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Publication

Targetable kinase-activating lesions in Ph-like acute lymphoblastic leukemia.

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N Engl J Med2014PMID 25207766PMC4191900stubpubmedProvenance
Source
PubMed
Retrieved
Sep 8, 2026
Layer
normalized (units and labels harmonized; values unchanged)
Run
ING-CIVIC-20260908-000001
Published

Abstract

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Linked entities

Linked entities (32)

How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.

Validated 32

Curated evidence

Evidence citing this paper (52)

50 items per page.

civicProvenance
Source
CIViC — Clinical Interpretation of Variants in Cancer
Dataset
CIViC evidence items
Version
civic-2026-09-08
Retrieved
Sep 8, 2026
Layer
normalized (units and labels harmonized; values unchanged)
Evidence
expert curation
License
CC0 1.0
PMID
25207766
Run
ING-CIVIC-20260908-000001
Open at source
CuratedShowing 51–52 of 52 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.
TherapyCancerTypeLevelDirection · significanceRating (1–5)StatusEvidenceSource
KDM6A Fusion1
(diagnostic)Childhood B-cell Acute Lymphoblastic LeukemiaUNRESOLVEDDiagnosticCSupports Positive2submitted
EID7255

In a cohort of 264 patients with Ph-like B-ALL, one patient with a CRLF2 rearrangement had a PTK2B-KDM6A rearrangement. This fusion partner for PTK2B had not been previously reported.

PMID 25207766 · Roberts et al., 2014 · Open in CIViC

civic
STAG2 Fusion1
(diagnostic)Childhood B-cell Acute Lymphoblastic LeukemiaUNRESOLVEDDiagnosticCSupports Positive2submitted
EID7256

In a cohort of 264 patients with Ph-like B-ALL, one patient with a CRLF2 rearrangement had a PTK2B-STAG2 rearrangement. This fusion partner for PTK2B had not been previously reported.

PMID 25207766 · Roberts et al., 2014 · Open in CIViC

civic