ABL2 Fusion

CI-VAR-00001316Explore in graph →CIViC 3526

Curated evidence

Evidence by cancer (8 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–8 of 8 evidence items across 3 cancer contexts on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
B Lymphoblastic Leukemia/Lymphoma5
RCSD1::ABL2 Fusion	(oncogenic)	Oncogenic	C	N/A N/A	3	rejected	EID9722 Type evidence here PMID 27125982 · Perwein et al., 2016 · Open in CIViC	civic
RCSD1::ABL2 Fusion	(oncogenic)	Oncogenic	C	Supports Oncogenicity	3	submitted	EID9768 In a cohort Dutch/German patients (age <15 years) with B cell precursor acute lymphoblastic leukemia, 14 tyrosine kinase fusions were identified among 77 BCR-ABL1-like cases, and zero were identified … (full text at CIViC) PMID 27894077 · Boer et al., 2017 · Open in CIViC	civic
RCSD1::ABL2 Fusion	(oncogenic)	Oncogenic

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.

B Lymphoblastic Leukemia/Lymphoma, BCR-ABL1-Like2
RCSD1::ABL2 Fusion	Dasatinib	Predictive	D	Supports Sensitivity Response	3	accepted	EID7251 The RCSD1-ABL2 fusion was identified in a 5 yo boy with Ph-like B-ALL and Klinefelter syndrome. Following standard induction therapy the patient had an MRD of 1.2% in bone marrow, and continued to be … (full text at CIViC) PMID 25207766 · Roberts et al., 2014 · Open in CIViC	civic
RCSD1::ABL2 Fusion	Imatinib	Predictive	C	Supports Sensitivity Response	3	submitted	EID9772 A 5 year-old male patient with B-ALL was described with an initial WBC of 57,700 (Supplementary Appendix 2). Chromosome analysis showed 47,XXYc with a confirmed diagnosis of Klinefelter syndrome. FISH… (full text at CIViC) PMID 25207766 · Roberts et al., 2014 · Open in CIViC	civic

Unmapped disease1unmapped disease
RCSD1::ABL2 Fusion	(functional)	Functional	D	Supports Gain Of Function	3	submitted	EID9773 To investigate the functional role and targetability of the tyrosine kinase fusions identified in Ph-like ALL, murine Arf−/− pre-B ALL expressing tyrosine kinase fusions were developed. It showed that… (full text at CIViC) PMID 29296813 · Roberts et al., 2017 · Open in CIViC	civic