Variant · Snv
BRAF G469A
CI-VAR-00001750Explore in graph →NP_004324.2:p.Gly469AlaNM_004333.4:c.1406G>CClinVar 13971 CIViC 992 rs121913355
Curated evidence
Evidence by cancer (9 items)
Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 31502118
- Run
- ING-CIVIC-20260908-000001
| Molecular profile | Therapy | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| Lung Adenocarcinoma2 | ||||||||
| BRAF G469A | Osimertinib | Predictive | D | Supports Resistance | 5 | rejected | EID10514PC9 cells harboring an in-frame deletion in exon 19 of the EGFR gene were cultured in the presence of increasing concentrations of osimertinib. Three clones resistant to osimertinib were isolated and … (full text at CIViC) PMID 31502118 · La Monica et al., 2019 · Open in CIViC | civic |
| BRAF G469A | Osimertinib | Predictive | D | Supports Resistance | 5 | rejected | EID10515PC9 cells harboring an in-frame deletion in exon 19 of the EGFR gene were cultured in the presence of increasing concentrations of osimertinib. Three clones resistant to osimertinib were isolated and … (full text at CIViC) PMID 31502118 · La Monica et al., 2019 · Open in CIViC | civic |
ClinVar
Clinical significance (1)
ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.
- Source
- NCBI ClinVar (variant_summary)
- Dataset
- ClinVar variant_summary
- Version
- 2026-09-06
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- database
- License
- Public domain (US Government work, NCBI/NLM); acknowledgment requested
- Run
- ING-CLINVAR-20260908-000001
| Variation | Clinical significance | Review status | Stars | Conditions | Origin | Submitters | Last evaluated | Source |
|---|---|---|---|---|---|---|---|---|
| 13971 | Pathogenic | criteria provided, single submitter | 1 | Non-Hodgkin lymphoma; Non-small cell lung carcinoma; Ganglioglioma; Nasopharyngeal carcinoma; Neoplasm; Neuroblastoma | somatic | 4 | Aug 25, 2014 | clinvar |