ABL1 Fusion

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Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
B Lymphoblastic Leukemia/Lymphoma9
RCSD1::ABL1 Fusion	(diagnostic)	Diagnostic	C	Supports Positive	2	accepted	EID9163 De Braekeleer et al. reported a 11-yr-old boy with pre-B ALL associated with a t(1;9)(q24;q34) translocation. FISH analysis using bacterial artificial chromosome (BAC) clones showed colocalization of … (full text at CIViC) PMID 17541395 · De Braekeleer et al., 2007 · Open in CIViC	civic
RCSD1::ABL1 Fusion	(diagnostic)	Diagnostic	C	Supports Positive	3	accepted	EID9167 Authors studied five patients with B-ALL and potential RCSD1-ABL1 fusion. Patients’ age ranged from 11 to 40 years. Patient 1 was previously reported in PMID 17541395. Sequencing showed that the first… (full text at CIViC) PMID 23168614 · De Braekeleer et al., 2013 · Open in CIViC	civic

Molecular profile

Therapy

Type

Level

Direction · significance

Rating (1–5)

Status

Evidence

Source

B Lymphoblastic Leukemia/Lymphoma9

RCSD1::ABL1 Fusion

(diagnostic)

Diagnostic

Supports Positive

accepted

EID9163

De Braekeleer et al. reported a 11-yr-old boy with pre-B ALL associated with a t(1;9)(q24;q34) translocation. FISH analysis using bacterial artificial chromosome (BAC) clones showed colocalization of … (full text at CIViC)

PMID 17541395 · De Braekeleer et al., 2007 · Open in CIViC

civic

RCSD1::ABL1 Fusion

(diagnostic)

Diagnostic

Supports Positive

accepted

EID9167

Authors studied five patients with B-ALL and potential RCSD1-ABL1 fusion. Patients’ age ranged from 11 to 40 years. Patient 1 was previously reported in PMID 17541395. Sequencing showed that the first… (full text at CIViC)

PMID 23168614 · De Braekeleer et al., 2013 · Open in CIViC

civic

B Lymphoblastic Leukemia/Lymphoma, BCR-ABL1-Like6
RCSD1::ABL1 Fusion	(diagnostic)	Diagnostic	C	Supports Positive	2	accepted	EID9075 This study included 1389 cases of high-risk pediatric B-ALL, of which 284 were identified by TaqMan Low Density Array to have a Ph-like gene expression signature. RT-PCR or RNAseq performed on Ph-like… (full text at CIViC) PMID 28408464 · Reshmi et al., 2017 · Open in CIViC	civic
RCSD1::ABL1 Fusion	(diagnostic)	Diagnostic	C	Supports Positive	2	accepted	EID9162 The study evaluated 15 B-ALL cases which were previously identified as Ph-like using prediction analysis of microarrays (PAM). Paired-end messenger RNA sequencing (RNA-seq) was performed to identify u… (full text at CIViC) PMID 22897847 · Roberts et al., 2012 · Open in CIViC	civic
RCSD1::ABL1 Fusion	(diagnostic)	Diagnostic	C	Supports Positive	1	submitted	EID11618 B-ALL cases with high-risk clinical features or suggestion of a kinase rearrangement were subjected to low density gene expression array to determine Ph-like status. 1 patient (6.9 years old) with a… (full text at CIViC) PMID 25207766 · Roberts et al., 2014 · Open in CIViC	civic
RCSD1::ABL1 Fusion	Dasatinib	Predictive	D	Supports Sensitivity Response	3	accepted	EID7249 The ABL1-RCSD1 fusion was identified in a 6 yo boy with Ph-like B-ALL and hyperleukocytosis. Following standard induction therapy the patient had an MRD of 16.4% in bone marrow, indicating a poor resp… (full text at CIViC) PMID 25207766 · Roberts et al., 2014 · Open in CIViC	civic
RCSD1::ABL1 Fusion	Imatinib	Predictive	C	Supports Sensitivity Response	3	accepted	EID7248 The RCSD1-ABL1 fusion was identified in a 6 yo boy with Ph-like B-ALL (expression signature verified by low density gene expression array) and hyperleukocytosis. Following standard induction therapy t… (full text at CIViC) PMID 25207766 · Roberts et al., 2014 · Open in CIViC	civic
RCSD1::ABL1 Fusion	Tyrosine Kinase Inhibitor	Predictive	C	Supports Sensitivity Response	2	accepted	EID9169 Authors reported a 15-year-old female diagnosed with B-ALL with the t(1;9)(q24;q34.1). RNAseq data were consistent with a fusion between the exon 3 of RCSD1 and exon 4 of ABL1, resulting in the format… (full text at CIViC) PMID 27855558 · Yap et al., 2017 · Open in CIViC	civic

B Lymphoblastic Leukemia/Lymphoma, BCR-ABL1-Like6

RCSD1::ABL1 Fusion

(diagnostic)

Diagnostic

Supports Positive

accepted

EID9075

This study included 1389 cases of high-risk pediatric B-ALL, of which 284 were identified by TaqMan Low Density Array to have a Ph-like gene expression signature. RT-PCR or RNAseq performed on Ph-like… (full text at CIViC)

PMID 28408464 · Reshmi et al., 2017 · Open in CIViC

civic

RCSD1::ABL1 Fusion

(diagnostic)

Diagnostic

Supports Positive

accepted

EID9162

The study evaluated 15 B-ALL cases which were previously identified as Ph-like using prediction analysis of microarrays (PAM). Paired-end messenger RNA sequencing (RNA-seq) was performed to identify u… (full text at CIViC)

PMID 22897847 · Roberts et al., 2012 · Open in CIViC

civic

RCSD1::ABL1 Fusion

(diagnostic)

Diagnostic

Supports Positive

submitted

EID11618

B-ALL cases with high-risk clinical features or suggestion of a kinase rearrangement were subjected to low density gene expression array to determine Ph-like status. 1 patient (6.9 years old) with a… (full text at CIViC)

PMID 25207766 · Roberts et al., 2014 · Open in CIViC

civic

RCSD1::ABL1 Fusion

Dasatinib

Predictive

Supports Sensitivity Response

accepted

EID7249

The ABL1-RCSD1 fusion was identified in a 6 yo boy with Ph-like B-ALL and hyperleukocytosis. Following standard induction therapy the patient had an MRD of 16.4% in bone marrow, indicating a poor resp… (full text at CIViC)

PMID 25207766 · Roberts et al., 2014 · Open in CIViC

civic

RCSD1::ABL1 Fusion

Imatinib

Predictive

Supports Sensitivity Response

accepted

EID7248

The RCSD1-ABL1 fusion was identified in a 6 yo boy with Ph-like B-ALL (expression signature verified by low density gene expression array) and hyperleukocytosis. Following standard induction therapy t… (full text at CIViC)

PMID 25207766 · Roberts et al., 2014 · Open in CIViC

civic

RCSD1::ABL1 Fusion

Tyrosine Kinase Inhibitor

Predictive

Supports Sensitivity Response

accepted

EID9169

Authors reported a 15-year-old female diagnosed with B-ALL with the t(1;9)(q24;q34.1). RNAseq data were consistent with a fusion between the exon 3 of RCSD1 and exon 4 of ABL1, resulting in the format… (full text at CIViC)

PMID 27855558 · Yap et al., 2017 · Open in CIViC

civic

Evidence by cancer (15 items)

Clinical significance (0)