Mature B-Cell Non-Hodgkin Lymphoma — Genomics

Mature B-Cell Non-Hodgkin Lymphoma — Genomics · CancerIndex

Genomics

Gene alteration frequencies by cohort

18 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.

Burkitt Lymphoma Genome Sequencing Project CGCI-BLGSPCGCI

263 cases with simple somatic mutation data · 324 cases total · Data Release 46.0 · mapped to Burkitt Lymphoma ONTOLOGY_EXACT

gdcObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1

Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.

Chronic Lymphocytic Leukemia (Broad, Cell 2013) lcll_broad_2013Broad

160 cases with simple somatic mutation data · 160 cases total · 2026-01-07 · mapped to Small Lymphocytic Lymphoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	SF3B1	Ssm	23	160	14.4%	cbioportal
2	TP53	Ssm	19	160	11.9%	cbioportal
3	NOTCH1	Ssm	15	160	9.4%	cbioportal
4	MYD88	Ssm	12	160	7.5%	cbioportal
5	ATM	Ssm	9	160	5.6%	cbioportal
7	MUC16	Ssm	6	160	3.8%	cbioportal
6	CHD2	Ssm	6	160	3.8%	cbioportal
8	FAT3	Ssm	5	160	3.1%	cbioportal
9	H1-4	Ssm	5	160	3.1%	cbioportal
10	POT1	Ssm	5	160	3.1%	cbioportal
12	XPO1	Ssm	5	160	3.1%	cbioportal
11	TTN	Ssm	5	160	3.1%	cbioportal
20	SCN2A	Ssm	4	160	2.5%	cbioportal
23	WDR72	Ssm	4	160	2.5%	cbioportal
22	SRCAP	Ssm	4	160	2.5%	cbioportal
21	SLIT3	Ssm	4	160	2.5%	cbioportal
19	SAMHD1	Ssm	4	160	2.5%	cbioportal
18	RIPK1	Ssm	4	160	2.5%	cbioportal
17	PCLO	Ssm	4	160	2.5%	cbioportal
16	NRAS	Ssm	4	160	2.5%	cbioportal
15	NAV2	Ssm	4	160	2.5%	cbioportal
14	FAT4	Ssm	4	160	2.5%	cbioportal
13	CSMD1	Ssm	4	160	2.5%	cbioportal
30	CECR2	Ssm	3	160	1.9%	cbioportal
24	ADCY2	Ssm	3	160	1.9%	cbioportal
25	ALMS1	Ssm	3	160	1.9%	cbioportal
26	BCR	Ssm	3	160	1.9%	cbioportal
27	BLTP1	Ssm	3	160	1.9%	cbioportal
28	CDH10	Ssm	3	160	1.9%	cbioportal
29	CDH9	Ssm	3	160	1.9%	cbioportal

Data updated 22 days agoSource updated 2026-01-07

Chronic Lymphocytic Leukemia (Broad, Nature 2015) cll_broad_2015Broad

537 cases with simple somatic mutation data · 537 cases total · 2026-01-06 · mapped to Small Lymphocytic Lymphoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	SF3B1	Ssm	113	537	21%	cbioportal
2	ATM	Ssm	82	537	15.3%	cbioportal
3	TP53	Ssm	39	537	7.3%	cbioportal
4	NOTCH1	Ssm	38	537	7.1%	cbioportal
5	POT1	Ssm	35	537	6.5%	cbioportal
6	PCLO	Ssm	28	537	5.2%	cbioportal
7	CHD2	Ssm	26	537	4.8%	cbioportal
8	XPO1	Ssm	24	537	4.5%	cbioportal
9	RPS15	Ssm	22	537	4.1%	cbioportal
10	MUC16	Ssm	21	537	3.9%	cbioportal
11	TTN	Ssm	21	537	3.9%	cbioportal
12	BRAF	Ssm	20	537	3.7%	cbioportal
14	CSMD3	Ssm	19	537	3.5%	cbioportal
13	BIRC3	Ssm	19	537	3.5%	cbioportal
15	EGR2	Ssm	17	537	3.2%	cbioportal
16	MGA	Ssm	17	537	3.2%	cbioportal
17	LRP1B	Ssm	16	537	3%	cbioportal
18	MYD88	Ssm	16	537	3%	cbioportal
20	USH2A	Ssm	15	537	2.8%	cbioportal
19	FAT4	Ssm	15	537	2.8%	cbioportal
21	FAT3	Ssm	14	537	2.6%	cbioportal
22	KRAS	Ssm	14	537	2.6%	cbioportal
24	PCDH15	Ssm	13	537	2.4%	cbioportal
23	DDX3X	Ssm	13	537	2.4%	cbioportal
28	IGLL5	Ssm	12	537	2.2%	cbioportal
26	CSMD1	Ssm	12	537	2.2%	cbioportal
25	BCOR	Ssm	12	537	2.2%	cbioportal
27	FBXW7	Ssm	12	537	2.2%	cbioportal
30	IKZF3	Ssm	11	537	2%	cbioportal
29	DST	Ssm	11	537	2%	cbioportal

Data updated 22 days agoSource updated 2026-01-06

Chronic Lymphocytic Leukemia (Broad, Nature Genetics 2022) cll_broad_2022Broad

1,075 cases with simple somatic mutation data · 1,154 cases total · 2026-02-19 · mapped to Small Lymphocytic Lymphoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	SF3B1	Ssm	174	1,075	16.2%	cbioportal
2	ATM	Ssm	111	1,075	10.3%	cbioportal
3	TP53	Ssm	91	1,075	8.5%	cbioportal
4	TTN	Ssm	76	1,075	7.1%	cbioportal
5	POT1	Ssm	60	1,075	5.6%	cbioportal
6	PCLO	Ssm	58	1,075	5.4%	cbioportal
7	CHD2	Ssm	55	1,075	5.1%	cbioportal
8	NOTCH1	Ssm	54	1,075	5%	cbioportal
9	XPO1	Ssm	51	1,075	4.7%	cbioportal
10	MUC16	Ssm	49	1,075	4.6%	cbioportal
11	LRP1B	Ssm	48	1,075	4.5%	cbioportal
12	CSMD3	Ssm	42	1,075	3.9%	cbioportal
13	USH2A	Ssm	37	1,075	3.4%	cbioportal
14	FAT4	Ssm	35	1,075	3.3%	cbioportal
17	RYR2	Ssm	34	1,075	3.2%	cbioportal
16	MGA	Ssm	34	1,075	3.2%	cbioportal
15	BRAF	Ssm	34	1,075	3.2%	cbioportal
20	MYD88	Ssm	33	1,075	3.1%	cbioportal
18	EGR2	Ssm	33	1,075	3.1%	cbioportal
19	FAT1	Ssm	33	1,075	3.1%	cbioportal
21	ZFHX4	Ssm	33	1,075	3.1%	cbioportal
22	HMCN1	Ssm	32	1,075	3%	cbioportal
24	ZNF292	Ssm	30	1,075	2.8%	cbioportal
23	BIRC3	Ssm	30	1,075	2.8%	cbioportal
25	DST	Ssm	28	1,075	2.6%	cbioportal
28	FBXW7	Ssm	27	1,075	2.5%	cbioportal
27	DDX3X	Ssm	27	1,075	2.5%	cbioportal
30	WDFY3	Ssm	27	1,075	2.5%	cbioportal
29	KRAS	Ssm	27	1,075	2.5%	cbioportal
26	CSMD1	Ssm	27	1,075	2.5%	cbioportal

Data updated 22 days agoSource updated 2026-02-19

Chronic lymphocytic leukemia (ICGC, Nature Genetics 2011) cllsll_icgc_2011ICGC

105 cases with simple somatic mutation data · 105 cases total · 2026-01-06 · mapped to Small Lymphocytic Lymphoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	SF3B1	Ssm	10	105	9.5%	cbioportal
2	LRP1B	Ssm	5	105	4.8%	cbioportal
5	CSMD3	Ssm	4	105	3.8%	cbioportal
4	CHD2	Ssm	4	105	3.8%	cbioportal
3	ATM	Ssm	4	105	3.8%	cbioportal
6	MUC2	Ssm	4	105	3.8%	cbioportal
7	SI	Ssm	4	105	3.8%	cbioportal
13	RIMS2	Ssm	3	105	2.9%	cbioportal
14	SLC4A10	Ssm	3	105	2.9%	cbioportal
8	ADGRL3	Ssm	3	105	2.9%	cbioportal
9	ASXL1	Ssm	3	105	2.9%	cbioportal
10	CDH23	Ssm	3	105	2.9%	cbioportal
12	POT1	Ssm	3	105	2.9%	cbioportal
11	NXF1	Ssm	3	105	2.9%	cbioportal
18	ADGRL2	Ssm	2	105	1.9%	cbioportal
30	DPP6	Ssm	2	105	1.9%	cbioportal
29	DOCK4	Ssm	2	105	1.9%	cbioportal
28	DLC1	Ssm	2	105	1.9%	cbioportal
27	DDX3X	Ssm	2	105	1.9%	cbioportal
26	DCAF1	Ssm	2	105	1.9%	cbioportal
25	COL25A1	Ssm	2	105	1.9%	cbioportal
24	COL22A1	Ssm	2	105	1.9%	cbioportal
23	CELF4	Ssm	2	105	1.9%	cbioportal
22	CD36	Ssm	2	105	1.9%	cbioportal
21	BRAF	Ssm	2	105	1.9%	cbioportal
20	ARID1A	Ssm	2	105	1.9%	cbioportal
19	AKAP6	Ssm	2	105	1.9%	cbioportal
17	ADAMTS18	Ssm	2	105	1.9%	cbioportal
16	ADAM2	Ssm	2	105	1.9%	cbioportal
15	ABCA4	Ssm	2	105	1.9%	cbioportal

Data updated 22 days agoSource updated 2026-01-06

Chronic Lymphocytic Leukemia (IUOPA, Nature 2015) cll_iuopa_2015IUOPA

506 cases with simple somatic mutation data · 506 cases total · 2026-01-06 · mapped to Small Lymphocytic Lymphoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	NOTCH1	Ssm	48	506	9.5%	cbioportal
2	SF3B1	Ssm	41	506	8.1%	cbioportal
3	ATM	Ssm	31	506	6.1%	cbioportal
4	IGLL5	Ssm	26	506	5.1%	cbioportal
5	CHD2	Ssm	24	506	4.7%	cbioportal
6	LRP1B	Ssm	23	506	4.5%	cbioportal
7	MUC16	Ssm	20	506	4%	cbioportal
8	MYD88	Ssm	18	506	3.6%	cbioportal
9	POT1	Ssm	17	506	3.4%	cbioportal
11	TP53	Ssm	15	506	3%	cbioportal
10	PCLO	Ssm	15	506	3%	cbioportal
12	KLHL6	Ssm	14	506	2.8%	cbioportal
13	CSMD3	Ssm	13	506	2.6%	cbioportal
14	ZNF292	Ssm	13	506	2.6%	cbioportal
17	MGA	Ssm	12	506	2.4%	cbioportal
15	CSMD1	Ssm	12	506	2.4%	cbioportal
16	DDX3X	Ssm	12	506	2.4%	cbioportal
18	ADGRL3	Ssm	11	506	2.2%	cbioportal
21	TTN	Ssm	10	506	2%	cbioportal
22	USH2A	Ssm	10	506	2%	cbioportal
20	FAT4	Ssm	10	506	2%	cbioportal
19	BRAF	Ssm	10	506	2%	cbioportal
25	DTX1	Ssm	9	506	1.8%	cbioportal
26	EGR2	Ssm	9	506	1.8%	cbioportal
27	RYR2	Ssm	9	506	1.8%	cbioportal
28	SYNE1	Ssm	9	506	1.8%	cbioportal
29	TENM1	Ssm	9	506	1.8%	cbioportal
30	XPO1	Ssm	9	506	1.8%	cbioportal
23	BIRC3	Ssm	9	506	1.8%	cbioportal
24	DNAH9	Ssm	9	506	1.8%	cbioportal

Data updated 22 days agoSource updated 2026-01-06

Chronic Lymphocytic Leukemia (MSK, 2026) cllsll_msk_2026MSK

21 cases with simple somatic mutation data · 21 cases total · 2026-03-25 · mapped to Small Lymphocytic Lymphoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	SF3B1	Ssm	14	21	66.7%	cbioportal
2	TP53	Ssm	13	21	61.9%	cbioportal
3	BTK	Ssm	12	21	57.1%	cbioportal
7	MYO18A	Ssm	6	19	31.6%	cbioportal
5	CBFB	Ssm	6	21	28.6%	cbioportal
6	FAT1	Ssm	6	21	28.6%	cbioportal
8	RB1	Ssm	6	21	28.6%	cbioportal
9	SETD2	Ssm	6	21	28.6%	cbioportal
4	ATM	Ssm	6	21	28.6%	cbioportal
11	FANCL	Ssm	5	19	26.3%	cbioportal
12	LRP1B	Ssm	5	19	26.3%	cbioportal
10	ATXN2	Ssm	5	21	23.8%	cbioportal
13	TRAF3	Ssm	4	21	19%	cbioportal
26	ZNF292	Ssm	2	19	10.5%	cbioportal
14	ARID1A	Ssm	2	21	9.5%	cbioportal
15	ARID1B	Ssm	2	21	9.5%	cbioportal
20	DIS3	Ssm	2	21	9.5%	cbioportal
25	TERT	Ssm	2	21	9.5%	cbioportal
24	MYD88	Ssm	2	21	9.5%	cbioportal
23	MGA	Ssm	2	21	9.5%	cbioportal
22	KRAS	Ssm	2	21	9.5%	cbioportal
21	GRIN2A	Ssm	2	21	9.5%	cbioportal
19	DDX3X	Ssm	2	21	9.5%	cbioportal
18	CXCR4	Ssm	2	21	9.5%	cbioportal
17	BCOR	Ssm	2	21	9.5%	cbioportal
16	BCL2	Ssm	2	21	9.5%	cbioportal
35	PPM1D	Ssm	1	19	5.3%	cbioportal
33	PIK3CD	Ssm	1	19	5.3%	cbioportal
31	NOTCH4	Ssm	1	21	4.8%	cbioportal
30	KMT2D	Ssm	1	21	4.8%	cbioportal

Data updated 22 days agoSource updated 2026-03-25

Diffuse Large B-Cell Lymphoma (Broad, PNAS 2012) dlbc_broad_2012Broad

58 cases with simple somatic mutation data · 58 cases total · 2026-01-07 · mapped to Diffuse Large B-Cell Lymphoma Unclassifiable EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	PCLO	Ssm	19	58	32.8%	cbioportal
2	BCL2	Ssm	15	58	25.9%	cbioportal
3	CREBBP	Ssm	14	58	24.1%	cbioportal
5	TP53	Ssm	13	58	22.4%	cbioportal
4	FAT4	Ssm	13	58	22.4%	cbioportal
6	KMT2D	Ssm	12	58	20.7%	cbioportal
7	PIM1	Ssm	12	58	20.7%	cbioportal
8	CARD11	Ssm	11	58	19%	cbioportal
9	GNA13	Ssm	9	58	15.5%	cbioportal
10	TENM1	Ssm	9	58	15.5%	cbioportal
12	CSMD3	Ssm	8	58	13.8%	cbioportal
11	BTG1	Ssm	8	58	13.8%	cbioportal
13	H1-4	Ssm	8	58	13.8%	cbioportal
14	MEF2B	Ssm	8	58	13.8%	cbioportal
15	MUC16	Ssm	8	58	13.8%	cbioportal
16	P2RY8	Ssm	8	58	13.8%	cbioportal
17	SGK1	Ssm	8	58	13.8%	cbioportal
18	TNFRSF14	Ssm	8	58	13.8%	cbioportal
19	CD79B	Ssm	7	58	12.1%	cbioportal
20	FAT1	Ssm	7	58	12.1%	cbioportal
21	LRRN3	Ssm	7	58	12.1%	cbioportal
22	MYD88	Ssm	7	58	12.1%	cbioportal
23	UNC5D	Ssm	7	58	12.1%	cbioportal
24	ABCA13	Ssm	6	58	10.3%	cbioportal
25	ATRX	Ssm	6	58	10.3%	cbioportal
26	B2M	Ssm	6	58	10.3%	cbioportal
27	BCR	Ssm	6	58	10.3%	cbioportal
28	BIRC6	Ssm	6	58	10.3%	cbioportal
29	EZH2	Ssm	6	58	10.3%	cbioportal
30	H1-2	Ssm	6	58	10.3%	cbioportal

Data updated 22 days agoSource updated 2026-01-07

Diffuse Large B cell Lymphoma (DFCI, Nat Med 2018) dlbcl_dfci_2018DFCI

135 cases with simple somatic mutation data · 135 cases total · 2026-01-07 · mapped to Diffuse Large B-Cell Lymphoma Unclassifiable EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	KMT2D	Ssm	35	135	25.9%	cbioportal
2	PCLO	Ssm	32	135	23.7%	cbioportal
3	PIM1	Ssm	31	135	23%	cbioportal
4	TP53	Ssm	31	135	23%	cbioportal
5	BCL2	Ssm	30	135	22.2%	cbioportal
6	CREBBP	Ssm	28	135	20.7%	cbioportal
7	BTG1	Ssm	25	135	18.5%	cbioportal
8	MYD88	Ssm	22	135	16.3%	cbioportal
10	FAT4	Ssm	20	135	14.8%	cbioportal
9	CD79B	Ssm	20	135	14.8%	cbioportal
11	SGK1	Ssm	19	135	14.1%	cbioportal
12	CARD11	Ssm	18	135	13.3%	cbioportal
13	TTN	Ssm	18	135	13.3%	cbioportal
14	FAT1	Ssm	17	135	12.6%	cbioportal
15	TNFRSF14	Ssm	17	135	12.6%	cbioportal
17	H1-2	Ssm	16	135	11.9%	cbioportal
16	CSMD3	Ssm	16	135	11.9%	cbioportal
18	USH2A	Ssm	16	135	11.9%	cbioportal
19	ACTB	Ssm	15	135	11.1%	cbioportal
20	ZFP36L1	Ssm	15	135	11.1%	cbioportal
22	LRP1B	Ssm	14	135	10.4%	cbioportal
21	H1-4	Ssm	14	135	10.4%	cbioportal
23	MUC16	Ssm	14	135	10.4%	cbioportal
25	SYNE1	Ssm	13	135	9.6%	cbioportal
24	CD70	Ssm	13	135	9.6%	cbioportal
26	TBL1XR1	Ssm	13	135	9.6%	cbioportal
30	HLA-A	Ssm	12	135	8.9%	cbioportal
27	BCL6	Ssm	12	135	8.9%	cbioportal
28	EBF1	Ssm	12	135	8.9%	cbioportal
29	GNA13	Ssm	12	135	8.9%	cbioportal

Data updated 22 days agoSource updated 2026-01-07

Diffuse Large B-Cell Lymphoma (Duke, Cell 2017) dlbcl_duke_2017Duke

1,001 cases with simple somatic mutation data · 1,001 cases total · 2026-01-07 · mapped to Diffuse Large B-Cell Lymphoma Unclassifiable EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	KMT2D	Ssm	247	1,001	24.7%	cbioportal
2	MYD88	Ssm	172	1,001	17.2%	cbioportal
3	PIM1	Ssm	147	1,001	14.7%	cbioportal
4	CREBBP	Ssm	115	1,001	11.5%	cbioportal
5	H1-4	Ssm	105	1,001	10.5%	cbioportal
7	SPEN	Ssm	101	1,001	10.1%	cbioportal
6	BCL2	Ssm	101	1,001	10.1%	cbioportal
8	ARID1A	Ssm	96	1,001	9.6%	cbioportal
9	TP53	Ssm	93	1,001	9.3%	cbioportal
10	SOCS1	Ssm	92	1,001	9.2%	cbioportal
11	CARD11	Ssm	89	1,001	8.9%	cbioportal
12	ARID1B	Ssm	83	1,001	8.3%	cbioportal
13	GNA13	Ssm	83	1,001	8.3%	cbioportal
14	SETD1B	Ssm	83	1,001	8.3%	cbioportal
15	TNFRSF14	Ssm	79	1,001	7.9%	cbioportal
16	DUSP2	Ssm	76	1,001	7.6%	cbioportal
18	SMARCA4	Ssm	75	1,001	7.5%	cbioportal
17	MGA	Ssm	75	1,001	7.5%	cbioportal
19	NOTCH2	Ssm	73	1,001	7.3%	cbioportal
20	ATM	Ssm	72	1,001	7.2%	cbioportal
21	ZNF608	Ssm	68	1,001	6.8%	cbioportal
22	KLHL6	Ssm	67	1,001	6.7%	cbioportal
23	SGK1	Ssm	67	1,001	6.7%	cbioportal
26	MTOR	Ssm	64	1,001	6.4%	cbioportal
25	IRF8	Ssm	64	1,001	6.4%	cbioportal
24	BIRC6	Ssm	64	1,001	6.4%	cbioportal
27	PIK3CD	Ssm	63	1,001	6.3%	cbioportal
29	TET2	Ssm	62	1,001	6.2%	cbioportal
28	SETD2	Ssm	62	1,001	6.2%	cbioportal
30	EZH2	Ssm	61	1,001	6.1%	cbioportal

Data updated 22 days agoSource updated 2026-01-07

Diffuse Large B-Cell Lymphoma, NOS (TCGA GDC, 2025) dlbclnos_tcga_gdcTCGA GDC

36 cases with simple somatic mutation data · 48 cases total · 2026-01-13 · mapped to Diffuse Large B-Cell Lymphoma Unclassifiable EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	KMT2D	Ssm	11	36	30.6%	cbioportal
2	BTG2	Ssm	10	36	27.8%	cbioportal
3	CARD11	Ssm	8	36	22.2%	cbioportal
4	PIM1	Ssm	8	36	22.2%	cbioportal
8	IGHG1	Ssm	7	36	19.4%	cbioportal
7	H1-4	Ssm	7	36	19.4%	cbioportal
6	FAT4	Ssm	7	36	19.4%	cbioportal
5	B2M	Ssm	7	36	19.4%	cbioportal
12	LRP1B	Ssm	7	36	19.4%	cbioportal
13	PCLO	Ssm	7	36	19.4%	cbioportal
11	IGLC2	Ssm	7	36	19.4%	cbioportal
10	IGHV2-70	Ssm	7	36	19.4%	cbioportal
9	IGHG2	Ssm	7	36	19.4%	cbioportal
20	SOCS1	Ssm	6	36	16.7%	cbioportal
18	MUC16	Ssm	6	36	16.7%	cbioportal
17	ITPKB	Ssm	6	36	16.7%	cbioportal
16	IGLV3-1	Ssm	6	36	16.7%	cbioportal
15	IGHM	Ssm	6	36	16.7%	cbioportal
14	H1-2	Ssm	6	36	16.7%	cbioportal
19	P2RY8	Ssm	6	36	16.7%	cbioportal
30	UBR4	Ssm	5	36	13.9%	cbioportal
21	ASXL3	Ssm	5	36	13.9%	cbioportal
22	BTG1	Ssm	5	36	13.9%	cbioportal
23	IGLC3	Ssm	5	36	13.9%	cbioportal
24	IRF4	Ssm	5	36	13.9%	cbioportal
25	PLCB1	Ssm	5	36	13.9%	cbioportal
26	STAT3	Ssm	5	36	13.9%	cbioportal
27	SYNE1	Ssm	5	36	13.9%	cbioportal
28	TMSB4X	Ssm	5	36	13.9%	cbioportal
29	TP53	Ssm	5	36	13.9%	cbioportal

Data updated 22 days agoSource updated 2026-01-13

Diffuse Large B-Cell Lymphoma (TCGA, PanCancer Atlas) dlbc_tcga_pan_can_atlas_2018TCGA

41 cases with simple somatic mutation data · 48 cases total · 2026-06-05 · mapped to Diffuse Large B-Cell Lymphoma Unclassifiable EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	IGHV2-70	Ssm	18	41	43.9%	cbioportal
2	IGLV3-1	Ssm	14	41	34.1%	cbioportal
3	KMT2D	Ssm	12	41	29.3%	cbioportal
5	IGLL5	Ssm	10	41	24.4%	cbioportal
4	BTG2	Ssm	10	41	24.4%	cbioportal
6	B2M	Ssm	9	41	22%	cbioportal
7	IGHV1-69	Ssm	9	41	22%	cbioportal
11	PIM1	Ssm	8	41	19.5%	cbioportal
9	IGHG1	Ssm	8	41	19.5%	cbioportal
8	CARD11	Ssm	8	41	19.5%	cbioportal
10	IGHM	Ssm	8	41	19.5%	cbioportal
19	TMSB4X	Ssm	7	41	17.1%	cbioportal
17	LRP1B	Ssm	7	41	17.1%	cbioportal
16	IGHV4-34	Ssm	7	41	17.1%	cbioportal
15	IGHG2	Ssm	7	41	17.1%	cbioportal
14	H1-4	Ssm	7	41	17.1%	cbioportal
13	H1-2	Ssm	7	41	17.1%	cbioportal
12	FAT4	Ssm	7	41	17.1%	cbioportal
18	MYD88	Ssm	7	41	17.1%	cbioportal
21	IGKV1-5	Ssm	6	41	14.6%	cbioportal
20	IGKJ4	Ssm	6	41	14.6%	cbioportal
30	ZFHX4	Ssm	6	41	14.6%	cbioportal
29	STAT3	Ssm	6	41	14.6%	cbioportal
28	SOCS1	Ssm	6	41	14.6%	cbioportal
27	PCLO	Ssm	6	41	14.6%	cbioportal
26	P2RY8	Ssm	6	41	14.6%	cbioportal
25	MUC16	Ssm	6	41	14.6%	cbioportal
24	ITPKB	Ssm	6	41	14.6%	cbioportal
23	IRF4	Ssm	6	41	14.6%	cbioportal
22	IGLC2	Ssm	6	41	14.6%	cbioportal

Data updated 22 days agoSource updated 2026-06-05

HIV+ Tumor Molecular Characterization Project - Diffuse Large B-Cell Lymphoma CGCI-HTMCP-DLBCLCGCI

50 cases with simple somatic mutation data · 70 cases total · Data Release 46.0 · mapped to Diffuse Large B-Cell Lymphoma CURATED_BROADER

gdcObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TPTE	Ssm	27	50	54%	gdc
2	MTRNR2L6	Ssm	22	50	44%	gdc
3	PRSS2	Ssm	22	50	44%	gdc
4	PRSS1	Ssm	22	50	44%	gdc
5	FOXD4L5	Ssm	21	50	42%	gdc
6	GLB1L2	Ssm	20	50	40%	gdc
7	B3GAT1	Ssm	20	50	40%	gdc
8	OR11H12	Ssm	20	50	40%	gdc
24	GLB1L3	Ssm	19

Data updated 22 days agoSource updated Data Release 46.0

Lymphoid Neoplasm Diffuse Large B-cell Lymphoma TCGA-DLBCTCGA

50 cases with simple somatic mutation data · 58 cases total · Data Release 46.0 · mapped to Diffuse Large B-Cell Lymphoma CURATED_BROADER

gdcObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	BTG2	Ssm	29	50	58%	gdc
2	MTRNR2L6	Ssm	23	50	46%	gdc
3	TUBB8B	Ssm	23	50	46%	gdc
8	CSMD1	Ssm	22	50	44%	gdc
9	DSEL	Ssm	22	50	44%	gdc
5	BCL6	Ssm	22	50	44%	gdc
4	LAMA1	Ssm	22	50	44%	gdc
10	ASPM	Ssm	22	50	44%	gdc
6	GPR149	Ssm	22	50	44%	gdc
7	KLHL6	Ssm	22	50	44%	gdc
26	THOC1	Ssm	21	50	42%	gdc
23	PRSS2	Ssm	21	50	42%	gdc
22	ENOSF1	Ssm	21	50	42%	gdc
21	AHR	Ssm	21	50	42%	gdc
20	YES1	Ssm	21	50	42%	gdc
19	BCL2	Ssm	21	50	42%	gdc
18	TPTE	Ssm	21	50	42%	gdc
17	CETN1	Ssm	21	50	42%	gdc
16	COLEC12	Ssm	21	50	42%	gdc
15	CLUL1	Ssm	21	50	42%	gdc
13	KALRN	Ssm	21	50	42%	gdc
14	SALL3	Ssm	21	50	42%	gdc
12	TBL1XR1	Ssm	21	50	42%	gdc
11	POTEC	Ssm	21	50	42%	gdc
30	ASXL3	Ssm	21	50	42%	gdc
29	USP14	Ssm	21	50	42%	gdc
28	ADCYAP1	Ssm	21	50	42%	gdc
27	TYMS	Ssm	21	50	42%	gdc
25	PRSS1	Ssm	21	50	42%	gdc
24	ABCA13	Ssm	21	50	42%	gdc

Data updated 22 days agoSource updated Data Release 46.0

Lymphoid Neoplasm Diffuse Large B-cell Lymphoma (TCGA, Firehose Legacy) dlbc_tcgaTCGA

48 cases with simple somatic mutation data · 48 cases total · 2026-01-07 · mapped to Diffuse Large B-Cell Lymphoma Unclassifiable EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	IGLL5	Ssm	17	48	35.4%	cbioportal
2	MUC4	Ssm	15	48	31.3%	cbioportal
4	MUC2	Ssm	14	48	29.2%	cbioportal
3	KMT2D	Ssm	14	48	29.2%	cbioportal
5	B2M	Ssm	13	48	27.1%	cbioportal
6	BTG2	Ssm	13	48	27.1%	cbioportal
7	MUC16	Ssm	11	48	22.9%	cbioportal
9	FAT4	Ssm	10	48	20.8%	cbioportal
10	PIM1	Ssm	10	48	20.8%	cbioportal
11	SYNE1	Ssm	10	48	20.8%	cbioportal
12	TTN	Ssm	10	48	20.8%	cbioportal
8	CARD11	Ssm	10	48	20.8%	cbioportal
14	MUC5B	Ssm	9	48	18.8%	cbioportal
13	H1-4	Ssm	9	48	18.8%	cbioportal
16	P2RY8	Ssm	8	48	16.7%	cbioportal
15	CSMD3	Ssm	8	48	16.7%	cbioportal
17	PCLO	Ssm	8	48	16.7%	cbioportal
27	MUC17	Ssm	7	48	14.6%	cbioportal
21	FAT1	Ssm	7	48	14.6%	cbioportal
30	RHPN2	Ssm	7	48	14.6%	cbioportal
29	OBSCN	Ssm	7	48	14.6%	cbioportal
28	MYD88	Ssm	7	48	14.6%	cbioportal
18	ATM	Ssm	7	48	14.6%	cbioportal
19	BTG1	Ssm	7	48	14.6%	cbioportal
20	DMBT1	Ssm	7	48	14.6%	cbioportal
22	H1-2	Ssm	7	48	14.6%	cbioportal
23	HLA-C	Ssm	7	48	14.6%	cbioportal
24	KLHL6	Ssm	7	48	14.6%	cbioportal
25	LRP1B	Ssm	7	48	14.6%	cbioportal
26	LRP2	Ssm	7	48	14.6%	cbioportal

Data updated 22 days agoSource updated 2026-01-07

Mantle Cell Lymphoma (IDIBIPS, PNAS 2013) mcl_idibips_2013IDIBIPS

29 cases with simple somatic mutation data · 29 cases total · 2026-01-08 · mapped to Mantle Cell Lymphoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	ATM	Ssm	12	29	41.4%	cbioportal
2	CCND1	Ssm	10	29	34.5%	cbioportal
3	TP53	Ssm	6	29	20.7%	cbioportal
4	KMT2D	Ssm	4	29	13.8%	cbioportal
5	NSD2	Ssm	4	29	13.8%	cbioportal
17	MEF2B	Ssm	2	29	6.9%	cbioportal
19	RGS4	Ssm	2	29	6.9%	cbioportal
20	SLC17A6	Ssm	2	29	6.9%	cbioportal
21	SP140	Ssm	2	29	6.9%	cbioportal
22	SYNE1	Ssm	2	29	6.9%	cbioportal
23	TAS2R41	Ssm	2	29	6.9%	cbioportal
24	TLR2	Ssm	2	29	6.9%	cbioportal
25	TNRC6B	Ssm	2	29	6.9%	cbioportal
26	TRPM6	Ssm	2	29	6.9%	cbioportal
27	TTN	Ssm	2	29	6.9%	cbioportal
28	UBR5	Ssm	2	29	6.9%	cbioportal
29	UNC80	Ssm	2	29	6.9%	cbioportal
6	ABCC9	Ssm	2	29	6.9%	cbioportal
7	BIRC3	Ssm	2	29	6.9%	cbioportal
8	CHMP4C	Ssm	2	29	6.9%	cbioportal
9	CRYBG3	Ssm	2	29	6.9%	cbioportal
10	CSMD2	Ssm	2	29	6.9%	cbioportal
11	DCP1B	Ssm	2	29	6.9%	cbioportal
12	DLGAP2	Ssm	2	29	6.9%	cbioportal
13	DNAJC6	Ssm	2	29	6.9%	cbioportal
14	FLNC	Ssm	2	29	6.9%	cbioportal
15	KIAA1671	Ssm	2	29	6.9%	cbioportal
18	PCSK2	Ssm	2	29	6.9%	cbioportal
16	LUZP4	Ssm	2	29	6.9%	cbioportal
30	ABCA10	Ssm	1	29	3.4%	cbioportal

Data updated 22 days agoSource updated 2026-01-08