Gene

TIMP1

TIMP metallopeptidase inhibitor 1

Curated evidence

Clinical evidence (2)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–2 of 2 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
TIMP1 Overexpression2
Fulvestrant	Malignant Breast Neoplasm	Predictive	D	Supports Resistance	2	accepted	EID901 TIMP1 overexpression was associated with resistance to fulvestrant in breast cancer cell lines. PMID 23881388 · Bjerre et al., 2013 · Open in CIViC	civic
Paclitaxel	Malignant Breast Neoplasm	Predictive	B	Supports Resistance	2	accepted	EID927 High expression of TIMP-1 was assessed by IHC in 99 primary breast cancers that had not spread beyond the breast after 6 postoperative courses of paclitaxel-based chemotherapy. High TIMP1 levels were … (full text at CIViC) PMID 22544540 · Zhu et al., 2012 · Open in CIViC	civic

Cohorts

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

Data not yet available

No cohort frequency recorded for this gene.

Literature

25 per page, newest first.

pubmedPublishedShowing 1–2 of 2 publications · bibliographic data as recorded by PubMed; abstracts are not reproduced.