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Hairy Cell Leukemia · CancerIndex

Cancers
Neoplasm
Neoplasm by Special Category
Malignant Neoplasm
B-Cell Malignant Neoplasm
Hairy Cell Leukemia

Hematologic Malignancy

Hairy Cell Leukemia

CI-CAN-00000949HCLExplore in graph →

Hematologic21 active trials2 approved drugs3 evidence items

NCIt: C7402
OncoTree: HCL
DOID: 285
UMLS CUI: C0023443
MeSH: D007943

Overview
Statistics
Survival
Genomics
Variants & evidence3
Drugs1
Trials103
Research
Rankings
Sources & provenance

Data completeness4 / 7 dimensions

Epidemiology (no data yet)
Survival (no data yet)
Trials (data present)
Literature (data present)
Genomics (no data yet)
Evidence (data present)
Therapies (data present)

Computed from entity_counters.completeness · refreshed after each connector run

Definition

What this entity is

A neoplasm of small B-lymphocytes with "hairy" projections in bone marrow, spleen, and peripheral blood. Most patients present with splenomegaly and pancytopenia. (WHO, 2001)

Definition text as published by ncit-evsProvenance

Source: NCI Thesaurus (NCIt)
Dataset: NCI Thesaurus
Version: 26.08e
Retrieved: Sep 8, 2026
Layer: raw (as published)
Evidence: expert curation
License: CC BY 4.0
Run: ING-NCITEVS-20260908-000001

Open at source Curated

Data updated 22 days agoSource updated 26.08e

Taxonomy

Position in the hierarchies

Several hierarchies coexist; edges are listed per hierarchy type with their source.

Parents

ncit

B-Cell Malignant NeoplasmCancer Family
Chronic LeukemiaHematologic Malignancy
Lymphoid LeukemiaHematologic Malignancy
Mature B-Cell NeoplasmHematologic Malignancy

oncotree

B-Cell Non-Hodgkin LymphomaHematologic Malignancy

Children (1)

ncit

Splenic Manifestation of Hairy Cell Leukemia

Anatomy

Anatomical sites

Hematopoietic and Lymphatic SystemC35813

Record

Identity

CancerIndex ID: CI-CAN-00000949
Entity type: Hematologic Malignancy
Malignant: Yes
Solid / hematologic: Hematologic
Pediatric relevant: Not flagged
Rare cancer: Unknown (no incidence data yet)
Hierarchy depth: 4
Classification version: 26.08e
Semantic types: Neoplastic Process
Status: Active
Record updated: 2026-09-08

Coverage

Data completeness

Trials (all / active)

103 / 21

Publications (all / 5y)

4,343 / 180

Evidence items

3

Genes / variants

2 / 2

Drugs (any / approved)

1 / 2

Genomic cohorts

0

Epidemiology / survival obs.

0 / 0

Data updated 12 minutes agoSource updated unknowncounters aggregate over descendants

Names

Synonyms (4)

Leukemia, Hairy Cellmesh_heading · MeSH
Hairy Cell Leukemiasynonym · OncoTree
Leukemic Reticuloendotheliosessynonym · MeSH
Leukemic Reticuloendotheliosissynonym · NCIt

CancerIndex is a research and information platform. It does not diagnose and does not recommend treatment.

Key figures

At a glance

Each figure carries its unit, period and source; ranks link to "Why this rank?".

US deaths23,740countUnited States · 2024 · both sexes · all agescdc-wonderObservedrank #7 of 31 (USA · both sexes · all ages · 2024 · top-level cancers)figures shown for Leukemia (registry level) — open Leukemia
US new cases58,254countUnited States · 2023 · both sexes · all agescdc-uscsObservedrank #11 of 32 (USA · both sexes · all ages · 2023 · top-level cancers)figures shown for Leukemia (registry level) — open Leukemia
US age-standardized mortality5.5per 100,000United States · 2024 · both sexes · all ages · 2000 U.S. Std. Populationcdc-wonderObservedrank #6 of 23 (USA · both sexes · all ages · 2024 · top-level cancers)figures shown for Leukemia (registry level) — open Leukemia
Active trials21countcurrent registry status · entity + descendantsclinicaltrialsComputedrank #428 of 1,654 (World · both sexes · all ages · latest · all malignant entities)
Recruiting trials9countstatus RECRUITING · entity + descendantsclinicaltrialsComputedrank #452 of 1,277 (World · both sexes · all ages · latest · all malignant entities)
Curated evidence items3countaccepted CIViC items · entity + descendantscivicComputedrank #300 of 492 (World · both sexes · all ages · latest · all malignant entities)
Publications, last 12 months19countPubMed records · stored query · 12-month windowpubmedComputedrank #744 of 2,294 (World · both sexes · all ages · latest · all malignant entities)
Genomic cohorts0countopen GDC projects · entity + descendantsgdcComputednot in a current ranking snapshot

Data updated 12 minutes agoSource updated unknownregistry figures: cdc-uscs · latest year available per metric · counters aggregate over descendants