Targetable kinase-activating lesions in Ph-like acute lymphoblastic leukemia.

An adult patient (82 yo) who presented with B-ALL (initial WBC of 183,000) with ETV6-ABL1 fusion was treated with dasatinib as a single agent after his chemotherapy had to be stopped due to toxicity. … (full text at CIViC)

PMID 25207766 · Roberts et al., 2014 · Open in CIViC

B-ALL cases with high-risk clinical features or suggestion of a kinase rearrangement were subjected to low density gene expression array to determine Ph-like status. 2 of 2 patients (ages 5 and 82 ye… (full text at CIViC)

PMID 25207766 · Roberts et al., 2014 · Open in CIViC

In the study involving 1725 B-ALL patients, 264 were identified by microarray-based algorithm to have a Ph-like expression signature. Next generation sequencing (RNAseq, WGS, and/or WES) performed on … (full text at CIViC)

PMID 25207766 · Roberts et al., 2014 · Open in CIViC

In the study involving 1725 B-ALL patients, 264 were identified by microarray-based algorithm to have a Ph-like expression signature. Next generation sequencing (RNAseq, WGS, and/or WES) performed on … (full text at CIViC)

PMID 25207766 · Roberts et al., 2014 · Open in CIViC

In the study involving 1725 B-ALL patients, 264 were identified by microarray-based algorithm to have a Ph-like expression signature. Next generation sequencing (RNAseq, WGS, and/or WES) performed on … (full text at CIViC)

PMID 25207766 · Roberts et al., 2014 · Open in CIViC

B-ALL cases with high-risk clinical features or suggestion of a kinase rearrangement were subjected to low density gene expression array to determine Ph-like status. 3 patients (ages 6, 14.4, and 19.… (full text at CIViC)

PMID 25207766 · Roberts et al., 2014 · Open in CIViC

EBF1-PDGFRB fusion was detected in leukemia cells of a 6 year old male who presented with B-ALL and an initial WBC of 244,400. He received 4-drug induction chemotherapy but failed to enter remission w… (full text at CIViC)

PMID 25207766 · Roberts et al., 2014 · Open in CIViC

The EBF1-PDGFRB fusion was detected in leukemia cells of a 7 year old Latino boy who presented with B-ALL and initial WBC of 600,000. He failed to enter remission with 4 drug induction (90% blasts at … (full text at CIViC)

PMID 25207766 · Roberts et al., 2014 · Open in CIViC

The study showed that the EPOR gene rearrangements with immunoglobulin loci are associated with Ph-like molecular subtype of B-ALL, characterized by a gene-expression profile similar to that of the BC… (full text at CIViC)

PMID 25207766 · Roberts et al., 2014 · Open in CIViC

In the study involving 1725 B-ALL patients, 264 were identified by microarray-based algorithm to have a Ph-like expression signature. Next generation sequencing (RNAseq, WGS, and/or WES) performed on … (full text at CIViC)

PMID 25207766 · Roberts et al., 2014 · Open in CIViC

B-lymphoblastic leukemia/lymphoma (B-ALL) cases with high-risk clinical features or suggestion of a kinase rearrangement were subjected to low density gene expression array to determine BCR::ABL1-like… (full text at CIViC)

PMID 25207766 · Roberts et al., 2014 · Open in CIViC

The authors performed genomic profiling of 1725 cases of B-lymphoblastic leukemia/lymphoma (B-ALL). Overall, 264 of 1725 B-ALL cases (15.3%) were identified as BCR::ABL1 (Ph)-like based on their expr… (full text at CIViC)

PMID 25207766 · Roberts et al., 2014 · Open in CIViC

B-ALL cases with high-risk clinical features or suggestion of a kinase rearrangement were subjected to low density gene expression array to determine Ph-like status. 2 patients (ages 7.6 and 16.3 yea… (full text at CIViC)

PMID 25207766 · Roberts et al., 2014 · Open in CIViC

In this 2014 genomic profiling study of 1,725 patients with precursor B-cell acute lymphoblastic leukemia (B-ALL), the authors define the high-risk "Philadelphia chromosome-like" (Ph-like or BCR::ABL1… (full text at CIViC)

PMID 25207766 · Roberts et al., 2014 · Open in CIViC

B-ALL cases with high-risk clinical features or suggestion of a kinase rearrangement were subjected to low density gene expression array to determine Ph-like status. 1 patient (12.1 years old) with a… (full text at CIViC)

PMID 25207766 · Roberts et al., 2014 · Open in CIViC

In this 2014 study by Roberts et al., a genomic analysis of 1725 patients with precursor B-cell acute lymphoblastic leukemia (B-ALL) was conducted to define the genetic landscape of the Philadelphia c… (full text at CIViC)

PMID 25207766 · Roberts et al., 2014 · Open in CIViC

P2RY8-CRLF2 fusion is associated with the Ph-like molecular/genetic subtype of B-cell ALL. Approximately half of the Ph-like ALL cases have high CRLF2 expression, with the frequency ranging from 24% a… (full text at CIViC)

PMID 25207766 · Roberts et al., 2014 · Open in CIViC

In the study involving 1725 B-ALL patients, 264 were identified by microarray-based algorithm to have a Ph-like expression signature. Next generation sequencing (RNAseq, WGS, and/or WES) performed on … (full text at CIViC)

PMID 25207766 · Roberts et al., 2014 · Open in CIViC

In the study involving 1725 B-ALL patients, 264 were identified by microarray-based algorithm to have a Ph-like expression signature. Next generation sequencing (RNAseq, WGS, and/or WES) performed on … (full text at CIViC)

PMID 25207766 · Roberts et al., 2014 · Open in CIViC

B-ALL cases with high-risk clinical features or suggestion of a kinase rearrangement were subjected to low density gene expression array to determine Ph-like status. 1 patient (5.3 years old) with a P… (full text at CIViC)

PMID 25207766 · Roberts et al., 2014 · Open in CIViC

In the study involving 1725 B-ALL patients, 264 were identified by microarray-based algorithm to have a Ph-like expression signature. Next generation sequencing (RNAseq, WGS, and/or WES) performed on … (full text at CIViC)

PMID 25207766 · Roberts et al., 2014 · Open in CIViC

B-ALL cases with high-risk clinical features or suggestion of a kinase rearrangement were subjected to low density gene expression array to determine Ph-like status. 2 of 2 patients (ages 2.7 and 12.… (full text at CIViC)

PMID 25207766 · Roberts et al., 2014 · Open in CIViC

B-ALL cases with high-risk clinical features or suggestion of a kinase rearrangement were subjected to low density gene expression array to determine Ph-like status. 1 patient (6.9 years old) with a… (full text at CIViC)

PMID 25207766 · Roberts et al., 2014 · Open in CIViC

The ABL1-RCSD1 fusion was identified in a 6 yo boy with Ph-like B-ALL and hyperleukocytosis. Following standard induction therapy the patient had an MRD of 16.4% in bone marrow, indicating a poor resp… (full text at CIViC)

PMID 25207766 · Roberts et al., 2014 · Open in CIViC

The RCSD1-ABL1 fusion was identified in a 6 yo boy with Ph-like B-ALL (expression signature verified by low density gene expression array) and hyperleukocytosis. Following standard induction therapy t… (full text at CIViC)

PMID 25207766 · Roberts et al., 2014 · Open in CIViC

The RCSD1-ABL2 fusion was identified in a 5 yo boy with Ph-like B-ALL and Klinefelter syndrome. Following standard induction therapy the patient had an MRD of 1.2% in bone marrow, and continued to be … (full text at CIViC)

PMID 25207766 · Roberts et al., 2014 · Open in CIViC

A 5 year-old male patient with B-ALL was described with an initial WBC of 57,700 (Supplementary Appendix 2). Chromosome analysis showed 47,XXYc with a confirmed diagnosis of Klinefelter syndrome. FISH… (full text at CIViC)

PMID 25207766 · Roberts et al., 2014 · Open in CIViC

In the study involving 1725 B-ALL patients, 264 were identified by microarray-based algorithm to have a Ph-like expression signature. Next generation sequencing (RNAseq, WGS, and/or WES) performed on … (full text at CIViC)

PMID 25207766 · Roberts et al., 2014 · Open in CIViC

B-ALL cases with high-risk clinical features or suggestion of a kinase rearrangement were subjected to low density gene expression array to determine Ph-like status. 1 patient (14 years old) with an … (full text at CIViC)

PMID 25207766 · Roberts et al., 2014 · Open in CIViC

The SSBP2-JAK2 fusion was identified in a 14 yo male with Ph-like B-ALL, a t(5;9)(q12;p1?3), and a WBC of 160,000. Following 4-drug induction therapy the patient had an MRD of 5.5%, indicating a poor … (full text at CIViC)

PMID 25207766 · Roberts et al., 2014 · Open in CIViC

In the study involving 1725 B-ALL patients, 264 were identified by microarray-based algorithm to have a Ph-like expression signature. Next generation sequencing (RNAseq, WGS, and/or WES) performed on … (full text at CIViC)

PMID 25207766 · Roberts et al., 2014 · Open in CIViC

In the study involving 1725 B-ALL patients, 264 were identified by microarray-based algorithm to have a Ph-like expression signature. Next generation sequencing (RNAseq, WGS, and/or WES) performed on … (full text at CIViC)

PMID 25207766 · Roberts et al., 2014 · Open in CIViC

B-ALL cases with high-risk clinical features or suggestion of a kinase rearrangement were subjected to low density gene expression array to determine Ph-like status. 1 patient (6 years old) with a TN… (full text at CIViC)

PMID 25207766 · Roberts et al., 2014 · Open in CIViC

In the study involving 1725 B-ALL patients, 264 were identified by microarray-based algorithm to have a Ph-like expression signature. Next generation sequencing (RNAseq, WGS, and/or WES) performed on … (full text at CIViC)

PMID 25207766 · Roberts et al., 2014 · Open in CIViC

The study showed association of the ABL1 fusions with partner genes other than BCR with a specific molecular/genetic subtype of B-lymphoblastic leukemia characterized by the expression signature simil… (full text at CIViC)

PMID 25207766 · Roberts et al., 2014 · Open in CIViC

The study showed that in B-ALL the the presence of ABL2 fusions with different partner genes is diagnostic for the so-called BCR-ABL1-like (or Philadelphia (Ph)-like) molecular subtype of B-ALL. Ph-l… (full text at CIViC)

PMID 25207766 · Roberts et al., 2014 · Open in CIViC

The RCSD1-ABL2 fusion was identified in a 5 yo boy with Ph-like B-ALL and Klinefelter syndrome. Following standard induction therapy the patient had an MRD of 1.2% in bone marrow, and continued to be … (full text at CIViC)

PMID 25207766 · Roberts et al., 2014 · Open in CIViC

In this study, 264 of 1725 precursor B-lymphoblastic leukemia (B-ALL) cases were identified as BCR::ABL1 (Ph)-like based on the expression signature similar to the BCR::ABL1 positive B-ALL; of those 2… (full text at CIViC)

PMID 25207766 · Roberts et al., 2014 · Open in CIViC

This study showed that, when detected in the context of B-cell lymphoblastic leukemia/lymphoma (B-ALL), PDGFRB fusions with different partner genes are associated with Ph-like molecular subtype of B-A… (full text at CIViC)

PMID 25207766 · Roberts et al., 2014 · Open in CIViC

B-ALL cases with high-risk clinical features or suggestion of a kinase rearrangement were subjected to low density gene expression array to determine Ph-like status. 2 patients (ages 6.4 and 10.4 yea… (full text at CIViC)

PMID 25207766 · Roberts et al., 2014 · Open in CIViC

A male adolescent patient with study ID SJBALL267_D was reported by gene expression profile to have Ph-like non CRLF2 B-ALL. White blood count was 1.7. WGS and RNA-seq was performed. ZEB2::PDGFR joini… (full text at CIViC)

PMID 25207766 · Roberts et al., 2014 · Open in CIViC

B-ALL cases with high-risk clinical features or suggestion of a kinase rearrangement were subjected to low density gene expression array to determine Ph-like status. 3 of 4 patients (ages 2.2, 2.6, a… (full text at CIViC)

PMID 25207766 · Roberts et al., 2014 · Open in CIViC

An 11 year old female (46,XX) had B-ALL. The patient received a 4-drug induction and end induction day 29 MRD was 5.4%. LDA card was used to analyze the patient and the leukemia was determined to be P… (full text at CIViC)

PMID 25207766 · Roberts et al., 2014 · Open in CIViC

BA/F3 cells transfected with ZMIZ1-ABL1 fusion were able to proliferate in the absence of IL3 by multiple orders of magnitude over 8 days, while cells transduced with empty vector failed to proliferat… (full text at CIViC)

PMID 25207766 · Roberts et al., 2014 · Open in CIViC

IL3 indépendant Ba/F3 cells transduced with ZMIZ1-ABL1 driver fusion were treated with dasatinib. ZMIZ1-ABL1 cells had IC50 of 1-2 nM, whereas cells transduced with the driver PAX5-JAK2 were not respo… (full text at CIViC)

PMID 25207766 · Roberts et al., 2014 · Open in CIViC

IL3 indépendant Ba/F3 cells transduced with ZMIZ1-ABL1 driver fusion were treated with dasatinib. ZMIZ1-ABL1 cells had IC50 of 1-2 nM, whereas cells transduced with the driver PAX5-JAK2 were not respo… (full text at CIViC)

PMID 25207766 · Roberts et al., 2014 · Open in CIViC

In a cohort of 264 patients with Ph-like B-ALL, an adolescent male had a DGKH-ZFAND3 rearrangement. ZFAND3 as a fusion partner had not been previously reported.

PMID 25207766 · Roberts et al., 2014 · Open in CIViC

In this study, 264 of 1725 precursor B-ALL cases were identified as being BCR-ABL1 like (Ph-like) based on their expression signature (which was is similar to BCR-ABL1 positive cases); of those, one c… (full text at CIViC)

PMID 25207766 · Roberts et al., 2014 · Open in CIViC

In a cohort of 264 patients with Ph-like B-ALL, a high risk female had a IL2RB-MYH9 rearrangement. MYH9 as a fusion partner had not been previously reported.

PMID 25207766 · Roberts et al., 2014 · Open in CIViC

In Roberts et al. (N. Engl. J. Med. 2014) the V253G was found in two cases of Ph-like B-ALL which also had CRLF2 overexpression.

PMID 25207766 · Roberts et al., 2014 · Open in CIViC