Variant · Expression
CCND1 Overexpression
CI-VAR-00003124Explore in graph →CIViC 20
Curated evidence
Evidence by cancer (10 items)
Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 16309541
- Run
- ING-CIVIC-20260908-000001
| Molecular profile | Therapy | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| Head and Neck Squamous Cell Carcinoma1 | ||||||||
| CCND1 Overexpression | (prognostic) | Prognostic | B | Supports Poor Outcome | 4 | accepted | EID357Cyclin D1 overexpression is associated with shorter overall survival and increased metastasis in head and neck squamous cell carcinoma. PMID 16309541 · Thomas et al., 2005 · Open in CIViC | civic |
| Malignant Breast Neoplasm2 | ||||||||
| CCND1 Overexpression | (diagnostic) | Diagnostic | B | Supports Positive | 4 | accepted | EID221Cyclin D1 overexpression is associated with the ER-positive subtype of breast cancer. PMID 15961768 · Arnold et al., 2005 · Open in CIViC | civic |
| CCND1 Overexpression | ||||||||
ClinVar
Clinical significance (0)
ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.
Data not yet available