TUBB3 — gene · CancerIndex

Curated evidence

Clinical evidence (2)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–2 of 2 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
TUBB3 EXPRESSION2
Paclitaxel	Malignant NeoplasmALIAS	Predictive	D	Supports Resistance	2	accepted	EID920 High expression of class 3 beta-tubulin led to decreased effect of paclitaxel on cell motility in HeLa, MCF-7 and CHO cell lines. PMID 21576762 · Ganguly et al., 2011 · Open in CIViC	civic
Taxane Compound	Malignant Breast Neoplasm	Predictive	B	Supports Sensitivity Response	2	accepted	EID921 High expression of betaIII-tubulin, as assessed in 85 breast cancers by IHC, was associated with better pathological response. PMID 23218766 · Wang et al., 2013 · Open in CIViC	civic

Cohorts

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

gdcObserved1 cohort row · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Adjuvant Lung Cancer Enrichment Marker Identification and Sequencing Trial ALCHEMIST-ALCH	unmapped	Ssm

Literature

25 per page, newest first.

pubmedPublishedShowing 1–2 of 2 publications · bibliographic data as recorded by PubMed; abstracts are not reproduced.