Variant · Snv
ABCB1 I1145I
CI-VAR-00001961Explore in graph →NP_000918.2:p.Ile1145=NM_000927.4:c.3435T>CClinVar 225939 CIViC 263 rs1045642
Curated evidence
Evidence by cancer (2 items)
Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 22296372
- Run
- ING-CIVIC-20260908-000001
| Molecular profile | Therapy | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| Lung Non-Small Cell Carcinoma1 | ||||||||
| ABCB1 I1145I | Carboplatin + CisplatinSubstitutes | Predictive | B | Supports Sensitivity Response | 2 | accepted | EID675The mutation at codon 3435 (C>T) correlated with a significantly higher response rate to platinum-based chemotherapy in patients with advanced non small cell lung cancer (NSCLC). 103 Chinese patients… (full text at CIViC) PMID 22296372 · Yan et al., 2011 · Open in CIViC | civic |
| Malignant Breast Neoplasm1 | ||||||||
| ABCB1 I1145I | (prognostic) | Prognostic | B | Supports Better Outcome | 3 | accepted | EID1076A total of 57 women with HER2-positive metastatic breast cancer were analyzed after taxane plus trastuzumab chemotherapy. ABCB1 C3435T carriers had a longer progression-free survival (p = 0.039) along… | |
ClinVar
Clinical significance (0)
ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.
Data not yet available