Malignant Urinary Tract Neoplasm — Genomics

Malignant Urinary Tract Neoplasm — Genomics · CancerIndex

Genomics

Gene alteration frequencies by cohort

24 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.

Bladder Cancer (MSK, Eur Urol 2014) blca_mskcc_solit_2014MSK

109 cases with simple somatic mutation data · 109 cases total · 2026-01-05 · mapped to Bladder Urothelial Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53

Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.

Bladder Cancer (MSK, Eur Urol Open Sci 2025) blca_msk_2025MSK

308 cases with simple somatic mutation data · 308 cases total · 2026-01-20 · mapped to Bladder Urothelial Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TERT	Ssm	190	308	61.7%	cbioportal
2	TP53	Ssm	154	308	50%	cbioportal
3	ARID1A	Ssm	81	308	26.3%	cbioportal
4	KDM6A	Ssm	70	308	22.7%	cbioportal
13	KMT2D	Ssm	24	107	22.4%	cbioportal
17	KMT2C	Ssm	20	107	18.7%	cbioportal
5	FGFR3	Ssm	52	308	16.9%	cbioportal
6	RB1	Ssm	46	308	14.9%	cbioportal
23	ELF3	Ssm	15	107	14%	cbioportal
7	ERBB2	Ssm	42	308	13.6%	cbioportal
8	PIK3CA	Ssm	42	308	13.6%	cbioportal
9	ATM	Ssm	35	308	11.4%	cbioportal
31	STAG2	Ssm	12	107	11.2%	cbioportal
10	TSC1	Ssm	33	308	10.7%	cbioportal
33	CDKN1A	Ssm	11	107	10.3%	cbioportal
34	FAT1	Ssm	11	107	10.3%	cbioportal
11	BRCA2	Ssm	28	308	9.1%	cbioportal
41	MGA	Ssm	9	107	8.4%	cbioportal
40	KMT2A	Ssm	9	107	8.4%	cbioportal
39	H3C7	Ssm	9	107	8.4%	cbioportal
12	SF3B1	Ssm	25	308	8.1%	cbioportal
47	NBN	Ssm	8	107	7.5%	cbioportal
14	BRCA1	Ssm	22	308	7.1%	cbioportal
15	ERBB3	Ssm	21	308	6.8%	cbioportal
51	ANKRD11	Ssm	7	107	6.5%	cbioportal
54	ZFHX3	Ssm	7	107	6.5%	cbioportal
53	NCOR1	Ssm	7	107	6.5%	cbioportal
16	CDKN2A	Ssm	20	308	6.5%	cbioportal
18	NF1	Ssm	20	308	6.5%	cbioportal
19	APC	Ssm	18	308	5.8%	cbioportal

Data updated 22 days agoSource updated 2026-01-20

Bladder Cancer (MSK, J Clin Onco 2013) blca_mskcc_solit_2012MSK

97 cases with simple somatic mutation data · 97 cases total · 2026-01-05 · mapped to Bladder Urothelial Carcinoma EXACT_IDENTIFIER

cbioportalObserved11 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	31	97	32%	cbioportal
2	PIK3CA	Ssm	17	97	17.5%	cbioportal
3	FGFR3	Ssm	14	97	14.4%	cbioportal
4	RB1	Ssm	10	97	10.3%	cbioportal
5	TSC1	Ssm	6	97	6.2%	cbioportal
6	KRAS	Ssm	4	97	4.1%	cbioportal
8	BRAF	Ssm	2	97	2.1%	cbioportal
9	CDKN2A	Ssm	2	97	2.1%	cbioportal
7	AKT1	Ssm	2	97	2.1%	cbioportal
11	PTEN	Ssm	1	97	1%	cbioportal
10	AKT3	Ssm	1	97	1%	cbioportal

Data updated 22 days agoSource updated 2026-01-05

Bladder Cancer (MSK, Nat Genet 2016) blca_plasmacytoid_mskcc_2016MSK

34 cases with simple somatic mutation data · 34 cases total · 2026-01-05 · mapped to Bladder Urothelial Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	CDH1	Ssm	27	34	79.4%	cbioportal
2	TP53	Ssm	20	34	58.8%	cbioportal
3	TERT	Ssm	12	34	35.3%	cbioportal
4	RB1	Ssm	9	34	26.5%	cbioportal
6	CDKN1A	Ssm	8	34	23.5%	cbioportal
5	ARID1A	Ssm	8	34	23.5%	cbioportal
7	PIK3R1	Ssm	7	34	20.6%	cbioportal
8	KMT2C	Ssm	6	34	17.6%	cbioportal
10	ERBB2	Ssm	5	34	14.7%	cbioportal
9	BAP1	Ssm	5	34	14.7%	cbioportal
11	ERBB3	Ssm	5	34	14.7%	cbioportal
12	ERCC2	Ssm	5	34	14.7%	cbioportal
13	KMT2A	Ssm	5	34	14.7%	cbioportal
14	KMT2D	Ssm	5	34	14.7%	cbioportal
15	PIK3CA	Ssm	5	34	14.7%	cbioportal
19	SMARCA4	Ssm	4	34	11.8%	cbioportal
16	ATR	Ssm	4	34	11.8%	cbioportal
17	EPHB1	Ssm	4	34	11.8%	cbioportal
18	NOTCH4	Ssm	4	34	11.8%	cbioportal
23	IRS2	Ssm	3	34	8.8%	cbioportal
22	FAT1	Ssm	3	34	8.8%	cbioportal
21	EP300	Ssm	3	34	8.8%	cbioportal
20	DICER1	Ssm	3	34	8.8%	cbioportal
28	PALB2	Ssm	3	34	8.8%	cbioportal
27	NRAS	Ssm	3	34	8.8%	cbioportal
26	NOTCH2	Ssm	3	34	8.8%	cbioportal
25	NF1	Ssm	3	34	8.8%	cbioportal
24	MTOR	Ssm	3	34	8.8%	cbioportal
29	PBRM1	Ssm	3	34	8.8%	cbioportal
30	PTEN	Ssm	3	34	8.8%	cbioportal

Data updated 22 days agoSource updated 2026-01-05

Bladder Cancer (MSK/TCGA, Eur Urol 2020) blca_msk_tcga_2020MSK/TCGA

474 cases with simple somatic mutation data · 476 cases total · 2026-01-27 · mapped to Bladder Urothelial Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	245	474	51.7%	cbioportal
2	TTN	Ssm	155	474	32.7%	cbioportal
3	KMT2D	Ssm	139	474	29.3%	cbioportal
4	ARID1A	Ssm	127	474	26.8%	cbioportal
5	KDM6A	Ssm	124	474	26.2%	cbioportal
6	PIK3CA	Ssm	103	474	21.7%	cbioportal
7	MUC16	Ssm	101	474	21.3%	cbioportal
8	TERT	Ssm	101	474	21.3%	cbioportal
9	RB1	Ssm	100	474	21.1%	cbioportal
10	KMT2C	Ssm	80	474	16.9%	cbioportal
11	EP300	Ssm	70	474	14.8%	cbioportal
12	ERBB2	Ssm	70	474	14.8%	cbioportal
13	SYNE1	Ssm	66	474	13.9%	cbioportal
14	ERBB3	Ssm	65	474	13.7%	cbioportal
15	RYR2	Ssm	64	474	13.5%	cbioportal
16	FGFR3	Ssm	60	474	12.7%	cbioportal
17	ATM	Ssm	58	474	12.2%	cbioportal
18	FAT1	Ssm	58	474	12.2%	cbioportal
20	CREBBP	Ssm	56	474	11.8%	cbioportal
19	BIRC6	Ssm	56	474	11.8%	cbioportal
22	STAG2	Ssm	55	474	11.6%	cbioportal
21	HMCN1	Ssm	55	474	11.6%	cbioportal
23	MACF1	Ssm	54	474	11.4%	cbioportal
25	KMT2A	Ssm	53	474	11.2%	cbioportal
24	FLG	Ssm	53	474	11.2%	cbioportal
26	FAT4	Ssm	52	474	11%	cbioportal
27	ERCC2	Ssm	50	474	10.5%	cbioportal
29	ELF3	Ssm	48	474	10.1%	cbioportal
28	CSMD3	Ssm	48	474	10.1%	cbioportal
30	BRCA2	Ssm	47	474	9.9%	cbioportal

Data updated 22 days agoSource updated 2026-01-27

Bladder Cancer (TCGA, Cell 2017) blca_tcga_pub_2017TCGA

412 cases with simple somatic mutation data · 413 cases total · 2026-01-05 · mapped to Bladder Urothelial Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
2	TTN	Ssm	198	412	48.1%	cbioportal
1	TP53	Ssm	198	412	48.1%	cbioportal
3	KMT2D	Ssm	117	412	28.4%	cbioportal
4	MUC16	Ssm	117	412	28.4%	cbioportal
5	KDM6A	Ssm	107	412	26%	cbioportal
6	ARID1A	Ssm	101	412	24.5%	cbioportal
7	PIK3CA	Ssm	91	412	22.1%	cbioportal
8	SYNE1	Ssm	84	412	20.4%	cbioportal
9	RYR2	Ssm	78	412	18.9%	cbioportal
10	KMT2C	Ssm	77	412	18.7%	cbioportal
11	HMCN1	Ssm	76	412	18.4%	cbioportal
12	RB1	Ssm	72	412	17.5%	cbioportal
13	FLG	Ssm	68	412	16.5%	cbioportal
14	MACF1	Ssm	66	412	16%	cbioportal
15	EP300	Ssm	63	412	15.3%	cbioportal
16	FAT4	Ssm	63	412	15.3%	cbioportal
17	FGFR3	Ssm	58	412	14.1%	cbioportal
20	STAG2	Ssm	57	412	13.8%	cbioportal
18	ATM	Ssm	57	412	13.8%	cbioportal
19	CSMD3	Ssm	57	412	13.8%	cbioportal
21	NEB	Ssm	56	412	13.6%	cbioportal
22	OBSCN	Ssm	56	412	13.6%	cbioportal
23	DNAH5	Ssm	54	412	13.1%	cbioportal
24	DNAH11	Ssm	53	412	12.9%	cbioportal
25	CUBN	Ssm	52	412	12.6%	cbioportal
26	SYNE2	Ssm	52	412	12.6%	cbioportal
28	FAT1	Ssm	51	412	12.4%	cbioportal
27	BIRC6	Ssm	51	412	12.4%	cbioportal
29	AHNAK2	Ssm	50	412	12.1%	cbioportal
30	CREBBP	Ssm	50	412	12.1%	cbioportal

Data updated 22 days agoSource updated 2026-01-05

Bladder Urothelial Carcinoma TCGA-BLCATCGA

412 cases with simple somatic mutation data · 412 cases total · Data Release 46.0 · mapped to Bladder Urothelial Carcinoma ONTOLOGY_EXACT

gdcObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	294	412	71.4%	gdc
2	TTN	Ssm	281	412	68.2%	gdc
3	CDKN2A	Ssm	269	412	65.3%	gdc
4	CDKN2B	Ssm	267	412	64.8%	gdc
5	AL359922.1	Ssm	264	412	64.1%	gdc
6	CSMD1	Ssm	263	412	63.8%	gdc
7	MTAP	Ssm	261	412	63.3%	gdc
9	CSMD3	Ssm	260	412	63.1%	gdc
8	VPS13B	Ssm	260	412	63.1%	gdc
10	UBR5	Ssm	259	412	62.9%	gdc
12	DMRTA1	Ssm	255	412	61.9%	gdc
11	GRHL2	Ssm	255	412	61.9%	gdc
19	TEX15	Ssm	253	412	61.4%	gdc
16	ZNF706	Ssm	253	412	61.4%	gdc
13	PABPC1	Ssm	253	412	61.4%	gdc
14	MYOM2	Ssm	253	412	61.4%	gdc
15	COL14A1	Ssm	253	412	61.4%	gdc
18	DNAH5	Ssm	253	412	61.4%	gdc
17	TNFRSF10A	Ssm	253	412	61.4%	gdc
21	ADRA1A	Ssm	252	412	61.2%	gdc
20	RIMS2	Ssm	252	412	61.2%	gdc
28	PKHD1L1	Ssm	251	412	60.9%	gdc
27	FBXO43	Ssm	251	412	60.9%	gdc
22	SORBS3	Ssm	251	412	60.9%	gdc
23	RNF19A	Ssm	251	412	60.9%	gdc
24	CDCA2	Ssm	251	412	60.9%	gdc
25	YWHAZ	Ssm	251	412	60.9%	gdc
26	NEFM	Ssm	251	412	60.9%	gdc
29	RGS22	Ssm	250	412	60.7%	gdc
30	PRAG1	Ssm	250	412	60.7%	gdc

Data updated 22 days agoSource updated Data Release 46.0

Bladder Urothelial Carcinoma (BGI, Nat Genet 2013) blca_bgiBGI

99 cases with simple somatic mutation data · 99 cases total · 2026-01-05 · mapped to Bladder Urothelial Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	KDM6A	Ssm	32	99	32.3%	cbioportal
2	TP53	Ssm	28	99	28.3%	cbioportal
3	PIK3CA	Ssm	24	99	24.2%	cbioportal
4	ZNF83	Ssm	18	99	18.2%	cbioportal
5	FGFR3	Ssm	16	99	16.2%	cbioportal
6	ARID1A	Ssm	15	99	15.2%	cbioportal
7	CREBBP	Ssm	15	99	15.2%	cbioportal
8	HRAS	Ssm	15	99	15.2%	cbioportal
9	EP300	Ssm	14	99	14.1%	cbioportal
10	RB1	Ssm	13	99	13.1%	cbioportal
11	STAG2	Ssm	13	99	13.1%	cbioportal
12	ZNF233	Ssm	13	99	13.1%	cbioportal
13	ERBB2	Ssm	10	99	10.1%	cbioportal
14	ERCC2	Ssm	10	99	10.1%	cbioportal
15	SYNE2	Ssm	10	99	10.1%	cbioportal
17	HMCN1	Ssm	9	99	9.1%	cbioportal
16	FGFRL1	Ssm	9	99	9.1%	cbioportal
18	SYNE1	Ssm	9	99	9.1%	cbioportal
19	XIRP2	Ssm	9	99	9.1%	cbioportal
20	ZFP36L1	Ssm	9	99	9.1%	cbioportal
22	KMT2A	Ssm	8	99	8.1%	cbioportal
21	CSMD3	Ssm	8	99	8.1%	cbioportal
24	ANK3	Ssm	7	99	7.1%	cbioportal
25	AQP7	Ssm	7	99	7.1%	cbioportal
30	LRP2	Ssm	7	99	7.1%	cbioportal
23	ACTB	Ssm	7	99	7.1%	cbioportal
26	DNAH8	Ssm	7	99	7.1%	cbioportal
27	FMN2	Ssm	7	99	7.1%	cbioportal
28	GOLGB1	Ssm	7	99	7.1%	cbioportal
29	KRAS	Ssm	7	99	7.1%	cbioportal

Data updated 22 days agoSource updated 2026-01-05

Bladder Urothelial Carcinoma (DFCI/MSK, Cancer Discov 2014) blca_dfarber_mskcc_2014DFCI/MSK

50 cases with simple somatic mutation data · 50 cases total · 2026-01-05 · mapped to Bladder Urothelial Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	29	50	58%	cbioportal
2	TTN	Ssm	24	50	48%	cbioportal
3	MUC16	Ssm	19	50	38%	cbioportal
4	ERBB4	Ssm	17	50	34%	cbioportal
5	KMT2D	Ssm	15	50	30%	cbioportal
6	ZAN	Ssm	14	50	28%	cbioportal
7	ARID1A	Ssm	13	50	26%	cbioportal
9	KDM6A	Ssm	12	50	24%	cbioportal
11	ZNF721	Ssm	12	50	24%	cbioportal
10	RB1	Ssm	12	50	24%	cbioportal
8	ERBB3	Ssm	12	50	24%	cbioportal
13	MUC17	Ssm	10	50	20%	cbioportal
12	AHNAK2	Ssm	10	50	20%	cbioportal
16	SYNE1	Ssm	10	50	20%	cbioportal
15	PRG4	Ssm	10	50	20%	cbioportal
14	PIK3CA	Ssm	10	50	20%	cbioportal
20	FAT4	Ssm	9	50	18%	cbioportal
19	ERCC2	Ssm	9	50	18%	cbioportal
18	ANKRD30A	Ssm	9	50	18%	cbioportal
17	AHNAK	Ssm	9	50	18%	cbioportal
23	SYNE2	Ssm	9	50	18%	cbioportal
22	RPTN	Ssm	9	50	18%	cbioportal
21	MAGEC1	Ssm	9	50	18%	cbioportal
26	F5	Ssm	8	50	16%	cbioportal
24	ALMS1	Ssm	8	50	16%	cbioportal
29	MDN1	Ssm	8	50	16%	cbioportal
30	MUC4	Ssm	8	50	16%	cbioportal
28	KMT2C	Ssm	8	50	16%	cbioportal
27	FLG	Ssm	8	50	16%	cbioportal
25	BIRC6	Ssm	8	50	16%	cbioportal

Data updated 22 days agoSource updated 2026-01-05

Bladder Urothelial Carcinoma SWOG S1314 Trial (MSK, JCO Precis Oncol 2024) blca_msk_2024MSK

184 cases with simple somatic mutation data · 184 cases total · 2026-01-05 · mapped to Bladder Urothelial Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TERT	Ssm	141	184	76.6%	cbioportal
2	TP53	Ssm	116	184	63%	cbioportal
3	KMT2D	Ssm	64	184	34.8%	cbioportal
4	KDM6A	Ssm	55	184	29.9%	cbioportal
5	ARID1A	Ssm	50	184	27.2%	cbioportal
6	RB1	Ssm	48	184	26.1%	cbioportal
7	PIK3CA	Ssm	42	184	22.8%	cbioportal
8	KMT2C	Ssm	35	184	19%	cbioportal
9	ATM	Ssm	31	184	16.8%	cbioportal
10	ELF3	Ssm	29	184	15.8%	cbioportal
11	FAT1	Ssm	29	184	15.8%	cbioportal
12	CREBBP	Ssm	27	184	14.7%	cbioportal
13	ERCC2	Ssm	27	184	14.7%	cbioportal
15	KMT2A	Ssm	26	184	14.1%	cbioportal
14	BRCA2	Ssm	26	184	14.1%	cbioportal
16	ERBB2	Ssm	25	184	13.6%	cbioportal
17	FGFR3	Ssm	25	184	13.6%	cbioportal
18	EP300	Ssm	24	184	13%	cbioportal
19	ERBB3	Ssm	24	184	13%	cbioportal
20	TSC1	Ssm	22	184	12%	cbioportal
21	FBXW7	Ssm	21	184	11.4%	cbioportal
22	CDKN1A	Ssm	20	184	10.9%	cbioportal
25	STAG2	Ssm	18	184	9.8%	cbioportal
24	NF1	Ssm	18	184	9.8%	cbioportal
23	H3C7	Ssm	18	184	9.8%	cbioportal
26	PTPRT	Ssm	17	184	9.2%	cbioportal
28	KMT2B	Ssm	16	184	8.7%	cbioportal
29	NSD1	Ssm	16	184	8.7%	cbioportal
27	CDKN2A	Ssm	16	184	8.7%	cbioportal
31	ATR	Ssm	15	184	8.2%	cbioportal

Data updated 22 days agoSource updated 2026-01-05

Bladder Urothelial Carcinoma (TCGA, Firehose Legacy) blca_tcgaTCGA

130 cases with simple somatic mutation data · 413 cases total · 2026-01-05 · mapped to Bladder Urothelial Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TTN	Ssm	73	130	56.2%	cbioportal
2	TP53	Ssm	64	130	49.2%	cbioportal
3	MUC16	Ssm	43	130	33.1%	cbioportal
4	KMT2D	Ssm	36	130	27.7%	cbioportal
5	ARID1A	Ssm	34	130	26.2%	cbioportal
6	KDM6A	Ssm	31	130	23.8%	cbioportal
7	KMT2C	Ssm	27	130	20.8%	cbioportal
8	PIK3CA	Ssm	26	130	20%	cbioportal
10	SYNE1	Ssm	24	130	18.5%	cbioportal
9	HMCN1	Ssm	24	130	18.5%	cbioportal
11	FLG	Ssm	23	130	17.7%	cbioportal
12	EP300	Ssm	21	130	16.2%	cbioportal
13	RYR2	Ssm	20	130	15.4%	cbioportal
17	ZFHX4	Ssm	19	130	14.6%	cbioportal
14	MACF1	Ssm	19	130	14.6%	cbioportal
15	PDE4DIP	Ssm	19	130	14.6%	cbioportal
16	PKHD1L1	Ssm	19	130	14.6%	cbioportal
20	KMT2A	Ssm	18	130	13.8%	cbioportal
19	CDKN1A	Ssm	18	130	13.8%	cbioportal
18	AHNAK2	Ssm	18	130	13.8%	cbioportal
24	LRP1B	Ssm	17	130	13.1%	cbioportal
23	FAT4	Ssm	17	130	13.1%	cbioportal
22	DNAH11	Ssm	17	130	13.1%	cbioportal
21	CREBBP	Ssm	17	130	13.1%	cbioportal
27	SYNE2	Ssm	17	130	13.1%	cbioportal
26	RB1	Ssm	17	130	13.1%	cbioportal
25	MUC17	Ssm	17	130	13.1%	cbioportal
28	ADGRV1	Ssm	16	130	12.3%	cbioportal
29	ERCC2	Ssm	16	130	12.3%	cbioportal
30	FGFR3	Ssm	16	130	12.3%	cbioportal

Data updated 22 days agoSource updated 2026-01-05

Bladder Urothelial Carcinoma (TCGA GDC, 2025) blca_tcga_gdcTCGA GDC

408 cases with simple somatic mutation data · 413 cases total · 2026-01-19 · mapped to Bladder Urothelial Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	202	408	49.5%	cbioportal
2	TTN	Ssm	176	408	43.1%	cbioportal
3	KMT2D	Ssm	109	408	26.7%	cbioportal
4	KDM6A	Ssm	104	408	25.5%	cbioportal
5	MUC16	Ssm	103	408	25.2%	cbioportal
6	ARID1A	Ssm	100	408	24.5%	cbioportal
7	PIK3CA	Ssm	86	408	21.1%	cbioportal
8	SYNE1	Ssm	80	408	19.6%	cbioportal
9	RB1	Ssm	72	408	17.6%	cbioportal
11	RYR2	Ssm	69	408	16.9%	cbioportal
10	KMT2C	Ssm	69	408	16.9%	cbioportal
12	HMCN1	Ssm	66	408	16.2%	cbioportal
13	EP300	Ssm	60	408	14.7%	cbioportal
14	FAT4	Ssm	60	408	14.7%	cbioportal
15	MACF1	Ssm	60	408	14.7%	cbioportal
16	FLG	Ssm	58	408	14.2%	cbioportal
18	STAG2	Ssm	56	408	13.7%	cbioportal
17	FGFR3	Ssm	56	408	13.7%	cbioportal
19	ELF3	Ssm	55	408	13.5%	cbioportal
20	CSMD3	Ssm	53	408	13%	cbioportal
21	ATM	Ssm	51	408	12.5%	cbioportal
22	OBSCN	Ssm	50	408	12.3%	cbioportal
23	NEB	Ssm	49	408	12%	cbioportal
24	CUBN	Ssm	48	408	11.8%	cbioportal
26	DNAH5	Ssm	47	408	11.5%	cbioportal
25	BIRC6	Ssm	47	408	11.5%	cbioportal
27	SYNE2	Ssm	47	408	11.5%	cbioportal
29	ERBB2	Ssm	46	408	11.3%	cbioportal
30	XIRP2	Ssm	46	408	11.3%	cbioportal
28	CREBBP	Ssm	46	408	11.3%	cbioportal

Data updated 22 days agoSource updated 2026-01-19

Bladder Urothelial Carcinoma (TCGA, Nature 2014) blca_tcga_pubTCGA

130 cases with simple somatic mutation data · 131 cases total · 2026-01-05 · mapped to Bladder Urothelial Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TTN	Ssm	72	130	55.4%	cbioportal
2	TP53	Ssm	64	130	49.2%	cbioportal
3	MUC16	Ssm	43	130	33.1%	cbioportal
4	KMT2D	Ssm	35	130	26.9%	cbioportal
5	ARID1A	Ssm	33	130	25.4%	cbioportal
6	KDM6A	Ssm	31	130	23.8%	cbioportal
7	KMT2C	Ssm	28	130	21.5%	cbioportal
8	PIK3CA	Ssm	26	130	20%	cbioportal
9	FLG	Ssm	25	130	19.2%	cbioportal
11	SYNE1	Ssm	24	130	18.5%	cbioportal
10	HMCN1	Ssm	24	130	18.5%	cbioportal
13	RYR2	Ssm	20	130	15.4%	cbioportal
12	EP300	Ssm	20	130	15.4%	cbioportal
16	PDE4DIP	Ssm	19	130	14.6%	cbioportal
17	PKHD1L1	Ssm	19	130	14.6%	cbioportal
14	AHNAK2	Ssm	19	130	14.6%	cbioportal
15	MACF1	Ssm	19	130	14.6%	cbioportal
18	ZFHX4	Ssm	19	130	14.6%	cbioportal
20	KMT2A	Ssm	18	130	13.8%	cbioportal
22	SYNE2	Ssm	18	130	13.8%	cbioportal
21	LRP1B	Ssm	18	130	13.8%	cbioportal
19	CDKN1A	Ssm	18	130	13.8%	cbioportal
24	MUC17	Ssm	17	130	13.1%	cbioportal
23	LYST	Ssm	17	130	13.1%	cbioportal
25	RB1	Ssm	17	130	13.1%	cbioportal
28	CSMD3	Ssm	16	130	12.3%	cbioportal
30	DNAH3	Ssm	16	130	12.3%	cbioportal
27	CREBBP	Ssm	16	130	12.3%	cbioportal
26	ADGRV1	Ssm	16	130	12.3%	cbioportal
29	DNAH11	Ssm	16	130	12.3%	cbioportal

Data updated 22 days agoSource updated 2026-01-05

Bladder Urothelial Carcinoma (TCGA, PanCancer Atlas) blca_tcga_pan_can_atlas_2018TCGA

410 cases with simple somatic mutation data · 411 cases total · 2026-08-20 · mapped to Bladder Urothelial Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	202	410	49.3%	cbioportal
2	TTN	Ssm	192	410	46.8%	cbioportal
3	MUC16	Ssm	119	410	29%	cbioportal
4	KMT2D	Ssm	117	410	28.5%	cbioportal
5	KDM6A	Ssm	106	410	25.9%	cbioportal
6	ARID1A	Ssm	105	410	25.6%	cbioportal
7	PIK3CA	Ssm	90	410	22%	cbioportal
8	SYNE1	Ssm	87	410	21.2%	cbioportal
9	KMT2C	Ssm	81	410	19.8%	cbioportal
10	RB1	Ssm	78	410	19%	cbioportal
11	MACF1	Ssm	76	410	18.5%	cbioportal
12	RYR2	Ssm	76	410	18.5%	cbioportal
13	HMCN1	Ssm	75	410	18.3%	cbioportal
14	FLG	Ssm	68	410	16.6%	cbioportal
16	FAT4	Ssm	63	410	15.4%	cbioportal
15	EP300	Ssm	63	410	15.4%	cbioportal
17	FGFR3	Ssm	59	410	14.4%	cbioportal
18	CSMD3	Ssm	58	410	14.1%	cbioportal
19	STAG2	Ssm	57	410	13.9%	cbioportal
20	ATM	Ssm	55	410	13.4%	cbioportal
21	BIRC6	Ssm	54	410	13.2%	cbioportal
22	ELF3	Ssm	54	410	13.2%	cbioportal
23	OBSCN	Ssm	54	410	13.2%	cbioportal
25	NEB	Ssm	53	410	12.9%	cbioportal
24	CUBN	Ssm	53	410	12.9%	cbioportal
27	LRP1B	Ssm	52	410	12.7%	cbioportal
28	SYNE2	Ssm	52	410	12.7%	cbioportal
26	DNAH11	Ssm	52	410	12.7%	cbioportal
30	CREBBP	Ssm	51	410	12.4%	cbioportal
29	AHNAK2	Ssm	51	410	12.4%	cbioportal

Data updated 22 days agoSource updated 2026-08-20

Metastatic Bladder Urothelial Carcinoma (IMvigor210 Phase II Trial, ESMO Open. 2024) - iAtlas Harmonized blca_iatlas_imvigor210_2017

242 cases with simple somatic mutation data · 347 cases total · 2026-02-11 · mapped to Bladder Urothelial Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TTN	Ssm	128	242	52.9%	cbioportal
2	TP53	Ssm	123	242	50.8%	cbioportal
3	MUC16	Ssm	80	242	33.1%	cbioportal
4	KMT2D	Ssm	70	242	28.9%	cbioportal
5	ARID1A	Ssm	64	242	26.4%	cbioportal
6	OBSCN	Ssm	61	242	25.2%	cbioportal
7	SYNE1	Ssm	55	242	22.7%	cbioportal
8	MACF1	Ssm	54	242	22.3%	cbioportal
9	KDM6A	Ssm	52	242	21.5%	cbioportal
11	PIK3CA	Ssm	46	242	19%	cbioportal
10	FAT1	Ssm	46	242	19%	cbioportal
12	RYR3	Ssm	45	242	18.6%	cbioportal
13	LRTM3	Ssm	44	242	18.2%	cbioportal
15	RNF213	Ssm	43	242	17.8%	cbioportal
14	LRP1B	Ssm	43	242	17.8%	cbioportal
16	FGFR3	Ssm	42	242	17.4%	cbioportal
17	ADGRV1	Ssm	41	242	16.9%	cbioportal
21	PKHD1L1	Ssm	40	242	16.5%	cbioportal
19	DST	Ssm	40	242	16.5%	cbioportal
18	CREBBP	Ssm	40	242	16.5%	cbioportal
20	FLG	Ssm	40	242	16.5%	cbioportal
24	FAT4	Ssm	39	242	16.1%	cbioportal
25	HMCN1	Ssm	39	242	16.1%	cbioportal
26	MUC5AC	Ssm	39	242	16.1%	cbioportal
27	PCLO	Ssm	39	242	16.1%	cbioportal
23	ELF3	Ssm	39	242	16.1%	cbioportal
22	AHNAK2	Ssm	39	242	16.1%	cbioportal
28	KMT2C	Ssm	38	242	15.7%	cbioportal
29	MUC3A	Ssm	38	242	15.7%	cbioportal
30	RYR2	Ssm	38	242	15.7%	cbioportal

Data updated 22 days agoSource updated 2026-02-11

Nonmuscle Invasive Bladder Cancer (MSK Eur Urol 2017) blca_nmibc_2017

105 cases with simple somatic mutation data · 105 cases total · 2026-01-05 · mapped to Bladder Urothelial Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TERT	Ssm	77	105	73.3%	cbioportal
2	KDM6A	Ssm	50	105	47.6%	cbioportal
3	FGFR3	Ssm	47	105	44.8%	cbioportal
4	ARID1A	Ssm	30	105	28.6%	cbioportal
5	PIK3CA	Ssm	29	105	27.6%	cbioportal
6	KMT2D	Ssm	25	105	23.8%	cbioportal
7	CREBBP	Ssm	22	105	21%	cbioportal
9	TP53	Ssm	22	105	21%	cbioportal
8	STAG2	Ssm	22	105	21%	cbioportal
10	ERBB2	Ssm	19	105	18.1%	cbioportal
11	ERCC2	Ssm	18	105	17.1%	cbioportal
13	FAT1	Ssm	17	105	16.2%	cbioportal
12	ARID1B	Ssm	17	105	16.2%	cbioportal
14	ATM	Ssm	16	105	15.2%	cbioportal
15	EP300	Ssm	15	105	14.3%	cbioportal
17	PBRM1	Ssm	15	105	14.3%	cbioportal
16	FBXW7	Ssm	15	105	14.3%	cbioportal
18	RBM10	Ssm	15	105	14.3%	cbioportal
19	MGA	Ssm	14	103	13.6%	cbioportal
20	BAP1	Ssm	13	105	12.4%	cbioportal
24	NF1	Ssm	12	105	11.4%	cbioportal
22	ERBB3	Ssm	12	105	11.4%	cbioportal
21	CDKN1A	Ssm	12	105	11.4%	cbioportal
23	KMT2C	Ssm	12	105	11.4%	cbioportal
27	SPEN	Ssm	11	105	10.5%	cbioportal
25	BRCA2	Ssm	11	105	10.5%	cbioportal
26	SMARCA4	Ssm	11	105	10.5%	cbioportal
28	TSC1	Ssm	11	105	10.5%	cbioportal
30	NCOR1	Ssm	10	105	9.5%	cbioportal
29	ATR	Ssm	10	105	9.5%	cbioportal

Data updated 22 days agoSource updated 2026-01-05

Upper Tract Urothelial Cancer (MSK, Eur Urol 2015) utuc_mskcc_2015MSK

85 cases with simple somatic mutation data · 85 cases total · 2026-01-16 · mapped to Renal Pelvis and Ureter Urothelial Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	FGFR3	Ssm	41	85	48.2%	cbioportal
2	KMT2D	Ssm	30	85	35.3%	cbioportal
3	KDM6A	Ssm	29	85	34.1%	cbioportal
4	KMT2C	Ssm	22	85	25.9%	cbioportal
5	STAG2	Ssm	19	85	22.4%	cbioportal
7	TP53	Ssm	15	85	17.6%	cbioportal
6	CREBBP	Ssm	15	85	17.6%	cbioportal
8	TSC1	Ssm	14	85	16.5%	cbioportal
9	PIK3CA	Ssm	13	85	15.3%	cbioportal
10	ARID1A	Ssm	11	85	12.9%	cbioportal
12	TERT	Ssm	10	85	11.8%	cbioportal
11	ATM	Ssm	10	85	11.8%	cbioportal
14	SMARCA4	Ssm	9	85	10.6%	cbioportal
13	HRAS	Ssm	9	85	10.6%	cbioportal
15	EP300	Ssm	8	85	9.4%	cbioportal
16	FAT1	Ssm	8	85	9.4%	cbioportal
17	ARID2	Ssm	7	85	8.2%	cbioportal
18	EPHA5	Ssm	7	85	8.2%	cbioportal
22	PBRM1	Ssm	6	85	7.1%	cbioportal
19	ERBB2	Ssm	6	85	7.1%	cbioportal
20	FBXW7	Ssm	6	85	7.1%	cbioportal
21	NF1	Ssm	6	85	7.1%	cbioportal
28	MET	Ssm	5	85	5.9%	cbioportal
27	INPP4A	Ssm	5	85	5.9%	cbioportal
26	GRIN2A	Ssm	5	85	5.9%	cbioportal
25	CDKN2A	Ssm	5	85	5.9%	cbioportal
24	CDKN1A	Ssm	5	85	5.9%	cbioportal
23	ARID1B	Ssm	5	85	5.9%	cbioportal
30	NOTCH1	Ssm	5	85	5.9%	cbioportal
29	MTOR	Ssm	5	85	5.9%	cbioportal

Data updated 22 days agoSource updated 2026-01-16

Upper Tract Urothelial Carcinoma (Cornell/Baylor/MDACC, Nat Commun 2019) utuc_cornell_baylor_mdacc_2019Cornell/Baylor/MDACC

37 cases with simple somatic mutation data · 47 cases total · 2026-01-19 · mapped to Renal Pelvis and Ureter Urothelial Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	KMT2D	Ssm	13	37	35.1%	cbioportal
2	TP53	Ssm	12	37	32.4%	cbioportal
3	FGFR3	Ssm	11	37	29.7%	cbioportal
4	PIK3CA	Ssm	8	37	21.6%	cbioportal
5	ATM	Ssm	7	37	18.9%	cbioportal
6	ADGRV1	Ssm	5	37	13.5%	cbioportal
7	CDKN1A	Ssm	5	37	13.5%	cbioportal
8	EYS	Ssm	5	37	13.5%	cbioportal
9	OBSCN	Ssm	5	37	13.5%	cbioportal
19	UTRN	Ssm	4	37	10.8%	cbioportal
20	ZFHX4	Ssm	4	37	10.8%	cbioportal
11	ARID1A	Ssm	4	37	10.8%	cbioportal
10	AFF1	Ssm	4	37	10.8%	cbioportal
12	KDM6A	Ssm	4	37	10.8%	cbioportal
13	MACF1	Ssm	4	37	10.8%	cbioportal
14	MUC17	Ssm	4	37	10.8%	cbioportal
15	PLXNA2	Ssm	4	37	10.8%	cbioportal
16	RNF213	Ssm	4	37	10.8%	cbioportal
17	SPTAN1	Ssm	4	37	10.8%	cbioportal
18	TTN	Ssm	4	37	10.8%	cbioportal
21	ABCC1	Ssm	3	37	8.1%	cbioportal
22	AHCTF1	Ssm	3	37	8.1%	cbioportal
23	AHNAK	Ssm	3	37	8.1%	cbioportal
24	ARK2N	Ssm	3	37	8.1%	cbioportal
25	ATG2A	Ssm	3	37	8.1%	cbioportal
26	ATP2B2	Ssm	3	37	8.1%	cbioportal
27	ATR	Ssm	3	37	8.1%	cbioportal
28	BAP1	Ssm	3	37	8.1%	cbioportal
29	BICD2	Ssm	3	37	8.1%	cbioportal
30	BIRC6	Ssm	3	37	8.1%	cbioportal

Data updated 22 days agoSource updated 2026-01-19

Upper Tract Urothelial Carcinoma (IGBMC, Genome Biology 2021) utuc_igbmc_2021IGBMC

30 cases with simple somatic mutation data · 30 cases total · 2026-01-19 · mapped to Renal Pelvis and Ureter Urothelial Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	FGFR3	Ssm	15	30	50%	cbioportal
2	TTN	Ssm	9	30	30%	cbioportal
3	KDM6A	Ssm	8	30	26.7%	cbioportal
4	KMT2D	Ssm	8	30	26.7%	cbioportal
6	MUC4	Ssm	7	30	23.3%	cbioportal
5	KMT2C	Ssm	7	30	23.3%	cbioportal
7	HYDIN	Ssm	6	30	20%	cbioportal
8	ZFP36L1	Ssm	6	30	20%	cbioportal
10	CELSR1	Ssm	5	30	16.7%	cbioportal
12	TP53	Ssm	5	30	16.7%	cbioportal
9	ARID1A	Ssm	5	30	16.7%	cbioportal
11	STAG2	Ssm	5	30	16.7%	cbioportal
16	GANAB	Ssm	4	30	13.3%	cbioportal
15	EP300	Ssm	4	30	13.3%	cbioportal
17	HECTD4	Ssm	4	30	13.3%	cbioportal
18	MUC16	Ssm	4	30	13.3%	cbioportal
19	ZNF469	Ssm	4	30	13.3%	cbioportal
13	ACACA	Ssm	4	30	13.3%	cbioportal
14	CRIPAK	Ssm	4	30	13.3%	cbioportal
45	SPTA1	Ssm	3	30	10%	cbioportal
38	MACF1	Ssm	3	30	10%	cbioportal
39	MUC17	Ssm	3	30	10%	cbioportal
40	NEB	Ssm	3	30	10%	cbioportal
41	PCDH15	Ssm	3	30	10%	cbioportal
42	RARG	Ssm	3	30	10%	cbioportal
44	SPATA31D1	Ssm	3	30	10%	cbioportal
46	USF3	Ssm	3	30	10%	cbioportal
47	VCAN	Ssm	3	30	10%	cbioportal
43	REPIN1	Ssm	3	30	10%	cbioportal
20	ADCY10	Ssm	3	30	10%	cbioportal

Data updated 22 days agoSource updated 2026-01-19

Upper Tract Urothelial Carcinoma (MSK, Nat Commun 2020) utuc_msk_2019MSK

119 cases with simple somatic mutation data · 119 cases total · 2026-01-16 · mapped to Renal Pelvis and Ureter Urothelial Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	FGFR3	Ssm	55	119	46.2%	cbioportal
2	KMT2D	Ssm	41	119	34.5%	cbioportal
3	KDM6A	Ssm	39	119	32.8%	cbioportal
4	TERT	Ssm	32	119	26.9%	cbioportal
5	KMT2C	Ssm	27	119	22.7%	cbioportal
7	TP53	Ssm	26	119	21.8%	cbioportal
6	ARID1A	Ssm	26	119	21.8%	cbioportal
8	STAG2	Ssm	24	119	20.2%	cbioportal
9	CREBBP	Ssm	21	119	17.6%	cbioportal
11	PIK3CA	Ssm	19	119	16%	cbioportal
10	ATM	Ssm	19	119	16%	cbioportal
12	TSC1	Ssm	16	119	13.4%	cbioportal
13	HRAS	Ssm	14	119	11.8%	cbioportal
45	ZFHX3	Ssm	7	60	11.7%	cbioportal
14	SMARCA4	Ssm	13	119	10.9%	cbioportal
16	EP300	Ssm	11	119	9.2%	cbioportal
18	FAT1	Ssm	11	119	9.2%	cbioportal
19	FBXW7	Ssm	11	119	9.2%	cbioportal
15	ARID1B	Ssm	11	119	9.2%	cbioportal
17	ERBB2	Ssm	11	119	9.2%	cbioportal
20	NF1	Ssm	10	119	8.4%	cbioportal
21	PBRM1	Ssm	10	119	8.4%	cbioportal
81	SPEN	Ssm	5	61	8.2%	cbioportal
25	MTOR	Ssm	9	119	7.6%	cbioportal
23	EPHA5	Ssm	9	119	7.6%	cbioportal
22	CDKN1A	Ssm	9	119	7.6%	cbioportal
24	MET	Ssm	9	119	7.6%	cbioportal
26	ARID2	Ssm	8	119	6.7%	cbioportal
29	KRAS	Ssm	8	119	6.7%	cbioportal
27	CDK12	Ssm	8	119	6.7%	cbioportal

Data updated 22 days agoSource updated 2026-01-16

Upper Tract Urothelial Carcinoma PDX (MSK, Nat Commun 2020) utuc_pdx_msk_2019MSK

78 cases with simple somatic mutation data · 78 cases total · 2026-01-16 · mapped to Renal Pelvis and Ureter Urothelial Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TERT	Ssm	37	78	47.4%	cbioportal
2	ARID1A	Ssm	29	78	37.2%	cbioportal
3	FGFR3	Ssm	28	78	35.9%	cbioportal
4	TP53	Ssm	27	78	34.6%	cbioportal
5	KMT2D	Ssm	25	78	32.1%	cbioportal
6	KDM6A	Ssm	24	78	30.8%	cbioportal
7	ATM	Ssm	19	78	24.4%	cbioportal
8	CREBBP	Ssm	17	78	21.8%	cbioportal
9	ZFHX3	Ssm	15	70	21.4%	cbioportal
10	SMARCA4	Ssm	14	78	17.9%	cbioportal
13	MDC1	Ssm	13	76	17.1%	cbioportal
99	MSH3	Ssm	5	30	16.7%	cbioportal
11	ASXL1	Ssm	13	78	16.7%	cbioportal
12	EP300	Ssm	13	78	16.7%	cbioportal
15	MSH2	Ssm	12	78	15.4%	cbioportal
14	BRCA1	Ssm	12	78	15.4%	cbioportal
17	SETD2	Ssm	12	78	15.4%	cbioportal
16	PIK3CA	Ssm	12	78	15.4%	cbioportal
18	NOTCH2	Ssm	11	78	14.1%	cbioportal
29	RECQL4	Ssm	10	76	13.2%	cbioportal
19	ARID1B	Ssm	10	78	12.8%	cbioportal
28	PIK3CB	Ssm	10	78	12.8%	cbioportal
20	BCOR	Ssm	10	78	12.8%	cbioportal
21	CDKN1A	Ssm	10	78	12.8%	cbioportal
22	CTCF	Ssm	10	78	12.8%	cbioportal
23	DNMT1	Ssm	10	78	12.8%	cbioportal
24	DNMT3A	Ssm	10	78	12.8%	cbioportal
25	FAT1	Ssm	10	78	12.8%	cbioportal
26	HRAS	Ssm	10	78	12.8%	cbioportal
27	MET	Ssm	10	78	12.8%	cbioportal

Data updated 22 days agoSource updated 2026-01-16

Urothelial Cancer Patient Derived Organoids (MSK, 2025) blca_pdx_msk_2025MSK

90 cases with simple somatic mutation data · 90 cases total · 2026-01-05 · mapped to Bladder Urothelial Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TERT	Ssm	71	90	78.9%	cbioportal
2	FGFR3	Ssm	35	90	38.9%	cbioportal
3	KDM6A	Ssm	35	90	38.9%	cbioportal
4	TP53	Ssm	34	90	37.8%	cbioportal
24	USP8	Ssm	12	34	35.3%	cbioportal
5	KMT2D	Ssm	31	90	34.4%	cbioportal
28	HLA-B	Ssm	11	46	23.9%	cbioportal
58	SERPINB3	Ssm	8	34	23.5%	cbioportal
6	MDC1	Ssm	21	90	23.3%	cbioportal
7	ARID1A	Ssm	20	90	22.2%	cbioportal
8	KMT2C	Ssm	19	90	21.1%	cbioportal
9	CREBBP	Ssm	18	90	20%	cbioportal
10	PIK3CA	Ssm	18	90	20%	cbioportal
11	TSC1	Ssm	18	90	20%	cbioportal
12	ZFHX3	Ssm	17	88	19.3%	cbioportal
13	ATM	Ssm	16	90	17.8%	cbioportal
102	SERPINB4	Ssm	6	34	17.6%	cbioportal
74	ATXN7	Ssm	6	34	17.6%	cbioportal
14	BRCA2	Ssm	15	90	16.7%	cbioportal
15	ATR	Ssm	14	90	15.6%	cbioportal
16	SPEN	Ssm	14	90	15.6%	cbioportal
71	PREX2	Ssm	7	46	15.2%	cbioportal
126	SMARCA2	Ssm	5	34	14.7%	cbioportal
112	HLA-C	Ssm	5	34	14.7%	cbioportal
17	STAG2	Ssm	13	90	14.4%	cbioportal
23	ROS1	Ssm	12	90	13.3%	cbioportal
19	FAT1	Ssm	12	90	13.3%	cbioportal
20	NF1	Ssm	12	90	13.3%	cbioportal
21	NOTCH3	Ssm	12	90	13.3%	cbioportal
22	PALB2	Ssm	12	90	13.3%	cbioportal

Data updated 22 days agoSource updated 2026-01-05

Urothelial Carcinoma (BCAN/HCRN, Nat Commun 2022) blca_bcan_hcrn_2022BCAN/HCRN

192 cases with simple somatic mutation data · 192 cases total · 2026-01-05 · mapped to Bladder Urothelial Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	108	192	56.3%	cbioportal
2	KMT2D	Ssm	62	192	32.3%	cbioportal
3	ARID1A	Ssm	55	192	28.6%	cbioportal
4	RNF213	Ssm	54	192	28.1%	cbioportal
5	KDM6A	Ssm	48	192	25%	cbioportal
6	LRP1B	Ssm	47	192	24.5%	cbioportal
7	AKAP9	Ssm	39	192	20.3%	cbioportal
8	SPEN	Ssm	38	192	19.8%	cbioportal
9	BRCA2	Ssm	37	192	19.3%	cbioportal
10	KMT2C	Ssm	35	192	18.2%	cbioportal
12	FGFR3	Ssm	34	192	17.7%	cbioportal
11	EP300	Ssm	34	192	17.7%	cbioportal
13	RB1	Ssm	32	192	16.7%	cbioportal
15	PRKDC	Ssm	31	192	16.1%	cbioportal
14	ATM	Ssm	31	192	16.1%	cbioportal
16	KMT2A	Ssm	30	192	15.6%	cbioportal
17	CREBBP	Ssm	29	192	15.1%	cbioportal
18	PDE4DIP	Ssm	29	192	15.1%	cbioportal
19	PIK3CA	Ssm	29	192	15.1%	cbioportal
21	PCM1	Ssm	26	192	13.5%	cbioportal
20	KIAA1549	Ssm	26	192	13.5%	cbioportal
25	NOTCH1	Ssm	25	192	13%	cbioportal
22	FANCA	Ssm	25	192	13%	cbioportal
23	KNL1	Ssm	25	192	13%	cbioportal
26	RECQL4	Ssm	25	192	13%	cbioportal
24	MYH9	Ssm	25	192	13%	cbioportal
27	ERBB3	Ssm	24	192	12.5%	cbioportal
28	ERCC2	Ssm	23	192	12%	cbioportal
30	TRIP11	Ssm	22	192	11.5%	cbioportal
29	CNTRL	Ssm	22	192	11.5%	cbioportal

Data updated 22 days agoSource updated 2026-01-05

Urothelial Carcinoma (Cornell/Trento, Nat Gen 2016) blca_cornell_2016Cornell/Trento

72 cases with simple somatic mutation data · 72 cases total · 2026-01-05 · mapped to Bladder Urothelial Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	41	72	56.9%	cbioportal
2	TTN	Ssm	26	72	36.1%	cbioportal
4	RYR2	Ssm	19	72	26.4%	cbioportal
3	MUC16	Ssm	19	72	26.4%	cbioportal
8	ZNF729	Ssm	17	72	23.6%	cbioportal
7	MYLK	Ssm	17	72	23.6%	cbioportal
6	MDC1	Ssm	17	72	23.6%	cbioportal
5	KMT2D	Ssm	17	72	23.6%	cbioportal
9	DLG2	Ssm	16	72	22.2%	cbioportal
13	PEAK1	Ssm	16	72	22.2%	cbioportal
12	NIN	Ssm	16	72	22.2%	cbioportal
11	MTCL2	Ssm	16	72	22.2%	cbioportal
10	MBD4	Ssm	16	72	22.2%	cbioportal
15	DYNC1H1	Ssm	15	72	20.8%	cbioportal
14	CTCF	Ssm	15	72	20.8%	cbioportal
19	USP48	Ssm	15	72	20.8%	cbioportal
18	TCHH	Ssm	15	72	20.8%	cbioportal
17	PCF11	Ssm	15	72	20.8%	cbioportal
16	NOM1	Ssm	15	72	20.8%	cbioportal
29	SYNE2	Ssm	14	72	19.4%	cbioportal
20	BICRA	Ssm	14	72	19.4%	cbioportal
21	IFIH1	Ssm	14	72	19.4%	cbioportal
22	LATS1	Ssm	14	72	19.4%	cbioportal
23	LRWD1	Ssm	14	72	19.4%	cbioportal
24	MLXIPL	Ssm	14	72	19.4%	cbioportal
25	NCOA3	Ssm	14	72	19.4%	cbioportal
26	PDCL	Ssm	14	72	19.4%	cbioportal
27	PXDN	Ssm	14	72	19.4%	cbioportal
28	SPTAN1	Ssm	14	72	19.4%	cbioportal
30	ACE	Ssm	13	72	18.1%	cbioportal

Data updated 22 days agoSource updated 2026-01-05