ABL1 Fusion

CI-VAR-00001234Explore in graph →CIViC 2575

Curated evidence

Evidence by cancer (5 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–5 of 5 evidence items across 3 cancer contexts on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
B Lymphoblastic Leukemia/Lymphoma2
ETV6::ABL1 Fusion	Dasatinib	Predictive	C	Supports Sensitivity Response	2	accepted	EID6969 An adult patient (82 yo) who presented with B-ALL (initial WBC of 183,000) with ETV6-ABL1 fusion was treated with dasatinib as a single agent after his chemotherapy had to be stopped due to toxicity. … (full text at CIViC) PMID 25207766 · Roberts et al., 2014 · Open in CIViC	civic
ETV6::ABL1 Fusion	Imatinib	Predictive	C	Supports Sensitivity Response	3	accepted	EID9171 A 4-year-old female presented with relapsed B-cell precursor ALL and no MLL or BCR-ABL1 rearrangement per cytogenetic studies. During multiple periods of short remission and relapse she was treated wi… (full text at CIViC) PMID 30028819 · Mankuzhy et al., 2019 · Open in CIViC	civic

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.

B Lymphoblastic Leukemia/Lymphoma, BCR-ABL1-Like2
ETV6::ABL1 Fusion	(diagnostic)	Diagnostic	B	Supports Positive	4	accepted	EID9073 This study determined the incidence, clinical characteristics and associated genetic abnormalities in hematologic malignancies with the ETV6-ABL1 fusion. The total of 44 new and previously published E… (full text at CIViC) PMID 27229714 · Zaliova et al., 2016 · Open in CIViC	civic
ETV6::ABL1 Fusion	(diagnostic)	Diagnostic	C	Supports Positive	2	submitted	EID11614 B-ALL cases with high-risk clinical features or suggestion of a kinase rearrangement were subjected to low density gene expression array to determine Ph-like status. 2 of 2 patients (ages 5 and 82 ye… (full text at CIViC) PMID 25207766 · Roberts et al., 2014 · Open in CIViC	civic

Myeloid Neoplasm1
ETV6::ABL1 Fusion	Dasatinib + Imatinib + NilotinibSubstitutes	Predictive	B	Supports Sensitivity Response	2	submitted	EID11326 In this study, 18 patients with PCM1-JAK2 (n = 8), BCR-JAK2 (n = 1), and ETV6-ABL1 (n = 9) fusion genes were enrolled. RT-PCR was performed for confirmation of PCM1-JAK2, BCR-JAK2 and ETV6-ABL1 fusion… (full text at CIViC) PMID 32279331 · Schwaab et al., 2020 · Open in CIViC	civic