Drug · Small Molecule

Cyclophosphamide

CI-DRUG-00000166Explore in graph →NCIt C405 CHEMBL1200796 CIViC Approved

Regulatory

Approvals (43)

Each record names the authority, jurisdiction, indication text and status. A drug approved in one jurisdiction for one indication is not 'approved' in general.

health-canada-dpdRegulatory43 approval records from 2 sources (hover a row badge for its dataset) · authority, jurisdiction and indication text as published.

Jurisdiction · authority	Cancer	Indication	Status	Approval date	Source
CA Health Canada	—	Marketed in Canada as CYCLOPHOSPHAMIDE FOR INJECTION USP (DIN 02560224) under ATC L01AA01 CYCLOPHOSPHAMIDE. Indications are not published in the Drug Product Database — see the Health Canada Product Monograph.	approvedsource: Marketed	Jul 24, 2026	health-canada-dpd

Health Canada records are DIN-level: one row per marketed product (brand, strength, form). The Drug Product Database does not publish indications, so no cancer is stated for these rows, and a cancelled or dormant DIN is the status of that one product — not a withdrawal of the molecule.

Data updated 18 hours agoSource updated unknown

Derived

Development pipeline

Most advanced stage across all cancers, then per top-level cancer reached through trial conditions or approval indications. Approval in any ingested jurisdiction outranks trial phase; counts are interventional studies.

Scope	Stage	Max phase	Active	Recruiting	Phase 3	Trials	Approvals	Jurisdictions	First approval	First trial
All cancers	Approved	Phase 4	703	369	500	2,823	43	CA, US	Nov 16, 1959	1987-08
Non-Hodgkin Lymphoma	Approved	Phase 4	209	102	95	660	2	US	Sep 12, 2023	1988-03
Multiple Myeloma	Approved	Phase 4	46	22	26	223	1	US	Sep 12, 2023	1988-03
Malignant Central Nervous System Neoplasm	Approved	Phase 3	26	17	11	58

Curated evidence

Clinical evidence (1)

CIViC items in which this therapy appears, grouped by cancer context, then molecular profile. 50 items per page.

civicCuratedShowing 1–1 of 1 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
TOP1 EXPRESSION1
Carboplatin + Cyclophosphamide

Clinical trials

Trials with this intervention (2,848)

Most recently updated first, 50 per page.

clinicaltrialsPublishedShowing 1–50 of 2,848 studies · status and phase as posted by the registrant; each row links to the study record.

NCT	Title	Status	Phase	Enrollment (n)	Sponsor	Countries	Last update	Source
NCT00092222	Virotherapy and Natural History Study of KHSV-Associated Multricentric Castleman s Disease With Correlates of Disease Activity	active not recruiting	Phase 2	75	National Cancer Institute (NCI)NIH	1	Sep 28, 2026	clinicaltrials
NCT03412877	Administration of Autologous T-Cells Genetically Engineered to Express T-Cell Receptors Reactive Against Neoantigens in People With Metastatic Cancer

Molecule

Record

Kind: Small Molecule
Mechanism: DNA inhibitor
UNII: 8N3DW7272P
Aliases: 1-bis(2-chloroethyl)-amino-1-oxo-2-aza-5-oxaphosphoridin Monohydrate, 2-[bis(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide Monohydrate, 2-[bis(b-chloroethyl)amino]-1-oxa-3-aza-2-phosphacyclohexane-2-oxide Monohydrate, 2-[di(chloroethyl)amino]-1-oxa-3-aza-2-phosphacyclohexane 2-oxide Monohydrate, 2H-1,3,2-Oxazaphosphorine, 2-[bis(2-chloroethyl)amino]tetrahydro-, 2-oxide, Monohydrate, Asta B 518, B 518, B-518, B518, Bis(2-chloroethyl)phosphamide Cyclic Propanolamide Ester Monohydrate, Bis(2-chloroethyl)phosphoramide Cyclic Propanolamide Ester Monohydrate, Carloxan, Ciclofosfamida, Ciclofosfamide, Cicloxal, Clafen, Claphene, CP Monohydrate, CTX, Cycloblastin, Cycloblastine, CYCLO-cell, Cyclophospham, (-)-Cyclophosphamide, Cyclophosphamide, Cyclophosphamide hydrate, Cyclophosphamide Monohydrate, Cyclophosphamid Monohydrate, Cyclophosphamidum, Cyclophosphan … (+34)

Data updated 21 hours agoSource updated unknown

Identifiers

Codes (63)

Upstream identifiers kept as first-class codes; each links to its registry where a stable public URL exists.

System	Code	Label
ATC (WHO)	L01AA01	CYCLOPHOSPHAMIDE