Variant · Fusion
BRAF Fusion
CI-VAR-00001166Explore in graph →CIViC 184
Curated evidence
Evidence by cancer (2 items)
Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 15630448
- Run
- ING-CIVIC-20260908-000001
| Molecular profile | Therapy | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| Thyroid Gland Papillary Carcinoma1 | ||||||||
| AKAP9::BRAF Fusion | (diagnostic) | Diagnostic | B | Supports Positive | 4 | accepted | EID462The AKAP9-BRAF fusion gene was found in 3/28 tumor samples of radiation-associated papillary thyroid carcinoma, and no samples of non-radiation associated papillary thyroid carcinoma. This fusion was … (full text at CIViC) PMID 15630448 · Ciampi et al., 2005 · Open in CIViC | civic |
| Large Congenital Melanocytic Nevus1unmapped disease | ||||||||
| AKAP9::BRAF Fusion | Trametinib | Predictive | C | Supports Sensitivity Response | 3 | submitted | EID7759Case report of a 7-year-old girl with a giant congenital melanocytic nevus that had an AKAP9-BRAF fusion and was treated with trametinib, which resulted in rapid resolution of the patient's pain and p… (full text at CIViC) | |
ClinVar
Clinical significance (0)
ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.
Data not yet available