BRAF L597R

CI-VAR-00002369Explore in graph →NP_004324.2:p.Leu597ArgNM_004333.4:c.1790T>GClinVar 13968 CIViC 288 rs121913366

Curated evidence

Evidence by cancer (3 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–3 of 3 evidence items across 3 cancer contexts on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Cutaneous Melanoma1
BRAF L597R	Trametinib + VemurafenibSubstitutes	Predictive	D	Supports Sensitivity Response	2	accepted	EID1458 Preclinical study in 293H cell line. Ectopic expression of V600E, L597R/Q/S, and K601E mutants elevated phospho-MEK and ERK levels. Vemurafenib treatment of all of the BRAF mutant–expressing cells led… (full text at CIViC) PMID 22798288 · Dahlman et al., 2012 · Open in CIViC	civic
Melanoma1
BRAF L597R	Vemurafenib	Predictive	C	Supports Sensitivity Response	4	accepted	EID728 A case report of a patient with BRAF L597R mutation and clinical response to BRAF-inhibition (Vemurafenib) that correlated to in-vitro models. PMID 23715574 ·

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
13968	Pathogenic	no assertion criteria provided	0	Lung adenocarcinoma; Neuroblastoma	somatic	2	Aug 15, 2003	clinvar

Multinodular and Vacuolated Neuronal Tumor1
BRAF L597R	(diagnostic)	Diagnostic	C	Supports Positive	2	submitted	EID12459 In a 54-year-old female with chronic headache and a right temporal lobe MVNT, NGS (479-gene panel) identified a BRAF p.L597R mutation (NM_004333.6:c.1790T>G; VAF 5%). PMID 29428973 · Pekmezci et al., 2018 · Open in CIViC	civic