BRAF L485F

CI-VAR-00002352Explore in graph →CIViC 2804

Curated evidence

Evidence by cancer (1 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–1 of 1 evidence items across 1 cancer context on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Unmapped disease1unmapped disease
BRAF L485F	(functional)	Functional	D	Supports Gain Of Function	4	submitted	EID7579 BRAF L485F led to strongly activated ERK signaling. This activation was abrogated by BRAF R509H (a variant thought to impair BRAF dimerization), indicating that BRAF L485F requires dimerization to sig… (full text at CIViC) PMID 31515458 · Yaeger et al., 2019 · Open in CIViC	civic

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.