ABL1 Fusion

CI-VAR-00001251Explore in graph →CIViC 2682

Curated evidence

Evidence by cancer (6 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–6 of 6 evidence items across 3 cancer contexts on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Acute Lymphoblastic Leukemia1
FOXP1::ABL1 Fusion	(diagnostic)	Diagnostic	B	Supports Positive	3	rejected	EID9155 FOXP1-ABL1 fusion was identified in Ph-like ALL PMID 31935290 · Harvey et al., 2020 · Open in CIViC	civic
B Lymphoblastic Leukemia/Lymphoma1
FOXP1::ABL1 Fusion	(prognostic)	Prognostic	D	Supports Poor Outcome	4	rejected	EID9154 This study comprised 127 consecutive patients (age ≥16 years) with newly diagnosed BCP-ALL with available molecular data.The non-response rate, defined as the proportion of patients who had not achiev… (full text at CIViC) PMID 25769542 · Boer et al., 2015 · Open in CIViC

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.

B Lymphoblastic Leukemia/Lymphoma, BCR-ABL1-Like4
FOXP1::ABL1 Fusion	(oncogenic)	Oncogenic	C	Supports Oncogenicity	2	accepted	EID7253 In a 16-year old Caucasian female with B-lymphoblastic leukemia (B-ALL), the t(3;9)(p12;q34) was identified by cytogenetic studies. 5'RACE PCR detected the in-frame FOXP1::ABL1 (exon 19::exon 4) fusio… (full text at CIViC) PMID 21391972 · Ernst et al., 2011 · Open in CIViC	civic
FOXP1::ABL1 Fusion	(prognostic)	Prognostic	C	Supports Poor Outcome	1	accepted	EID7651 The FOXP1::ABL1 fusion was identified in a male patient in a Dutch/German cohort of 77 BCR::ABL1-like cases. The FOXP1::ABL1 fusion was confirmed by PCR and targeted ligation amplification, and was fo… (full text at CIViC) PMID 27894077 · Boer et al., 2017 · Open in CIViC	civic
FOXP1::ABL1 Fusion	(diagnostic)	Diagnostic	C	Supports Positive	1	accepted	EID11615 B-lymphoblastic leukemia/lymphoma (B-ALL) cases with high-risk clinical features or suggestion of a kinase rearrangement were subjected to low density gene expression array to determine BCR::ABL1-like… (full text at CIViC) PMID 25207766 · Roberts et al., 2014 · Open in CIViC	civic
FOXP1::ABL1 Fusion	Dasatinib	Predictive	C	Supports Sensitivity Response	1	accepted	EID7292 A 16-year-old Caucasian boy was diagnosed with B-lymphoblastic leukemia (B-ALL). Karyotype showed an abnormal clone characterized by the t(3;9)(p13;q34.1). This translocation has been shown previously… (full text at CIViC) PMID 30938769 · Yenamandra et al., 2019 · Open in CIViC	civic