BRAF

← targets

Tovorafenibsmall_molecule

—

INHIBITOR

—

Curated

← targets

Sorafenib Tosylatesmall_molecule

—

INHIBITOR

—

Curated

← targets

Sorafenibsmall_molecule

—

INHIBITOR

—

Curated

← targets

Regorafenib Anhydroussmall_molecule

—

INHIBITOR

—

Curated

← targets

Regorafenibsmall_molecule

—

INHIBITOR

—

Curated

← targets

Pan-RAF Inhibitor LY3009120small_molecule

—

INHIBITOR

—

Curated

← targets

Lifirafenibsmall_molecule

—

INHIBITOR

—

Curated

← targets

Encorafenibsmall_molecule

—

INHIBITOR

—

Curated

← targets

Dabrafenibsmall_molecule

—

INHIBITOR

—

Curated

← targets

Belvarafenibsmall_molecule

—

INHIBITOR

—

Curated

← targets

Agerafenibsmall_molecule

—

INHIBITOR

—

Curated

Malignant Neoplasm,Solid Neoplasm,Melanoma+2

BRAF has variant …HAS_VARIANTderived200 of 318show all (up to 200)
→ has variant	V600ESNV 115 accepted CIViC evidence items	—	—	Malignant Neoplasm,Solid Neoplasm,Melanoma+2	115	Curated	civic	graph →
→ has variant	V600 26 accepted CIViC evidence items	—	—	Melanoma,Cutaneous Melanoma,Histiocytic Sarcoma+2	26	Curated	civic	graph →
→ has variant	V600KSNV 14 accepted CIViC evidence items	—	—	Melanoma,Cutaneous Melanoma	14	Curated	civic	graph →
→ has variant	Fusionfusion 13 accepted CIViC evidence items	—	—	Cutaneous Melanoma,Spindle Cell Sarcoma,Childhood Low Grade Glioma+2	13	Curated	civic	graph →
→ has variant	Mutationother 12 accepted CIViC evidence items	—	—	Malignant Neoplasm,Malignant Colorectal Neoplasm	12	Curated	civic	graph →
→ has variant	D594GSNV 8 accepted CIViC evidence items	—	—	Malignant Neoplasm,Cutaneous Melanoma,Malignant Colorectal Neoplasm	8	Curated	civic	graph →
→ has variant	V600DSNV 5 accepted CIViC evidence items	—	—	Melanoma	5	Curated	civic	graph →
→ has variant	Amplificationamplification 4 accepted CIViC evidence items	—	—	Melanoma,Malignant Colorectal Neoplasm	4	Curated	civic	graph →
→ has variant	G466VSNV 4 accepted CIViC evidence items	—	—	Malignant Neoplasm,Solid Neoplasm,Malignant Colorectal Neoplasm	4	Curated	civic	graph →
→ has variant	Fusionfusion 3 accepted CIViC evidence items	—	—	Melanoma	3	Curated	civic	graph →
→ has variant	L597QSNV 3 accepted CIViC evidence items	—	—	Malignant Neoplasm,Cutaneous Melanoma	3	Curated	civic	graph →
→ has variant	D594KSNV 2 accepted CIViC evidence items	—	—	Malignant Colorectal Neoplasm	2	Curated	civic	graph →
→ has variant	Exon 15 Mutation 2 accepted CIViC evidence items	—	—	Gastrointestinal Stromal Tumor	2	Curated	civic	graph →
→ has variant	Fusionfusion 2 accepted CIViC evidence items	—	—	Melanoma,Cutaneous Melanoma	2	Curated	civic	graph →
→ has variant	Fusionfusion 2 accepted CIViC evidence items	—	—	Melanoma	2	Curated	civic	graph →
→ has variant	G469ESNV 2 accepted CIViC evidence items	—	—	Cutaneous Melanoma	2	Curated	civic	graph →
→ has variant	G596RSNV 2 accepted CIViC evidence items	—	—	Malignant Neoplasm,Malignant Colorectal Neoplasm	2	Curated	civic	graph →
→ has variant	intron 10 rearrangementstructural 2 accepted CIViC evidence items	—	—	Malignant Neoplasm,Melanoma	2	Curated	civic	graph →
→ has variant	intron 9 rearrangementstructural 2 accepted CIViC evidence items	—	—	Malignant Neoplasm,Melanoma	2	Curated	civic	graph →
→ has variant	K601ESNV 2 accepted CIViC evidence items	—	—	Cutaneous Melanoma,Malignant Colorectal Neoplasm	2	Curated	civic	graph →
→ has variant	L505HSNV 2 accepted CIViC evidence items	—	—	Melanoma	2	Curated	civic	graph →
→ has variant	L525RSNV 2 accepted CIViC evidence items	—	—	Solid Neoplasm	2	Curated	civic	graph →
→ has variant	L597RSNV 2 accepted CIViC evidence items	—	—	Melanoma,Cutaneous Melanoma	2	Curated	civic	graph →
→ has variant	L597SSNV 2 accepted CIViC evidence items	—	—	Cutaneous Melanoma	2	Curated	civic	graph →
→ has variant	Non-V600 2 accepted CIViC evidence items	—	—	Solid Neoplasm,Malignant Colorectal Neoplasm	2	Curated	civic	graph →
→ has variant	A598VSNV 1 accepted CIViC evidence items	—	—	Melanoma	1	Curated	civic	graph →
→ has variant	A728VSNV 1 accepted CIViC evidence items	—	—	not mapped	1	Curated	civic	graph →
→ has variant	D594ASNV 1 accepted CIViC evidence items	—	—	Cutaneous Melanoma	1	Curated	civic	graph →
→ has variant	D594VSNV 1 accepted CIViC evidence items	—	—	Cutaneous Melanoma	1	Curated	civic	graph →
→ has variant	Fusionfusion 1 accepted CIViC evidence items	—	—	Thyroid Gland Papillary Carcinoma	1	Curated	civic	graph →
→ has variant	Fusionfusion 1 accepted CIViC evidence items	—	—	Melanoma	1	Curated	civic	graph →
→ has variant	Fusionfusion 1 accepted CIViC evidence items	—	—	Cutaneous Melanoma	1	Curated	civic	graph →
→ has variant	Fusionfusion 1 accepted CIViC evidence items	—	—	Transitional Cell Carcinoma	1	Curated	civic	graph →
→ has variant	Fusionfusion 1 accepted CIViC evidence items	—	—	Cutaneous Melanoma	1	Curated	civic	graph →
→ has variant	Fusionfusion 1 accepted CIViC evidence items	—	—	Malignant Pancreatic Neoplasm	1	Curated	civic	graph →
→ has variant	Fusionfusion 1 accepted CIViC evidence items	—	—	Malignant Neoplasm	1	Curated	civic	graph →
→ has variant	Fusionfusion 1 accepted CIViC evidence items	—	—	Childhood Low Grade Glioma	1	Curated	civic	graph →
→ has variant	G463ESNV 1 accepted CIViC evidence items	—	—	Malignant Neoplasm	1	Curated	civic	graph →
→ has variant	G464VSNV 1 accepted CIViC evidence items	—	—	Malignant Neoplasm	1	Curated	civic	graph →
→ has variant	G469 1 accepted CIViC evidence items	—	—	Melanoma	1	Curated	civic	graph →
→ has variant	G469ASNV 1 accepted CIViC evidence items	—	—	Malignant Neoplasm	1	Curated	civic	graph →
→ has variant	G496ASNV 1 accepted CIViC evidence items	—	—	Malignant Neoplasm	1	Curated	civic	graph →
→ has variant	G596CSNV 1 accepted CIViC evidence items	—	—	Lung Non-Small Cell Carcinoma	1	Curated	civic	graph →
→ has variant	G606ESNV 1 accepted CIViC evidence items	—	—	Malignant Neoplasm	1	Curated	civic	graph →
→ has variant	K483MSNV 1 accepted CIViC evidence items	—	—	Cutaneous Melanoma	1	Curated	civic	graph →
→ has variant	L485_P490deldeletion 1 accepted CIViC evidence items	—	—	Malignant Neoplasm	1	Curated	civic	graph →
→ has variant	L597VSNV 1 accepted CIViC evidence items	—	—	Cutaneous Melanoma	1	Curated	civic	graph →
→ has variant	N486_P490deldeletion 1 accepted CIViC evidence items	—	—	Malignant Pancreatic Neoplasm	1	Curated	civic	graph →
→ has variant	N581SSNV 1 accepted CIViC evidence items	—	—	Malignant Neoplasm	1	Curated	civic	graph →
→ has variant	P731TSNV 1 accepted CIViC evidence items	—	—	Malignant Neoplasm	1	Curated	civic	graph →
→ has variant	T599dup 1 accepted CIViC evidence items	—	—	Ganglioglioma	1	Curated	civic	graph →
→ has variant	V600_K601>E 1 accepted CIViC evidence items	—	—	Melanoma	1	Curated	civic	graph →
→ has variant	V600MSNV 1 accepted CIViC evidence items	—	—	Melanoma	1	Curated	civic	graph →
→ has variant	Wildtypeother 1 accepted CIViC evidence items	—	—	Melanoma	1	Curated	civic	graph →
→ has variant	A31GSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	Alterationother no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	APC no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	Asn486_Pro490deldeletion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	Class 2 Mutations no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	Class 3 Mutations no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	D445HSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	D594 no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	D594ESNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	D594HSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	D594NSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	delL485_P490insY no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	DELNVTAPdeletion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	E585KSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	E586KSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	EXON 15 MUTATION no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	F247LSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	F594LSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	F595LSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	Fusionfusion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	Fusionfusion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	Fusionfusion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	G463VSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	G464ESNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	G465ASNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	G466ASNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	G466ESNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	G468ASNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	G469RSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	G469SSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	G469VSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	G593DSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	G596 no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	G596VSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	I326VSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	I462SSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	I463SSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	Inactivating Mutation no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	K439QSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	K439TSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	K600ESNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	K601 no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	Kinase Domain Duplicationinsertion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	L485FSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	L596VSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	L597 no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	N486_P490 no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	N580SSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_004333.6(BRAF):c.1061G>T (p.Arg354Leu)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_004333.6(BRAF):c.1166G>A (p.Arg389His)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_004333.6(BRAF):c.1264C>A (p.Pro422Thr)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_004333.6(BRAF):c.1277G>C (p.Arg426Thr)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_004333.6(BRAF):c.1315-15A>TSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_004333.6(BRAF):c.1315-35T>ASNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_004333.6(BRAF):c.1321C>T (p.Leu441Phe)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_004333.6(BRAF):c.1323T>G (p.Leu441=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_004333.6(BRAF):c.1326T>G (p.Gly442=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_004333.6(BRAF):c.1333G>T (p.Asp445Tyr)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_004333.6(BRAF):c.1335C>T (p.Asp445=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_004333.6(BRAF):c.1337C>A (p.Ser446Ter)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_004333.6(BRAF):c.1338G>T (p.Ser446=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_004333.6(BRAF):c.1339A>T (p.Ser447Cys)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_004333.6(BRAF):c.1342_1343insT (p.Asp448fs)insertion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_004333.6(BRAF):c.1348_1349insC (p.Trp450fs)insertion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_004333.6(BRAF):c.1351dup (p.Glu451fs)insertion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_004333.6(BRAF):c.1351G>A (p.Glu451Lys)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_004333.6(BRAF):c.1353_1354insC (p.Ile452fs)insertion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_004333.6(BRAF):c.1358C>T (p.Pro453Leu)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_004333.6(BRAF):c.1365del (p.Gln456fs)deletion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_004333.6(BRAF):c.1365G>T (p.Gly455=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_004333.6(BRAF):c.1367A>T (p.Gln456Leu)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_004333.6(BRAF):c.1368dup (p.Ile457fs)insertion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_004333.6(BRAF):c.1371del (p.Thr458fs)deletion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_004333.6(BRAF):c.1372A>C (p.Thr458Pro)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_004333.6(BRAF):c.1373del (p.Thr458fs)deletion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_004333.6(BRAF):c.1375_1376insC (p.Val459fs)insertion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_004333.6(BRAF):c.1375dup (p.Val459fs)insertion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_004333.6(BRAF):c.1376T>G (p.Val459Gly)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_004333.6(BRAF):c.1377_1378insT (p.Gly460fs)insertion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_004333.6(BRAF):c.1379del (p.Gly460fs)deletion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_004333.6(BRAF):c.1379G>A (p.Gly460Glu)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_004333.6(BRAF):c.1385G>T (p.Arg462Ile)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_004333.6(BRAF):c.1388T>C (p.Ile463Thr)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_004333.6(BRAF):c.1388T>G (p.Ile463Ser)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_004333.6(BRAF):c.1389T>C (p.Ile463=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_004333.6(BRAF):c.1390G>A (p.Gly464Arg)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_004333.6(BRAF):c.1391G>A (p.Gly464Glu)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_004333.6(BRAF):c.1394C>G (p.Ser465Cys)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_004333.6(BRAF):c.1395del (p.Gly466fs)deletion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_004333.6(BRAF):c.1396G>A (p.Gly466Arg)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_004333.6(BRAF):c.1397G>C (p.Gly466Ala)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_004333.6(BRAF):c.1404_1405del (p.Phe468fs)deletion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_004333.6(BRAF):c.1404T>G (p.Phe468Leu)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_004333.6(BRAF):c.1405_1407del (p.Gly469del)deletion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_004333.6(BRAF):c.1405G>A (p.Gly469Arg)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_004333.6(BRAF):c.1408A>G (p.Thr470Ala)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_004333.6(BRAF):c.1411G>T (p.Val471Phe)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_004333.6(BRAF):c.1413C>T (p.Val471=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_004333.6(BRAF):c.1415A>C (p.Tyr472Ser)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_004333.6(BRAF):c.1415A>G (p.Tyr472Cys)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_004333.6(BRAF):c.1416_1417insT (p.Lys473Ter)insertion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_004333.6(BRAF):c.1426T>G (p.Trp476Gly)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_004333.6(BRAF):c.1428_1429insA (p.His477fs)insertion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_004333.6(BRAF):c.1430A>C (p.His477Pro)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_004333.6(BRAF):c.1432+102C>ASNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_004333.6(BRAF):c.1432+114A>GSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_004333.6(BRAF):c.1432+120A>TSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_004333.6(BRAF):c.1432+128C>TSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_004333.6(BRAF):c.1432+136C>TSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_004333.6(BRAF):c.1432+141A>CSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_004333.6(BRAF):c.1432+142A>CSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_004333.6(BRAF):c.1432+144G>ASNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_004333.6(BRAF):c.1432+157A>GSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_004333.6(BRAF):c.1432+15T>ASNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_004333.6(BRAF):c.1432+176G>CSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_004333.6(BRAF):c.1432+181C>TSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_004333.6(BRAF):c.1432+18deldeletion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_004333.6(BRAF):c.1432+201A>TSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_004333.6(BRAF):c.1432+20A>CSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_004333.6(BRAF):c.1432+20A>GSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_004333.6(BRAF):c.1432+20A>TSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_004333.6(BRAF):c.1432+22A>TSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_004333.6(BRAF):c.1432+230G>ASNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_004333.6(BRAF):c.1432+234T>ASNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_004333.6(BRAF):c.1432+237T>CSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_004333.6(BRAF):c.1432+246A>GSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_004333.6(BRAF):c.1432+276T>GSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_004333.6(BRAF):c.1432+282C>TSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_004333.6(BRAF):c.1432+296T>ASNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_004333.6(BRAF):c.1432+296T>CSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_004333.6(BRAF):c.1432+298T>GSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_004333.6(BRAF):c.1432+304G>TSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_004333.6(BRAF):c.1432+306A>GSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_004333.6(BRAF):c.1432+308T>ASNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_004333.6(BRAF):c.1432+33T>CSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_004333.6(BRAF):c.1432+34C>GSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_004333.6(BRAF):c.1432+34C>TSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_004333.6(BRAF):c.1432+35A>GSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_004333.6(BRAF):c.1432+38A>CSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_004333.6(BRAF):c.1432+3A>TSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_004333.6(BRAF):c.1432+41G>ASNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_004333.6(BRAF):c.1432+43A>TSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_004333.6(BRAF):c.1432+46T>CSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_004333.6(BRAF):c.1432+52A>TSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_004333.6(BRAF):c.1432+65T>GSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_004333.6(BRAF):c.1432+67T>CSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →

BRAF has variant …HAS_VARIANTderived200 of 318show all (up to 200)

→ has variant

V600ESNV

115 accepted CIViC evidence items

—

115

Curated

Melanoma,Cutaneous Melanoma,Histiocytic Sarcoma+2

→ has variant

V600

26 accepted CIViC evidence items

—

Curated

Melanoma,Cutaneous Melanoma

→ has variant

V600KSNV

14 accepted CIViC evidence items

—

Curated

Cutaneous Melanoma,Spindle Cell Sarcoma,Childhood Low Grade Glioma+2

→ has variant

Fusionfusion

13 accepted CIViC evidence items

—

Curated

Malignant Neoplasm,Malignant Colorectal Neoplasm

→ has variant

Mutationother

12 accepted CIViC evidence items

—

Curated

Malignant Neoplasm,Cutaneous Melanoma,Malignant Colorectal Neoplasm

→ has variant

D594GSNV

8 accepted CIViC evidence items

—

Curated

→ has variant

V600DSNV

5 accepted CIViC evidence items

—

Curated

Melanoma,Malignant Colorectal Neoplasm

→ has variant

Amplificationamplification

4 accepted CIViC evidence items

—

Curated

Malignant Neoplasm,Solid Neoplasm,Malignant Colorectal Neoplasm

→ has variant

G466VSNV

4 accepted CIViC evidence items

—

Curated

→ has variant

Fusionfusion

3 accepted CIViC evidence items

—

Curated

Malignant Neoplasm,Cutaneous Melanoma

→ has variant

L597QSNV

3 accepted CIViC evidence items

—

Curated

Malignant Colorectal Neoplasm

→ has variant

D594KSNV

2 accepted CIViC evidence items

—

Curated

Gastrointestinal Stromal Tumor

→ has variant

Exon 15 Mutation

2 accepted CIViC evidence items

—

Curated

Melanoma,Cutaneous Melanoma

→ has variant

Fusionfusion

2 accepted CIViC evidence items

—

Curated

→ has variant

Fusionfusion

2 accepted CIViC evidence items

—

Curated

→ has variant

G469ESNV

2 accepted CIViC evidence items

—

Curated

Malignant Neoplasm,Malignant Colorectal Neoplasm

→ has variant

G596RSNV

2 accepted CIViC evidence items

—

Curated

Malignant Neoplasm,Melanoma

→ has variant

intron 10 rearrangementstructural

2 accepted CIViC evidence items

—

Curated

Malignant Neoplasm,Melanoma

→ has variant

intron 9 rearrangementstructural

2 accepted CIViC evidence items

—

Curated

Cutaneous Melanoma,Malignant Colorectal Neoplasm

→ has variant

K601ESNV

2 accepted CIViC evidence items

—

Curated

→ has variant

L505HSNV

2 accepted CIViC evidence items

—

Curated

→ has variant

L525RSNV

2 accepted CIViC evidence items

—

Solid Neoplasm

Curated

Melanoma,Cutaneous Melanoma

→ has variant

L597RSNV

2 accepted CIViC evidence items

—

Curated

Solid Neoplasm,Malignant Colorectal Neoplasm

→ has variant

L597SSNV

2 accepted CIViC evidence items

—

Curated

→ has variant

2 accepted CIViC evidence items

—

Curated

→ has variant

A598VSNV

1 accepted CIViC evidence items

—

Curated

→ has variant

A728VSNV

1 accepted CIViC evidence items

—

not mapped

Curated

→ has variant

D594ASNV

1 accepted CIViC evidence items

—

Curated

→ has variant

D594VSNV

1 accepted CIViC evidence items

—

Curated

Thyroid Gland Papillary Carcinoma

→ has variant

Fusionfusion

1 accepted CIViC evidence items

—

Curated

→ has variant

Fusionfusion

1 accepted CIViC evidence items

—

Curated

→ has variant

Fusionfusion

1 accepted CIViC evidence items

—

Curated

Transitional Cell Carcinoma

→ has variant

Fusionfusion

1 accepted CIViC evidence items

—

Curated

→ has variant

Fusionfusion

1 accepted CIViC evidence items

—

Curated

Malignant Pancreatic Neoplasm

→ has variant

Fusionfusion

1 accepted CIViC evidence items

—

Curated

→ has variant

Fusionfusion

1 accepted CIViC evidence items

—

Curated

Childhood Low Grade Glioma

→ has variant

Fusionfusion

1 accepted CIViC evidence items

—

Curated

→ has variant

G463ESNV

1 accepted CIViC evidence items

—

Curated

→ has variant

G464VSNV

1 accepted CIViC evidence items

—

Curated

→ has variant

1 accepted CIViC evidence items

—

Curated

→ has variant

G469ASNV

1 accepted CIViC evidence items

—

Curated

→ has variant

G496ASNV

1 accepted CIViC evidence items

—

Curated

Lung Non-Small Cell Carcinoma

→ has variant

G596CSNV

1 accepted CIViC evidence items

—

Curated

→ has variant

G606ESNV

1 accepted CIViC evidence items

—

Curated

→ has variant

K483MSNV

1 accepted CIViC evidence items

—

Curated

→ has variant

L485_P490deldeletion

1 accepted CIViC evidence items

—

Curated

→ has variant

L597VSNV

1 accepted CIViC evidence items

—

Curated

Malignant Pancreatic Neoplasm

→ has variant

N486_P490deldeletion

1 accepted CIViC evidence items

—

Curated

→ has variant

N581SSNV

1 accepted CIViC evidence items

—

Curated

→ has variant

P731TSNV

1 accepted CIViC evidence items

—

Curated

→ has variant

1 accepted CIViC evidence items

—

Curated

→ has variant

1 accepted CIViC evidence items

—

Curated

→ has variant

V600MSNV

1 accepted CIViC evidence items

—

Curated

→ has variant

Wildtypeother

1 accepted CIViC evidence items

—

Curated

→ has variant

A31GSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

Alterationother

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

APC

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

Asn486_Pro490deldeletion

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

Class 2 Mutations

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

Class 3 Mutations

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

D445HSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

D594

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

D594ESNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

D594HSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

D594NSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

delL485_P490insY

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

DELNVTAPdeletion

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

E585KSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

E586KSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

EXON 15 MUTATION

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

F247LSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

F594LSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

F595LSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

Fusionfusion

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

Fusionfusion

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

Fusionfusion

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

G463VSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

G464ESNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

G465ASNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

G466ASNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

G466ESNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

G468ASNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

G469RSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

G469SSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

G469VSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

G593DSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

G596

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

G596VSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

I326VSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

I462SSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

I463SSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

Inactivating Mutation

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

K439QSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

K439TSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

K600ESNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

K601

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

Kinase Domain Duplicationinsertion

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

L485FSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

L596VSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

L597

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

N486_P490

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

N580SSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_004333.6(BRAF):c.1061G>T (p.Arg354Leu)SNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_004333.6(BRAF):c.1166G>A (p.Arg389His)SNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_004333.6(BRAF):c.1264C>A (p.Pro422Thr)SNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_004333.6(BRAF):c.1277G>C (p.Arg426Thr)SNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_004333.6(BRAF):c.1315-15A>TSNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_004333.6(BRAF):c.1315-35T>ASNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_004333.6(BRAF):c.1321C>T (p.Leu441Phe)SNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_004333.6(BRAF):c.1323T>G (p.Leu441=)SNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_004333.6(BRAF):c.1326T>G (p.Gly442=)SNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_004333.6(BRAF):c.1333G>T (p.Asp445Tyr)SNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_004333.6(BRAF):c.1335C>T (p.Asp445=)SNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_004333.6(BRAF):c.1337C>A (p.Ser446Ter)SNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_004333.6(BRAF):c.1338G>T (p.Ser446=)SNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_004333.6(BRAF):c.1339A>T (p.Ser447Cys)SNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

NM_004333.6(BRAF):c.1342_1343insT (p.Asp448fs)insertion

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

NM_004333.6(BRAF):c.1348_1349insC (p.Trp450fs)insertion

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

NM_004333.6(BRAF):c.1351dup (p.Glu451fs)insertion

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_004333.6(BRAF):c.1351G>A (p.Glu451Lys)SNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

NM_004333.6(BRAF):c.1353_1354insC (p.Ile452fs)insertion

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_004333.6(BRAF):c.1358C>T (p.Pro453Leu)SNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

NM_004333.6(BRAF):c.1365del (p.Gln456fs)deletion

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_004333.6(BRAF):c.1365G>T (p.Gly455=)SNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_004333.6(BRAF):c.1367A>T (p.Gln456Leu)SNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

NM_004333.6(BRAF):c.1368dup (p.Ile457fs)insertion

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

NM_004333.6(BRAF):c.1371del (p.Thr458fs)deletion

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_004333.6(BRAF):c.1372A>C (p.Thr458Pro)SNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

NM_004333.6(BRAF):c.1373del (p.Thr458fs)deletion

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

NM_004333.6(BRAF):c.1375_1376insC (p.Val459fs)insertion

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

NM_004333.6(BRAF):c.1375dup (p.Val459fs)insertion

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_004333.6(BRAF):c.1376T>G (p.Val459Gly)SNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

NM_004333.6(BRAF):c.1377_1378insT (p.Gly460fs)insertion

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

NM_004333.6(BRAF):c.1379del (p.Gly460fs)deletion

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_004333.6(BRAF):c.1379G>A (p.Gly460Glu)SNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_004333.6(BRAF):c.1385G>T (p.Arg462Ile)SNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_004333.6(BRAF):c.1388T>C (p.Ile463Thr)SNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_004333.6(BRAF):c.1388T>G (p.Ile463Ser)SNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_004333.6(BRAF):c.1389T>C (p.Ile463=)SNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_004333.6(BRAF):c.1390G>A (p.Gly464Arg)SNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_004333.6(BRAF):c.1391G>A (p.Gly464Glu)SNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_004333.6(BRAF):c.1394C>G (p.Ser465Cys)SNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

NM_004333.6(BRAF):c.1395del (p.Gly466fs)deletion

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_004333.6(BRAF):c.1396G>A (p.Gly466Arg)SNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_004333.6(BRAF):c.1397G>C (p.Gly466Ala)SNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

NM_004333.6(BRAF):c.1404_1405del (p.Phe468fs)deletion

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_004333.6(BRAF):c.1404T>G (p.Phe468Leu)SNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

NM_004333.6(BRAF):c.1405_1407del (p.Gly469del)deletion

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_004333.6(BRAF):c.1405G>A (p.Gly469Arg)SNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_004333.6(BRAF):c.1408A>G (p.Thr470Ala)SNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_004333.6(BRAF):c.1411G>T (p.Val471Phe)SNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_004333.6(BRAF):c.1413C>T (p.Val471=)SNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_004333.6(BRAF):c.1415A>C (p.Tyr472Ser)SNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_004333.6(BRAF):c.1415A>G (p.Tyr472Cys)SNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

NM_004333.6(BRAF):c.1416_1417insT (p.Lys473Ter)insertion

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_004333.6(BRAF):c.1426T>G (p.Trp476Gly)SNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

NM_004333.6(BRAF):c.1428_1429insA (p.His477fs)insertion

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_004333.6(BRAF):c.1430A>C (p.His477Pro)SNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_004333.6(BRAF):c.1432+102C>ASNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_004333.6(BRAF):c.1432+114A>GSNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_004333.6(BRAF):c.1432+120A>TSNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_004333.6(BRAF):c.1432+128C>TSNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_004333.6(BRAF):c.1432+136C>TSNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_004333.6(BRAF):c.1432+141A>CSNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_004333.6(BRAF):c.1432+142A>CSNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_004333.6(BRAF):c.1432+144G>ASNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_004333.6(BRAF):c.1432+157A>GSNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_004333.6(BRAF):c.1432+15T>ASNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_004333.6(BRAF):c.1432+176G>CSNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_004333.6(BRAF):c.1432+181C>TSNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

NM_004333.6(BRAF):c.1432+18deldeletion

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_004333.6(BRAF):c.1432+201A>TSNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_004333.6(BRAF):c.1432+20A>CSNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_004333.6(BRAF):c.1432+20A>GSNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_004333.6(BRAF):c.1432+20A>TSNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_004333.6(BRAF):c.1432+22A>TSNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_004333.6(BRAF):c.1432+230G>ASNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_004333.6(BRAF):c.1432+234T>ASNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_004333.6(BRAF):c.1432+237T>CSNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_004333.6(BRAF):c.1432+246A>GSNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_004333.6(BRAF):c.1432+276T>GSNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_004333.6(BRAF):c.1432+282C>TSNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_004333.6(BRAF):c.1432+296T>ASNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_004333.6(BRAF):c.1432+296T>CSNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_004333.6(BRAF):c.1432+298T>GSNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_004333.6(BRAF):c.1432+304G>TSNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_004333.6(BRAF):c.1432+306A>GSNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_004333.6(BRAF):c.1432+308T>ASNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_004333.6(BRAF):c.1432+33T>CSNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_004333.6(BRAF):c.1432+34C>GSNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_004333.6(BRAF):c.1432+34C>TSNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_004333.6(BRAF):c.1432+35A>GSNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_004333.6(BRAF):c.1432+38A>CSNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_004333.6(BRAF):c.1432+3A>TSNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_004333.6(BRAF):c.1432+41G>ASNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_004333.6(BRAF):c.1432+43A>TSNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_004333.6(BRAF):c.1432+46T>CSNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_004333.6(BRAF):c.1432+52A>TSNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_004333.6(BRAF):c.1432+65T>GSNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

NM_004333.6(BRAF):c.1432+67T>CSNV

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

BRAF altered in cohorts of …ALTERED_INderived11 of 11
→ altered in cohorts of	Thyroid Gland Carcinoma 302 / 507 cases (60 %) · ssm · TCGA-THCA	—	—	Thyroid Gland Carcinoma	1	Observed	gdc	graph →
→ altered in cohorts of	Thyroid Gland Papillary Carcinomasubtype 293 / 496 cases (59 %) · ssm · thpa_tcga_gdc · largest of 4 cohorts	—	—	Thyroid Gland Papillary Carcinoma	4	Observed	cbioportal	graph →
→ altered in cohorts of	Cutaneous Melanomacancer 301 / 696 cases (43 %) · ssm · mel_mskimpact_2020 · largest of 12 cohorts	—	—	Cutaneous Melanoma	12	Observed	cbioportal	graph →
→ altered in cohorts of	Melanomacancer_family 56 / 144 cases (39 %) · ssm · mel_dfci_2019 · largest of 3 cohorts	—	—	Melanoma	3	Observed	cbioportal	graph →
→ altered in cohorts of	Histiocytic and Dendritic Cell Neoplasm 224 / 1,270 cases (18 %) · ssm · hdcn_msk_2025	—	—	Histiocytic and Dendritic Cell Neoplasm	1	Observed	cbioportal	graph →
→ altered in cohorts of	Colon Adenocarcinoma 61 / 429 cases (14 %) · ssm · coad_tcga_gdc · largest of 2 cohorts	—	—	Colon Adenocarcinoma	2	Observed	cbioportal	graph →
→ altered in cohorts of	Colorectal Adenocarcinoma 133 / 1,134 cases (12 %) · ssm · crc_msk_2017 · largest of 6 cohorts	—	—	Colorectal Adenocarcinoma	6	Observed	cbioportal	graph →
→ altered in cohorts of	Rectal Adenocarcinoma 813 / 7,237 cases (11 %) · ssm · crc_msk_2026	—	—	Rectal Adenocarcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Multiple Myeloma 69 / 961 cases (7.2 %) · ssm · MMRF-COMMPASS	—	—	Multiple Myeloma	1	Observed	gdc	graph →
→ altered in cohorts of	Intrahepatic Cholangiocarcinoma 26 / 412 cases (6.3 %) · ssm · ihch_msk_2021	—	—	Intrahepatic Cholangiocarcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Lung Adenocarcinoma 50 / 915 cases (5.5 %) · ssm · lung_msk_2017 · largest of 5 cohorts	—	—	Lung Adenocarcinoma	5	Observed	cbioportal	graph →

BRAF altered in cohorts of …ALTERED_INderived11 of 11

→ altered in cohorts of

Thyroid Gland Carcinoma

302 / 507 cases (60 %) · ssm · TCGA-THCA

—

Thyroid Gland Carcinoma

Observed

gdc