Gene

CRLF2

cytokine receptor like factor 2

Explore in graph →CI-GENE-00042241HGNC:14281 ENSG00000205755 NCBI 64109 CIViC Cancer geneApproved

Curated evidence

Clinical evidence (24)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–24 of 24 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
CRLF2 F232C2
(prognostic)	Adult B Acute Lymphoblastic LeukemiaALIAS	Prognostic	D	Supports Poor Outcome	4	submitted

Cohorts

Alteration frequency by cohort (9)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved9 cohort rows · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Mature B-Cell Neoplasms (Simon Fraser University, Blood 2023) mbn_sfu_2023	B-Cell Non-Hodgkin Lymphoma	Ssm	15

Literature

Linked publications (4)

25 per page, newest first.

pubmedPublishedShowing 1–4 of 4 publications · bibliographic data as recorded by PubMed; abstracts are not reproduced.

Targetable kinase-activating lesions in Ph-like acute lymphoblastic leukemia.
· N Engl J Med · 2014 · PMID 25207766 · validated civic_curation pubmed
Rearrangement of CRLF2 is associated with mutation of JAK kinases, alteration of IKZF1, Hispanic/Latino ethnicity, and a poor outcome in pediatric B-progenitor acute lymphoblastic leukemia.
· Blood · 2010 · PMID 20139093 · validated civic_curation pubmed
Functional screening identifies CRLF2 in precursor B-cell acute lymphoblastic leukemia.
· Proc Natl Acad Sci U S A · 2010 · PMID 20018760 · validated civic_curation pubmed
Targetable kinase gene fusions in high-risk B-ALL: a study from the Children's Oncology Group.
· Blood · 2017 · PMID 28408464 · validated civic_curation

CRLF2 Fusion8
(prognostic)	Childhood B-cell Acute Lymphoblastic LeukemiaUNRESOLVED	Prognostic	B	Supports Poor Outcome	5	accepted	EID7238 Gene expression profiling of 207 uniformly treated children with high-risk B-progenitor acute lymphoblastic leukemia enrolled in COG P9906 study identified 29/207 (14%) with increased expression of CR… (full text at CIViC) PMID 20139093 · Harvey et al., 2010 · Open in CIViC	civic
(diagnostic)	B Lymphoblastic Leukemia/Lymphoma, BCR-ABL1-Like	Diagnostic	B	Supports Positive	5	accepted	EID11613 The authors performed genomic profiling of 1725 cases of B-lymphoblastic leukemia/lymphoma (B-ALL). Overall, 264 of 1725 B-ALL cases (15.3%) were identified as BCR::ABL1 (Ph)-like based on their expr… (full text at CIViC) PMID 25207766 · Roberts et al., 2014 · Open in CIViC	civic
(prognostic)	Adult B Acute Lymphoblastic LeukemiaALIAS	Prognostic	B	Supports Poor Outcome	4	accepted	EID7212 CRLF2 overexpression was examined in 90 adult B-ALL patients with demographic data that lacked characteristic rearrangements and identified overexpression in 15/90 (16.67%). Disease-free survival was … (full text at CIViC) PMID 20018760 · Yoda et al., 2010 · Open in CIViC	civic
(diagnostic)	B Lymphoblastic Leukemia/Lymphoma, BCR-ABL1-Like	Diagnostic	C	Supports Positive	4	accepted	EID8233 Among 284 cases with Ph-like expression signature who were identified by testing 1389 high-risk cases of pediatric B-ALL, overexpression and rearrangement of CRLF2 were identified in 124 (43.7%). This… (full text at CIViC) PMID 28408464 · Reshmi et al., 2017 · Open in CIViC	civic
(oncogenic)	Childhood B-cell Acute Lymphoblastic LeukemiaUNRESOLVED	Oncogenic	C	Supports Oncogenicity	2	submitted	EID7240 Gene expression profiling of 207 uniformly treated children with high-risk B-progenitor acute lymphoblastic leukemia enrolled in COG P9906 study identified 29/207 (14%) with increased expression of CR… (full text at CIViC) PMID 20139093 · Harvey et al., 2010 · Open in CIViC	civic
(diagnostic)	B Lymphoblastic Leukemia/Lymphoma, BCR-ABL1-Like	Diagnostic	C	Supports Positive	2	accepted	EID11621 B-ALL cases with high-risk clinical features or suggestion of a kinase rearrangement were subjected to low density gene expression array to determine Ph-like status. 2 patients (ages 7.6 and 16.3 yea… (full text at CIViC) PMID 25207766 · Roberts et al., 2014 · Open in CIViC	civic
(functional)	—UNRESOLVED	Functional	D	Supports Gain Of Function	4	submitted	EID7214 Authors identified overexpression of CRLF2 arises from a translocation juxtaposing CRLF2 to the IGH promoter or an interstitial deletion of the PAR1 region. They hypothesize the PAR1 deletion can plac… (full text at CIViC) PMID 19641190 · Russell et al., 2009 · Open in CIViC	civic
Ruxolitinib	Acute Lymphoblastic Leukemia	Predictive	D	Supports Sensitivity Response	3	submitted	EID8540 To investigate the therapeutic potential of JAK inhibitors in Ph-like ALL, the authors examined the efficacy of ruxolitinib in murine xenograft models of 8 pediatric B-ALL cases. Six xenografts (I to … (full text at CIViC) PMID 22955920 · Maude et al., 2012 · Open in CIViC	civic

CRLF2 Fusion8
(diagnostic)	Childhood B-cell Acute Lymphoblastic LeukemiaUNRESOLVED	Diagnostic	B	Supports Positive	5	submitted	EID7065 In a study of B-ALL, 19/272 (7%) patients had a deletion in the pseudoautosomal region resulting in a fusion of P2RY8-CRLF2 and elevated CRLF2 cell surface expression. In addition, 40/75 (53%) patient… (full text at CIViC) PMID 19838194 · Mullighan et al., 2009 · Open in CIViC	civic
(prognostic)	Adult B Acute Lymphoblastic LeukemiaALIAS	Prognostic	B	Supports Poor Outcome	4	submitted	EID7211 CRLF2 overexpression was examined in 90 adult B-ALL patients with demographic data that lacked characteristic rearrangements and identified overexpression in 15/90 (16.67%). Disease-free survival was … (full text at CIViC) PMID 20018760 · Yoda et al., 2010 · Open in CIViC	civic
(diagnostic)	Adult B Acute Lymphoblastic LeukemiaALIAS	Diagnostic	B	Supports Positive	4	submitted	EID7213 CRLF2 overexpression was performed by Q-PCR, IHC, and gene-expression profiling of 254 adult B-ALL samples. CRLF2 overexpression was identified in 15/120 (12.5%) or adult B-ALL cases that lacked chara… (full text at CIViC) PMID 20018760 · Yoda et al., 2010 · Open in CIViC	civic
(prognostic)	B Lymphoblastic Leukemia/LymphomaCURATED_BROADER	Prognostic	B	Supports Poor Outcome	3	submitted	EID6231 CRLF2 overexpression due to P2RY8-CRLF2 fusion or IGH translocation was found in 14% of high risk pediatric B-ALL cases (in the cohort of 209 high-risk patients). 62% of the cases had IGH translocatio… (full text at CIViC) PMID 20139093 · Harvey et al., 2010 · Open in CIViC	civic
(diagnostic)	Childhood B-cell Acute Lymphoblastic LeukemiaUNRESOLVED	Diagnostic	C	Supports Positive	5	submitted	EID6229 P2RY8-CRLF2 fusion is associated with the Ph-like molecular/genetic subtype of B-cell ALL. Approximately half of the Ph-like ALL cases have high CRLF2 expression, with the frequency ranging from 24% a… (full text at CIViC) PMID 25207766 · Roberts et al., 2014 · Open in CIViC	civic
(oncogenic)	Childhood B-cell Acute Lymphoblastic LeukemiaUNRESOLVED	Oncogenic	C	Supports Oncogenicity	5	submitted	EID7239 Gene expression profiling of 207 uniformly treated children with high-risk B-progenitor acute lymphoblastic leukemia enrolled in COG P9906 study identified 29/207 (14%) with increased expression of CR… (full text at CIViC) PMID 20139093 · Harvey et al., 2010 · Open in CIViC	civic
(diagnostic)	Childhood B-cell Acute Lymphoblastic LeukemiaUNRESOLVED	Diagnostic	C	Supports Positive	4	submitted	EID6230 Among 284 cases with Ph-like expression signature who were identified by testing 1389 high-risk cases of pediatric B-ALL, overexpression and rearrangement of CRLF2 (IGH-CRLF2 or P2RY8-CRLF2) were id… (full text at CIViC) PMID 28408464 · Reshmi et al., 2017 · Open in CIViC	civic
〃	B Lymphoblastic Leukemia/Lymphoma, BCR-ABL1-Like	Diagnostic	C	Supports Positive	1	accepted	EID11622 In this 2014 study by Roberts et al., a genomic analysis of 1725 patients with precursor B-cell acute lymphoblastic leukemia (B-ALL) was conducted to define the genetic landscape of the Philadelphia c… (full text at CIViC) PMID 25207766 · Roberts et al., 2014 · Open in CIViC	civic