ABCB1 S893A/T

CI-VAR-00004144Explore in graph →p.Ser893ThrNM_001348946.2:c.2677T>AClinVar 166619 CIViC 451 rs2032582

Curated evidence

Evidence by cancer (1 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–1 of 1 evidence items across 1 cancer context on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Malignant Breast Neoplasm1
ABCB1 S893A/T	(prognostic)	Prognostic	B	Supports Better Outcome	3	accepted	EID1075 A total of 57 women with HER2-positive metastatic breast cancer were analyzed after taxane plus trastuzumab chemotherapy. ABCB1 G2677T carriers had a longer progression-free survival (p = 0.037) along… (full text at CIViC) PMID 22906996 · Kim et al., 2012 · Open in CIViC	civic

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
166619	Benign	criteria provided, multiple submitters, no conflicts	2	ABCB1-related disorder; Acute myeloid leukemia; Uterine corpus endometrial carcinoma; Clear cell carcinoma of kidney; Sarcoma; Ovarian serous cystadenocarcinoma; Thymoma; Lung cancer; Gastric cancer	germline	5	Jan 06, 2014