ABL2 Fusion

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Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Adult B Acute Lymphoblastic Leukemia1
ZC3HAV1::ABL2 Fusion	(oncogenic)	Oncogenic	C	Supports Oncogenicity	2	submitted	EID12963 A 16.6-year-old Taiwanese male (Case #299) with B-ALL harbored a ZC3HAV1(exon 12)::ABL2(exon 2) fusion and concurrent deletions of CDKN2A/2B, PAX5 (exons 2–5), and IKZF1 (exons 2–8). The fusion was de… (full text at CIViC) PMID 33707599 · Hsu et al., 2021 · Open in CIViC	civic
B Acute Lymphoblastic Leukemia1
ZC3HAV1::ABL2 Fusion	Chemotherapy + DasatinibCombination	Predictive	C	Supports Sensitivity Response	2	submitted	EID12969 A 38-year-old male with Ph-negative B ALL was found to harbor a ZC3HAV1 ABL2 rearrangement identified by massively parallel DNA sequencing (MPDS), consistent with a Philadelphia-like genotype. The leu…

Molecular profile

Therapy

Type

Level

Direction · significance

Rating (1–5)

Status

Evidence

Source

Adult B Acute Lymphoblastic Leukemia1

ZC3HAV1::ABL2 Fusion

(oncogenic)

Oncogenic

Supports Oncogenicity

submitted

EID12963

A 16.6-year-old Taiwanese male (Case #299) with B-ALL harbored a ZC3HAV1(exon 12)::ABL2(exon 2) fusion and concurrent deletions of CDKN2A/2B, PAX5 (exons 2–5), and IKZF1 (exons 2–8). The fusion was de… (full text at CIViC)

PMID 33707599 · Hsu et al., 2021 · Open in CIViC

civic

B Acute Lymphoblastic Leukemia1

ZC3HAV1::ABL2 Fusion

Chemotherapy + DasatinibCombination

Predictive

Supports Sensitivity Response

submitted

EID12969

A 38-year-old male with Ph-negative B ALL was found to harbor a ZC3HAV1 ABL2 rearrangement identified by massively parallel DNA sequencing (MPDS), consistent with a Philadelphia-like genotype. The leu…

B Lymphoblastic Leukemia/Lymphoma2
ZC3HAV1::ABL2 Fusion	Imatinib	Predictive	C	Supports Sensitivity Response	3	submitted	EID9804 An 18-year-old male with B-ALL presented with hyperleukocytosis (WBC 171×10⁹/L, 90% blasts). Conventional cytogenetics showed a normal male karyotype (46,XY), and FISH/PCR were negative for ETV6-RUNX1… (full text at CIViC) PMID 31723830 · Decool et al., 2019 · Open in CIViC	civic
ZC3HAV1::ABL2 Fusion	Imatinib	Predictive	C	Supports Sensitivity Response	1	submitted	EID12513 A 27-year-old male (Patient #17, Table 1) with B-ALL harbored a ZC3HAV1(exon 12)::ABL2(exon 2) fusion, concurrent CD200-BTLA and IKZF1 (exons 2–7) deletions, and a gain of chromosome X, presenting wit… (full text at CIViC) PMID 31434701 · Tanasi et al., 2019 · Open in CIViC	civic

B Lymphoblastic Leukemia/Lymphoma2

ZC3HAV1::ABL2 Fusion

Imatinib

Predictive

Supports Sensitivity Response

submitted

EID9804

An 18-year-old male with B-ALL presented with hyperleukocytosis (WBC 171×10⁹/L, 90% blasts). Conventional cytogenetics showed a normal male karyotype (46,XY), and FISH/PCR were negative for ETV6-RUNX1… (full text at CIViC)

PMID 31723830 · Decool et al., 2019 · Open in CIViC

civic

ZC3HAV1::ABL2 Fusion

Imatinib

Predictive

Supports Sensitivity Response

submitted

EID12513

A 27-year-old male (Patient #17, Table 1) with B-ALL harbored a ZC3HAV1(exon 12)::ABL2(exon 2) fusion, concurrent CD200-BTLA and IKZF1 (exons 2–7) deletions, and a gain of chromosome X, presenting wit… (full text at CIViC)

PMID 31434701 · Tanasi et al., 2019 · Open in CIViC

civic

B Lymphoblastic Leukemia/Lymphoma, BCR-ABL1-Like4
ZC3HAV1::ABL2 Fusion	(diagnostic)	Diagnostic	B	Supports Positive	2	submitted	EID13064 An adult patient (>18 years old) with B-ALL harbored an in-frame ZC3HAV1::ABL2 fusion, identified by targeted RNA sequencing, with no IKZF1 deletion, and presented with a white blood cell count of 72 … (full text at CIViC) PMID 33781217 · Norvilas et al., 2021 · Open in CIViC	civic
ZC3HAV1::ABL2 Fusion	(diagnostic)	Diagnostic	C	Supports Positive	2	submitted	EID11620 B-ALL cases with high-risk clinical features or suggestion of a kinase rearrangement were subjected to low density gene expression array to determine Ph-like status. 2 patients (ages 6.4 and 10.4 yea… (full text at CIViC) PMID 25207766 · Roberts et al., 2014 · Open in CIViC	civic
ZC3HAV1::ABL2 Fusion	(diagnostic)	Diagnostic	C	Supports Positive	3	submitted	EID12962 A 10-year-old female (Case #62) with B-ALL harbored a ZC3HAV1::ABL2 fusion and a PAX5 deletion. The fusion was identified by RNA sequencing and confirmed by RT-PCR and Sanger sequencing; breakpoints w… (full text at CIViC) PMID 27265895 · Lilljebjörn et al., 2016 · Open in CIViC	civic
ZC3HAV1::ABL2 Fusion	(prognostic)	Prognostic	C	Supports Poor Outcome	3	submitted	EID13063 A male patient older than 10 years with B-ALL harbored a ZC3HAV1(exon 12)::ABL2(exon 3) fusion and a concomitant IKZF1 deletion, presenting with a white blood cell count >50 × 10⁹/L. He was enrolled o… (full text at CIViC) PMID 29507076 · Tran et al., 2018 · Open in CIViC	civic

B Lymphoblastic Leukemia/Lymphoma, BCR-ABL1-Like4

ZC3HAV1::ABL2 Fusion

(diagnostic)

Diagnostic

Supports Positive

submitted

EID13064

An adult patient (>18 years old) with B-ALL harbored an in-frame ZC3HAV1::ABL2 fusion, identified by targeted RNA sequencing, with no IKZF1 deletion, and presented with a white blood cell count of 72 … (full text at CIViC)

PMID 33781217 · Norvilas et al., 2021 · Open in CIViC

civic

ZC3HAV1::ABL2 Fusion

(diagnostic)

Diagnostic

Supports Positive

submitted

EID11620

B-ALL cases with high-risk clinical features or suggestion of a kinase rearrangement were subjected to low density gene expression array to determine Ph-like status. 2 patients (ages 6.4 and 10.4 yea… (full text at CIViC)

PMID 25207766 · Roberts et al., 2014 · Open in CIViC

civic

ZC3HAV1::ABL2 Fusion

(diagnostic)

Diagnostic

Supports Positive

submitted

EID12962

A 10-year-old female (Case #62) with B-ALL harbored a ZC3HAV1::ABL2 fusion and a PAX5 deletion. The fusion was identified by RNA sequencing and confirmed by RT-PCR and Sanger sequencing; breakpoints w… (full text at CIViC)

PMID 27265895 · Lilljebjörn et al., 2016 · Open in CIViC

civic

ZC3HAV1::ABL2 Fusion

(prognostic)

Prognostic

Supports Poor Outcome

submitted

EID13063

A male patient older than 10 years with B-ALL harbored a ZC3HAV1(exon 12)::ABL2(exon 3) fusion and a concomitant IKZF1 deletion, presenting with a white blood cell count >50 × 10⁹/L. He was enrolled o… (full text at CIViC)

PMID 29507076 · Tran et al., 2018 · Open in CIViC

civic

B Lymphoblastic Leukemia/Lymphoma with Intrachromosomal Amplification of Chromosome 211
ZC3HAV1::ABL2 Fusion	Asciminib + BCR-ABL Inhibitor HS-10382Substitutes	Predictive	D	Supports Sensitivity Response	3	submitted	EID12504 ABL2-rearranged (ABL2r) acute lymphoblastic leukemia (ALL) is a high-risk subtype of Ph-like ALL, typically treated with intensive chemotherapy. The ZC3HAV1::ABL2 fusion is a rare mutation in ABL2r an… (full text at CIViC) PMID 40678005 · Lagonik et al., 2025 · Open in CIViC	civic

B Lymphoblastic Leukemia/Lymphoma with Intrachromosomal Amplification of Chromosome 211

ZC3HAV1::ABL2 Fusion

Asciminib + BCR-ABL Inhibitor HS-10382Substitutes

Predictive

Supports Sensitivity Response

submitted

EID12504

ABL2-rearranged (ABL2r) acute lymphoblastic leukemia (ALL) is a high-risk subtype of Ph-like ALL, typically treated with intensive chemotherapy. The ZC3HAV1::ABL2 fusion is a rare mutation in ABL2r an… (full text at CIViC)

PMID 40678005 · Lagonik et al., 2025 · Open in CIViC

civic

Evidence by cancer (9 items)

Clinical significance (0)