MCL1

MCL1 apoptosis regulator, BCL2 family member

Curated evidence

Clinical evidence (1)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–1 of 1 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
MCL1 Amplification1
Mcl-1 Inhibitor MIK665	Multiple Myeloma	Predictive	D	Supports Sensitivity Response	3	submitted	EID11768 In this preclinical study, the sensitivity of Multiple Myeloma tumors harboring 1q21 amplification to MCL-1 inhibitor S63845 was tested. The effect of the MCL-1 inhibitor was tested in 21 human myelom… (full text at CIViC) PMID 31856269 · Slomp et al., 2019 · Open in CIViC	civic

Cohorts

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

gdcObserved35 cohort rows · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
APOLLO1: Proteogenomic characterization of lung adenocarcinoma APOLLO-LUAD	Lung Adenocarcinoma

Literature

Data not yet available

No publication linked to this gene yet.