ABL1 Fusion

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Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
B Lymphoblastic Leukemia/Lymphoma2
ZMIZ1::ABL1 Fusion	(oncogenic)	Oncogenic	B	Supports Oncogenicity	3	submitted	EID12638 In a multicentre retrospective cohort study of 122 paediatric patients (aged 1-18 years) with newly diagnosed ABL-class fusion (ABL1 fusion-positive, ABL2 fusion-positive, CSF1R fusion-positive, and P… (full text at CIViC) PMID 33357483 · den Boer et al., 2021 · Open in CIViC	civic
ZMIZ1::ABL1 Fusion	(oncogenic)	Oncogenic	C	Supports Oncogenicity	1	accepted	EID9151 A 18-month-old female with B-cell acute lymphoblastic leukemia. Chromosome and FISH analysis using a BCR-ABL1 probe confirmed the involvement of ABL1 in a t(9;10)(q34;q22.3) translocation. Follow-up m… (full text at CIViC) PMID 18007576 · Soler et al., 2008 · Open in CIViC	civic

Molecular profile

Therapy

Type

Level

Direction · significance

Rating (1–5)

Status

Evidence

Source

B Lymphoblastic Leukemia/Lymphoma2

ZMIZ1::ABL1 Fusion

(oncogenic)

Oncogenic

Supports Oncogenicity

submitted

EID12638

In a multicentre retrospective cohort study of 122 paediatric patients (aged 1-18 years) with newly diagnosed ABL-class fusion (ABL1 fusion-positive, ABL2 fusion-positive, CSF1R fusion-positive, and P… (full text at CIViC)

PMID 33357483 · den Boer et al., 2021 · Open in CIViC

civic

ZMIZ1::ABL1 Fusion

(oncogenic)

Oncogenic

Supports Oncogenicity

accepted

EID9151

A 18-month-old female with B-cell acute lymphoblastic leukemia. Chromosome and FISH analysis using a BCR-ABL1 probe confirmed the involvement of ABL1 in a t(9;10)(q34;q22.3) translocation. Follow-up m… (full text at CIViC)

PMID 18007576 · Soler et al., 2008 · Open in CIViC

civic

B Lymphoblastic Leukemia/Lymphoma, BCR-ABL1-Like7
ZMIZ1::ABL1 Fusion	(prognostic)	Prognostic	B	Supports Better Outcome	4	accepted	EID9149 A multicenter, retrospective, cohort study that included 122 paediatric patients (aged 1-18 years) with newly diagnosed ABL-class fusion B-cell acute lymphocytic leukemia who had not received tyrosine… (full text at CIViC) PMID 33357483 · den Boer et al., 2021 · Open in CIViC	civic
ZMIZ1::ABL1 Fusion	(diagnostic)	Diagnostic	C	Supports Positive	2	accepted	EID9077 This study included 1389 cases of high-risk pediatric B-ALL, of which 284 were identified by TaqMan Low Density Array to have a BCR-ABL1-like (Ph-like) gene expression signature. RT-PCR or RNAseq perf… (full text at CIViC) PMID 28408464 · Reshmi et al., 2017 · Open in CIViC	civic
ZMIZ1::ABL1 Fusion	(diagnostic)	Diagnostic	C	Supports Positive	2	accepted	EID9152 Study comprised 574 children with newly diagnosed B-cell precursor acute lymphoblastic leukemia (BCP-ALL) and focused on B-other/BCR-ABL-like which were identified by hierarchical clustering of gene e… (full text at CIViC) PMID 27894077 · Boer et al., 2017 · Open in CIViC	civic
ZMIZ1::ABL1 Fusion	(diagnostic)	Diagnostic	C	Supports Positive	2	accepted	EID11619 B-ALL cases with high-risk clinical features or suggestion of a kinase rearrangement were subjected to low density gene expression array to determine Ph-like status. 3 of 4 patients (ages 2.2, 2.6, a… (full text at CIViC) PMID 25207766 · Roberts et al., 2014 · Open in CIViC	civic
ZMIZ1::ABL1 Fusion	(oncogenic)	Oncogenic	C	Supports Oncogenicity	2	submitted	EID12635 A study of 204 children with B-cell precursor acute lymphoblastic leukemia from three Dutch trials (DCOG ALL-8, 9, 10) and two German trials (COALL 06-97, 07-03) included 73 cases of BCR-ABL1-like B-A… (full text at CIViC) Open in CIViC	civic
ZMIZ1::ABL1 Fusion	Chemotherapy + DasatinibCombination	Predictive	C	Supports Sensitivity Response	4	submitted	EID11119 An 11 year old female (46,XX) had B-ALL. The patient received a 4-drug induction and end induction day 29 MRD was 5.4%. LDA card was used to analyze the patient and the leukemia was determined to be P… (full text at CIViC) PMID 25207766 · Roberts et al., 2014 · Open in CIViC	civic
ZMIZ1::ABL1 Fusion	Chemotherapy + ImatinibCombination	Predictive	C	Supports Sensitivity Response	4	submitted	EID12615 A pediatric patient had a hematopathologic diagnosis of B-ALL determined through bone marrow aspirate analysis. The patient had a hemoglobin level of 3 g/dL, severe neutropenia, and a normal platelet … (full text at CIViC) PMID 38749501 · Booth et al., 2025 · Open in CIViC	civic

B Lymphoblastic Leukemia/Lymphoma, BCR-ABL1-Like7

ZMIZ1::ABL1 Fusion

(prognostic)

Prognostic

Supports Better Outcome

accepted

EID9149

A multicenter, retrospective, cohort study that included 122 paediatric patients (aged 1-18 years) with newly diagnosed ABL-class fusion B-cell acute lymphocytic leukemia who had not received tyrosine… (full text at CIViC)

PMID 33357483 · den Boer et al., 2021 · Open in CIViC

civic

ZMIZ1::ABL1 Fusion

(diagnostic)

Diagnostic

Supports Positive

accepted

EID9077

This study included 1389 cases of high-risk pediatric B-ALL, of which 284 were identified by TaqMan Low Density Array to have a BCR-ABL1-like (Ph-like) gene expression signature. RT-PCR or RNAseq perf… (full text at CIViC)

PMID 28408464 · Reshmi et al., 2017 · Open in CIViC

civic

ZMIZ1::ABL1 Fusion

(diagnostic)

Diagnostic

Supports Positive

accepted

EID9152

Study comprised 574 children with newly diagnosed B-cell precursor acute lymphoblastic leukemia (BCP-ALL) and focused on B-other/BCR-ABL-like which were identified by hierarchical clustering of gene e… (full text at CIViC)

PMID 27894077 · Boer et al., 2017 · Open in CIViC

civic

ZMIZ1::ABL1 Fusion

(diagnostic)

Diagnostic

Supports Positive

accepted

EID11619

B-ALL cases with high-risk clinical features or suggestion of a kinase rearrangement were subjected to low density gene expression array to determine Ph-like status. 3 of 4 patients (ages 2.2, 2.6, a… (full text at CIViC)

PMID 25207766 · Roberts et al., 2014 · Open in CIViC

civic

ZMIZ1::ABL1 Fusion

(oncogenic)

Oncogenic

Supports Oncogenicity

submitted

EID12635

A study of 204 children with B-cell precursor acute lymphoblastic leukemia from three Dutch trials (DCOG ALL-8, 9, 10) and two German trials (COALL 06-97, 07-03) included 73 cases of BCR-ABL1-like B-A… (full text at CIViC)

Open in CIViC

civic

ZMIZ1::ABL1 Fusion

Chemotherapy + DasatinibCombination

Predictive

Supports Sensitivity Response

submitted

EID11119

An 11 year old female (46,XX) had B-ALL. The patient received a 4-drug induction and end induction day 29 MRD was 5.4%. LDA card was used to analyze the patient and the leukemia was determined to be P… (full text at CIViC)

PMID 25207766 · Roberts et al., 2014 · Open in CIViC

civic

ZMIZ1::ABL1 Fusion

Chemotherapy + ImatinibCombination

Predictive

Supports Sensitivity Response

submitted

EID12615

A pediatric patient had a hematopathologic diagnosis of B-ALL determined through bone marrow aspirate analysis. The patient had a hemoglobin level of 3 g/dL, severe neutropenia, and a normal platelet … (full text at CIViC)

PMID 38749501 · Booth et al., 2025 · Open in CIViC

civic

Chronic Myelomonocytic Leukemia1
ZMIZ1::ABL1 Fusion	Azacitidine + DasatinibCombination	Predictive	C	Supports Sensitivity Response	4	submitted	EID12636 A 60-year-old presented with bloating and shortness of breath. Records showed leukocytosis (white blood cell count of 12 × 109/L) with enlarged spleen. WBC was 16.43 × 10^9/L. abdominal ultrasound sho… (full text at CIViC) PMID 36694063 · Liu et al., 2023 · Open in CIViC	civic

Chronic Myelomonocytic Leukemia1

ZMIZ1::ABL1 Fusion

Azacitidine + DasatinibCombination

Predictive

Supports Sensitivity Response

submitted

EID12636

A 60-year-old presented with bloating and shortness of breath. Records showed leukocytosis (white blood cell count of 12 × 109/L) with enlarged spleen. WBC was 16.43 × 10^9/L. abdominal ultrasound sho… (full text at CIViC)

PMID 36694063 · Liu et al., 2023 · Open in CIViC

civic

Malignant Neoplasm3
ZMIZ1::ABL1 Fusion	(oncogenic)	Oncogenic	D	Supports Oncogenicity	3	submitted	EID11117 BA/F3 cells transfected with ZMIZ1-ABL1 fusion were able to proliferate in the absence of IL3 by multiple orders of magnitude over 8 days, while cells transduced with empty vector failed to proliferat… (full text at CIViC) PMID 25207766 · Roberts et al., 2014 · Open in CIViC	civic
ZMIZ1::ABL1 Fusion	Dasatinib	Predictive	D	Supports Sensitivity Response	3	rejected	EID11118 IL3 indépendant Ba/F3 cells transduced with ZMIZ1-ABL1 driver fusion were treated with dasatinib. ZMIZ1-ABL1 cells had IC50 of 1-2 nM, whereas cells transduced with the driver PAX5-JAK2 were not respo… (full text at CIViC) PMID 25207766 · Roberts et al., 2014 · Open in CIViC	civic
ZMIZ1::ABL1 Fusion	Dasatinib + ImatinibSubstitutes	Predictive	D	Supports Sensitivity Response	3	submitted	EID11120 IL3 indépendant Ba/F3 cells transduced with ZMIZ1-ABL1 driver fusion were treated with dasatinib. ZMIZ1-ABL1 cells had IC50 of 1-2 nM, whereas cells transduced with the driver PAX5-JAK2 were not respo… (full text at CIViC) PMID 25207766 · Roberts et al., 2014 · Open in CIViC	civic

Malignant Neoplasm3

ZMIZ1::ABL1 Fusion

(oncogenic)

Oncogenic

Supports Oncogenicity

submitted

EID11117

BA/F3 cells transfected with ZMIZ1-ABL1 fusion were able to proliferate in the absence of IL3 by multiple orders of magnitude over 8 days, while cells transduced with empty vector failed to proliferat… (full text at CIViC)

PMID 25207766 · Roberts et al., 2014 · Open in CIViC

civic

ZMIZ1::ABL1 Fusion

Dasatinib

Predictive

Supports Sensitivity Response

rejected

EID11118

IL3 indépendant Ba/F3 cells transduced with ZMIZ1-ABL1 driver fusion were treated with dasatinib. ZMIZ1-ABL1 cells had IC50 of 1-2 nM, whereas cells transduced with the driver PAX5-JAK2 were not respo… (full text at CIViC)

PMID 25207766 · Roberts et al., 2014 · Open in CIViC

civic

ZMIZ1::ABL1 Fusion

Dasatinib + ImatinibSubstitutes

Predictive

Supports Sensitivity Response

submitted

EID11120

PMID 25207766 · Roberts et al., 2014 · Open in CIViC

civic

Evidence by cancer (13 items)

Clinical significance (0)