Malignant Breast Neoplasm

Curated

in context · predicts response to

PIK3CA Q546RSNV → predicts response to Fulvestrant

2 source records aggregated

sensitivity

Curated

in context · predicts response to

PIK3CA Q546ESNV → predicts response to Fulvestrant

2 source records aggregated

sensitivity

Curated

in context · predicts response to

PIK3CA E542KSNV → predicts response to Fulvestrant

2 source records aggregated

sensitivity

Curated

in context · predicts response to

PIK3CA E545DSNV → predicts response to Fulvestrant

2 source records aggregated

sensitivity

Curated

in context · predicts response to

PIK3CA E545GSNV → predicts response to Fulvestrant

2 source records aggregated

sensitivity

Curated

in context · predicts response to

PIK3CA E545ASNV → predicts response to Fulvestrant

2 source records aggregated

sensitivity

Curated

in context · predicts response to

PIK3CA E545KSNV → predicts response to Fulvestrant

2 source records aggregated

sensitivity

Curated

in context · predicts response to

PIK3CA H1047LSNV → predicts response to Fulvestrant

2 source records aggregated

sensitivity

Curated

in context · predicts response to

PIK3CA H1047YSNV → predicts response to Fulvestrant

2 source records aggregated

sensitivity

Curated

in context · predicts response to

PIK3CA H1047RSNV → predicts response to Fulvestrant

2 source records aggregated

sensitivity

Curated

in context · predicts response to

PIK3CA Mutationother → predicts response to Fulvestrant

2 source records aggregated

sensitivity

Curated

in context · predicts response to

PIK3CA E453VSNV → predicts response to Fulvestrant

sensitivity

Curated

in context · predicts response to

PIK3CA E453VSNV → predicts response to Palbociclib

sensitivity

Curated

in context · predicts response to

PIK3CA E453GSNV → predicts response to Fulvestrant

sensitivity

Curated

Malignant Breast Neoplasm prognostic in …PROGNOSTIC_IN15 of 26show all (up to 200)
← prognostic in	FGFR1 Amplificationamplification 3 source records aggregated	supports	B	Malignant Breast Neoplasm	3	Curated	civic	graph →
← prognostic in	CD274 Expressionexpression 2 source records aggregated	supports	B	Malignant Breast Neoplasm	2	Curated	civic	graph →
← prognostic in	PIK3CA H1047RSNV 2 source records aggregated	supports	B	Malignant Breast Neoplasm	2	Curated	civic	graph →
← prognostic in	PIK3CA Mutationother 2 source records aggregated	supports	B	Malignant Breast Neoplasm	2	Curated	civic	graph →
← prognostic in	PGR Expressionexpression 2 source records aggregated	supports	B	Malignant Breast Neoplasm	2	Curated	civic	graph →
← prognostic in	TP53 R273HSNV 2 source records aggregated	supports	B	Malignant Breast Neoplasm	2	Curated	civic	graph →
← prognostic in	TP53 R273CSNV 2 source records aggregated	supports	B	Malignant Breast Neoplasm	2	Curated	civic	graph →
← prognostic in	TP53 R248QSNV 2 source records aggregated	supports	B	Malignant Breast Neoplasm	2	Curated	civic	graph →
← prognostic in	PIK3CA Rare Mutation	supports	B	Malignant Breast Neoplasm	1	Curated	civic	graph →
← prognostic in	FGFR1 Expressionexpression	supports	B	Malignant Breast Neoplasm	1	Curated	civic	graph →
← prognostic in	Positive	supports	B	Malignant Breast Neoplasm	1	Curated	civic	graph →
← prognostic in	ABCB1 I1145ISNV	supports	B	Malignant Breast Neoplasm	1	Curated	civic	graph →
← prognostic in	ABCB1 S893A/TSNV	supports	B	Malignant Breast Neoplasm	1	Curated	civic	graph →
← prognostic in	ERBB2 SERUM LEVELS	supports	B	Malignant Breast Neoplasm	1	Curated	civic	graph →
← prognostic in	NCOA3 OVEREXPRESSIONexpression	supports	B	Malignant Breast Neoplasm	1	Curated	civic	graph →

Malignant Breast Neoplasm prognostic in …PROGNOSTIC_IN15 of 26show all (up to 200)

← prognostic in

FGFR1 Amplificationamplification

3 source records aggregated

supports

Curated

← prognostic in

CD274 Expressionexpression

2 source records aggregated

supports

Curated

← prognostic in

PIK3CA H1047RSNV

2 source records aggregated

supports

Curated

← prognostic in

PIK3CA Mutationother

2 source records aggregated

supports

Curated

← prognostic in

PGR Expressionexpression

2 source records aggregated

supports

Curated

← prognostic in

TP53 R273HSNV

2 source records aggregated

supports

Curated

← prognostic in

TP53 R273CSNV

2 source records aggregated

supports

Curated

← prognostic in

TP53 R248QSNV

2 source records aggregated

supports

Curated

← prognostic in

PIK3CA Rare Mutation

supports

Curated

← prognostic in

FGFR1 Expressionexpression

supports

Curated

← prognostic in

Positive

supports

Curated

← prognostic in

ABCB1 I1145ISNV

supports

Curated

← prognostic in

ABCB1 S893A/TSNV

supports

Curated

← prognostic in

ERBB2 SERUM LEVELS

supports

Curated

← prognostic in

NCOA3 OVEREXPRESSIONexpression

supports

Curated

Malignant Breast Neoplasm diagnostic of …DIAGNOSTIC_OF2 of 2
← diagnostic of	PALB2 L531FS*30indel	supports	B	Malignant Breast Neoplasm	1	Curated	civic	graph →
← diagnostic of	CCND1 Overexpressionexpression	supports	B	Malignant Breast Neoplasm	1	Curated	civic	graph →

Malignant Breast Neoplasm diagnostic of …DIAGNOSTIC_OF2 of 2

← diagnostic of

PALB2 L531FS*30indel

supports

Curated

← diagnostic of

CCND1 Overexpressionexpression

supports

Curated

Malignant Breast Neoplasm predisposes to …PREDISPOSES_TO5 of 5
← predisposes to	KLLN PROMOTER METHYLATIONepigenetic	supports	B	Malignant Breast Neoplasm	1	Curated	civic	graph →
← predisposes to	BRCA2 TRUNCATING MUTATIONdeletion_cna	supports	C	Malignant Breast Neoplasm	1	Curated	civic	graph →
← predisposes to	BRCA1 Alu insertioninsertion	supports	C	Malignant Breast Neoplasm	1	Curated	civic	graph →
← predisposes to	BRCA2 D3095ESNV	supports	C	Malignant Breast Neoplasm	1	Curated	civic	graph →
← predisposes to	BRCA1 P968FSindel	supports	C	Malignant Breast Neoplasm	1	Curated	civic	graph →

Malignant Breast Neoplasm predisposes to …PREDISPOSES_TO5 of 5

← predisposes to

KLLN PROMOTER METHYLATIONepigenetic

supports

Curated

← predisposes to

BRCA2 TRUNCATING MUTATIONdeletion_cna

supports

Curated

← predisposes to

BRCA1 Alu insertioninsertion

supports

Curated

← predisposes to

BRCA2 D3095ESNV

supports

Curated

← predisposes to

BRCA1 P968FSindel

supports

Curated

Malignant Breast Neoplasm associated with …ASSOCIATED_WITH72 of 72show fewer
← associated with	PIK3CA 15 source records aggregated	supports	A	Malignant Breast Neoplasm	15	Curated	civic	graph →
← associated with	AKT1	supports	A	Malignant Breast Neoplasm	1	Curated	civic	graph →
← associated with	PTEN	supports	A	Malignant Breast Neoplasm	1	Curated	civic	graph →
← associated with	ESR1	supports	A	Malignant Breast Neoplasm	1	Curated	civic	graph →
← associated with	ERBB2	supports	A	Malignant Breast Neoplasm	1	Curated	civic	graph →
← associated with	TP53 11 source records aggregated	supports	B	Malignant Breast Neoplasm	11	Curated	civic	graph →
← associated with	FGFR1 9 source records aggregated	supports	B	Malignant Breast Neoplasm	9	Curated	civic	graph →
← associated with	PIK3CA 9 source records aggregated	supports	B	Malignant Breast Neoplasm	9	Curated	civic	graph →
← associated with	PTEN 3 source records aggregated	supports	B	Malignant Breast Neoplasm	3	Curated	civic	graph →
← associated with	ERBB2 3 source records aggregated	supports	B	Malignant Breast Neoplasm	3	Curated	civic	graph →
← associated with	CD274 2 source records aggregated	supports	B	Malignant Breast Neoplasm	2	Curated	civic	graph →
← associated with	ESR1 2 source records aggregated	supports	B	Malignant Breast Neoplasm	2	Curated	civic	graph →
← associated with	RB1 2 source records aggregated	supports	B	Malignant Breast Neoplasm	2	Curated	civic	graph →
← associated with	CCNE1 2 source records aggregated	supports	B	Malignant Breast Neoplasm	2	Curated	civic	graph →
← associated with	ABCB1 2 source records aggregated	supports	B	Malignant Breast Neoplasm	2	Curated	civic	graph →
← associated with	PGR 2 source records aggregated	supports	B	Malignant Breast Neoplasm	2	Curated	civic	graph →
← associated with	NCOA3 2 source records aggregated	supports	B	Malignant Breast Neoplasm	2	Curated	civic	graph →
← associated with	BRCA2 2 source records aggregated	supports	B	Malignant Breast Neoplasm	2	Curated	civic	graph →
← associated with	CCND1 2 source records aggregated	supports	B	Malignant Breast Neoplasm	2	Curated	civic	graph →
← associated with	AGR2	supports	B	Malignant Breast Neoplasm	1	Curated	civic	graph →
← associated with	FGF3	supports	B	Malignant Breast Neoplasm	1	Curated	civic	graph →
← associated with	FGFR2	supports	B	Malignant Breast Neoplasm	1	Curated	civic	graph →
← associated with	TIMP1	supports	B	Malignant Breast Neoplasm	1	Curated	civic	graph →
← associated with	TUBB3	supports	B	Malignant Breast Neoplasm	1	Curated	civic	graph →
← associated with	TOP2A	supports	B	Malignant Breast Neoplasm	1	Curated	civic	graph →
← associated with	RSF1	supports	B	Malignant Breast Neoplasm	1	Curated	civic	graph →
← associated with	KMT2C	supports	B	Malignant Breast Neoplasm	1	Curated	civic	graph →
← associated with	KLLN	supports	B	Malignant Breast Neoplasm	1	Curated	civic	graph →
← associated with	SGK1	supports	B	Malignant Breast Neoplasm	1	Curated	civic	graph →
← associated with	PALB2	supports	B	Malignant Breast Neoplasm	1	Curated	civic	graph →
← associated with	TFF3	supports	B	Malignant Breast Neoplasm	1	Curated	civic	graph →
← associated with	AKT2	supports	B	Malignant Breast Neoplasm	1	Curated	civic	graph →
← associated with	IGF1R	supports	B	Malignant Breast Neoplasm	1	Curated	civic	graph →
← associated with	BRCA1	supports	B	Malignant Breast Neoplasm	1	Curated	civic	graph →
← associated with	MKI67	supports	B	Malignant Breast Neoplasm	1	Curated	civic	graph →
← associated with	FCGR2B	supports	B	Malignant Breast Neoplasm	1	Curated	civic	graph →
← associated with	FOXP3	supports	B	Malignant Breast Neoplasm	1	Curated	civic	graph →
← associated with	ERBB2 2 source records aggregated	supports	C	Malignant Breast Neoplasm	2	Curated	civic	graph →
← associated with	BRCA2 2 source records aggregated	supports	C	Malignant Breast Neoplasm	2	Curated	civic	graph →
← associated with	NTRK1 2 source records aggregated	supports	C	Malignant Breast Neoplasm	2	Curated	civic	graph →
← associated with	BRCA1 2 source records aggregated	supports	C	Malignant Breast Neoplasm	2	Curated	civic	graph →
← associated with	TP53	supports	C	Malignant Breast Neoplasm	1	Curated	civic	graph →
← associated with	FGFR1	supports	C	Malignant Breast Neoplasm	1	Curated	civic	graph →
← associated with	NF2	supports	C	Malignant Breast Neoplasm	1	Curated	civic	graph →
← associated with	AKT1	supports	C	Malignant Breast Neoplasm	1	Curated	civic	graph →
← associated with	PIK3CA 17 source records aggregated	supports	D	Malignant Breast Neoplasm	17	Curated	civic	graph →
← associated with	ERBB2 16 source records aggregated	supports	D	Malignant Breast Neoplasm	16	Curated	civic	graph →
← associated with	ESR1 10 source records aggregated	supports	D	Malignant Breast Neoplasm	10	Curated	civic	graph →
← associated with	FGFR1 4 source records aggregated	supports	D	Malignant Breast Neoplasm	4	Curated	civic	graph →
← associated with	PTEN 3 source records aggregated	supports	D	Malignant Breast Neoplasm	3	Curated	civic	graph →
← associated with	MTOR 3 source records aggregated	supports	D	Malignant Breast Neoplasm	3	Curated	civic	graph →
← associated with	SF3B1 2 source records aggregated	supports	D	Malignant Breast Neoplasm	2	Curated	civic	graph →
← associated with	ERBB4 2 source records aggregated	supports	D	Malignant Breast Neoplasm	2	Curated	civic	graph →
← associated with	TP53 2 source records aggregated	supports	D	Malignant Breast Neoplasm	2	Curated	civic	graph →
← associated with	SGK1 2 source records aggregated	supports	D	Malignant Breast Neoplasm	2	Curated	civic	graph →
← associated with	MTAP	supports	D	Malignant Breast Neoplasm	1	Curated	civic	graph →
← associated with	PIK3R1	supports	D	Malignant Breast Neoplasm	1	Curated	civic	graph →
← associated with	CCND1	supports	D	Malignant Breast Neoplasm	1	Curated	civic	graph →
← associated with	TIMP1	supports	D	Malignant Breast Neoplasm	1	Curated	civic	graph →
← associated with	RET	supports	D	Malignant Breast Neoplasm	1	Curated	civic	graph →
← associated with	MYD88	supports	D	Malignant Breast Neoplasm	1	Curated	civic	graph →
← associated with	TLK2	supports	D	Malignant Breast Neoplasm	1	Curated	civic	graph →
← associated with	RB1	supports	D	Malignant Breast Neoplasm	1	Curated	civic	graph →
← associated with	ABCC3	supports	D	Malignant Breast Neoplasm	1	Curated	civic	graph →
← associated with	CDKN1B	supports	D	Malignant Breast Neoplasm	1	Curated	civic	graph →
← associated with	AR	supports	D	Malignant Breast Neoplasm	1	Curated	civic	graph →
← associated with	KRAS	supports	D	Malignant Breast Neoplasm	1	Curated	civic	graph →
← associated with	BRCA2	supports	D	Malignant Breast Neoplasm	1	Curated	civic	graph →
← associated with	BRCA1	supports	D	Malignant Breast Neoplasm	1	Curated	civic	graph →
← associated with	AKT3	supports	D	Malignant Breast Neoplasm	1	Curated	civic	graph →
← associated with	ALK	supports	E	Malignant Breast Neoplasm	1	Curated	civic	graph →
← associated with	TP53	supports	E	Malignant Breast Neoplasm	1	Curated	civic	graph →

Malignant Breast Neoplasm associated with …ASSOCIATED_WITH72 of 72show fewer

← associated with

PIK3CA

15 source records aggregated

supports

Curated

← associated with

AKT1

supports

Curated

← associated with

PTEN

supports

Curated

← associated with

ESR1

supports

Curated

← associated with

supports

Curated

← associated with

11 source records aggregated

supports

Curated

← associated with

FGFR1

9 source records aggregated

supports

Curated

← associated with

PIK3CA

9 source records aggregated

supports

Curated

← associated with

PTEN

3 source records aggregated

supports

Curated

← associated with

3 source records aggregated

supports

Curated

← associated with

CD274

2 source records aggregated

supports

Curated

← associated with

ESR1

2 source records aggregated

supports

Curated

← associated with

RB1

2 source records aggregated

supports

Curated

← associated with

CCNE1

2 source records aggregated

supports

Curated

← associated with

ABCB1

2 source records aggregated

supports

Curated

← associated with

PGR

2 source records aggregated

supports

Curated

← associated with

NCOA3

2 source records aggregated

supports

Curated

← associated with

BRCA2

2 source records aggregated

supports

Curated

← associated with

CCND1

2 source records aggregated

supports

Curated

← associated with

AGR2

supports

Curated

← associated with

FGF3

supports

Curated

← associated with

FGFR2

supports

Curated

← associated with

TIMP1

supports

Curated

← associated with

TUBB3

supports

Curated

← associated with

TOP2A

supports

Curated

← associated with

RSF1

supports

Curated

← associated with

KMT2C

supports

Curated

← associated with

KLLN

supports

Curated

← associated with

SGK1

supports

Curated

← associated with

PALB2

supports

Curated

← associated with

TFF3

supports

Curated

← associated with

AKT2

supports

Curated

← associated with

IGF1R

supports

Curated

← associated with

BRCA1

supports

Curated

← associated with

MKI67

supports

Curated

← associated with

FCGR2B

supports

Curated

← associated with

FOXP3

supports

Curated

← associated with

2 source records aggregated

supports

Curated

← associated with

BRCA2

2 source records aggregated

supports

Curated

← associated with

NTRK1

2 source records aggregated

supports

Curated

← associated with

BRCA1

2 source records aggregated

supports

Curated

← associated with

supports

Curated

← associated with

FGFR1

supports

Curated

← associated with

NF2

supports

Curated

← associated with

AKT1

supports

Curated

← associated with

PIK3CA

17 source records aggregated

supports

Curated

← associated with

16 source records aggregated

supports

Curated

← associated with

ESR1

10 source records aggregated

supports

Curated

← associated with

FGFR1

4 source records aggregated

supports

Curated

← associated with

PTEN

3 source records aggregated

supports

Curated

← associated with

MTOR

3 source records aggregated

supports

Curated

← associated with

SF3B1

2 source records aggregated

supports

Curated

← associated with

ERBB4

2 source records aggregated

supports

Curated

← associated with

2 source records aggregated

supports

Curated

← associated with

SGK1

2 source records aggregated

supports

Curated

← associated with

MTAP

supports

Curated

← associated with

PIK3R1

supports

Curated

← associated with

CCND1

supports

Curated

← associated with

TIMP1

supports

Curated

← associated with

RET

supports

Curated

← associated with

MYD88

supports

Curated

← associated with

TLK2

supports

Curated

← associated with

RB1

supports

Curated

← associated with

ABCC3

supports

Curated

← associated with

CDKN1B

supports

Curated

← associated with

supports

Curated

← associated with

KRAS

supports

Curated

← associated with

BRCA2

supports

Curated

← associated with

BRCA1

supports

Curated

← associated with

AKT3

supports

Curated

← associated with

ALK

supports

Curated

← associated with

supports

Curated

Malignant Breast Neoplasm investigated for …INVESTIGATED_FOR15 of 74show all (up to 200)
← investigated for	Fulvestrantsmall_molecule 15 source records aggregated	supports	A	Malignant Breast Neoplasm	15	Curated	civic	graph →
← investigated for	Inavolisibsmall_molecule 8 source records aggregated	supports	A	Malignant Breast Neoplasm	8	Curated	civic	graph →
← investigated for	Palbociclibsmall_molecule 8 source records aggregated	supports	A	Malignant Breast Neoplasm	8	Curated	civic	graph →
← investigated for	Alpelisibsmall_molecule 6 source records aggregated	supports	A	Malignant Breast Neoplasm	6	Curated	civic	graph →
← investigated for	Capivasertibsmall_molecule	supports	A	Malignant Breast Neoplasm	1	Curated	civic	graph →
← investigated for	Elacestrantsmall_molecule	supports	A	Malignant Breast Neoplasm	1	Curated	civic	graph →
← investigated for	Margetuximabmonoclonal_antibody	supports	A	Malignant Breast Neoplasm	1	Curated	civic	graph →
← investigated for	Trastuzumabmonoclonal_antibody 5 source records aggregated	supports	B	Malignant Breast Neoplasm	5	Curated	civic	graph →
← investigated for	Tamoxifensmall_molecule 4 source records aggregated	supports	B	Malignant Breast Neoplasm	4	Curated	civic	graph →
← investigated for	Dovitinibsmall_molecule 4 source records aggregated	supports	B	Malignant Breast Neoplasm	4	Curated	civic	graph →
← investigated for	Palbociclibsmall_molecule 3 source records aggregated	supports	B	Malignant Breast Neoplasm	3	Curated	civic	graph →
← investigated for	Doxorubicinsmall_molecule 2 source records aggregated	supports	B	Malignant Breast Neoplasm	2	Curated	civic	graph →
← investigated for	Fulvestrantsmall_molecule 2 source records aggregated	supports	B	Malignant Breast Neoplasm	2	Curated	civic	graph →
← investigated for	Alpelisibsmall_molecule 2 source records aggregated	supports	B	Malignant Breast Neoplasm	2	Curated	civic	graph →
← investigated for	Talazoparibsmall_molecule 2 source records aggregated	supports	B	Malignant Breast Neoplasm	2	Curated	civic	graph →

Malignant Breast Neoplasm investigated for …INVESTIGATED_FOR15 of 74show all (up to 200)

← investigated for

Fulvestrantsmall_molecule

15 source records aggregated

supports

Curated

← investigated for

Inavolisibsmall_molecule

8 source records aggregated

supports

Curated

← investigated for

Palbociclibsmall_molecule

8 source records aggregated

supports

Curated

← investigated for

Alpelisibsmall_molecule

6 source records aggregated

supports

Curated

← investigated for

Capivasertibsmall_molecule

supports

Curated

← investigated for

Elacestrantsmall_molecule

supports

Curated

← investigated for

Margetuximabmonoclonal_antibody

supports

Curated

← investigated for

Trastuzumabmonoclonal_antibody

5 source records aggregated

supports

Curated

← investigated for

Tamoxifensmall_molecule

4 source records aggregated

supports

Curated

← investigated for

Dovitinibsmall_molecule

4 source records aggregated

supports

Curated

← investigated for

Palbociclibsmall_molecule

3 source records aggregated

supports

Curated

← investigated for

Doxorubicinsmall_molecule

2 source records aggregated

supports

Curated

← investigated for

Fulvestrantsmall_molecule

2 source records aggregated

supports

Curated

← investigated for

Alpelisibsmall_molecule

2 source records aggregated

supports

Curated

← investigated for

Talazoparibsmall_molecule

2 source records aggregated

supports

Curated

Malignant Breast Neoplasm altered in cohorts of …ALTERED_INderived15 of 276show all (up to 200)
← altered in cohorts of	OBSCN 806 / 1,098 cases (73 %) · ssm · TCGA-BRCA · largest of 3 cohorts	—	—	Breast Invasive Carcinoma, NOS	3	Observed	gdc	graph →
← altered in cohorts of	PIK3C2B 804 / 1,098 cases (73 %) · ssm · TCGA-BRCA	—	—	Breast Invasive Carcinoma, NOS	1	Observed	gdc	graph →
← altered in cohorts of	LRRN2 803 / 1,098 cases (73 %) · ssm · TCGA-BRCA	—	—	Breast Invasive Carcinoma, NOS	1	Observed	gdc	graph →
← altered in cohorts of	MDM4 803 / 1,098 cases (73 %) · ssm · TCGA-BRCA	—	—	Breast Invasive Carcinoma, NOS	1	Observed	gdc	graph →
← altered in cohorts of	NFASC 803 / 1,098 cases (73 %) · ssm · TCGA-BRCA	—	—	Breast Invasive Carcinoma, NOS	1	Observed	gdc	graph →
← altered in cohorts of	NID1 803 / 1,098 cases (73 %) · ssm · TCGA-BRCA	—	—	Breast Invasive Carcinoma, NOS	1	Observed	gdc	graph →
← altered in cohorts of	PLEKHA6 802 / 1,098 cases (73 %) · ssm · TCGA-BRCA	—	—	Breast Invasive Carcinoma, NOS	1	Observed	gdc	graph →
← altered in cohorts of	PPP1R15B 801 / 1,098 cases (73 %) · ssm · TCGA-BRCA	—	—	Breast Invasive Carcinoma, NOS	1	Observed	gdc	graph →
← altered in cohorts of	ASPM 800 / 1,098 cases (73 %) · ssm · TCGA-BRCA · largest of 2 cohorts	—	—	Breast Invasive Carcinoma, NOS	2	Observed	gdc	graph →
← altered in cohorts of	CDK18 800 / 1,098 cases (73 %) · ssm · TCGA-BRCA	—	—	Breast Invasive Carcinoma, NOS	1	Observed	gdc	graph →
← altered in cohorts of	CHI3L1 799 / 1,098 cases (73 %) · ssm · TCGA-BRCA	—	—	Breast Invasive Carcinoma, NOS	1	Observed	gdc	graph →
← altered in cohorts of	CNTN2 799 / 1,098 cases (73 %) · ssm · TCGA-BRCA	—	—	Breast Invasive Carcinoma, NOS	1	Observed	gdc	graph →
← altered in cohorts of	DSTYK 799 / 1,098 cases (73 %) · ssm · TCGA-BRCA	—	—	Breast Invasive Carcinoma, NOS	1	Observed	gdc	graph →
← altered in cohorts of	EXOC8 799 / 1,098 cases (73 %) · ssm · TCGA-BRCA	—	—	Breast Invasive Carcinoma, NOS	1	Observed	gdc	graph →
← altered in cohorts of	LYST 799 / 1,098 cases (73 %) · ssm · TCGA-BRCA	—	—	Breast Invasive Carcinoma, NOS	1	Observed	gdc	graph →

Malignant Breast Neoplasm altered in cohorts of …ALTERED_INderived15 of 276show all (up to 200)

← altered in cohorts of

OBSCN

806 / 1,098 cases (73 %) · ssm · TCGA-BRCA · largest of 3 cohorts

—

Observed

← altered in cohorts of

PIK3C2B

804 / 1,098 cases (73 %) · ssm · TCGA-BRCA

—

Observed

← altered in cohorts of

LRRN2

803 / 1,098 cases (73 %) · ssm · TCGA-BRCA

—

Observed

← altered in cohorts of

MDM4

803 / 1,098 cases (73 %) · ssm · TCGA-BRCA

—

Observed

← altered in cohorts of

NFASC

803 / 1,098 cases (73 %) · ssm · TCGA-BRCA

—

Observed

← altered in cohorts of

NID1

803 / 1,098 cases (73 %) · ssm · TCGA-BRCA

—

Observed

← altered in cohorts of

PLEKHA6

802 / 1,098 cases (73 %) · ssm · TCGA-BRCA

—

Observed

← altered in cohorts of

PPP1R15B

801 / 1,098 cases (73 %) · ssm · TCGA-BRCA

—

Observed

← altered in cohorts of

ASPM

800 / 1,098 cases (73 %) · ssm · TCGA-BRCA · largest of 2 cohorts

—

Observed

← altered in cohorts of

CDK18

800 / 1,098 cases (73 %) · ssm · TCGA-BRCA

—

Observed

← altered in cohorts of

CHI3L1

799 / 1,098 cases (73 %) · ssm · TCGA-BRCA

—

Observed

← altered in cohorts of

CNTN2

799 / 1,098 cases (73 %) · ssm · TCGA-BRCA

—

Observed

← altered in cohorts of

DSTYK

799 / 1,098 cases (73 %) · ssm · TCGA-BRCA

—

Observed

← altered in cohorts of

EXOC8

799 / 1,098 cases (73 %) · ssm · TCGA-BRCA

—

Observed

← altered in cohorts of

LYST

799 / 1,098 cases (73 %) · ssm · TCGA-BRCA

—

Observed

Malignant Breast Neoplasm investigated in trials for …INVESTIGATED_IN_TRIALSderived15 of 315show all (up to 200)
→ investigated in trials for	Paclitaxelsmall_molecule 516 trials (114 active) · roll-up of the cancer and its descendants	—	—	Malignant Breast Neoplasm	516	Observed	clinicaltrials	graph →
→ investigated in trials for	Trastuzumabmonoclonal_antibody 516 trials (98 active) · roll-up of the cancer and its descendants	—	—	Malignant Breast Neoplasm	516	Observed	clinicaltrials	graph →
→ investigated in trials for	Cyclophosphamidesmall molecule 463 trials (80 active) · roll-up of the cancer and its descendants	—	—	Malignant Breast Neoplasm	463	Observed	clinicaltrials	graph →
→ investigated in trials for	Docetaxelsmall_molecule 358 trials (52 active) · roll-up of the cancer and its descendants	—	—	Malignant Breast Neoplasm	358	Observed	clinicaltrials	graph →
→ investigated in trials for	Capecitabinesmall molecule 321 trials (75 active) · roll-up of the cancer and its descendants	—	—	Malignant Breast Neoplasm	321	Observed	clinicaltrials	graph →
→ investigated in trials for	Carboplatinsmall molecule 270 trials (88 active) · roll-up of the cancer and its descendants	—	—	Malignant Breast Neoplasm	270	Observed	clinicaltrials	graph →
→ investigated in trials for	Doxorubicinsmall_molecule 258 trials (37 active) · roll-up of the cancer and its descendants	—	—	Malignant Breast Neoplasm	258	Observed	clinicaltrials	graph →
→ investigated in trials for	Letrozolesmall_molecule 251 trials (61 active) · roll-up of the cancer and its descendants	—	—	Malignant Breast Neoplasm	251	Observed	clinicaltrials	graph →
→ investigated in trials for	Fulvestrantsmall_molecule 249 trials (83 active) · roll-up of the cancer and its descendants	—	—	Malignant Breast Neoplasm	249	Observed	clinicaltrials	graph →
→ investigated in trials for	Pembrolizumabmonoclonal antibody 223 trials (113 active) · roll-up of the cancer and its descendants	—	—	Malignant Breast Neoplasm	223	Observed	clinicaltrials	graph →
→ investigated in trials for	Tamoxifensmall_molecule 214 trials (36 active) · roll-up of the cancer and its descendants	—	—	Malignant Breast Neoplasm	214	Observed	clinicaltrials	graph →
→ investigated in trials for	Bevacizumabmonoclonal antibody 166 trials (20 active) · roll-up of the cancer and its descendants	—	—	Malignant Breast Neoplasm	166	Observed	clinicaltrials	graph →
→ investigated in trials for	Anastrozolesmall molecule 163 trials (36 active) · roll-up of the cancer and its descendants	—	—	Malignant Breast Neoplasm	163	Observed	clinicaltrials	graph →
→ investigated in trials for	Pertuzumabmonoclonal_antibody 161 trials (72 active) · roll-up of the cancer and its descendants	—	—	Malignant Breast Neoplasm	161	Observed	clinicaltrials	graph →
→ investigated in trials for	Epirubicinsmall molecule 154 trials (26 active) · roll-up of the cancer and its descendants	—	—	Malignant Breast Neoplasm	154	Observed	clinicaltrials	graph →

Malignant Breast Neoplasm investigated in trials for …INVESTIGATED_IN_TRIALSderived15 of 315show all (up to 200)

→ investigated in trials for

Paclitaxelsmall_molecule

516 trials (114 active) · roll-up of the cancer and its descendants

—

516

Observed

→ investigated in trials for

Trastuzumabmonoclonal_antibody

516 trials (98 active) · roll-up of the cancer and its descendants

—

516

Observed

→ investigated in trials for

Cyclophosphamidesmall molecule

463 trials (80 active) · roll-up of the cancer and its descendants

—

463

Observed

→ investigated in trials for

Docetaxelsmall_molecule

358 trials (52 active) · roll-up of the cancer and its descendants

—

358

Observed

→ investigated in trials for

Capecitabinesmall molecule

321 trials (75 active) · roll-up of the cancer and its descendants

—

321

Observed

→ investigated in trials for

Carboplatinsmall molecule

270 trials (88 active) · roll-up of the cancer and its descendants

—

270

Observed

→ investigated in trials for

Doxorubicinsmall_molecule

258 trials (37 active) · roll-up of the cancer and its descendants

—

258

Observed

→ investigated in trials for

Letrozolesmall_molecule

251 trials (61 active) · roll-up of the cancer and its descendants

—

251

Observed

→ investigated in trials for

Fulvestrantsmall_molecule

249 trials (83 active) · roll-up of the cancer and its descendants

—

249

Observed

→ investigated in trials for

Pembrolizumabmonoclonal antibody

223 trials (113 active) · roll-up of the cancer and its descendants

—

223

Observed

→ investigated in trials for

Tamoxifensmall_molecule

214 trials (36 active) · roll-up of the cancer and its descendants

—

214

Observed

→ investigated in trials for

Bevacizumabmonoclonal antibody

166 trials (20 active) · roll-up of the cancer and its descendants

—

166

Observed

→ investigated in trials for

Anastrozolesmall molecule

163 trials (36 active) · roll-up of the cancer and its descendants

—

163

Observed

→ investigated in trials for

Pertuzumabmonoclonal_antibody

161 trials (72 active) · roll-up of the cancer and its descendants

—

161

Observed

→ investigated in trials for

Epirubicinsmall molecule

154 trials (26 active) · roll-up of the cancer and its descendants

—

154

Observed

Malignant Breast Neoplasm studied in …STUDIED_INderived10 of 12,355show all (up to 200)
→ studied in	NCT00006421completed Breast Imaging Studies in Women at High Genetic Risk of Breast Cancer: Annual Follow-Up Study · condition mapped CURATED_EXACT · 12,355 trials mapped (3,335 active)	—	—	Malignant Breast Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT00034216recruiting Collection of Blood From Patients With Cancer · condition mapped CURATED_EXACT · 12,355 trials mapped (3,335 active)	—	—	Malignant Breast Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT00043472completed Removal of the Ovaries/Fallopian Tubes and CA-125 Screening to Reduce the Risk of Ovarian Cancer in Women at Increased Genetic Risk · condition mapped CURATED_EXACT · 12,355 trials mapped (3,335 active)	—	—	Malignant Breast Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT00068003enrolling by invitation Harvesting Cells for Experimental Cancer Treatments · condition mapped CURATED_EXACT · 12,355 trials mapped (3,335 active)	—	—	Malignant Breast Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT01441089recruiting Collection of Blood From Patients With Cancer, Other Tumors, or Tumor Predisposition Syndromes for Genetic Analysis · condition mapped CURATED_EXACT · 12,355 trials mapped (3,335 active)	—	—	Malignant Breast Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT02595957recruiting Genomic Services Research Program · condition mapped CURATED_EXACT · 12,355 trials mapped (3,335 active)	—	—	Malignant Breast Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT02791581NA · active not recruiting Understanding and Predicting Breast Cancer Events After Treatment · condition mapped CURATED_EXACT · 12,355 trials mapped (3,335 active)	—	—	Malignant Breast Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT03412877Phase 2 · recruiting Administration of Autologous T-Cells Genetically Engineered to Express T-Cell Receptors Reactive Against Neoantigens in People With Metastatic Cancer · condition mapped CURATED_EXACT · 12,355 trials mapped (3,335 active)	—	—	Malignant Breast Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT03451383recruiting Older Breast Cancer Patients: Risk for Cognitive Decline · condition mapped CURATED_EXACT · 12,355 trials mapped (3,335 active)	—	—	Malignant Breast Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT03734029Phase 3 · completed Trastuzumab Deruxtecan (DS-8201a) Versus Investigator's Choice for HER2-low Breast Cancer That Has Spread or Cannot be Surgically Removed [DESTINY-Breast04] · condition mapped CURATED_EXACT · 12,355 trials mapped (3,335 active)	—	—	Malignant Breast Neoplasm	1	Observed	clinicaltrials	graph →

Malignant Breast Neoplasm studied in …STUDIED_INderived10 of 12,355show all (up to 200)

→ studied in

NCT00006421completed

Breast Imaging Studies in Women at High Genetic Risk of Breast Cancer: Annual Follow-Up Study · condition mapped CURATED_EXACT · 12,355 trials mapped (3,335 active)

—

Observed

→ studied in

NCT00034216recruiting

Collection of Blood From Patients With Cancer · condition mapped CURATED_EXACT · 12,355 trials mapped (3,335 active)

—

Observed

→ studied in

NCT00043472completed

Removal of the Ovaries/Fallopian Tubes and CA-125 Screening to Reduce the Risk of Ovarian Cancer in Women at Increased Genetic Risk · condition mapped CURATED_EXACT · 12,355 trials mapped (3,335 active)

—

Observed

→ studied in

NCT00068003enrolling by invitation

Harvesting Cells for Experimental Cancer Treatments · condition mapped CURATED_EXACT · 12,355 trials mapped (3,335 active)

—

Observed

→ studied in

NCT01441089recruiting

Collection of Blood From Patients With Cancer, Other Tumors, or Tumor Predisposition Syndromes for Genetic Analysis · condition mapped CURATED_EXACT · 12,355 trials mapped (3,335 active)

—

Observed

→ studied in

NCT02595957recruiting

Genomic Services Research Program · condition mapped CURATED_EXACT · 12,355 trials mapped (3,335 active)

—

Observed

→ studied in

NCT02791581NA · active not recruiting

Understanding and Predicting Breast Cancer Events After Treatment · condition mapped CURATED_EXACT · 12,355 trials mapped (3,335 active)

—

Observed

→ studied in

NCT03412877Phase 2 · recruiting

Administration of Autologous T-Cells Genetically Engineered to Express T-Cell Receptors Reactive Against Neoantigens in People With Metastatic Cancer · condition mapped CURATED_EXACT · 12,355 trials mapped (3,335 active)

—

Observed

→ studied in

NCT03451383recruiting

Older Breast Cancer Patients: Risk for Cognitive Decline · condition mapped CURATED_EXACT · 12,355 trials mapped (3,335 active)

—

Observed

→ studied in

NCT03734029Phase 3 · completed

Trastuzumab Deruxtecan (DS-8201a) Versus Investigator's Choice for HER2-low Breast Cancer That Has Spread or Cannot be Surgically Removed [DESTINY-Breast04] · condition mapped CURATED_EXACT · 12,355 trials mapped (3,335 active)

—

Observed