Variant · Expression
PGR Expression
CI-VAR-00001031Explore in graph →CIViC 210
Curated evidence
Evidence by cancer (5 items)
Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 32062536
- Run
- ING-CIVIC-20260908-000001
| Molecular profile | Therapy | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| Malignant Breast Neoplasm5 | ||||||||
| NOT ERBB2 Overexpression AND ( PGR Expression OR ESR1 Expression ) | Everolimus/Exemestane Regimen | Predictive | B | Supports Sensitivity Response | 2 | submitted | EID12909In the multicenter open-label single-arm non-interventional STEPAUT study of postmenopausal women with HR+, HER2− advanced breast cancer progressing or recurring on/after prior NSAIs (n = 236), the HR… (full text at CIViC) PMID 32062536 · Steger et al., 2020 · Open in CIViC | civic |
| PGR Expression | (prognostic) | Prognostic | B | Supports Better Outcome | 3 | accepted | EID500In patients with breast cancer, those with expression of PgR (determined by immunohistochemical staining) had better relapse-free survival than those without expression. PMID 16497822 · Dowsett et al., 2006 · Open in CIViC | |
ClinVar
Clinical significance (0)
ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.
Data not yet available