PIK3CA Rare Mutation

CI-VAR-00003958Explore in graph →CIViC 3222

Curated evidence

Evidence by cancer (2 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–2 of 2 evidence items across 1 cancer context on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Malignant Breast Neoplasm2
PIK3CA Rare Mutation	(prognostic)	Prognostic	B	Supports Better Outcome	2	accepted	EID2042 Prognostic significance of PIK3CA mutations was evaluated in a retrospective study of 590 patients with surgically resected invasive breast cancer. Tumors harboring rare PIK3CA mutations (N345K: 2.4%,… (full text at CIViC) PMID 19671852 · Kalinsky et al., 2009 · Open in CIViC	civic
PIK3CA Rare Mutation	(prognostic)	Prognostic	B	Supports Better Outcome	2	rejected	EID8915 Prognostic significance of PIK3CA mutations was evaluated in a retrospective study of 590 patients with surgically resected invasive breast cancer. Tumors harboring rare PIK3CA mutations (N345K: 2.4%,… (full text at CIViC) PMID 19671852 · Kalinsky et al., 2009 · Open in CIViC	civic

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.