	cbioportal
12	FLNA	Ssm	6	57	10.5%	cbioportal
11	ARHGAP35	Ssm	6	57	10.5%	cbioportal
10	AHNAK	Ssm	6	57	10.5%	cbioportal
23	LRP1B	Ssm	5	57	8.8%	cbioportal
26	RB1	Ssm	5	57	8.8%	cbioportal
20	DOP1A	Ssm	5	57	8.8%	cbioportal
21	FER1L6	Ssm	5	57	8.8%	cbioportal
22	FLG	Ssm	5	57	8.8%	cbioportal
25	MUC17	Ssm	5	57	8.8%	cbioportal
24	LRP2	Ssm	5	57	8.8%	cbioportal
30	COL11A1	Ssm	4	57	7%	cbioportal
28	ADAMTSL1	Ssm	4	57	7%	cbioportal
29	BRWD1	Ssm	4	57	7%	cbioportal
27	ABCA12	Ssm	4	57	7%	cbioportal

Data updated 22 days agoSource updated 2026-06-05

Uterine Carcinosarcoma/Uterine Malignant Mixed Mullerian Tumor (TCGA GDC, 2025) ucs_tcga_gdcTCGA GDC

57 cases with simple somatic mutation data · 57 cases total · 2026-01-14 · mapped to Uterine Malignant Mixed Mesodermal (Mullerian) Tumor EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	49	57	86%	cbioportal
2	FBXW7	Ssm	22	57	38.6%	cbioportal
3	PIK3CA	Ssm	20	57	35.1%	cbioportal
4	PPP2R1A	Ssm	16	57	28.1%	cbioportal
5	PTEN	Ssm	11	57	19.3%	cbioportal
6	CHD4	Ssm	10	57	17.5%	cbioportal
7	PIK3R1	Ssm	9	57	15.8%	cbioportal
8	ARID1A	Ssm	7	57	12.3%	cbioportal
10	TTN	Ssm	7	57	12.3%	cbioportal
9	KRAS	Ssm	7	57	12.3%	cbioportal
12	ARHGAP35	Ssm	6	57	10.5%	cbioportal
17	SYNE1	Ssm	6	57	10.5%	cbioportal
16	MGAM	Ssm	6	57	10.5%	cbioportal
15	LRP2	Ssm	6	57	10.5%	cbioportal
14	KMT2D	Ssm	6	57	10.5%	cbioportal
13	FLNA	Ssm	6	57	10.5%	cbioportal
11	AHNAK	Ssm	6	57	10.5%	cbioportal
18	ZBTB7B	Ssm	6	57	10.5%	cbioportal
23	VPS13B	Ssm	5	57	8.8%	cbioportal
22	RB1	Ssm	5	57	8.8%	cbioportal
21	MUC17	Ssm	5	57	8.8%	cbioportal
19	DOP1A	Ssm	5	57	8.8%	cbioportal
20	MUC16	Ssm	5	57	8.8%	cbioportal
26	BRWD1	Ssm	4	57	7%	cbioportal
24	ABCA12	Ssm	4	57	7%	cbioportal
28	CUBN	Ssm	4	57	7%	cbioportal
29	DNAH2	Ssm	4	57	7%	cbioportal
30	DPP10	Ssm	4	57	7%	cbioportal
27	COPB1	Ssm	4	57	7%	cbioportal
25	ADAMTSL1	Ssm	4	57	7%	cbioportal

Data updated 22 days agoSource updated 2026-01-14

Uterine Clear Cell Carcinoma (NIH, Cancer 2017) uccc_nih_2017NIH

16 cases with simple somatic mutation data · 16 cases total · 2026-01-13 · mapped to Human Papillomavirus-Independent Cervical Adenocarcinoma, Clear Cell-Type EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	7	16	43.8%	cbioportal
2	KMT2C	Ssm	5	16	31.3%	cbioportal
4	ZNF717	Ssm	4	16	25%	cbioportal
3	TAF1	Ssm	4	16	25%	cbioportal
5	AGAP4	Ssm	3	16	18.8%	cbioportal
6	FAM136A	Ssm	3	16	18.8%	cbioportal
7	PIK3CA	Ssm	3	16	18.8%	cbioportal
16	COIL	Ssm	2	16	12.5%	cbioportal
29	FRG2C	Ssm	2	16	12.5%	cbioportal
28	FRG1	Ssm	2	16	12.5%	cbioportal
27	FOXA2	Ssm	2	16	12.5%	cbioportal
26	FAT3	Ssm	2	16	12.5%	cbioportal
25	ERBB3	Ssm	2	16	12.5%	cbioportal
24	EPC2	Ssm	2	16	12.5%	cbioportal
23	DYSF	Ssm	2	16	12.5%	cbioportal
22	DST	Ssm	2	16	12.5%	cbioportal
21	DNAH3	Ssm	2	16	12.5%	cbioportal
20	DNAH11	Ssm	2	16	12.5%	cbioportal
19	DMAP1	Ssm	2	16	12.5%	cbioportal
18	DENND4A	Ssm	2	16	12.5%	cbioportal
17	COL5A1	Ssm	2	16	12.5%	cbioportal
30	GART	Ssm	2	16	12.5%	cbioportal
15	CHRM5	Ssm	2	16	12.5%	cbioportal
14	CHL1	Ssm	2	16	12.5%	cbioportal
13	CCDC178	Ssm	2	16	12.5%	cbioportal
12	ASTE1	Ssm	2	16	12.5%	cbioportal
11	ARID1A	Ssm	2	16	12.5%	cbioportal
10	AP3D1	Ssm	2	16	12.5%	cbioportal
9	AHNAK2	Ssm	2	16	12.5%	cbioportal
8	ABCD1	Ssm	2	16	12.5%	cbioportal

Data updated 22 days agoSource updated 2026-01-13

Uterine Corpus Endometrial Carcinoma TCGA-UCECTCGA

559 cases with simple somatic mutation data · 560 cases total · Data Release 46.0 · mapped to Endometrial Carcinoma ONTOLOGY_EXACT

gdcObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	PTEN	Ssm	418	559	74.8%	gdc
2	PIK3CA	Ssm	349	559	62.4%	gdc
3	ARID1A	Ssm	319	559	57.1%	gdc
4	TTN	Ssm	297	559	53.1%	gdc
5	OBSCN	Ssm	296	559	53%	gdc
6	RYR2	Ssm	291	559	52.1%	gdc
7	ASH1L	Ssm	289	559	51.7%	gdc
8	USH2A	Ssm	286	559	51.2%	gdc
9	FLG	Ssm	283	559	50.6%	gdc
10	CACNA1E	Ssm	281	559	50.3%	gdc
11	HMCN1	Ssm	278	559	49.7%	gdc
13	HRNR	Ssm	277	559	49.6%	gdc
12	CSMD3	Ssm	277	559	49.6%	gdc
14	CEP350	Ssm	277	559	49.6%	gdc
15	CTCF	Ssm	276	559	49.4%	gdc
16	GON4L	Ssm	275	559	49.2%	gdc
18	ZFHX3	Ssm	275	559	49.2%	gdc
17	ASPM	Ssm	275	559	49.2%	gdc
19	NFASC	Ssm	271	559	48.5%	gdc
20	CSMD1	Ssm	270	559	48.3%	gdc
22	SPTA1	Ssm	269	559	48.1%	gdc
23	INSRR	Ssm	269	559	48.1%	gdc
21	PDE4DIP	Ssm	269	559	48.1%	gdc
24	SETDB1	Ssm	267	559	47.8%	gdc
26	MUC16	Ssm	266	559	47.6%	gdc
25	F5	Ssm	266	559	47.6%	gdc
27	COPA	Ssm	266	559	47.6%	gdc
28	PRRC2C	Ssm	265	559	47.4%	gdc
29	ARHGEF2	Ssm	265	559	47.4%	gdc
30	LYST	Ssm	264	559	47.2%	gdc

Data updated 22 days agoSource updated Data Release 46.0

Uterine Corpus Endometrial Carcinoma (TCGA, Firehose Legacy) ucec_tcgaTCGA

248 cases with simple somatic mutation data · 549 cases total · 2026-01-13 · mapped to Endometrial Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	PTEN	Ssm	161	248	64.9%	cbioportal
2	PIK3CA	Ssm	132	248	53.2%	cbioportal
3	ARID1A	Ssm	83	248	33.5%	cbioportal
4	PIK3R1	Ssm	82	248	33.1%	cbioportal
5	TTN	Ssm	79	248	31.9%	cbioportal
6	CTNNB1	Ssm	74	248	29.8%	cbioportal
7	TP53	Ssm	69	248	27.8%	cbioportal
8	KRAS	Ssm	52	248	21%	cbioportal
9	MUC16	Ssm	48	248	19.4%	cbioportal
10	CSMD3	Ssm	47	248	19%	cbioportal
11	CTCF	Ssm	45	248	18.1%	cbioportal
12	ZFHX3	Ssm	44	248	17.7%	cbioportal
13	MUC5B	Ssm	43	248	17.3%	cbioportal
14	RYR2	Ssm	41	248	16.5%	cbioportal
16	FAT4	Ssm	40	248	16.1%	cbioportal
15	FAT1	Ssm	40	248	16.1%	cbioportal
17	OBSCN	Ssm	39	248	15.7%	cbioportal
18	DMD	Ssm	38	248	15.3%	cbioportal
19	FBXW7	Ssm	38	248	15.3%	cbioportal
20	NEB	Ssm	37	248	14.9%	cbioportal
22	FAT3	Ssm	36	248	14.5%	cbioportal
21	ARHGAP35	Ssm	36	248	14.5%	cbioportal
23	ZFHX4	Ssm	36	248	14.5%	cbioportal
27	USH2A	Ssm	35	248	14.1%	cbioportal
24	CHD4	Ssm	35	248	14.1%	cbioportal
25	DNAH5	Ssm	35	248	14.1%	cbioportal
26	TAF1	Ssm	35	248	14.1%	cbioportal
28	RYR3	Ssm	34	248	13.7%	cbioportal
32	LRP2	Ssm	33	248	13.3%	cbioportal
29	ANK3	Ssm	33	248	13.3%	cbioportal

Data updated 22 days agoSource updated 2026-01-13

Uterine Corpus Endometrial Carcinoma (TCGA, Nature 2013) ucec_tcga_pubTCGA

248 cases with simple somatic mutation data · 373 cases total · 2026-01-16 · mapped to Endometrial Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	PTEN	Ssm	161	248	64.9%	cbioportal
2	PIK3CA	Ssm	132	248	53.2%	cbioportal
3	ARID1A	Ssm	83	248	33.5%	cbioportal
4	PIK3R1	Ssm	81	248	32.7%	cbioportal
5	TTN	Ssm	79	248	31.9%	cbioportal
6	CTNNB1	Ssm	74	248	29.8%	cbioportal
7	TP53	Ssm	69	248	27.8%	cbioportal
8	KRAS	Ssm	52	248	21%	cbioportal
9	MUC16	Ssm	48	248	19.4%	cbioportal
10	CSMD3	Ssm	47	248	19%	cbioportal
11	CTCF	Ssm	45	248	18.1%	cbioportal
12	ZFHX3	Ssm	44	248	17.7%	cbioportal
13	MUC5B	Ssm	43	248	17.3%	cbioportal
14	RYR2	Ssm	41	248	16.5%	cbioportal
15	FAT1	Ssm	40	248	16.1%	cbioportal
16	FAT4	Ssm	40	248	16.1%	cbioportal
17	OBSCN	Ssm	39	248	15.7%	cbioportal
19	FBXW7	Ssm	38	248	15.3%	cbioportal
18	DMD	Ssm	38	248	15.3%	cbioportal
20	NEB	Ssm	37	248	14.9%	cbioportal
21	ARHGAP35	Ssm	36	248	14.5%	cbioportal
22	FAT3	Ssm	36	248	14.5%	cbioportal
23	ZFHX4	Ssm	36	248	14.5%	cbioportal
24	CHD4	Ssm	35	248	14.1%	cbioportal
25	DNAH5	Ssm	35	248	14.1%	cbioportal
26	TAF1	Ssm	35	248	14.1%	cbioportal
27	USH2A	Ssm	35	248	14.1%	cbioportal
28	RYR3	Ssm	34	248	13.7%	cbioportal
31	KMT2D	Ssm	33	248	13.3%	cbioportal
30	DNAH10	Ssm	33	248	13.3%	cbioportal

Data updated 22 days agoSource updated 2026-01-16

Uterine Corpus Endometrial Carcinoma (TCGA, PanCancer Atlas) ucec_tcga_pan_can_atlas_2018TCGA

517 cases with simple somatic mutation data · 529 cases total · 2026-06-04 · mapped to Endometrial Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	PTEN	Ssm	337	517	65.2%	cbioportal
2	PIK3CA	Ssm	259	517	50.1%	cbioportal
3	ARID1A	Ssm	227	517	43.9%	cbioportal
4	TTN	Ssm	206	517	39.8%	cbioportal
5	TP53	Ssm	193	517	37.3%	cbioportal
6	PIK3R1	Ssm	159	517	30.8%	cbioportal
7	KMT2D	Ssm	143	517	27.7%	cbioportal
8	MUC16	Ssm	142	517	27.5%	cbioportal
9	CTNNB1	Ssm	133	517	25.7%	cbioportal
10	CTCF	Ssm	127	517	24.6%	cbioportal
11	RYR2	Ssm	125	517	24.2%	cbioportal
12	ZFHX3	Ssm	123	517	23.8%	cbioportal
13	CSMD3	Ssm	122	517	23.6%	cbioportal
14	MUC5B	Ssm	117	517	22.6%	cbioportal
15	OBSCN	Ssm	117	517	22.6%	cbioportal
16	SYNE1	Ssm	114	517	22.1%	cbioportal
18	KMT2B	Ssm	113	517	21.9%	cbioportal
17	CHD4	Ssm	113	517	21.9%	cbioportal
19	FLG	Ssm	112	517	21.7%	cbioportal
21	ZFHX4	Ssm	109	517	21.1%	cbioportal
20	MACF1	Ssm	109	517	21.1%	cbioportal
22	FAT4	Ssm	108	517	20.9%	cbioportal
23	NEB	Ssm	106	517	20.5%	cbioportal
24	USH2A	Ssm	105	517	20.3%	cbioportal
25	TAF1	Ssm	104	517	20.1%	cbioportal
28	DNAH7	Ssm	103	517	19.9%	cbioportal
26	ARHGAP35	Ssm	103	517	19.9%	cbioportal
27	DMD	Ssm	103	517	19.9%	cbioportal
29	FAT1	Ssm	103	517	19.9%	cbioportal
30	PCLO	Ssm	102	517	19.7%	cbioportal

Data updated 22 days agoSource updated 2026-06-04

Uterine Endometrioid Carcinoma (CPTAC GDC, 2025) uec_cptac_gdcCPTAC GDC

247 cases with simple somatic mutation data · 442 cases total · 2026-01-14 · mapped to Endometrial Endometrioid Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	PTEN	Ssm	194	247	78.5%	cbioportal
2	ARID1A	Ssm	136	247	55.1%	cbioportal
3	PIK3CA	Ssm	105	247	42.5%	cbioportal
4	PIK3R1	Ssm	91	247	36.8%	cbioportal
5	TTN	Ssm	89	247	36%	cbioportal
6	CTNNB1	Ssm	71	247	28.7%	cbioportal
7	KRAS	Ssm	67	247	27.1%	cbioportal
8	OBSCN	Ssm	65	247	26.3%	cbioportal
9	KMT2B	Ssm	62	247	25.1%	cbioportal
10	INPPL1	Ssm	61	247	24.7%	cbioportal
12	TP53	Ssm	61	247	24.7%	cbioportal
11	KMT2D	Ssm	61	247	24.7%	cbioportal
13	CTCF	Ssm	56	247	22.7%	cbioportal
14	SYNE1	Ssm	54	247	21.9%	cbioportal
15	ZFHX3	Ssm	54	247	21.9%	cbioportal
16	PCLO	Ssm	51	247	20.6%	cbioportal
17	MUC16	Ssm	49	247	19.8%	cbioportal
18	MUC5B	Ssm	48	247	19.4%	cbioportal
19	FSIP2	Ssm	47	247	19%	cbioportal
20	CSMD3	Ssm	46	247	18.6%	cbioportal
22	ZFHX4	Ssm	45	247	18.2%	cbioportal
21	RYR1	Ssm	45	247	18.2%	cbioportal
24	RYR2	Ssm	43	247	17.4%	cbioportal
23	JAK1	Ssm	43	247	17.4%	cbioportal
25	DNAH5	Ssm	42	247	17%	cbioportal
28	HERC2	Ssm	41	247	16.6%	cbioportal
26	CHD4	Ssm	41	247	16.6%	cbioportal
27	FAT3	Ssm	41	247	16.6%	cbioportal
32	RYR3	Ssm	40	247	16.2%	cbioportal
31	LRTM3	Ssm	40	247	16.2%	cbioportal

Data updated 22 days agoSource updated 2026-01-14

Uterine Sarcoma/Mesenchymal (MSK, Clin Cancer Res 2020) usarc_msk_2020MSK

108 cases with simple somatic mutation data · 108 cases total · 2026-01-19 · mapped to Uterine Corpus Sarcoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	40	108	37%	cbioportal
2	ATRX	Ssm	25	108	23.1%	cbioportal
3	RB1	Ssm	12	108	11.1%	cbioportal
4	MED12	Ssm	11	108	10.2%	cbioportal
5	BRCA2	Ssm	7	108	6.5%	cbioportal
6	FAT1	Ssm	6	108	5.6%	cbioportal
7	PTEN	Ssm	6	108	5.6%	cbioportal
57	AGO2	Ssm	1	20	5%	cbioportal
145	TEK	Ssm	1	20	5%	cbioportal
130	PPARG	Ssm	1	20	5%	cbioportal
8	AR	Ssm	5	108	4.6%	cbioportal
9	ROS1	Ssm	5	108	4.6%	cbioportal
10	ARID2	Ssm	4	108	3.7%	cbioportal
11	KDR	Ssm	4	108	3.7%	cbioportal
12	NSD1	Ssm	4	108	3.7%	cbioportal
13	PDGFRB	Ssm	4	108	3.7%	cbioportal
14	PIK3CA	Ssm	4	108	3.7%	cbioportal
17	BRD4	Ssm	3	108	2.8%	cbioportal
15	ARID1A	Ssm	3	108	2.8%	cbioportal
16	ASXL1	Ssm	3	108	2.8%	cbioportal
18	CARD11	Ssm	3	108	2.8%	cbioportal
19	DAXX	Ssm	3	108	2.8%	cbioportal
20	ERBB4	Ssm	3	108	2.8%	cbioportal
21	KMT2A	Ssm	3	108	2.8%	cbioportal
22	MET	Ssm	3	108	2.8%	cbioportal
23	NF1	Ssm	3	108	2.8%	cbioportal
24	TERT	Ssm	3	108	2.8%	cbioportal
44	MEN1	Ssm	2	108	1.9%	cbioportal
51	PTPRS	Ssm	2	108	1.9%	cbioportal
52	RBM10	Ssm	2	108	1.9%	cbioportal

Data updated 22 days agoSource updated 2026-01-19