TOP2A — gene · CancerIndex

Curated evidence

Clinical evidence (3)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–3 of 3 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
TOP2A EXPRESSION1
Doxorubicin	Malignant Breast Neoplasm	Predictive	B	Supports Sensitivity Response	2	accepted	EID909 In a retrospective study, TOP2A expression was assessed by IHC for 108 breast cancer patients (from TAX 303 trial). TOP2A expression was associated with a higher probability of response in doxorubicin… (full text at CIViC) PMID 15486187 · Durbecq et al., 2004 · Open in CIViC	civic
TOP2A TOP2A/902
Etoposide	Leukemia	Predictive	D	Supports Resistance	4	submitted	EID9634 In an in vitro study, leukemia cells expressing TOP2A/90 show increased inhibition (p < 0.025) upon KD of TOP2A/90 when treated with etoposide. Moreover cells expressing TOP2A/170 but not TOP2A/90 sho… (full text at CIViC) PMID 29514855 ·

Cohorts

Alteration frequency by cohort (8)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved8 cohort rows · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Cholangiocarcinoma (TCGA GDC, 2025) chol_tcga_gdc	Cholangiocarcinoma	Ssm	3	51	5.9%	50

Literature

Linked publications (1)

25 per page, newest first.

pubmedPublishedShowing 1–1 of 1 publications · bibliographic data as recorded by PubMed; abstracts are not reproduced.

Topoisomerase-II alpha expression as a predictive marker in a population of advanced breast cancer patients randomly treated either with single-agent doxorubicin or single-agent docetaxel.
· Mol Cancer Ther · 2004 · PMID 15486187 · validated civic_curation pubmed