Variant · Insertion
BRAF Kinase Domain Duplication
CI-VAR-00002191Explore in graph →CIViC 5194
Curated evidence
Evidence by cancer (3 items)
Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 26562024
- Run
- ING-CIVIC-20260908-000001
| Molecular profile | Therapy | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| Acinar Cell Carcinoma1 | ||||||||
| BRAF Kinase Domain Duplication | Regorafenib | Predictive | C | Supports Sensitivity Response | 4 | submitted | EID12470A 30 year old women with advanced acinic cell tumor of the right parotid gland had her disease progressed after initial systemic chemotherapy, followed by empirical erlotinib hydrochloride therapy. Pr… (full text at CIViC) PMID 26562024 · Klempner et al., 2016 · Open in CIViC | civic |
| Childhood Visual Pathway Glioma1 | ||||||||
| BRAF Kinase Domain Duplication | (oncogenic) | Oncogenic | B | Supports Oncogenicity | 4 | submitted | EID12471Fluorescence in situ hybridization (FISH) studies were performed using home brew probes targeting 3′ BRAF, 5′ BRAF, and a commercial CEP7 probe on 59 patients with optic nerve glioma. Duplication of t… (full text at CIViC) | |
ClinVar
Clinical significance (0)
ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.
Data not yet available