PDGFRB Fusion

CI-VAR-00001184Explore in graph →CIViC 535

Curated evidence

Evidence by cancer (8 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–8 of 8 evidence items across 2 cancer contexts on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
B Lymphoblastic Leukemia/Lymphoma, BCR-ABL1-Like6
EBF1::PDGFRB Fusion	(diagnostic)	Diagnostic	C	Supports Positive	3	submitted	EID11625 B-ALL cases with high-risk clinical features or suggestion of a kinase rearrangement were subjected to low density gene expression array to determine Ph-like status. 3 patients (ages 6, 14.4, and 19.… (full text at CIViC) PMID 25207766 · Roberts et al., 2014 · Open in CIViC	civic
EBF1::PDGFRB Fusion	Imatinib	Predictive	C	Supports Sensitivity Response	3	accepted	EID1310 A 10-year-old boy with B-cell acute lymphoblastic leukemia refractory to conventional chemotherapy and harboring an EBF1-PDGFRB fusion responded to imatinib plus induction chemotherapy (vincristine, d… (full text at CIViC) PMID 23835704 · Weston et al., 2013 · Open in CIViC

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.

Childhood B-cell Acute Lymphoblastic Leukemia2unmapped disease
EBF1::PDGFRB Fusion	Imatinib	Predictive	C	Supports Sensitivity Response	3	accepted	EID6976 A 16-year-old boy with B-cell acute lymphoblastic leukemia refractory to conventional chemotherapy and harboring an IKZF1 deletion (delta 2-7) and a 5q33 microdeletion resulting in an EBF1-PDGFRB fusi… (full text at CIViC) PMID 24186319 · Lengline et al., 2013 · Open in CIViC	civic
EBF1::PDGFRB Fusion	Imatinib	Predictive	C	Supports Sensitivity Response	2	accepted	EID7028 Two patients with EBF1-PDGFRB positive pediatric B-ALL were treated with induction/post-induction therapy and Imatinib. Neither patient experienced disease relapse. One patient died of an undefined en… (full text at CIViC) PMID 26872634 · Schwab et al., 2016 · Open in CIViC	civic