Malignant Large Intestinal Neoplasm — Genomics

Malignant Large Intestinal Neoplasm — Genomics · CancerIndex

Genomics

Gene alteration frequencies by cohort

27 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.

Colon Adenocarcinoma TCGA-COADTCGA

461 cases with simple somatic mutation data · 461 cases total · Data Release 46.0 · mapped to Colon Adenocarcinoma ONTOLOGY_EXACT

gdcObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	ZNF831

Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.

Colon Adenocarcinoma (CaseCCC, PNAS 2015) coad_caseccc_2015CaseCCC

29 cases with simple somatic mutation data · 29 cases total · 2026-01-06 · mapped to Colon Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	APC	Ssm	22	29	75.9%	cbioportal
2	TP53	Ssm	20	29	69%	cbioportal
3	KRAS	Ssm	16	29	55.2%	cbioportal
4	TTN	Ssm	11	29	37.9%	cbioportal
5	FLG	Ssm	8	29	27.6%	cbioportal
6	SMAD4	Ssm	7	29	24.1%	cbioportal
7	HYDIN	Ssm	6	29	20.7%	cbioportal
11	PIK3CA	Ssm	5	29	17.2%	cbioportal
9	CSMD1	Ssm	5	29	17.2%	cbioportal
8	COL11A1	Ssm	5	29	17.2%	cbioportal
10	NEB	Ssm	5	29	17.2%	cbioportal
25	TENM1	Ssm	4	29	13.8%	cbioportal
12	AHNAK2	Ssm	4	29	13.8%	cbioportal
13	APOB	Ssm	4	29	13.8%	cbioportal
14	CSMD2	Ssm	4	29	13.8%	cbioportal
15	CYP19A1	Ssm	4	29	13.8%	cbioportal
16	DNAH3	Ssm	4	29	13.8%	cbioportal
17	FBXW7	Ssm	4	29	13.8%	cbioportal
18	FRAS1	Ssm	4	29	13.8%	cbioportal
19	KMT2D	Ssm	4	29	13.8%	cbioportal
20	PCDH17	Ssm	4	29	13.8%	cbioportal
21	PCLO	Ssm	4	29	13.8%	cbioportal
22	PXDNL	Ssm	4	29	13.8%	cbioportal
23	SPATA31A3	Ssm	4	29	13.8%	cbioportal
24	SYNE1	Ssm	4	29	13.8%	cbioportal
26	ABCA12	Ssm	3	29	10.3%	cbioportal
30	ANKRD36	Ssm	3	29	10.3%	cbioportal
29	ANK2	Ssm	3	29	10.3%	cbioportal
28	AHCTF1	Ssm	3	29	10.3%	cbioportal
27	ABCA13	Ssm	3	29	10.3%	cbioportal

Data updated 22 days agoSource updated 2026-01-06

Colon Adenocarcinoma (CPTAC GDC, 2025) coad_cptac_gdcCPTAC GDC

104 cases with simple somatic mutation data · 109 cases total · 2026-01-14 · mapped to Colon Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	APC	Ssm	79	104	76%	cbioportal
2	TP53	Ssm	57	104	54.8%	cbioportal
3	TTN	Ssm	50	104	48.1%	cbioportal
4	KRAS	Ssm	36	104	34.6%	cbioportal
5	MUC16	Ssm	28	104	26.9%	cbioportal
6	SYNE1	Ssm	27	104	26%	cbioportal
7	CSMD3	Ssm	25	104	24%	cbioportal
8	FAT3	Ssm	25	104	24%	cbioportal
9	RYR1	Ssm	24	104	23.1%	cbioportal
11	HMCN1	Ssm	23	104	22.1%	cbioportal
10	FAT4	Ssm	23	104	22.1%	cbioportal
13	PIK3CA	Ssm	22	104	21.2%	cbioportal
14	ZNF469	Ssm	22	104	21.2%	cbioportal
12	OBSCN	Ssm	22	104	21.2%	cbioportal
15	ACVR2A	Ssm	21	104	20.2%	cbioportal
16	DNAH5	Ssm	21	104	20.2%	cbioportal
17	LRTM3	Ssm	21	104	20.2%	cbioportal
19	SOX9	Ssm	20	104	19.2%	cbioportal
18	COL5A1	Ssm	20	104	19.2%	cbioportal
20	SPEG	Ssm	20	104	19.2%	cbioportal
21	ARID1A	Ssm	19	104	18.3%	cbioportal
24	NBEA	Ssm	19	104	18.3%	cbioportal
25	RYR2	Ssm	19	104	18.3%	cbioportal
23	MYCBP2	Ssm	19	104	18.3%	cbioportal
22	DMD	Ssm	19	104	18.3%	cbioportal
28	HERC2	Ssm	18	104	17.3%	cbioportal
26	ADGRV1	Ssm	18	104	17.3%	cbioportal
27	FSIP2	Ssm	18	104	17.3%	cbioportal
29	PCLO	Ssm	18	104	17.3%	cbioportal
30	PLEC	Ssm	18	104	17.3%	cbioportal

Data updated 22 days agoSource updated 2026-01-14

Colon Adenocarcinoma (TCGA GDC, 2025) coad_tcga_gdcTCGA GDC

429 cases with simple somatic mutation data · 463 cases total · 2026-01-19 · mapped to Colon Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	APC	Ssm	308	429	71.8%	cbioportal
2	TP53	Ssm	237	429	55.2%	cbioportal
3	TTN	Ssm	202	429	47.1%	cbioportal
4	KRAS	Ssm	183	429	42.7%	cbioportal
5	PIK3CA	Ssm	127	429	29.6%	cbioportal
6	SYNE1	Ssm	122	429	28.4%	cbioportal
7	MUC16	Ssm	121	429	28.2%	cbioportal
8	FAT4	Ssm	99	429	23.1%	cbioportal
10	ZFHX4	Ssm	86	429	20%	cbioportal
9	RYR2	Ssm	86	429	20%	cbioportal
11	OBSCN	Ssm	84	429	19.6%	cbioportal
13	DNAH5	Ssm	80	429	18.6%	cbioportal
12	CSMD3	Ssm	80	429	18.6%	cbioportal
14	LRP1B	Ssm	75	429	17.5%	cbioportal
15	PCLO	Ssm	73	429	17%	cbioportal
16	RYR3	Ssm	71	429	16.6%	cbioportal
17	FBXW7	Ssm	70	429	16.3%	cbioportal
19	USH2A	Ssm	69	429	16.1%	cbioportal
18	DNAH11	Ssm	69	429	16.1%	cbioportal
20	CSMD1	Ssm	67	429	15.6%	cbioportal
21	RYR1	Ssm	67	429	15.6%	cbioportal
22	ABCA13	Ssm	66	429	15.4%	cbioportal
23	ADGRV1	Ssm	65	429	15.2%	cbioportal
24	FAT3	Ssm	63	429	14.7%	cbioportal
25	NEB	Ssm	62	429	14.5%	cbioportal
26	BRAF	Ssm	61	429	14.2%	cbioportal
28	LRP2	Ssm	61	429	14.2%	cbioportal
29	SOX9	Ssm	61	429	14.2%	cbioportal
27	DST	Ssm	61	429	14.2%	cbioportal
30	MDN1	Ssm	60	429	14%	cbioportal

Data updated 22 days agoSource updated 2026-01-19

Colon Cancer (CPTAC-2 Prospective, Cell 2019) coad_cptac_2019CPTAC-2 Prospective

106 cases with simple somatic mutation data · 110 cases total · 2026-01-06 · mapped to Colon Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	APC	Ssm	79	106	74.5%	cbioportal
2	TTN	Ssm	58	106	54.7%	cbioportal
3	TP53	Ssm	56	106	52.8%	cbioportal
4	MUC16	Ssm	39	106	36.8%	cbioportal
5	KRAS	Ssm	35	106	33%	cbioportal
6	OBSCN	Ssm	29	106	27.4%	cbioportal
7	SYNE1	Ssm	28	106	26.4%	cbioportal
8	DNAH5	Ssm	27	106	25.5%	cbioportal
9	FAT3	Ssm	27	106	25.5%	cbioportal
10	CSMD3	Ssm	26	106	24.5%	cbioportal
11	FAT4	Ssm	26	106	24.5%	cbioportal
12	MUC5B	Ssm	26	106	24.5%	cbioportal
13	RYR1	Ssm	25	106	23.6%	cbioportal
14	PCLO	Ssm	24	106	22.6%	cbioportal
15	ZNF469	Ssm	24	106	22.6%	cbioportal
17	COL5A1	Ssm	23	106	21.7%	cbioportal
16	ACVR2A	Ssm	23	106	21.7%	cbioportal
20	PLEC	Ssm	23	106	21.7%	cbioportal
19	PIK3CA	Ssm	23	106	21.7%	cbioportal
18	HMCN1	Ssm	23	106	21.7%	cbioportal
22	FSIP2	Ssm	22	106	20.8%	cbioportal
21	ARID1A	Ssm	22	106	20.8%	cbioportal
27	TCF7L2	Ssm	21	106	19.8%	cbioportal
26	RYR2	Ssm	21	106	19.8%	cbioportal
25	NBEA	Ssm	21	106	19.8%	cbioportal
24	HERC2	Ssm	21	106	19.8%	cbioportal
23	AHNAK2	Ssm	21	106	19.8%	cbioportal
30	MUC4	Ssm	20	106	18.9%	cbioportal
29	DOCK3	Ssm	20	106	18.9%	cbioportal
28	DMD	Ssm	20	106	18.9%	cbioportal

Data updated 22 days agoSource updated 2026-01-06

Colon Cancer (Sidra-LUMC AC-ICAM, Nat Med 2023) coad_silu_2022Sidra-LUMC AC-ICAM

281 cases with simple somatic mutation data · 348 cases total · 2026-01-06 · mapped to Colon Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	APC	Ssm	196	281	69.8%	cbioportal
2	TTN	Ssm	142	281	50.5%	cbioportal
3	TP53	Ssm	119	281	42.3%	cbioportal
4	KRAS	Ssm	100	281	35.6%	cbioportal
5	SYNE1	Ssm	90	281	32%	cbioportal
6	MUC16	Ssm	76	281	27%	cbioportal
7	FAT4	Ssm	74	281	26.3%	cbioportal
8	OBSCN	Ssm	72	281	25.6%	cbioportal
9	RYR2	Ssm	66	281	23.5%	cbioportal
10	BRAF	Ssm	65	281	23.1%	cbioportal
11	LRP1B	Ssm	65	281	23.1%	cbioportal
12	ACVR2A	Ssm	64	281	22.8%	cbioportal
13	RYR1	Ssm	64	281	22.8%	cbioportal
14	CSMD1	Ssm	63	281	22.4%	cbioportal
15	DNAH5	Ssm	62	281	22.1%	cbioportal
16	PCLO	Ssm	61	281	21.7%	cbioportal
17	CSMD3	Ssm	60	281	21.4%	cbioportal
18	MUC5B	Ssm	57	281	20.3%	cbioportal
19	ZFHX4	Ssm	57	281	20.3%	cbioportal
20	FAT2	Ssm	56	281	19.9%	cbioportal
21	FSIP2	Ssm	56	281	19.9%	cbioportal
22	RYR3	Ssm	55	281	19.6%	cbioportal
23	USH2A	Ssm	55	281	19.6%	cbioportal
24	DMD	Ssm	54	281	19.2%	cbioportal
25	FAT3	Ssm	54	281	19.2%	cbioportal
26	ABCA13	Ssm	52	281	18.5%	cbioportal
27	SACS	Ssm	52	281	18.5%	cbioportal
28	ZNF469	Ssm	52	281	18.5%	cbioportal
29	APOB	Ssm	51	281	18.1%	cbioportal
30	PLEC	Ssm	51	281	18.1%	cbioportal

Data updated 22 days agoSource updated 2026-01-06

Colorectal Adenocarcinoma (DFCI, Cell Reports 2016) coadread_dfci_2016DFCI

619 cases with simple somatic mutation data · 619 cases total · 2026-01-06 · mapped to Colorectal Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	APC	Ssm	361	619	58.3%	cbioportal
2	TP53	Ssm	320	619	51.7%	cbioportal
3	TTN	Ssm	295	619	47.7%	cbioportal
4	KRAS	Ssm	173	619	27.9%	cbioportal
5	SYNE1	Ssm	167	619	27%	cbioportal
6	FLG	Ssm	154	619	24.9%	cbioportal
7	MUC16	Ssm	150	619	24.2%	cbioportal
8	PIK3CA	Ssm	132	619	21.3%	cbioportal
9	MUC17	Ssm	129	619	20.8%	cbioportal
10	BRAF	Ssm	127	619	20.5%	cbioportal
11	OBSCN	Ssm	116	619	18.7%	cbioportal
12	RYR1	Ssm	111	619	17.9%	cbioportal
13	FAT4	Ssm	109	619	17.6%	cbioportal
14	AHNAK2	Ssm	106	619	17.1%	cbioportal
15	NEB	Ssm	106	619	17.1%	cbioportal
16	CSMD3	Ssm	104	619	16.8%	cbioportal
17	LRP1B	Ssm	100	619	16.2%	cbioportal
18	PLEC	Ssm	99	619	16%	cbioportal
19	DNAH5	Ssm	98	619	15.8%	cbioportal
20	SDK1	Ssm	93	619	15%	cbioportal
21	KMT2C	Ssm	92	619	14.9%	cbioportal
22	UBR4	Ssm	91	619	14.7%	cbioportal
24	HRNR	Ssm	90	619	14.5%	cbioportal
23	FAT3	Ssm	90	619	14.5%	cbioportal
25	DIDO1	Ssm	89	619	14.4%	cbioportal
26	AHNAK	Ssm	87	619	14.1%	cbioportal
27	FBXW7	Ssm	86	619	13.9%	cbioportal
28	USH2A	Ssm	84	619	13.6%	cbioportal
29	HMCN1	Ssm	81	619	13.1%	cbioportal
30	RNF213	Ssm	80	619	12.9%	cbioportal

Data updated 22 days agoSource updated 2026-01-06

Colorectal Adenocarcinoma (Genentech, Nature 2012) coadread_genentechGenentech

72 cases with simple somatic mutation data · 74 cases total · 2026-01-06 · mapped to Colorectal Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	40	72	55.6%	cbioportal
2	KRAS	Ssm	37	72	51.4%	cbioportal
4	TTN	Ssm	29	72	40.3%	cbioportal
3	APC	Ssm	29	72	40.3%	cbioportal
5	PIK3CA	Ssm	22	72	30.6%	cbioportal
6	SYNE1	Ssm	19	72	26.4%	cbioportal
7	DNAH5	Ssm	18	72	25%	cbioportal
11	SMAD4	Ssm	17	72	23.6%	cbioportal
8	CSMD1	Ssm	17	72	23.6%	cbioportal
9	FAT3	Ssm	17	72	23.6%	cbioportal
10	FAT4	Ssm	17	72	23.6%	cbioportal
12	RYR2	Ssm	16	72	22.2%	cbioportal
16	PLEC	Ssm	15	72	20.8%	cbioportal
15	OBSCN	Ssm	15	72	20.8%	cbioportal
14	NEB	Ssm	15	72	20.8%	cbioportal
13	FBXW7	Ssm	15	72	20.8%	cbioportal
19	LRP2	Ssm	14	72	19.4%	cbioportal
17	HERC2	Ssm	14	72	19.4%	cbioportal
18	LAMA5	Ssm	14	72	19.4%	cbioportal
20	MYO15A	Ssm	14	72	19.4%	cbioportal
21	NRXN1	Ssm	14	72	19.4%	cbioportal
22	PCLO	Ssm	14	72	19.4%	cbioportal
23	RYR1	Ssm	14	72	19.4%	cbioportal
30	LRP1B	Ssm	13	72	18.1%	cbioportal
24	ADGRV1	Ssm	13	72	18.1%	cbioportal
25	ATM	Ssm	13	72	18.1%	cbioportal
26	ATP10A	Ssm	13	72	18.1%	cbioportal
27	CSMD3	Ssm	13	72	18.1%	cbioportal
28	DNAH11	Ssm	13	72	18.1%	cbioportal
29	DNHD1	Ssm	13	72	18.1%	cbioportal

Data updated 22 days agoSource updated 2026-01-06

Colorectal Adenocarcinoma (MSK, 2026) crc_msk_2026MSK

7,237 cases with simple somatic mutation data · 7,237 cases total · 2026-09-01 · mapped to Rectal Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	APC	Ssm	5,400	7,237	74.6%	cbioportal
2	TP53	Ssm	5,295	7,237	73.2%	cbioportal
3	KRAS	Ssm	3,096	7,237	42.8%	cbioportal
4	PIK3CA	Ssm	1,486	7,237	20.5%	cbioportal
5	FBXW7	Ssm	1,127	7,237	15.6%	cbioportal
6	TCF7L2	Ssm	1,088	7,035	15.5%	cbioportal
7	SMAD4	Ssm	1,078	7,237	14.9%	cbioportal
8	ARID1A	Ssm	912	7,237	12.6%	cbioportal
9	SOX9	Ssm	869	7,237	12%	cbioportal
10	BRAF	Ssm	813	7,237	11.2%	cbioportal
11	KMT2D	Ssm	805	7,237	11.1%	cbioportal
15	KMT2B	Ssm	653	6,120	10.7%	cbioportal
12	RNF43	Ssm	734	7,237	10.1%	cbioportal
13	PTPRS	Ssm	708	7,237	9.8%	cbioportal
14	ZFHX3	Ssm	658	7,035	9.4%	cbioportal
16	ATM	Ssm	646	7,237	8.9%	cbioportal
17	PTPRT	Ssm	636	7,237	8.8%	cbioportal
18	KMT2C	Ssm	605	7,237	8.4%	cbioportal
19	NOTCH3	Ssm	571	7,237	7.9%	cbioportal
21	FAT1	Ssm	550	7,237	7.6%	cbioportal
20	AMER1	Ssm	550	7,237	7.6%	cbioportal
29	MSH3	Ssm	453	6,120	7.4%	cbioportal
22	CREBBP	Ssm	517	7,237	7.1%	cbioportal
23	CTNNB1	Ssm	503	7,237	7%	cbioportal
26	ANKRD11	Ssm	468	7,035	6.7%	cbioportal
44	PREX2	Ssm	404	6,120	6.6%	cbioportal
24	GRIN2A	Ssm	470	7,237	6.5%	cbioportal
25	CARD11	Ssm	469	7,237	6.5%	cbioportal
27	NOTCH1	Ssm	459	7,237	6.3%	cbioportal
28	BRCA2	Ssm	454	7,237	6.3%	cbioportal

Data updated 22 days agoSource updated 2026-09-01

Colorectal Adenocarcinoma (TCGA, Firehose Legacy) coadread_tcgaTCGA

223 cases with simple somatic mutation data · 640 cases total · 2026-01-06 · mapped to Colorectal Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	APC	Ssm	160	223	71.7%	cbioportal
2	TP53	Ssm	120	223	53.8%	cbioportal
3	KRAS	Ssm	96	223	43%	cbioportal
4	TTN	Ssm	80	223	35.9%	cbioportal
5	SYNE1	Ssm	47	223	21.1%	cbioportal
6	LRP1B	Ssm	40	223	17.9%	cbioportal
7	FAT4	Ssm	39	223	17.5%	cbioportal
8	MUC16	Ssm	39	223	17.5%	cbioportal
9	FBXW7	Ssm	38	223	17%	cbioportal
10	LRP2	Ssm	35	223	15.7%	cbioportal
12	DNAH5	Ssm	34	223	15.2%	cbioportal
11	DMD	Ssm	34	223	15.2%	cbioportal
13	PIK3CA	Ssm	33	223	14.8%	cbioportal
14	FLG	Ssm	32	223	14.3%	cbioportal
17	HMCN1	Ssm	30	223	13.5%	cbioportal
15	ANK2	Ssm	30	223	13.5%	cbioportal
16	FAT2	Ssm	30	223	13.5%	cbioportal
18	RYR2	Ssm	29	223	13%	cbioportal
21	CSMD3	Ssm	28	223	12.6%	cbioportal
20	CSMD1	Ssm	28	223	12.6%	cbioportal
19	COL6A3	Ssm	28	223	12.6%	cbioportal
22	SDK1	Ssm	27	223	12.1%	cbioportal
26	USH2A	Ssm	26	223	11.7%	cbioportal
25	SMAD4	Ssm	26	223	11.7%	cbioportal
24	PKHD1	Ssm	26	223	11.7%	cbioportal
23	DNAH2	Ssm	26	223	11.7%	cbioportal
27	AMER1	Ssm	25	223	11.2%	cbioportal
28	ATM	Ssm	25	223	11.2%	cbioportal
29	HYDIN	Ssm	25	223	11.2%	cbioportal
30	CSMD2	Ssm	24	223	10.8%	cbioportal

Data updated 22 days agoSource updated 2026-01-06

Colorectal Adenocarcinoma (TCGA, Nature 2012) coadread_tcga_pubTCGA

224 cases with simple somatic mutation data · 276 cases total · 2026-02-19 · mapped to Colorectal Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	APC	Ssm	168	224	75%	cbioportal
2	TP53	Ssm	121	224	54%	cbioportal
3	KRAS	Ssm	94	224	42%	cbioportal
4	TTN	Ssm	80	224	35.7%	cbioportal
5	SYNE1	Ssm	47	224	21%	cbioportal
6	PIK3CA	Ssm	45	224	20.1%	cbioportal
7	LRP1B	Ssm	40	224	17.9%	cbioportal
9	MUC16	Ssm	39	224	17.4%	cbioportal
8	FAT4	Ssm	39	224	17.4%	cbioportal
10	FBXW7	Ssm	37	224	16.5%	cbioportal
12	LRP2	Ssm	34	224	15.2%	cbioportal
11	DNAH5	Ssm	34	224	15.2%	cbioportal
13	DMD	Ssm	33	224	14.7%	cbioportal
14	FLG	Ssm	32	224	14.3%	cbioportal
16	FAT2	Ssm	30	224	13.4%	cbioportal
15	ANK2	Ssm	30	224	13.4%	cbioportal
17	HMCN1	Ssm	29	224	12.9%	cbioportal
18	COL6A3	Ssm	28	224	12.5%	cbioportal
19	CSMD1	Ssm	28	224	12.5%	cbioportal
20	CSMD3	Ssm	28	224	12.5%	cbioportal
21	RYR2	Ssm	28	224	12.5%	cbioportal
23	TCF7L2	Ssm	27	224	12.1%	cbioportal
22	SDK1	Ssm	27	224	12.1%	cbioportal
27	USH2A	Ssm	26	224	11.6%	cbioportal
26	SMAD4	Ssm	26	224	11.6%	cbioportal
25	PKHD1	Ssm	26	224	11.6%	cbioportal
24	DNAH2	Ssm	26	224	11.6%	cbioportal
30	ATM	Ssm	25	224	11.2%	cbioportal
29	AMER1	Ssm	25	224	11.2%	cbioportal
28	ACVR2A	Ssm	25	224	11.2%	cbioportal

Data updated 22 days agoSource updated 2026-02-19

Colorectal Adenocarcinoma (TCGA, PanCancer Atlas) coadread_tcga_pan_can_atlas_2018TCGA

534 cases with simple somatic mutation data · 594 cases total · 2026-06-05 · mapped to Colorectal Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	APC	Ssm	387	534	72.5%	cbioportal
2	TP53	Ssm	314	534	58.8%	cbioportal
3	TTN	Ssm	257	534	48.1%	cbioportal
4	KRAS	Ssm	218	534	40.8%	cbioportal
5	PIK3CA	Ssm	147	534	27.5%	cbioportal
6	MUC16	Ssm	146	534	27.3%	cbioportal
7	SYNE1	Ssm	144	534	27%	cbioportal
8	FAT4	Ssm	124	534	23.2%	cbioportal
9	RYR2	Ssm	105	534	19.7%	cbioportal
10	OBSCN	Ssm	99	534	18.5%	cbioportal
11	ZFHX4	Ssm	95	534	17.8%	cbioportal
13	LRP1B	Ssm	94	534	17.6%	cbioportal
12	FLG	Ssm	94	534	17.6%	cbioportal
15	DNAH5	Ssm	92	534	17.2%	cbioportal
14	CSMD1	Ssm	92	534	17.2%	cbioportal
16	FBXW7	Ssm	90	534	16.9%	cbioportal
17	CSMD3	Ssm	89	534	16.7%	cbioportal
18	DNAH11	Ssm	85	534	15.9%	cbioportal
19	RYR1	Ssm	83	534	15.5%	cbioportal
20	FAT3	Ssm	81	534	15.2%	cbioportal
21	PCLO	Ssm	80	534	15%	cbioportal
22	USH2A	Ssm	79	534	14.8%	cbioportal
23	ABCA13	Ssm	77	534	14.4%	cbioportal
24	RYR3	Ssm	77	534	14.4%	cbioportal
25	HYDIN	Ssm	76	534	14.2%	cbioportal
26	NEB	Ssm	74	534	13.9%	cbioportal
27	ADGRV1	Ssm	72	534	13.5%	cbioportal
28	DMD	Ssm	72	534	13.5%	cbioportal
30	LRP2	Ssm	70	534	13.1%	cbioportal
29	ATM	Ssm	70	534	13.1%	cbioportal

Data updated 22 days agoSource updated 2026-06-05

Colorectal Adenocarcinoma Triplets (MSK, Genome Biol 2014) coadread_mskccMSK

138 cases with simple somatic mutation data · 138 cases total · 2026-01-06 · mapped to Colorectal Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	APC	Ssm	125	138	90.6%	cbioportal
2	TP53	Ssm	111	138	80.4%	cbioportal
3	KRAS	Ssm	76	138	55.1%	cbioportal
4	PIK3CA	Ssm	27	138	19.6%	cbioportal
5	SMAD4	Ssm	17	138	12.3%	cbioportal
6	AMER1	Ssm	12	138	8.7%	cbioportal
7	FBXW7	Ssm	12	138	8.7%	cbioportal
8	CTNNB1	Ssm	10	138	7.2%	cbioportal
9	ERBB3	Ssm	8	138	5.8%	cbioportal
10	EPHA5	Ssm	7	138	5.1%	cbioportal
11	PTPRS	Ssm	7	138	5.1%	cbioportal
12	ASXL1	Ssm	6	138	4.3%	cbioportal
14	CREBBP	Ssm	6	138	4.3%	cbioportal
13	BRAF	Ssm	6	138	4.3%	cbioportal
18	ERBB2	Ssm	5	138	3.6%	cbioportal
17	EPHB1	Ssm	5	138	3.6%	cbioportal
16	ATRX	Ssm	5	138	3.6%	cbioportal
15	AR	Ssm	5	138	3.6%	cbioportal
19	GRIN2A	Ssm	5	138	3.6%	cbioportal
36	PAX5	Ssm	4	138	2.9%	cbioportal
39	PREX2	Ssm	4	138	2.9%	cbioportal
46	TSHR	Ssm	4	138	2.9%	cbioportal
45	TET1	Ssm	4	138	2.9%	cbioportal
44	TERT	Ssm	4	138	2.9%	cbioportal
43	SMO	Ssm	4	138	2.9%	cbioportal
42	RARA	Ssm	4	138	2.9%	cbioportal
41	PTPRD	Ssm	4	138	2.9%	cbioportal
40	PTCH1	Ssm	4	138	2.9%	cbioportal
38	PIK3CG	Ssm	4	138	2.9%	cbioportal
37	PDGFRA	Ssm	4	138	2.9%	cbioportal

Data updated 22 days agoSource updated 2026-01-06

Colorectal Cancer (CAS Shanghai, Cancer Cell 2020) coadread_cass_2020CAS Shanghai

146 cases with simple somatic mutation data · 146 cases total · 2026-01-06 · mapped to Colorectal Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	APC	Ssm	95	146	65.1%	cbioportal
2	TP53	Ssm	93	146	63.7%	cbioportal
3	TTN	Ssm	57	146	39%	cbioportal
4	KRAS	Ssm	47	146	32.2%	cbioportal
5	MUC16	Ssm	34	146	23.3%	cbioportal
6	FLG	Ssm	28	146	19.2%	cbioportal
7	OBSCN	Ssm	27	146	18.5%	cbioportal
8	PRRC2A	Ssm	26	146	17.8%	cbioportal
9	MUC5B	Ssm	25	146	17.1%	cbioportal
10	PLEC	Ssm	25	146	17.1%	cbioportal
11	FAT3	Ssm	24	146	16.4%	cbioportal
13	SOX9	Ssm	24	146	16.4%	cbioportal
12	LRP1B	Ssm	24	146	16.4%	cbioportal
14	FBXW7	Ssm	23	146	15.8%	cbioportal
15	PPFIA4	Ssm	23	146	15.8%	cbioportal
18	RYR1	Ssm	22	146	15.1%	cbioportal
16	CPD	Ssm	22	146	15.1%	cbioportal
17	HYDIN	Ssm	22	146	15.1%	cbioportal
20	CACNA1H	Ssm	21	146	14.4%	cbioportal
19	AHNAK2	Ssm	21	146	14.4%	cbioportal
21	MTUS2	Ssm	21	146	14.4%	cbioportal
23	MUC4	Ssm	20	146	13.7%	cbioportal
24	NUPR2	Ssm	20	146	13.7%	cbioportal
22	FSIP2	Ssm	20	146	13.7%	cbioportal
28	ZNF469	Ssm	19	146	13%	cbioportal
25	CSMD1	Ssm	19	146	13%	cbioportal
26	HSPG2	Ssm	19	146	13%	cbioportal
27	SMAD4	Ssm	19	146	13%	cbioportal
30	CSMD2	Ssm	18	146	12.3%	cbioportal
29	COL5A1	Ssm	18	146	12.3%	cbioportal

Data updated 22 days agoSource updated 2026-01-06

Colorectal Cancer- ChangKang Project (SYSUCC, Nat Commun 2022) crc_sysucc_2022SYSUCC

1,015 cases with simple somatic mutation data · 1,015 cases total · 2026-01-19 · mapped to Colorectal Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	458	1,015	45.1%	cbioportal
2	APC	Ssm	451	1,015	44.4%	cbioportal
3	TTN	Ssm	278	1,015	27.4%	cbioportal
4	KRAS	Ssm	239	1,015	23.5%	cbioportal
5	MUC16	Ssm	167	1,015	16.5%	cbioportal
6	SYNE1	Ssm	147	1,015	14.5%	cbioportal
7	PIK3CA	Ssm	130	1,015	12.8%	cbioportal
8	OBSCN	Ssm	126	1,015	12.4%	cbioportal
9	FBXW7	Ssm	121	1,015	11.9%	cbioportal
10	FLG	Ssm	116	1,015	11.4%	cbioportal
12	RYR2	Ssm	112	1,015	11%	cbioportal
11	FAT4	Ssm	112	1,015	11%	cbioportal
13	ZFHX4	Ssm	108	1,015	10.6%	cbioportal
14	LRP1B	Ssm	105	1,015	10.3%	cbioportal
15	RYR1	Ssm	101	1,015	10%	cbioportal
16	CSMD3	Ssm	100	1,015	9.9%	cbioportal
18	PCLO	Ssm	97	1,015	9.6%	cbioportal
17	NEB	Ssm	97	1,015	9.6%	cbioportal
19	DNAH11	Ssm	96	1,015	9.5%	cbioportal
20	USH2A	Ssm	95	1,015	9.4%	cbioportal
22	MUC5B	Ssm	93	1,015	9.2%	cbioportal
21	ABCA13	Ssm	93	1,015	9.2%	cbioportal
23	DNAH5	Ssm	92	1,015	9.1%	cbioportal
24	APOB	Ssm	91	1,015	9%	cbioportal
25	CSMD1	Ssm	90	1,015	8.9%	cbioportal
26	TCF7L2	Ssm	90	1,015	8.9%	cbioportal
27	FAT3	Ssm	87	1,015	8.6%	cbioportal
28	RYR3	Ssm	83	1,015	8.2%	cbioportal
29	AHNAK2	Ssm	82	1,015	8.1%	cbioportal
30	HMCN1	Ssm	82	1,015	8.1%	cbioportal

Data updated 22 days agoSource updated 2026-01-19

Colorectal Cancer (HTAN MSK, Nature 2025) crc_hta8_htan_2024HTAN MSK

28 cases with simple somatic mutation data · 83 cases total · 2026-02-17 · mapped to Colorectal Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	26	28	92.9%	cbioportal
2	APC	Ssm	23	28	82.1%	cbioportal
3	KRAS	Ssm	10	28	35.7%	cbioportal
5	TCF7L2	Ssm	5	28	17.9%	cbioportal
4	FBXW7	Ssm	5	28	17.9%	cbioportal
6	PIK3CA	Ssm	4	28	14.3%	cbioportal
8	SOX9	Ssm	3	28	10.7%	cbioportal
7	ATM	Ssm	3	28	10.7%	cbioportal
14	JUN	Ssm	2	28	7.1%	cbioportal
16	KMT2C	Ssm	2	28	7.1%	cbioportal
17	MDC1	Ssm	2	28	7.1%	cbioportal
18	NRAS	Ssm	2	28	7.1%	cbioportal
19	RB1	Ssm	2	28	7.1%	cbioportal
20	SMAD4	Ssm	2	28	7.1%	cbioportal
12	GNA11	Ssm	2	28	7.1%	cbioportal
9	BARD1	Ssm	2	28	7.1%	cbioportal
10	CARD11	Ssm	2	28	7.1%	cbioportal
11	FLT4	Ssm	2	28	7.1%	cbioportal
13	INHBA	Ssm	2	28	7.1%	cbioportal
15	KMT2B	Ssm	2	28	7.1%	cbioportal
29	BRCA2	Ssm	1	28	3.6%	cbioportal
22	ARID1A	Ssm	1	28	3.6%	cbioportal
23	ASXL1	Ssm	1	28	3.6%	cbioportal
24	AXIN2	Ssm	1	28	3.6%	cbioportal
25	AXL	Ssm	1	28	3.6%	cbioportal
26	B2M	Ssm	1	28	3.6%	cbioportal
27	BCOR	Ssm	1	28	3.6%	cbioportal
28	BRAF	Ssm	1	28	3.6%	cbioportal
30	BRD4	Ssm	1	28	3.6%	cbioportal
55	KIT	Ssm	1	28	3.6%	cbioportal

Data updated 22 days agoSource updated 2026-02-17

Colorectal Cancer (MSK, Cancer Discovery 2022) coadread_mskresistance_2022MSK

22 cases with simple somatic mutation data · 22 cases total · 2026-01-06 · mapped to Colorectal Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	KRAS	Ssm	22	22	100%	cbioportal
3	TP53	Ssm	21	22	95.5%	cbioportal
2	APC	Ssm	21	22	95.5%	cbioportal
7	USP8	Ssm	13	19	68.4%	cbioportal
4	SMAD4	Ssm	14	22	63.6%	cbioportal
9	HLA-C	Ssm	12	19	63.2%	cbioportal
6	PDCD1	Ssm	13	22	59.1%	cbioportal
5	ATM	Ssm	13	22	59.1%	cbioportal
8	ABRAXAS1	Ssm	12	22	54.5%	cbioportal
10	MGA	Ssm	12	22	54.5%	cbioportal
11	PIK3C2G	Ssm	12	22	54.5%	cbioportal
12	TET2	Ssm	12	22	54.5%	cbioportal
15	ZFHX3	Ssm	11	22	50%	cbioportal
14	TCF7L2	Ssm	11	22	50%	cbioportal
13	HLA-A	Ssm	11	22	50%	cbioportal
50	SETDB1	Ssm	9	19	47.4%	cbioportal
42	GAB1	Ssm	9	19	47.4%	cbioportal
20	FANCA	Ssm	10	22	45.5%	cbioportal
21	IGF1	Ssm	10	22	45.5%	cbioportal
22	JAK1	Ssm	10	22	45.5%	cbioportal
23	KMT2D	Ssm	10	22	45.5%	cbioportal
25	MST1R	Ssm	10	22	45.5%	cbioportal
26	MYCN	Ssm	10	22	45.5%	cbioportal
27	NEGR1	Ssm	10	22	45.5%	cbioportal
28	NSD1	Ssm	10	22	45.5%	cbioportal
16	ALK	Ssm	10	22	45.5%	cbioportal
17	AMER1	Ssm	10	22	45.5%	cbioportal
24	MLH1	Ssm	10	22	45.5%	cbioportal
18	BRCA1	Ssm	10	22	45.5%	cbioportal
19	ERCC5	Ssm	10	22	45.5%	cbioportal

Data updated 22 days agoSource updated 2026-01-06

Colorectal Cancer (MSK, Gastroenterology 2020) crc_apc_impact_2020MSK

471 cases with simple somatic mutation data · 471 cases total · 2026-01-07 · mapped to Colorectal Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	345	471	73.2%	cbioportal
2	APC	Ssm	325	471	69%	cbioportal
3	KRAS	Ssm	238	471	50.5%	cbioportal
4	PIK3CA	Ssm	88	471	18.7%	cbioportal
5	SMAD4	Ssm	69	471	14.6%	cbioportal
6	BRAF	Ssm	58	471	12.3%	cbioportal
7	FBXW7	Ssm	51	471	10.8%	cbioportal
12	TCF7L2	Ssm	36	392	9.2%	cbioportal
8	SOX9	Ssm	39	471	8.3%	cbioportal
9	RNF43	Ssm	38	471	8.1%	cbioportal
10	ARID1A	Ssm	36	471	7.6%	cbioportal
11	KMT2D	Ssm	36	471	7.6%	cbioportal
13	PTPRS	Ssm	33	471	7%	cbioportal
102	KMT2B	Ssm	10	153	6.5%	cbioportal
14	CTNNB1	Ssm	28	471	5.9%	cbioportal
23	ZFHX3	Ssm	22	392	5.6%	cbioportal
15	ERBB4	Ssm	26	471	5.5%	cbioportal
16	ATM	Ssm	25	471	5.3%	cbioportal
17	PTPRT	Ssm	25	471	5.3%	cbioportal
18	AMER1	Ssm	24	471	5.1%	cbioportal
19	NF1	Ssm	24	471	5.1%	cbioportal
21	SMARCA4	Ssm	23	471	4.9%	cbioportal
20	PTEN	Ssm	23	471	4.9%	cbioportal
32	ANKRD11	Ssm	19	392	4.8%	cbioportal
22	ERBB3	Ssm	22	471	4.7%	cbioportal
151	INPPL1	Ssm	7	153	4.6%	cbioportal
162	PREX2	Ssm	7	153	4.6%	cbioportal
26	FLT4	Ssm	21	471	4.5%	cbioportal
24	BCOR	Ssm	21	471	4.5%	cbioportal
25	BRCA2	Ssm	21	471	4.5%	cbioportal

Data updated 22 days agoSource updated 2026-01-07

Colorectal Cancer (MSK, JCO Precis Oncol 2022) crc_dd_2022MSK

47 cases with simple somatic mutation data · 47 cases total · 2026-01-16 · mapped to Colorectal Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	KRAS	Ssm	45	47	95.7%	cbioportal
2	APC	Ssm	39	47	83%	cbioportal
3	TP53	Ssm	20	47	42.6%	cbioportal
5	TCF7L2	Ssm	17	45	37.8%	cbioportal
4	PIK3CA	Ssm	17	47	36.2%	cbioportal
7	PTPRS	Ssm	14	47	29.8%	cbioportal
6	NRAS	Ssm	14	47	29.8%	cbioportal
8	FBXW7	Ssm	13	47	27.7%	cbioportal
10	FLT4	Ssm	12	47	25.5%	cbioportal
9	ARID1A	Ssm	12	47	25.5%	cbioportal
11	CREBBP	Ssm	11	47	23.4%	cbioportal
12	SMAD4	Ssm	11	47	23.4%	cbioportal
13	SOX9	Ssm	11	47	23.4%	cbioportal
22	KMT2B	Ssm	9	40	22.5%	cbioportal
18	POLE	Ssm	10	47	21.3%	cbioportal
19	PTEN	Ssm	10	47	21.3%	cbioportal
14	AMER1	Ssm	10	47	21.3%	cbioportal
15	FAT1	Ssm	10	47	21.3%	cbioportal
16	KMT2A	Ssm	10	47	21.3%	cbioportal
17	NOTCH3	Ssm	10	47	21.3%	cbioportal
25	ZFHX3	Ssm	9	45	20%	cbioportal
20	AXIN2	Ssm	9	47	19.1%	cbioportal
21	BCOR	Ssm	9	47	19.1%	cbioportal
23	KMT2D	Ssm	9	47	19.1%	cbioportal
24	SPEN	Ssm	9	47	19.1%	cbioportal
39	INPPL1	Ssm	7	40	17.5%	cbioportal
30	PIK3R1	Ssm	8	47	17%	cbioportal
28	EPHA5	Ssm	8	47	17%	cbioportal
29	MSH6	Ssm	8	47	17%	cbioportal
27	CIC	Ssm	8	47	17%	cbioportal

Data updated 22 days agoSource updated 2026-01-16

Colorectal Cancer Radiation (MSK, 2024) rectal_radiation_msk_2024MSK

48 cases with simple somatic mutation data · 48 cases total · 2026-01-20 · mapped to Rectal Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	36	48	75%	cbioportal
5	TTN	Ssm	9	17	52.9%	cbioportal
2	APC	Ssm	23	48	47.9%	cbioportal
3	KRAS	Ssm	17	48	35.4%	cbioportal
13	SYNE1	Ssm	6	17	35.3%	cbioportal
9	BSN	Ssm	6	17	35.3%	cbioportal
12	SPTBN4	Ssm	6	17	35.3%	cbioportal
15	DNAH11	Ssm	5	17	29.4%	cbioportal
16	MAST4	Ssm	5	17	29.4%	cbioportal
4	SMAD4	Ssm	12	48	25%	cbioportal
19	ARHGAP24	Ssm	4	17	23.5%	cbioportal
33	TBL3	Ssm	4	17	23.5%	cbioportal
18	ACTA1	Ssm	4	17	23.5%	cbioportal
23	FLG	Ssm	4	17	23.5%	cbioportal
30	PAPLN	Ssm	4	17	23.5%	cbioportal
45	COL20A1	Ssm	3	17	17.6%	cbioportal
51	DOCK10	Ssm	3	17	17.6%	cbioportal
50	DNAH9	Ssm	3	17	17.6%	cbioportal
49	DMD	Ssm	3	17	17.6%	cbioportal
48	DCHS1	Ssm	3	17	17.6%	cbioportal
47	CPZ	Ssm	3	17	17.6%	cbioportal
46	CPNE4	Ssm	3	17	17.6%	cbioportal
44	CLTCL1	Ssm	3	17	17.6%	cbioportal
43	CHD8	Ssm	3	17	17.6%	cbioportal
42	CHD4	Ssm	3	17	17.6%	cbioportal
41	CDH18	Ssm	3	17	17.6%	cbioportal
37	ALS2CL	Ssm	3	17	17.6%	cbioportal
36	AK3	Ssm	3	17	17.6%	cbioportal
35	ABR	Ssm	3	17	17.6%	cbioportal
55	FGD3	Ssm	3	17	17.6%	cbioportal

Data updated 22 days agoSource updated 2026-01-20

Disparities in metastatic colorectal cancer between Africans and Americans (MSK, 2020) crc_nigerian_2020MSK

64 cases with simple somatic mutation data · 64 cases total · 2026-01-07 · mapped to Colorectal Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	37	64	57.8%	cbioportal
2	KRAS	Ssm	35	64	54.7%	cbioportal
3	APC	Ssm	28	64	43.8%	cbioportal
4	PIK3CA	Ssm	16	64	25%	cbioportal
9	TCF7L2	Ssm	13	55	23.6%	cbioportal
5	ARID1A	Ssm	15	64	23.4%	cbioportal
6	CREBBP	Ssm	14	64	21.9%	cbioportal
8	PTPRS	Ssm	13	64	20.3%	cbioportal
7	KMT2C	Ssm	13	64	20.3%	cbioportal
18	ZFHX3	Ssm	10	55	18.2%	cbioportal
11	PTPRT	Ssm	11	64	17.2%	cbioportal
10	CIC	Ssm	11	64	17.2%	cbioportal
12	SOX9	Ssm	11	64	17.2%	cbioportal
13	SPEN	Ssm	11	64	17.2%	cbioportal
15	FAT1	Ssm	10	64	15.6%	cbioportal
14	AMER1	Ssm	10	64	15.6%	cbioportal
16	KMT2D	Ssm	10	64	15.6%	cbioportal
17	RNF43	Ssm	10	64	15.6%	cbioportal
23	POLE	Ssm	9	64	14.1%	cbioportal
22	NOTCH3	Ssm	9	64	14.1%	cbioportal
21	NOTCH1	Ssm	9	64	14.1%	cbioportal
20	FLT4	Ssm	9	64	14.1%	cbioportal
19	ALK	Ssm	9	64	14.1%	cbioportal
25	ARID1B	Ssm	8	64	12.5%	cbioportal
24	ABL1	Ssm	8	64	12.5%	cbioportal
26	BRCA2	Ssm	8	64	12.5%	cbioportal
27	MLH1	Ssm	8	64	12.5%	cbioportal
28	NOTCH4	Ssm	8	64	12.5%	cbioportal
29	PIK3R1	Ssm	8	64	12.5%	cbioportal
30	RPS6KA4	Ssm	8	64	12.5%	cbioportal

Data updated 22 days agoSource updated 2026-01-07

Metastatic Colorectal Cancer (MSK, Cancer Cell 2018) crc_msk_2017MSK

1,134 cases with simple somatic mutation data · 1,134 cases total · 2026-01-16 · mapped to Colorectal Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	APC	Ssm	867	1,134	76.5%	cbioportal
2	TP53	Ssm	824	1,134	72.7%	cbioportal
3	KRAS	Ssm	495	1,134	43.7%	cbioportal
4	PIK3CA	Ssm	229	1,134	20.2%	cbioportal
5	SMAD4	Ssm	173	1,134	15.3%	cbioportal
8	TCF7L2	Ssm	124	920	13.5%	cbioportal
6	FBXW7	Ssm	145	1,134	12.8%	cbioportal
7	BRAF	Ssm	133	1,134	11.7%	cbioportal
10	SOX9	Ssm	107	1,134	9.4%	cbioportal
9	KMT2D	Ssm	107	1,134	9.4%	cbioportal
11	ARID1A	Ssm	104	1,134	9.2%	cbioportal
12	PTPRS	Ssm	102	1,134	9%	cbioportal
13	RNF43	Ssm	95	1,134	8.4%	cbioportal
14	ATM	Ssm	85	1,134	7.5%	cbioportal
15	NOTCH3	Ssm	85	1,134	7.5%	cbioportal
16	CTNNB1	Ssm	84	1,134	7.4%	cbioportal
22	ZFHX3	Ssm	68	920	7.4%	cbioportal
18	PTPRT	Ssm	78	1,134	6.9%	cbioportal
17	FAT1	Ssm	78	1,134	6.9%	cbioportal
38	MGA	Ssm	57	920	6.2%	cbioportal
19	NOTCH1	Ssm	70	1,134	6.2%	cbioportal
21	PTEN	Ssm	68	1,134	6%	cbioportal
20	KMT2C	Ssm	68	1,134	6%	cbioportal
23	EPHA5	Ssm	66	1,134	5.8%	cbioportal
24	SMARCA4	Ssm	66	1,134	5.8%	cbioportal
25	AMER1	Ssm	65	1,134	5.7%	cbioportal
26	BRCA2	Ssm	65	1,134	5.7%	cbioportal
27	ERBB4	Ssm	64	1,134	5.6%	cbioportal
28	ARID1B	Ssm	63	1,134	5.6%	cbioportal
29	EP300	Ssm	63	1,134	5.6%	cbioportal

Data updated 22 days agoSource updated 2026-01-16

Pre-cancer Colorectal Polyps (HTAN Vanderbilt, Cell 2021) crc_hta11_htan_2021HTAN Vanderbilt

30 cases with simple somatic mutation data · 61 cases total · 2026-01-16 · mapped to Colorectal Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TTN	Ssm	20	30	66.7%	cbioportal
3	PCLO	Ssm	17	30	56.7%	cbioportal
2	MUC16	Ssm	17	30	56.7%	cbioportal
6	SYNE1	Ssm	16	30	53.3%	cbioportal
5	MUC19	Ssm	16	30	53.3%	cbioportal
4	MUC17	Ssm	16	30	53.3%	cbioportal
7	APC	Ssm	15	30	50%	cbioportal
8	FLG	Ssm	15	30	50%	cbioportal
10	RNF213	Ssm	14	30	46.7%	cbioportal
9	FSIP2	Ssm	14	30	46.7%	cbioportal
12	CUBN	Ssm	13	30	43.3%	cbioportal
13	DNAH10	Ssm	13	30	43.3%	cbioportal
14	DNAH5	Ssm	13	30	43.3%	cbioportal
15	HECTD4	Ssm	13	30	43.3%	cbioportal
16	HMCN1	Ssm	13	30	43.3%	cbioportal
17	LAMA3	Ssm	13	30	43.3%	cbioportal
22	TENM2	Ssm	13	30	43.3%	cbioportal
21	PRRC2C	Ssm	13	30	43.3%	cbioportal
18	MKI67	Ssm	13	30	43.3%	cbioportal
19	MUC12	Ssm	13	30	43.3%	cbioportal
20	MUC4	Ssm	13	30	43.3%	cbioportal
11	CHD7	Ssm	13	30	43.3%	cbioportal
30	UBR5	Ssm	12	30	40%	cbioportal
29	POGZ	Ssm	12	30	40%	cbioportal
28	OBSCN	Ssm	12	30	40%	cbioportal
27	MACF1	Ssm	12	30	40%	cbioportal
26	LRP2	Ssm	12	30	40%	cbioportal
25	KMT2C	Ssm	12	30	40%	cbioportal
24	KMT2A	Ssm	12	30	40%	cbioportal
23	CEP350	Ssm	12	30	40%	cbioportal

Data updated 22 days agoSource updated 2026-01-16

Rectal Adenocarcinoma (TCGA GDC, 2025) read_tcga_gdcTCGA GDC

155 cases with simple somatic mutation data · 171 cases total · 2026-01-13 · mapped to Rectal Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	APC	Ssm	126	155	81.3%	cbioportal
2	TP53	Ssm	110	155	71%	cbioportal
3	KRAS	Ssm	63	155	40.6%	cbioportal
4	TTN	Ssm	61	155	39.4%	cbioportal
5	SYNE1	Ssm	35	155	22.6%	cbioportal
6	MUC16	Ssm	28	155	18.1%	cbioportal
7	FBXW7	Ssm	26	155	16.8%	cbioportal
9	RYR2	Ssm	25	155	16.1%	cbioportal
8	FAT4	Ssm	25	155	16.1%	cbioportal
10	LRP1B	Ssm	24	155	15.5%	cbioportal
12	SMAD4	Ssm	23	155	14.8%	cbioportal
11	CSMD1	Ssm	23	155	14.8%	cbioportal
13	PIK3CA	Ssm	22	155	14.2%	cbioportal
15	FAT3	Ssm	19	155	12.3%	cbioportal
14	DNAH11	Ssm	19	155	12.3%	cbioportal
16	SACS	Ssm	18	155	11.6%	cbioportal
19	ZFHX4	Ssm	17	155	11%	cbioportal
17	CSMD3	Ssm	17	155	11%	cbioportal
18	OBSCN	Ssm	17	155	11%	cbioportal
20	FLG	Ssm	16	155	10.3%	cbioportal
21	HYDIN	Ssm	16	155	10.3%	cbioportal
24	DNAH7	Ssm	15	155	9.7%	cbioportal
25	NBEA	Ssm	15	155	9.7%	cbioportal
26	NRAS	Ssm	15	155	9.7%	cbioportal
22	ABCA13	Ssm	15	155	9.7%	cbioportal
28	SPTA1	Ssm	15	155	9.7%	cbioportal
29	TCF7L2	Ssm	15	155	9.7%	cbioportal
27	RYR1	Ssm	15	155	9.7%	cbioportal
23	ATM	Ssm	15	155	9.7%	cbioportal
33	RIMS1	Ssm	14	155	9%	cbioportal

Data updated 22 days agoSource updated 2026-01-13

Rectal Cancer (MSK,Nature Medicine 2019) rectal_msk_2019MSK

339 cases with simple somatic mutation data · 339 cases total · 2026-01-16 · mapped to Colorectal Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	268	339	79.1%	cbioportal
2	APC	Ssm	257	339	75.8%	cbioportal
3	KRAS	Ssm	152	339	44.8%	cbioportal
4	FBXW7	Ssm	66	339	19.5%	cbioportal
5	SMAD4	Ssm	47	339	13.9%	cbioportal
130	CYLD	Ssm	5	49	10.2%	cbioportal
6	PIK3CA	Ssm	33	339	9.7%	cbioportal
8	TCF7L2	Ssm	28	300	9.3%	cbioportal
7	ARID1A	Ssm	28	339	8.3%	cbioportal
181	KMT2B	Ssm	4	49	8.2%	cbioportal
199	TP53BP1	Ssm	4	49	8.2%	cbioportal
200	UPF1	Ssm	4	49	8.2%	cbioportal
196	SESN3	Ssm	4	49	8.2%	cbioportal
192	PREX2	Ssm	4	49	8.2%	cbioportal
9	SOX9	Ssm	21	339	6.2%	cbioportal
10	ERBB3	Ssm	20	339	5.9%	cbioportal
11	NOTCH3	Ssm	20	339	5.9%	cbioportal
19	MGA	Ssm	17	300	5.7%	cbioportal
14	KMT2C	Ssm	19	339	5.6%	cbioportal
12	AMER1	Ssm	19	339	5.6%	cbioportal
13	ATM	Ssm	19	339	5.6%	cbioportal
15	PTPRS	Ssm	19	339	5.6%	cbioportal
16	BRAF	Ssm	18	339	5.3%	cbioportal
17	PTPRT	Ssm	18	339	5.3%	cbioportal
18	AR	Ssm	17	339	5%	cbioportal
22	ANKRD11	Ssm	15	300	5%	cbioportal
20	EPHA5	Ssm	16	339	4.7%	cbioportal
21	KMT2A	Ssm	16	339	4.7%	cbioportal
23	CREBBP	Ssm	15	339	4.4%	cbioportal
24	NRAS	Ssm	15	339	4.4%	cbioportal

Data updated 22 days agoSource updated 2026-01-16

Rectum Adenocarcinoma TCGA-READTCGA

171 cases with simple somatic mutation data · 172 cases total · Data Release 46.0 · mapped to Rectal Adenocarcinoma ALIAS

gdcObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	PTPRT	Ssm	154	171	90.1%	gdc
3	TOP1	Ssm	152	171	88.9%	gdc
2	TAF4	Ssm	152	171	88.9%	gdc
7	ZNF831	Ssm	151	171	88.3%	gdc
10	DNMT3B	Ssm	151	171	88.3%	gdc
11	RALGAPB	Ssm	151	171	88.3%	gdc
9	STAU1	Ssm	151	171	88.3%	gdc
8	CHD6	Ssm	151	171	88.3%	gdc
6	EPB41L1	Ssm	151	171	88.3%	gdc
5	KCNB1	Ssm	151	171	88.3%	gdc
4	CD40	Ssm	151	171	88.3%	gdc
21	SOGA1	Ssm	150	171	87.7%	gdc
22	CEP250	Ssm	150	171	87.7%	gdc
23	HNF4A	Ssm	150	171	87.7%	gdc
24	KIAA1755	Ssm	150	171	87.7%	gdc
25	RBPJL	Ssm	150	171	87.7%	gdc
26	ZNF334	Ssm	150	171	87.7%	gdc
27	PREX1	Ssm	150	171	87.7%	gdc
28	ZNFX1	Ssm	150	171	87.7%	gdc
29	ARFGEF2	Ssm	150	171	87.7%	gdc
30	GNAS	Ssm	150	171	87.7%	gdc
13	PCK1	Ssm	150	171	87.7%	gdc
12	LAMA5	Ssm	150	171	87.7%	gdc
15	NCOA3	Ssm	150	171	87.7%	gdc
14	MMP9	Ssm	150	171	87.7%	gdc
16	JPH2	Ssm	150	171	87.7%	gdc
17	FAM217B	Ssm	150	171	87.7%	gdc
18	PPP1R16B	Ssm	150	171	87.7%	gdc
19	SLC12A5	Ssm	150	171	87.7%	gdc
20	RIMS4	Ssm	150	171	87.7%	gdc

Data updated 22 days agoSource updated Data Release 46.0